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Human Papilloma Virus 18-Positive Submucosal Small Cell Neuroendocrine Carcinoma of the Vagina: An Immunohistochemical and Genomic Study.

Ikumi Kitazono, Toshiaki Akahane, Mika Sakihama, Shintaro Yanazume, Michiko Matsushita, Kazuhiro Tabata, Yusuke Kobayashi, Hiroaki Kobayashi, Yoshihisa Umekita, Akihide Tanimoto,

Primary vaginal neuroendocrine carcinoma (NEC) is extremely rare among female genital tract tumors. Here, we report 2 cases of vaginal small cell NEC (SCNEC) using immunohistochemistry and next-generation sequencing (NGS) analysis. The 2 patients were in their mid-to-late 70s, presented with abnormal vaginal bleeding and had a vaginal submucosal mass. ... Read more >>

Int J Surg Pathol (International journal of surgical pathology)
[2021, :10668969211007569]

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Excess All-Cause Deaths during Coronavirus Disease Pandemic, Japan, January-May 20201.

Takayuki Kawashima, Shuhei Nomura, Yuta Tanoue, Daisuke Yoneoka, Akifumi Eguchi, Chris Fook Sheng Ng, Kentaro Matsuura, Shoi Shi, Koji Makiyama, Shinya Uryu, Yumi Kawamura, Shinichi Takayanagi, Stuart Gilmour, Hiroaki Miyata, Tomimasa Sunagawa, Takuri Takahashi, Yuuki Tsuchihashi, Yusuke Kobayashi, Yuzo Arima, Kazuhiko Kanou, Motoi Suzuki, Masahiro Hashizume,

To provide insight into the mortality burden of coronavirus disease (COVID-19) in Japan, we estimated the excess all-cause deaths for each week during the pandemic, January-May 2020, by prefecture and age group. We applied quasi-Poisson regression models to vital statistics data. Excess deaths were expressed as the range of differences ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(3):789-795]

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Current status and future directions of ovarian cancer prognostic models.

Yusuke Kobayashi, Kouji Banno, Daisuke Aoki,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e34]

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Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer.

Yusuke Kobayashi, Kensuke Kumamoto, Hirokazu Okayama, Takuro Matsumoto, Hiroshi Nakano, Katsuharu Saito, Yoshiko Matsumoto, Eisei Endo, Yasuyuki Kanke, Yohei Watanabe, Hisashi Onozawa, Shotaro Fujita, Wataru Sakamoto, Motonobu Saito, Tomoyuki Momma, Seiichi Takenoshita, Koji Kono,

Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) encodes an enzyme that catalyzes de novo purine biosynthesis. Although PAICS has been implicated as a potential therapeutic target in several cancers, its clinical and prognostic significance in colorectal cancer (CRC) is not fully understood. To elucidate the roles of PAICS in CRC, we ... Read more >>

PLoS One (PloS one)
[2021, 16(2):e0247169]

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Retrospective evaluation of risk-reducing salpingo-oophorectomy for BRCA1/2 pathogenic variant carriers among a cohort study in a single institution.

Yusuke Kobayashi, Akira Hirasawa, Tatsuyuki Chiyoda, Arisa Ueki, Kenta Masuda, Kumiko Misu, Miho Kawaida, Shigenori Hayashi, Fumio Kataoka, Kouji Banno, Kenjiro Kosaki, Daisuke Aoki,

<h4>Background</h4>Risk-reducing salpingo-oophorectomy is performed for the primary prevention of ovarian cancer in patients with hereditary breast-ovarian cancer syndrome. We performed risk-reducing salpingo-oophorectomy for the first time in Japan in 2008, and we experienced 20 cases of risk-reducing salpingo-oophorectomy through 2019. In the past, the use of risk-reducing salpingo-oophorectomy in Japan ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(2):213-217]

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Azolium/Hydroquinone Organo-Radical Co-Catalysis: Aerobic C-C-Bond Cleavage in Ketones.

Yuya Nakatsuji, Yusuke Kobayashi, Sakyo Masuda, Yoshiji Takemoto,

Organo-radical catalysts have recently attracted great interest, and the development of this field can be expected to broaden the applications of organocatalysis. Herein, the first example of a radical-generating system is reported that does not require any photoirradiation, radical initiators, or preactivated substrates. The oxidative C-C-bond cleavage of 2-substituted cyclohexanones ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2021, 27(8):2633-2637]

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Relationship between basal sodium intake and the effects of dapagliflozin in albuminuric diabetic kidney disease.

Sho Kinguchi, Hiromichi Wakui, Yuzuru Ito, Yoshinobu Kondo, Kengo Azushima, Uru Osada, Tadashi Yamakawa, Tamio Iwamoto, Jun Yutoh, Toshihiro Misumi, Gen Yasuda, Taishi Yoshii, Kotaro Haruhara, Yusuke Kobayashi, Takeharu Yamanaka, Yasuo Terauchi, Kouichi Tamura,

We investigated the impact of basal dietary sodium intake on the dapagliflozin-induced changes in albuminuria and blood pressure (BP) measured at home in patients with diabetic kidney disease (DKD).This was a secondary analysis of the Y-AIDA Study, in which DKD patients with estimated glomerular filtration rate (eGFR) ≥ 45 ml/min/1.73 m<sup>2</sup> and urinary albumin-to-creatinine ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):951]

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HGG-29. A CASE OF CIRCUMSCRIBED HIGH-GRADE ASTROCYTOMA WITH ATRX AND CDKN2A/B ALTERNATIONS WHO WAS INITIALLY DIAGNOSED AS GLIOBLASTOMA AND HAS 20 YEARS SURVIVAL

Yusuke Kobayashi, Yosuke Sato, Takashi Kon, Daisuke Tanioka, Katsuyoshi Shimizu, Tohru Mizutani,

Abstract Pediatric high-grade gliomas are rare and often hard to classify, which grow locally and show longer survival than diffuse high-grade gliomas in adults. We report a case of circumscribed high-grade astrocytoma who was initially diagnosed as glioblastoma and has 20 years survival. A 7-year-old girl suffered from epileptic seizure ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, 22(Suppl 3):iii349-iii349]

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Evaluating the importance of routine drainage following laparoscopic pelvic lymph node dissection for gynecological malignancies.

Kensuke Sakai, Masaru Nakamura, Wataru Yamagami, Tatsuyuki Chiyoda, Yusuke Kobayashi, Hiroshi Nishio, Shigenori Hayashi, Hiroyuki Nomura, Fumio Kataoka, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki,

<h4>Objective</h4>To determine the efficacy of drainage following pelvic lymph node (PLN) dissection, especially for cases involving laparoscopic surgery.<h4>Methods</h4>In this retrospective study, 368 patients with malignant gynecological tumors who underwent systemic PLN dissection at Keio University Hospital between January 2012 and October 2018 were enrolled. Drainage tubes were placed in the ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, :]

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Nitro-Substituted Benzaldehydes in the Generation of Azomethine Ylides and Retro-1,3-Dipolar Cycloadditions.

Ahmed G Taha, Elghareeb E Elboray, Yusuke Kobayashi, Takumi Furuta, Hussien H Abbas-Temirek, Moustafa F Aly,

1,3-Dipolar cycloaddition of 2- and 3-nitrobenzaldehydes with 2-aminomethylpyridine and ethyl (2<i>E</i>)-2-cyano-3-(4-nitrophenyl)prop-2-enoate yielded <i>endo</i>-cycloadducts as the sole products under various reaction conditions. Fortuitously, 4-nitrobenzaldehyde behaved differently in three- and four-component cascades to produce a mixture of <i>endo</i>- and <i>exo</i>'-cycloadducts. This reaction is solvent- and temperature-dependent, and consequently, both the <i>endo</i>- and ... Read more >>

J Org Chem (The Journal of organic chemistry)
[2021, 86(1):547-558]

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Time for enhancing government-led primary prevention of cervical cancer.

Kyung Jin Min, Dong Hoon Suh, Tsukasa Baba, Xiaojun Chen, Jae Weon Kim, Yusuke Kobayashi, Janice Kwon, Myong Cheol Lim, Jung Yun Lee, Satoru Nagase, Jeong Yeol Park, Siriwan Tangjitgamol, Hidemichi Watari,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(1):e12]

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Evaluation of preoperative prediction of intestinal invasion in patients with ovarian cancer.

Takashi Takeda, Shigenori Hayashi, Yusuke Kobayashi, Kosuke Tsuji, Shimpei Nagai, Eiichiro Tominaga, Tatsuya Suzuki, Shigeo Okuda, Kouji Banno, Daisuke Aoki,

<h4>Objective</h4>To optimize prediction for intestinal invasion of epithelial ovarian cancer. It is important to achieve debulking surgery to improve prognosis in ovarian cancer; intestinal resection is adopted if the cancer is invaded and resectable, but the preoperative evaluation method of intestinal invasion is still controversial.<h4>Methods</h4>Patients (n = 174) who underwent primary debulking ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, :]

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COT-11 Administration of Bevacizumab for patients who failed to complete Stupp regimen after glioblastoma surgery

Takashi Kon, Yoichi Imaizumi, Yusuke Kobayashi, Yosuke Sato, Katsuyoshi Shimizu, Tohru Mizutani,

Abstract Stupp regimen is widely used as the standard treatment after glioblastoma surgery, but in some cases treatment must be discontinued for various reasons. We experienced Bevacizumab in two patients who were unable to continue treatment in the Stupp regimen, and report our experience with literature review. First patient is ... Read more >>

Neurooncol Adv (Neuro-oncology advances)
[2020, 2(Suppl 3):ii22-ii22]

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Improved Diagnostic Accuracy of Bone Metastasis Detection by Water-HAP Associated to Non-contrast CT.

Yoshinobu Ishiwata, Yojiro Hieda, Soichiro Kaki, Shinjiro Aso, Keiichi Horie, Yusuke Kobayashi, Motoki Nakamura, Kazuhiko Yamada, Tsuneo Yamashiro, Daisuke Utsunomiya,

We examined whether water-hydroxyapatite (HAP) images improve the diagnostic accuracy of bone metastasis compared with non-contrast CT alone. We retrospectively evaluated dual-energy computed tomography (DECT) images of 83 cancer patients (bone metastasis, 31; without bone metastasis, 52) from May 2018 to June 2019. Initially, two evaluators examined for bone metastasis ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(10):]

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Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease.

Seiji Itano, Yuichiro Yano, Hajime Nagasu, Hirofumi Tomiyama, Hiroshi Kanegae, Hirofumi Makino, Yukihito Higashi, Yusuke Kobayashi, Yuji Sogawa, Minoru Satoh, Kenji Suzuki, Raymond R Townsend, Matthew Budoff, George Bakris, Naoki Kashihara,

<h4>Background</h4>Our aims were to assess whether arterial stiffness is associated with a higher risk for kidney dysfunction among persons without chronic kidney disease (CKD).<h4>Methods</h4>We analyzed data from the national health checkup system in Japan; for our analyses, we selected records of individuals who completed assessments of cardio-ankle vascular index (CAVI) ... Read more >>

Am J Hypertens (American journal of hypertension)
[2020, 33(11):1003-1010]

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[Glioblastoma Mimicking Meningioma Recurrence: A Case Report].

Yusuke Kobayashi, Kazuhiko Mishima, Jun-Ichi Adachi, Tomonari Suzuki, Atsushi Sasaki, Ryo Nishikawa,

Meningioma and glioma represent two common primary intracranial tumors. However, the coexistence of these two lesions in the same patient at the same location is rare. Here, we present a case of a fibroblastic meningioma with a secondary glioblastoma occurring at the same location. A 67-year-old woman underwent surgery for ... Read more >>

Brain Nerve (Brain and nerve = Shinkei kenkyu no shinpo)
[2020, 72(10):1105-1111]

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Holliday Junction Resolvase MOC1 Maintains Plastid and Mitochondrial Genome Integrity in Algae and Bryophytes.

Yusuke Kobayashi, Masaki Odahara, Yasuhiko Sekine, Takashi Hamaji, Sumire Fujiwara, Yoshiki Nishimura, Shin-Ya Miyagishima,

When DNA double-strand breaks occur, four-stranded DNA structures called Holliday junctions (HJs) form during homologous recombination. Because HJs connect homologous DNA by a covalent link, resolution of HJ is crucial to terminate homologous recombination and segregate the pair of DNA molecules faithfully. We recently identified Monokaryotic Chloroplast1 (MOC1) as a ... Read more >>

Plant Physiol (Plant physiology)
[2020, 184(4):1870-1883]

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Impact of the COVID-19 epidemic at a high-volume facility in gynecological oncology in Tokyo, Japan: a single-center experience.

Yuya Nogami, Yusuke Kobayashi, Kosuke Tsuji, Megumi Yokota, Hiroshi Nishio, Masaru Nakamura, Wataru Yamagami, Tohru Morisada, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki,

<h4>Background</h4>The number of cases of novel coronavirus disease 2019 (COVID-19) in Japan have risen since the first case was reported on January 24, 2020, and 6225 infections have been reported as of June 30, 2020. On April 8, 2020, our hospital began screening patients via pre-admission reverse transcriptase-polymerase chain reaction ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):105]

Cited: 1 time

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Evaluation of safety and diagnostic performance for flexible hysteroscopy in 1591 outpatient cases.

Yusuke Kobayashi, Kosuke Tsuji, Kanako Nakamura, Shimpei Nagai, Takayuki Takahashi, Arata Kobayashi, Mayuka Anko, Takuro Hirano, Keiko Watanabe, Yusuke Matoba, Haruko Kunitomi, Masataka Adachi, Wataru Yamagami, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki,

<h4>Background</h4>To date, only few large studies are available concerning the safety and diagnostic concordance rates of outpatient flexible hysteroscopy. In our institution, outpatient hysteroscopy has been routinely and educationally applied Kosuke Tsuji to intrauterine lesions; thus, we retrospectively investigated the institution's outpatient flexible hysteroscopy cases.<h4>Methods</h4>A total of 1591 cases of ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2020, 50(10):1157-1161]

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Erratum: Author Correction. Management of ovarian cancer patients in affected areas during COVID-19 pandemic: Japan and Korea.

Yusuke Kobayashi, Dong Hoon Suh, Kosuke Tsuji, Jin Young Kim, Sojin Shin, Daisuke Aoki, Jae Weon Kim,

This corrects the article on p. e65 in vol. 31, PMID: 32342678. ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(5):e87]

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Early drop in systolic blood pressure, heart rate at admission, and their effects on worsening renal function in elderly patients with acute heart failure.

Makoto Takeuchi, Michiaki Nagai, Keigo Dote, Masaya Kato, Noboru Oda, Eiji Kunita, Eisuke Kagawa, Aya Yamane, Yusuke Kobayashi, Haruko Shiota, Ayano Osawa, Hiroshi Kobatake,

<h4>Background</h4>Regardless of patients' baseline renal function, worsening renal function (WRF) during hospitalization is associated with poor outcomes. In individuals with acute heart failure (AHF), one predictor of WRF is an early drop in systolic blood pressure (SBP). Few studies have investigated WRF in elderly AHF patients or the influence of ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):366]

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Associations Between Changes in Plasma Renin Activity and Aldosterone Concentrations and Changes in Kidney Function After Treatment for Primary Aldosteronism.

Yusuke Kobayashi, Tatsuya Haze, Yuichiro Yano, Kouichi Tamura, Isao Kurihara, Takamasa Ichijo, Takashi Yoneda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Tetsuya Yamada, Ryuji Okamoto, Megumi Fujita, Kohei Kamemura, Koichi Yamamoto, Shoichiro Izawa, Akiyo Tanabe, Mitsuhide Naruse, ,

Introduction:Greater reduction in estimated glomerular filtration rate (eGFR) after specific treatment for primary aldosteronism (PA) reflects improvement in glomerular hyperfiltration associated with PA and leads to better patient outcomes. However, little is known regarding the mechanisms underlying eGFR reduction after treatment for PA. Methods:We analyzed data from the nationwide PA ... Read more >>

Kidney Int Rep (Kidney international reports)
[2020, 5(8):1291-1297]

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Severe Acute Respiratory Syndrome Coronavirus 2 Infection among Returnees to Japan from Wuhan, China, 2020.

Yuzo Arima, Tomoe Shimada, Motoi Suzuki, Tadaki Suzuki, Yusuke Kobayashi, Yuuki Tsuchihashi, Haruna Nakamura, Kaoru Matsumoto, Asuka Takeda, Keisuke Kadokura, Tetsuro Sato, Yuichiro Yahata, Noriko Nakajima, Minoru Tobiume, Ikuyo Takayama, Tsutomu Kageyama, Shinji Saito, Naganori Nao, Tamano Matsui, Tomimasa Sunagawa, Hideki Hasegawa, Makoto Ohnishi, Takaji Wakita,

In early 2020, Japan repatriated 566 nationals from China. Universal laboratory testing and 14-day monitoring of returnees detected 12 cases of severe acute respiratory syndrome coronavirus 2 infection; initial screening results were negative for 5. Common outcomes were remaining asymptomatic (n = 4) and pneumonia (n = 6). Overall, screening ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2020, 26(7):]

Cited: 5 times

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SARS-CoV-2 Genome Analysis of Japanese Travelers in Nile River Cruise.

Tsuyoshi Sekizuka, Sanae Kuramoto, Eri Nariai, Masakatsu Taira, Yushi Hachisu, Akihiko Tokaji, Michiyo Shinohara, Tsuyoshi Kishimoto, Kentaro Itokawa, Yusuke Kobayashi, Keisuke Kadokura, Hajime Kamiya, Tamano Matsui, Motoi Suzuki, Makoto Kuroda,

Japan has reported 26 cases of coronavirus disease 2019 (COVID-19) linked to cruise tours on the River Nile in Egypt between March 5 and 15, 2020. Here, we characterized the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome of isolates from 10 travelers who returned from Egypt and from patients ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:1316]

Cited: 2 times

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Stereoselective Synthesis of 1,1'-Disaccharides by Organoboron Catalysis.

Sanae Izumi, Yusuke Kobayashi, Yoshiji Takemoto,

The highly stereoselective synthesis of 1,1'-disaccharides was achieved by using 1,2-dihydroxyglycosyl acceptors and glycosyl donors in the presence of a tricyclic borinic acid catalyst. In this reaction, the complexation of the diols and the catalyst is crucial for the activation of glycosyl donors, as well as for the 1,2-cis-configuration of ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2020, 59(33):14054-14059]

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