Full Text Journal Articles by
Author Yuta Aizawa

Advertisement

Find full text journal articles






Association of Empiric Antibiotic Regimen Discordance With 30-Day Mortality in Neonatal and Pediatric Bloodstream Infection-A Global Retrospective Cohort Study.

Aislinn Cook, Yingfen Hsia, Neal Russell, Mike Sharland, Kaman Cheung, Keith Grimwood, Jack Cross, Denise Cotrim da Cunha, Gloria Regina Magalhães, Hanna Renk, Avni Hindocha, Paddy McMaster, Uduak Okomo, Saffiatou Darboe, Gerardo Alvarez-Uria, Dasaratha R Jinka, Srinivas Murki, Hemasree Kandraju, Dhanya Dharmapalan, Susanna Esposito, Sonia Bianchini, Kahoru Fukuoka, Yuta Aizawa, Rodolfo Norberto Jimenez-Juarez, Karla Ojeda-Diezbarroso, Mateja Pirš, Mojca Rožič, Suvaporn Anugulruengkitt, Watsamon Jantarabenjakul, Ching-Lan Cheng, Bai-Xiu Jian, Evangelos Spyridakis, Theoklis Zaoutis, Julia Bielicki,

<h4>Background</h4>While there have been studies in adults reporting discordant empiric antibiotic treatment associated with poor outcomes, this area is relatively unexplored in children and neonates despite evidence of increasing resistance to recommended first-line treatment regimens.<h4>Methods</h4>Patient characteristics, antibiotic treatment, microbiology, and 30-day all-cause outcome from children <18 years with blood-culture-confirmed bacterial ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(2):137-143]

Cited: 0 times

View full text PDF listing >>



Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018.

Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

<h4>Background</h4>Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018.<h4>Study design</h4>To determine whether EV-D68 was responsible for ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):6-10]

Cited: 0 times

View full text PDF listing >>



Advertisement

Impact of methicillin-resistant Staphylococcus aureus colonization in a neonatal intensive care unit after discharge.

Jumpei Kuroda, Kaoru Okazaki, Takemi Murai, Yuta Aizawa, Yuho Horikoshi,

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Pott's puffy tumour: a rare and life-threatening disease.

Nahoko Ikoma, Yuta Aizawa, Takanobu Sasaki, Makoto Oishi, Naka Saito, Hiroshi Yoshida, Akihiko Saitoh,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(12):1482]

Cited: 0 times

View full text PDF listing >>



Bach1 promotes muscle regeneration through repressing Smad-mediated inhibition of myoblast differentiation.

Katsushi Suzuki, Mitsuyo Matsumoto, Yasutake Katoh, Liang Liu, Kyoko Ochiai, Yuta Aizawa, Ryoichi Nagatomi, Hiroshi Okuno, Eiji Itoi, Kazuhiko Igarashi,

It has been reported that Bach1-deficient mice show reduced tissue injuries in diverse disease models due to increased expression of heme oxygenase-1 (HO-1)that possesses an antioxidant function. In contrast, we found that Bach1 deficiency in mice exacerbated skeletal muscle injury induced by cardiotoxin. Inhibition of Bach1 expression in C2C12 myoblast ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0236781]

Cited: 0 times

View full text PDF listing >>



Innate Immune Responses in Serum and Cerebrospinal Fluid From Neonates and Infants Infected With Parechovirus-A3 or Enteroviruses.

Rie Habuka, Yuta Aizawa, Ryohei Izumita, Hisanori Domon, Yutaka Terao, Hayato Takihara, Shujiro Okuda, Akihiko Saitoh,

BACKGROUND:Parechovirus (PeV)-A3 and enteroviruses (EV) are the most common viruses causing sepsis and meningoencephalitis in neonates and young infants. Clinical manifestations of PeV-A3 infection are more severe than those of EV infection, and no pleocytosis with a positive polymerase chain reaction (PCR) result for PeV-A3 in cerebrospinal fluid (CSF) are ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(4):681-689]

Cited: 1 time

View full text PDF listing >>



Changes in laboratory findings in Parechovirus-A infection in nine neonates and infants.

Keiko Nimura, Yuta Maruyama, Yuta Aizawa, Akihiko Saitoh, Yozo Nakazawa,

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, 62(6):755-758]

Cited: 0 times

View full text PDF listing >>



Parechovirus-A3 encephalitis presenting with focal seizure mimicking herpes simplex virus infection.

Sakiko Arai, Takayuki Yamanaka, Masashi Kasai, Tetsuhiro Fukuyama, Yuta Aizawa, Ko Matsui, Masanori Sato, Hiroko Matsui, Akihiko Saitoh,

BACKGROUND:Febrile neonates and young infants presenting with seizure require immediate evaluation and treatment. Herein we experienced two young infants with parechovirus-A3 (PeV-A3) encephalitis, initially presented with focal seizure suspecting herpes simplex virus (HSV) encephalitis. CASES:We have experienced 2 infantile cases, initially presented with focal seizure. At presentation, HSV encephalitis was ... Read more >>

J Infect Chemother (Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy)
[2020, 26(7):736-740]

Cited: 0 times

View full text PDF listing >>



Novel scoring system for differentiating parechovirus-A3 and enterovirus infection in neonates and young infants.

Ryohei Izumita, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Nobutaka Kitamura, Kohei Akazawa, Akihiko Saitoh,

BACKGROUND:Parechovirus-A3 (PeV-A3) and the enteroviruses (EVs) are the most common viral pathogens responsible for sepsis and meningoencephalitis in neonates and young infants; however, differences in the clinical presentations of two infections are not well described. OBJECTIVES:To describe the clinical presentations of PeV-A3- and EVs-related diseases and develop a novel scoring ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2020, 124:104256]

Cited: 0 times

View full text PDF listing >>



Intrafamilial Transmission of Parechovirus A and Enteroviruses in Neonates and Young Infants.

Ryohei Izumita, Kazuki Deuchi, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

<h4>Background</h4>Parechovirus A (PeV-A) is an important cause of sepsis and meningoencephalitis in neonates and young infants. Thus, identifying the source of PeV-A is essential for prevention; however, little is known regarding the spread of PeV-A among family members of PeV-A-infected neonates and young infants.<h4>Methods</h4>In this prospective study, we evaluated stool ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, 8(6):501-506]

Cited: 2 times

View full text PDF listing >>



2853. Innate Immune Response in Serum and Cerebrospinal Fluid of Neonates and Infants Infected with Parechovirus-A3 and Enteroviruses.

Rie Habuka, Yuta Aizawa, Ryohei Izumita, Hisanori Domon, Yutaka Terao, Akihiko Saitoh,

AbstractBackgroundParechovirus-A3 (PeV-A3) and enteroviruses (EVs) are the most common viral causes of neonatal and infantile sepsis. We previously reported that the clinical manifestations of PeV-A3 infection—e.g., high body temperature, tachycardia, and poor peripheral circulation, but not cerebrospinal fluid (CSF) pleocytosis—tend be more severe than those of EV infection. We tested ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S74-S74]

Cited: 0 times

View full text PDF listing >>



2585. Changing Epidemiological Profile of Infantile Parechovirus-A3 Infection in Japan

Yuta Aizawa, Ryohei Izumita, Takayuki Yamanaka, Rie Habuka, Tatsuki Ikuse, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

Abstract <h4>Background</h4> Parechovirus-A3 (PeV-A3) causes severe disease, including sepsis and meningoencephalitis in young infants. The first case of PeV-A3 was reported in Japan in 1999 and, although epidemics have been reported every 2 to 3 years in more than 20 countries, no major epidemic has occurred in Japan since 2014. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S898-S899]

Cited: 0 times

View full text PDF listing >>



Diagnostic errors in pediatric bacterial osteomyelitis.

Yuki Otani, Yuta Aizawa, Hiroshi Hataya, Yuho Horikoshi,

<h4>Background</h4>Clinical evidence for improving diagnostic accuracy in pediatric medicine is still scarce. Septic osteomyelitis is sometimes challenging for physicians to diagnose. The aim of this study was to improve patient care through identifying the incidence and reasons for errors in the diagnosis of bacterial osteomyelitis in pediatric patients.<h4>Methods</h4>We retrospectively identified ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, 61(10):988-993]

Cited: 0 times

View full text PDF listing >>



2635. Outbreak of Enterovirus D68 Among Children in Japan and Simultaneous Circulation of Clade B3 in Europe.

Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

AbstractBackgroundEnterovirus D68 (EV-D68) is a re-emerging, high-morbidity pathogen that causes severe respiratory infection and acute flaccid myelitis in children. EV-D68 is phylogenetically divided into 4 major groups—clade A through D—and each clade has subclades defined by genetic variant. Outbreaks of all strains have been reported in more than 10 countries. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S920-S921]

Cited: 0 times

View full text PDF listing >>



2586. Human Breast Milk Inhibits the Replication of Parechovirus-A3.

Ryohei Izumita, Kazuki Kon, Yuta Aizawa, Kanako Watanabe, Akihiko Saitoh,

AbstractBackgroundParechovirus-A3 (PeV-A3) is an emerging pathogen causing sepsis and meningoencephalitis in neonates and young infants. We previously reported that maternal antibodies against PeV-A3 are important to protect neonates and young infants from the infection. Recent studies showed that (1) breastfeeding had a protective effect against enterovirus, which is closely-related virus ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S899-S899]

Cited: 0 times

View full text PDF listing >>



Clinical Characteristics of Saffold Virus Infection in Children.

Satoko Ugai, Atsushi Iwaya, Hiromichi Taneichi, Chika Hirokawa, Yuta Aizawa, Shuji Hatakeyama, Akihiko Saitoh,

BACKGROUND:Saffold virus (SAFV) is a novel human cardiovirus that was identified in 2007. Recently, SAFV has been isolated from nasal and stool specimens of infants presenting with respiratory and gastrointestinal symptoms and from cerebrospinal fluid (CSF) specimens of children with central nervous system infection. However, little is known regarding clinical ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(8):781-785]

Cited: 0 times

View full text PDF listing >>



Persistence of High Neutralizing Antibody Titers After Neonatal and Early Infantile Infection with Parechovirus-A3.

Ryohei Izumita, Yuta Aizawa, Kanako Watanabe, Akihiko Saitoh,

This 3-year follow-up study evaluated neutralizing antibody titers (NATs) against parechovirus-A3 (PeV-A3) in neonates and young infants who developed PeV-A3 infection. All children had low NATs at disease onset and high NATs after infection during infancy. At age 3 years, all 16 patients tested had high NATs (≥1:512) against PeV-A3 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(7):e159-e161]

Cited: 0 times

View full text PDF listing >>



Cefmetazole for extended-spectrum β-lactamase-producing Enterobacteriaceae in pediatric pyelonephritis.

Kotaro Araki, Kahoru Fukuoka, Hiroshi Higuchi, Yuta Aizawa, Yuho Horikoshi,

BACKGROUND:Pyelonephritis caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae is an urgent problem in pediatrics. Although carbapenem is the standard therapy for infections caused by ESBL-producing Enterobacteriaceae, some cephamycins, including cefmetazole, are stable against hydrolysis by ESBL. There are few reports, however, on the use of cefmetazole in children. The aim of ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, 61(6):572-577]

Cited: 0 times

View full text PDF listing >>



Multidrug-resistant Gram-negative Bacterial Bloodstream Infections in Children's Hospitals in Japan, 2010-2017.

Yuta Aizawa, Takayo Shoji, Kenta Ito, Masashi Kasai, Hiroki Sakurai, Etsushi Toyofuku, Kisei Minami, Tadashi Hoshino, Yuho Horikoshi,

<h4>Background</h4>The risk factors of multidrug-resistant (MDR) Gram-negative bacilli (GNB) bloodstream infection (BSI) are not yet known in children. Our aim was to evaluate risk factors and outcomes associated with MDR GNB BSI in children.<h4>Methods</h4>Patients with GNB BSI were enrolled between April 2010 and March 2017 at 8 children's hospitals in ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(7):653-659]

Cited: 1 time

View full text PDF listing >>



1917. Diagnostic Errors in Bacterial Osteomyelitis in Children.

Yuki Otani, Yuta Aizawa, Hiroshi Hataya, Yuho Horikoshi,

AbstractBackgroundDelayed or erroneous diagnoses of bacterial infections may cause adverse outcomes in patients. Bacterial osteomyelitis has a low incidence, is only infrequently encountered by primary care pediatricians, and has obscure symptoms in children that make an early and accurate diagnosis challenging. The aim of this study was to determine the ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S552-S552]

Cited: 0 times

View full text PDF listing >>



2349. Long-Term Neurological Outcome and Neutralizing Antibody Titers Against Paraechovirus-A3 (PeV-A3) in Children who Developed PeV-A3-Related Diseases in Neonatal and Infantile Periods.

Ryohei Izumita, Yuta Aizawa, Kanako Watanabe, Akihiko Saitoh,

AbstractBackgroundParechovirus-A3 (PeV-A3) is an emerging pathogen causing sepsis and meningoencephalitis in neonates and young infants. We previously reported that maternal antibodies against PeV-A3 are important to protect neonates and young infants from the infection. We showed that all neonates and infants who developed PeV-A3-related diseases had low neutralizing antibody titers ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S698-S699]

Cited: 0 times

View full text PDF listing >>



2334. Risk Factors of Multidrug-Resistant Gram-Negative Bacterial Bloodstream Infections in Children’s Hospitals in Japan.

Yuta Aizawa, Takayo Shoji, Kenta Ito, Masashi Kasai, Hiroki Sakurai, Etsushi Toyofuku, Kisei Minami, Tadashi Hoshino, Yuho Horikoshi,

AbstractBackgroundAlthough multidrug-resistant (MDR) Gram-negative bacilli (GNB) are a serious and growing concern worldwide, the epidemiological data on children are still limited. Our aim was to evaluate the risk factors for MDR GNB bloodstream infections (BSI) in children.MethodsPatients with GNB BSI were enrolled between April 2010 and March 2017 at eight ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S693-S694]

Cited: 0 times

View full text PDF listing >>



Antimicrobial Stewardship Program in a Pediatric Intensive Care Unit.

Yuta Aizawa, Junichi Suwa, Hiroshi Higuchi, Kahoru Fukuoka, Mihoko Furuichi, Tetsuji Kaneko, Yoshihiko Morikawa, Kaoru Okazaki, Naoki Shimizu, Yuho Horikoshi,

We conducted an antimicrobial stewardship program in a pediatric intensive care unit. An interrupted time-series analysis revealed a significant reduction in level and trend of days of therapy per 1000 patient-days for antipseudomonal agents. No increase in adverse patient outcomes was found. ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2018, 7(3):e156-e159]

Cited: 3 times

View full text PDF listing >>



Parvovirus B19: A Cause of Sepsislike Syndrome in an Infant.

Satoko Ugai, Yuta Aizawa, Tetsuya Kanayama, Akihiko Saitoh,

Parvovirus B19 (PB19) is an important human pathogen that results in a wide spectrum of clinical outcomes, from mild, self-limiting erythema infectiosum in immunocompetent children and arthralgia in adults to lethal cytopenia in immunocompromised patients and intrauterine fetal death. However, there have been few reports of PB19 infection in neonates ... Read more >>

Pediatrics (Pediatrics)
[2018, 141(6):]

Cited: 0 times

View full text PDF listing >>



Sibling visits and viral infection in the neonatal intensive care unit.

Yuho Horikoshi, Kaoru Okazaki, Shigeko Miyokawa, Kazue Kinoshita, Hiroshi Higuchi, Junichi Suwa, Yuta Aizawa, Kahoru Fukuoka,

Sibling visits to the neonatal intensive care unit (NICU) are a part of family-centered care, which is now being increasingly endorsed as a positive development in patient care. Sibling visits, however, pose a risk of viral infection, and hence many NICU in Japan impose strict limits on the practice. The ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2018, 60(2):153-156]

Cited: 1 time

View full text PDF listing >>



Advertisement

Disclaimer
2.0244 s