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Publisher Correction: A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(10):1149]

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MiR-199a-3p/5p participated in TGF-β and EGF induced EMT by targeting DUSP5/MAP3K11 in pterygium.

Siying He, Yifang Huang, Shiqi Dong, Chen Qiao, Guohua Yang, Shuai Zhang, Chen Wang, Yuting Xu, Fang Zheng, Ming Yan,

BACKGROUND:Recently, it has been reported that miRNA is involved in pterygium, however the exact underlying mechanism in pterygium is unrevealed and require further investigation. METHODS:The differential expression of miRNA in pterygium was profiled using microarray and validated with quantitative real-time polymerase chain reaction (qRT-PCR). Human conjunctival epithelial cells (HCEs) were ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):332]

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PDPK1 regulates autophagosome biogenesis by binding to PIK3C3.

Boli Hu, Yina Zhang, Tingjuan Deng, Jinyan Gu, Juan Liu, Hui Yang, Yuting Xu, Yan Yan, Fan Yang, Heng Zhang, Yulan Jin, Jiyong Zhou,

PDPK1 (3-phosphoinositide dependent protein kinase 1) is a phosphorylation-regulated kinase that plays a central role in activating multiple signaling pathways and cellular processes. Here, this study shows that PDPK1 turns on macroautophagy/autophagy as a SUMOylation-regulated kinase. In vivo data demonstrate that the SUMO modification of PDPK1 is a physiological feature ... Read more >>

Autophagy (Autophagy)
[2020, :1-18]

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Outcome of Hypotensive Trauma Patients by Time and Day of Arrival.

Adrian W Ong, Jacqueline Stephenson, Krista J Gile, Rachel A Aronow, Xiaoyun Wang, Yuting Xu, Niels D Martin, Patrick K Kim, Forrest B Fernandez,

BACKGROUND:Although most studies of trauma patients have not demonstrated a "weekend" or "night" effect on mortality, outcomes of hypotensive (systolic blood pressure <90 mm Hg) patients have not been studied. We sought to evaluate whether outcomes of hypotensive patients were associated with admission time and day. METHODS:We retrospectively analyzed patients from ... Read more >>

J Surg Res (The Journal of surgical research)
[2020, 258:113-118]

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Immunohistochemical study of STAT3, HIF-1α and VEGF in pterygium and normal conjunctiva: Experimental research and literature review.

Shiqi Dong, Xiying Wu, Yuting Xu, Guohua Yang, Ming Yan,

Purpose:Signal transducer and activator of transcription 3 (STAT3) is a DNA-binding protein that regulates various biologic processes, including cell growth, apoptosis, and malignant transformation. Abnormal activation of STAT3 is associated with many diseases, and there is currently no relevant study on the pathogenesis of pterygium. The purpose of this study ... Read more >>

Mol. Vis. (Molecular vision)
[2020, 26:510-516]

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A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

Mass spectrometry-based discovery proteomics is an essential tool for the proximal readout of cellular drug action. Here, we apply a robust proteomic workflow to rapidly profile the proteomes of five lung cancer cell lines in response to more than 50 drugs. Integration of millions of quantitative protein-drug associations substantially improved ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1111-1119]

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Mitochondrial replacement in macaque monkey offspring by first polar body transfer.

Zhanyang Wang, Yuzhuo Li, Xianfa Yang, Yan Wang, Yanhong Nie, Yuting Xu, Xiaotong Zhang, Yong Lu, Tikui Zhang, Qiming Liu, Naihe Jing, Zhen Liu, Qiang Sun,

Cell Res. (Cell research)
[2020, :]

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MiR-199a-3p/5p participated in TGF-β and EGF induced EMT by targeting DUSP5/MAP3K11 in pterygium

Siying He, Yifang Huang, Shiqi Dong, Chen Qiao, Guohua Yang, Shuai Zhang, Chen Wang, Yuting Xu, Fang Zheng, Ming Yan,

Abstract Background Recently, it has been reported that miRNA is involved in pterygium, however the exact underlying mechanism in pterygium is unrevealed and require further investigation. Methods The differential expression of miRNA in pterygium was profiled using microarray and validated with quantitative real-time polymerase chain reaction(qRT-PCR). Human conjunctival ... Read more >>

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Deep Dive into Machine Learning Models for Protein Engineering.

Yuting Xu, Deeptak Verma, Robert P Sheridan, Andy Liaw, Junshui Ma, Nicholas M Marshall, John McIntosh, Edward C Sherer, Vladimir Svetnik, Jennifer M Johnston,

Protein redesign and engineering has become an important task in pharmaceutical research and development. Recent advances in technology have enabled efficient protein redesign by mimicking natural evolutionary mutation, selection, and amplification steps in the laboratory environment. For any given protein, the number of possible mutations is astronomical. It is impractical ... Read more >>

J Chem Inf Model (Journal of chemical information and modeling)
[2020, 60(6):2773-2790]

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Vinculin presents unfavorable prediction in ovarian cancer and prevents proliferation and migration of ovarian cancer cells.

Fei Wang, Meixia Fang, Min Kong, Changhe Wang, Yuting Xu,

The influences of Vinculin on many cancers were blurry, including ovarian cancer. Thus, we concentrated on the efficient role of Vinculin in ovarian cancer and explored the potential mechanism(s). Expression of Vinculin in ovarian cancer tissues and cell lines was investigated by real-time polymerase chain reaction, immunohistochemistry, and Western blot. ... Read more >>

J. Biochem. Mol. Toxicol. (Journal of biochemical and molecular toxicology)
[2020, :e22525]

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Comparison of Different Colorectal Cancer With Liver Metastases Models Using Six Colorectal Cancer Cell Lines.

Yuting Xu, Lin Zhang, Qingling Wang, Maojin Zheng,

At present, modeling methods of colorectal cancer with liver metastases have significant limitations. Here, we established orthotopic and ectopic hepatic metastases models using six colorectal cancer cell lines to choose an ideal animal model for studying colorectal cancer growth and liver metastases. Luciferin-expressing six colorectal cancer cell lines were used ... Read more >>

Pathol. Oncol. Res. (Pathology oncology research : POR)
[2020, 26(4):2177-2183]

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Development of an electrochemical biosensor for phylogenetic analysis of Amaryllidaceae based on the enhanced electrochemical fingerprint recorded from plant tissue.

Li Fu, Yuhong Zheng, Pengcong Zhang, Haoyang Zhang, Yuting Xu, Jingtao Zhou, Huaiwei Zhang, Hassan Karimi-Maleh, Guosong Lai, Shichao Zhao, Weitao Su, Jinhong Yu, Cheng-Te Lin,

A biosensor has been developed based on disposable screen-printed electrode for recording the electrochemical fingerprint of plant leaf tissue. A thin layer of polydopamine functionalized graphene sheets was coated on the plant tissue modified electrode for signal enhancement. The voltammetric data recorded under different buffer solutions can be derived as ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2020, 159:112212]

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A review of microplastics in the aquatic environmental: distribution, transport, ecotoxicology, and toxicological mechanisms.

Jia Du, Shaodan Xu, Qingwei Zhou, Huanxuan Li, Li Fu, Junhong Tang, Yangyang Wang, Xu Peng, Yuting Xu, Xinpeng Du,

The interactions between microplastics (MPs) and aquatic organisms are becoming increasingly frequent due to the extensive distribution of MPs in aquatic environments. MPs from the aquatic environment tend to accumulate and move through living organisms. Therefore, MPs can affect human health though the food chain and human consumption. In this ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, 27(11):11494-11505]

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A Deep Learning Approach for Automated Sleep-Wake Scoring in Pre-Clinical Animal Models.

Vladimir Svetnik, Ting-Chuan Wang, Yuting Xu, Bryan J Hansen, Steven V Fox,

BACKGROUND:Experimental investigation of sleep-wake dynamics in animals is an important part of pharmaceutical development. Typically, it involves recording of electroencephalogram, electromyogram, locomotor activity, and electrooculogram. Visual identification, or scoring, of the sleep-wake states from these recordings is time-consuming. We sought to develop software for automated sleep-wake scoring capable of processing ... Read more >>

J. Neurosci. Methods (Journal of neuroscience methods)
[2020, 337:108668]

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Experimental Error, Kurtosis, Activity Cliffs, and Methodology: What Limits the Predictivity of Quantitative Structure-Activity Relationship Models?

Robert P Sheridan, Prabha Karnachi, Matthew Tudor, Yuting Xu, Andy Liaw, Falgun Shah, Alan C Cheng, Elizabeth Joshi, Meir Glick, Juan Alvarez,

Given a particular descriptor/method combination, some quantitative structure-activity relationship (QSAR) datasets are very predictive by random-split cross-validation while others are not. Recent literature in modelability suggests that the limiting issue for predictivity is in the data, not the QSAR methodology, and the limits are due to activity cliffs. Here, we ... Read more >>

J Chem Inf Model (Journal of chemical information and modeling)
[2020, 60(4):1969-1982]

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UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop.

Xu Liu, Fei Ma, Chunxiao Liu, Kaiyuan Zhu, Wenjie Li, Yuting Xu, Ge Li, Zhenbo Niu, Jiaxin Liu, Du Chen, Zhigao Li, Yingqiang Fu, Cheng Qian,

Ubiquitin-conjugating enzyme E2O (UBE2O) is a large E2 ubiquitin-conjugating enzyme that possesses both E2 and E3 ligase activities. Ectopic UBE2O overexpression is associated with a variety of human diseases, especially cancers. However, the expression profile and functional biology of UBE2O in human breast cancer (BC) remain unclear. In this study, ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(1):10]

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Binding of Avibirnavirus VP3 to the PIK3C3-PDPK1 complex inhibits autophagy by activating the AKT-MTOR pathway.

Yina Zhang, Boli Hu, Yahui Li, Tingjuan Deng, Yuting Xu, Jing Lei, Jiyong Zhou,

Macroautophagy/autophagy is a host natural defense response. Viruses have developed various strategies to subvert autophagy during their life cycle. Recently, we revealed that autophagy was activated by binding of Avibirnavirus to cells. In the present study, we report the inhibition of autophagy initiated by PIK3C3/VPS34 via the PDPK1-dependent AKT-MTOR pathway. ... Read more >>

Autophagy (Autophagy)
[2020, 16(9):1697-1710]

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Sinomenine hydrochloride exerts antitumor outcome in ovarian cancer cells by inhibition of long non-coding RNA HOST2 expression.

Yuting Xu, Tao Jiang, Changhe Wang, Fei Wang,

Background: Accumulating evidence displays that sinomenine hydrochloride (SH) are utilised to treat a variety of cancers. Nevertheless, the influences of SH on ovarian cancer stay blurry. We endeavoured to uncover the antitumor effects of SH on ovarian cancer and underlying mechanism(s).Methods: Human ovarian epithelial cell line (HOEpiC), Caov3 and SKOV3 ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2019, 47(1):4131-4138]

Cited: 1 time

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Infrageneric phylogenetics investigation of Chimonanthus based on electroactive compound profiles.

Yuting Xu, Yijun Lu, Pengchong Zhang, Yangyang Wang, Yuhong Zheng, Li Fu, Huaiwei Zhang, Cheng-Te Lin, Aimin Yu,

Voltammetric scan can record the profile of electrochemical active substances in plant tissues. Because the distribution of chemical components in plants is controlled by genes, these profiles can reflect differences at the genetic level in different species. In this study, the voltammetric scan was applied to the investigation of macrophanerophytes ... Read more >>

Bioelectrochemistry (Bioelectrochemistry (Amsterdam, Netherlands))
[2020, 133:107455]

Cited: 1 time

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Simultaneously performing optical and electrical responses from a plasmonic sensor based on gold/silicon Schottky junction.

Bowen Sui, Yuting Xu, Ziwei Wang, Cheng Zhang, Linling Qin, Xiaofeng Li, Shaolong Wu,

Making the chemical or biological sensors simpler and more compatible with other measurements is a key enabling technology for commercial application. In this work, we propose a plasmonic refractive-index sensor only based on gold/silicon Schottky junction to simultaneously perform optical and electrical read-out responses. Via exciting surface plasmon resonance (SPR), ... Read more >>

Opt Express (Optics express)
[2019, 27(26):38382-38390]

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Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas.

WenChao Gao, YuTing Xu, Tao Chen, ZunGuo Du, XiuJuan Liu, ZhiQian Hu, Dong Wei, ChunFang Gao, Wei Zhang, QingQuan Li,

Recurrent tumors originate from cancer stem cells (CSCs) that survive conventional treatments. CSCs consist of heterogeneous subpopulations that display distinct sensitivity to anticancer drugs. Such a heterogeneity presents a significant challenge in preventing tumor recurrence. In the current study, we observed that quiescent CUB-domain-containing protein 1 (CDCP1)+ CSCs are enriched ... Read more >>

PLoS Biol (PLoS biology)
[2019, 17(8):e3000425]

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Comparison of curative effects between mammotome-assisted minimally invasive resection (MAMIR) and traditional open surgery for gynecomastia in Chinese patients: A prospective clinical study.

Yu Wang, Jiyan Wang, Lin Liu, Wenlong Liang, Youyou Qin, Zihao Zheng, Shifang Zou, Yuting Xu, Cuicui Chen, Zhenchu Feng, Jianguo Zhang, Lin Tao, Xi Chen,

To analyze and compare prospectively the curative effects between mammotome-assisted minimally invasive resection (MAMIR) and traditional open surgery (TOS) for gynecomastia in Chinese male patients, a total of 60 patients suffering from grade I and II gynecomastia, evaluated by automated whole-breast ultrasound (AWBU), were recruited and randomly divided into TOS ... Read more >>

Breast J (The breast journal)
[2019, 25(6):1084-1089]

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Efficient base editing in G/C-rich regions to model androgen insensitivity syndrome.

Jianan Li, Zhen Liu, Shisheng Huang, Xiao Wang, Guanglei Li, Yuting Xu, Wenxia Yu, Shanshan Chen, Yu Zhang, Hanhui Ma, Zunfu Ke, Jia Chen, Qiang Sun, Xingxu Huang,

Cell Res. (Cell research)
[2019, 29(2):174-176]

Cited: 2 times

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Dermoscopic Monitoring for Treatment and Follow-Up of Actinic Keratosis With 5-Aminolaevulinic Acid Photodynamic Therapy.

Yang Xiaoqin, Hu Chan, Wen Long, Xu Yuting, Uma Keyal, Zhang Guolong, Wang Peiru, Wang Xiuli,

Objectives:To assess the usefulness of dermoscopy in monitoring the treatment response and recurrence of actinic keratosis treated with 5-aminolaevulinic acid photodynamic therapy.Methods:In total, 35 patients with 75 actinic keratosis lesions were treated with 5-aminolaevulinic acid photodynamic therapy. The patients were divided randomly into 2 groups, dermoscopic group and the control ... Read more >>

Technol. Cancer Res. Treat. (Technology in cancer research & treatment)
[2018, 17:]

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Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer.

Zhen Liu, Yijun Cai, Yan Wang, Yanhong Nie, Chenchen Zhang, Yuting Xu, Xiaotong Zhang, Yong Lu, Zhanyang Wang, Muming Poo, Qiang Sun,

Cell (Cell)
[2018, 174(1):245]

Cited: 8 times

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