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[Effects of the Otago Exercise Program on Lower Extremity Strength in Residents of a Long-Term Care Institution].

Yung-Chi Cheng, Yen-Chi Liao, Ling-Yu Hsieh,

BACKGROUND:Falls are a very common problem in older adults. Improving lower extremity muscle strength is the primary objective of fall-prevention programs. PURPOSE:The aim of the study was to evaluate the effects of the Otago Exercise Program (OEP) on the lower extremity muscle strength of residents living in a long-term care ... Read more >>

Hu Li Za Zhi (Hu li za zhi The journal of nursing)
[2020, 67(3):48-55]

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An Ethnobotanical Study on Qīng-Căo-Chá Tea in Taiwan.

Shyh-Shyun Huang, Ting-Yang Chen, Jeng-Shyan Deng, Li-Heng Pao, Yung-Chi Cheng, Jung Chao,

Herbal tea, a beverage prepared from a variety of plant materials excluding the leaves of the tea plant Camellia sinensis (L.) Kuntze of the family Theaceae, for a long time, has been consumed by most Chinese people for preventive and/or therapeutic health care. Usually, it is brewed or prepared as ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:931]

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Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems.

Chan Li, Junying Huang, Yung-Chi Cheng, Yuan-Wei Zhang,

Depression is a multigenetic or multifactorial syndrome. The central neuron system (CNS)-orientated, single target, and conventional antidepressants are insufficient and far from ideal. Traditional Chinese Medicine (TCM) has historically been used to treat depression up till today, particularly in Asia. Its holistic, multidrug, multitarget nature fits well with the therapeutic ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:586]

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2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication.

Angela Corona, Valentina Onnis, Claudia Del Vecchio, Francesca Esposito, Yung-Chi Cheng, Enzo Tramontano,

The persistence of the AIDS epidemic, and the life-long treatment required, indicate the constant need of novel HIV-1 inhibitors. In this scenario the HIV-1 Reverse Transcriptase (RT)-associated ribonuclease H (RNase H) function is a promising drug target. Here we report a series of compounds, developed on the 2-amino-6-(trifluoromethyl)nicotinic acid scaffold, ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(6):]

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Natural deep eutectic characteristics of honey improve the bioactivity and safety of traditional medicines.

Yuntao Dai, Runa Jin, Robert Verpoorte, Wing Lam, Yung-Chi Cheng, Yongqin Xiao, Jiang Xu, Liwei Zhang, Xue-Mei Qin, Shilin Chen,

ETHNOPHARMACOLOGICAL RELEVANCE:Honey, an important additive with natural deep eutectic solvent (NADES) characteristics, has been used in traditional medicine for thousands of years. AIM OF THE STUDY:We investigated the quality-improving effects of honey on Astragali Radix (Mikvetch Root) (RA) as an example. MATERIALS AND METHODS:Decoctions of raw RA, fried RA, honey-fried ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 250:112460]

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The Comparative Study of the Therapeutic Effects and Mechanism of Baicalin, Baicalein, and Their Combination on Ulcerative Colitis Rat.

Shuai Liang, Xin Deng, Lei Lei, Yao Zheng, Jiao Ai, Linlin Chen, Hui Xiong, Zhinan Mei, Yung-Chi Cheng, Yongshen Ren,

Introduction: Ulcerative colitis (UC) is an inflammatory bowel disease with a high incidence rate and a difficult treatment regimen. Recently, significant advances in the treatment of intestinal diseases, particularly UC, have been made with the use of the drugs baicalin and baicalein, separately or in combination. However, the therapeutic efficacy ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1466]

Cited: 1 time

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State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report.

Dan Xi, Ting Bao, Qi Chen, Sushing Chen, Yung-Chi Cheng, Joseph Cullen, David A Frank, Jonathan W Friedberg, Ian Kronish, Jeffrey E Lee, Mark Levine, Pingping Li, Shao Li, Weidong Lu, Jun J Mao, Stephen O'Keefe, Larry Rubinstein, Manish A Shah, Leanna Standish, Channing J Paller, Edward Chu,

In May 2016, the Office of Cancer Complementary and Alternative Medicine, Division of Cancer Diagnosis and Treatment, of the National Cancer Institute convened a special workshop focused on the State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research. The current state of the science, gaps, and future opportunities ... Read more >>

J. Natl. Cancer Inst. Monographs (Journal of the National Cancer Institute. Monographs)
[2017, 2017(52):]

Cited: 2 times

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Fischeriana A, a meroterpenoid with an unusual 6/6/5/5/5/6/6 heptacyclic carbon skeleton from the roots of Euphorbia fischeriana.

Jun He, Jie-Kun Xu, Jia Zhang, Hong-Jin Bai, Bing-Zhi Ma, Yung-Chi Cheng, Wei-Ku Zhang,

Fischeriana A (1), a new meroterpenoid with a rare carbon skeleton, along with one of its known biosynthesis-related compounds 2,4-dihydroxy-6-methoxyacetophenone (2) and two known ent-abietane-type diterpenoids (3-4), were isolated from the roots of Euphorbia fischeriana. Their structures, including the stereochemistry, were elucidated using comprehensive spectroscopic methods, single-crystal X-ray diffraction, and ... Read more >>

Org. Biomol. Chem. (Organic & biomolecular chemistry)
[2019, 17(10):2721-2724]

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Cancer Biomarkers for Integrative Oncology.

Aniruddha Ganguly, David Frank, Nagi Kumar, Yung-Chi Cheng, Edward Chu,

PURPOSE OF REVIEW:There has been an increasing interest in using complementary and alternative medicine (CAM) approaches to treat cancer. It is therefore relevant and timely to determine if CAM biomarkers can be identified and developed to guide cancer diagnosis and treatment. Herein, we review the status of cancer biomarkers in ... Read more >>

Curr Oncol Rep (Current oncology reports)
[2019, 21(4):32]

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Challenge and Prospect of Traditional Chinese Medicine in Depression Treatment.

Yuan-Wei Zhang, Yung-Chi Cheng,

Current medication for depression is inadequate and far from ideal. Development of novel antidepressant drugs is a pressing task. The discovery of ketamine and related agents represents a new era in drug discovery for the rapid treatment of depression. Due to potential neurotoxicity, short-lasting efficacy, the limitation of a single ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2019, 13:190]

Cited: 3 times

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Mechanism Based Quality Control (MBQC) of Herbal Products: A Case Study YIV-906 (PHY906).

Wing Lam, Yongshen Ren, Fulan Guan, Zaoli Jiang, William Cheng, Chang-Hua Xu, Shwu-Huey Liu, Yung-Chi Cheng,

YIV-906 (PHY906), a four-herb Chinese medicine formulation, is inspired by an 1800 year-old Chinese formulation called Huang Qin Tang which is traditionally used to treat gastrointestinal (GI) symptoms. In animal studies, it could enhance anti-tumor activity of different classes of anticancer agents and promote faster recovery of the damaged intestines ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:1324]

Cited: 1 time

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Unusual cadinane-type sesquiterpene glycosides with α-glucosidase inhibitory activities from the fruit of Cornus officinalis Sieb. et Zuuc.

Jun He, Jie-Kun Xu, Xue-Ge Pan, Xian-Sheng Ye, Pin-Yi Gao, Yu Yan, Chun-Yang Xu, Gui-Fen Qiang, Guan-Hua Du, Yung-Chi Cheng, Wei-Ku Zhang,

Five novel and rare cadinane-type sesquiterpene glycosides, cornucadinoside A-E (1-5) were isolated from water extract of the fruit of Cornus officinalis Sieb. et Zuuc.. The new chemical structures, together with their absolute configurations, were elucidated on the basis of extensive spectroscopic analysis, including a comparison of their experimental and calculated ... Read more >>

Bioorg. Chem. (Bioorganic chemistry)
[2019, 82:1-5]

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Effects of processing adjuvants on traditional Chinese herbs.

Lin-Lin Chen, Robert Verpoorte, Hung-Rong Yen, Wen-Huang Peng, Yung-Chi Cheng, Jung Chao, Li-Heng Pao,

Processing of Chinese medicines is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces for use in different therapies. Various adjuvants, such as vinegar, wine, honey, and brine, are used in the processing to enhance the efficacy and reduce the toxicity of crude drugs. Proper processing is essential ... Read more >>

J Food Drug Anal (Journal of food and drug analysis)
[2018, 26(2S):S96-S114]

Cited: 2 times

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Promotion of quality standard of Chinese herbal medicine by the integrated and efficacy-oriented quality marker of Effect-constituent Index.

Yin Xiong, Yupiao Hu, Fan Li, Lijuan Chen, Qin Dong, Jiabo Wang, Elizabeth A Gullen, Yung-Chi Cheng, Xiaohe Xiao,

Multiple constituents have been applied currently as markers to control the quality of Chinese herbal medicine (CHM). However, those constituents are isolated from each other, failed to present their contribution differences to the bioeffect of CHM. Besides, a CHM for different clinic uses is often controlled by the same quality ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2018, 45:26-35]

Cited: 2 times

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Targeting tumour microenvironment by tyrosine kinase inhibitor.

Hor-Yue Tan, Ning Wang, Wing Lam, Wei Guo, Yibin Feng, Yung-Chi Cheng,

Tumour microenvironment (TME) is a key determinant of tumour growth and metastasis. TME could be very different for each type and location of tumour and TME may change constantly during tumour growth. Multiple counterparts in surrounding microenvironment including mesenchymal-, hematopoietic-originated cells as well as non-cellular components affect TME. Thus, therapeutics ... Read more >>

Mol. Cancer (Molecular cancer)
[2018, 17(1):43]

Cited: 14 times

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Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis.

Xian-Sheng Ye, Jun He, Yung-Chi Cheng, Lei Zhang, Hao-Yi Qiao, Xue-Ge Pan, Jia Zhang, Shu-Na Liu, Wei-Ku Zhang, Jie-Kun Xu,

Fifteen new and rare iridoid glucoside dimers, cornusides A-O (1-15), and 10 known iridoid glucosides (16-25) were isolated from the fruit of Cornus officinalis. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1-25 were tested for their inhibitory activities by measuring ... Read more >>

J. Nat. Prod. (Journal of natural products)
[2017, 80(12):3103-3111]

Cited: 5 times

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Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells.

Huang-Hui Chen, Hsin-Huei Chang, Jang-Yang Chang, Ya-Chu Tang, Yung-Chi Cheng, Li-Mei Lin, Shu-Ying Cheng, Chih-Hsiang Huang, Man-Wu Sun, Chiung-Tong Chen, Ching-Chuan Kuo,

Nuclear factor erythroid-2-related factor 2 (NRF2) mainly regulates transcriptional activation through antioxidant-responsive elements (AREs) present in the promoters of NRF2 target genes. Recently, we found that NRF2 was overexpressed in a KB-derived drug-resistant cancer cell panel. In this panel, KB-7D cells, which show acquired resistance to topoisomerase II (Top II) ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2017, 113:505-518]

Cited: 3 times

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Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions.

Angela Corona, Valentina Onnis, Alessandro Deplano, Giulia Bianco, Monica Demurtas, Simona Distinto, Yung-Chi Cheng, Stefano Alcaro, Francesca Esposito, Enzo Tramontano,

In the continuous effort to identify new HIV-1 inhibitors endowed with innovative mechanisms, the dual inhibition of different viral functions would provide a significant advantage against drug-resistant variants. The HIV-1 reverse transcriptase (RT)-associated ribonuclease H (RNase H) is the only viral-encoded enzymatic activity that still lacks an efficient inhibitor. We ... Read more >>

Pathog Dis (Pathogens and disease)
[2017, 75(6):]

Cited: 2 times

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Major achievements of evidence-based traditional Chinese medicine in treating major diseases.

Jung Chao, Yuntao Dai, Robert Verpoorte, Wing Lam, Yung-Chi Cheng, Li-Heng Pao, Wei Zhang, Shilin Chen,

A long history of use and extensive documentation of the clinical practices of traditional Chinese medicine resulted in a considerable number of classical preparations, which are still widely used. This heritage of our ancestors provides a unique resource for drug discovery. Already, a number of important drugs have been developed ... Read more >>

Biochem. Pharmacol. (Biochemical pharmacology)
[2017, 139:94-104]

Cited: 18 times

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Improving the Concentrations of the Active Components in the Herbal Tea Ingredient, Uraria crinita: The Effect of Post-harvest Oven-drying Processing.

Jung Chao, Yuntao Dai, Hao-Yuan Cheng, Wing Lam, Yung-Chi Cheng, Ke Li, Wen-Huang Peng, Li-Heng Pao, Ming-Tsuen Hsieh, Xue-Mei Qin, Meng-Shiou Lee,

Uraria crinita is widely used as a popular folk drink; however, little is known about how the post-harvest operations affect the chemical composition and bioactivity of UC. We assessed three drying methods (Oven-drying, Air-drying, Sun-drying), as well as the Oven-drying temperature using metabolomics approaches and bioactivity assays. The samples processed ... Read more >>

Sci Rep (Scientific reports)
[2017, 7:38763]

Cited: 4 times

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Chemosynthesis pathway and bioactivities comparison of saponins in radix and flower of Panax notoginseng (Burk.) F.H. Chen.

Xin Zhou, Lin-Lin Chen, Rui Fang Xie, Wing Lam, Zi-Jia Zhang, Zao-Li Jiang, Yung-Chi Cheng,

Panax notoginseng (Burk.) F.H. Chen is a well known medicinal plant. Its radix is used in the history while its flower is recently used for health care. In this study we compared chemical ingredients and bioactivities in cell culture for radix and flower of Panax notoginseng (Burk.) F.H. Chen.The liquid ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2017, 201:56-72]

Cited: 5 times

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Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates.

Lun K Tsou, María Lara-Tejero, Jordan RoseFigura, Zhenrun J Zhang, Yen-Chih Wang, Jacob S Yount, Matthew Lefebre, Paul D Dossa, Junya Kato, Fulan Guan, Wing Lam, Yung-Chi Cheng, Jorge E Galán, Howard C Hang,

Traditional Chinese Medicines (TCMs) have been historically used to treat bacterial infections. However, the molecules responsible for these anti-infective properties and their potential mechanisms of action have remained elusive. Using a high-throughput assay for type III protein secretion in Salmonella enterica serovar Typhimurium, we discovered that several TCMs can attenuate ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2016, 138(7):2209-2218]

Cited: 16 times

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Steroidal saponins from stems and leaves of Paris polyphylla var. yunnanensis.

Xu-Jie Qin, Mu-Yuan Yu, Wei Ni, Huan Yan, Chang-Xiang Chen, Yung-Chi Cheng, Li He, Hai-Yang Liu,

Phytochemical investigation of the stems and leaves of Paris polyphylla var. yunnanensis led to isolation of 12 steroidal saponins, chonglouosides SL-9-SL-20, which had not been described previously, along with 13 known compounds. Their structures were established on the basis of extensive spectroscopic analysis and chemical methods. Four of the twelve ... Read more >>

Phytochemistry (Phytochemistry)
[2016, 121:20-29]

Cited: 14 times

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Study of Malformin C, a Fungal Source Cyclic Pentapeptide, as an Anti-Cancer Drug.

Jing Wang, Zaoli Jiang, Wing Lam, Elizabeth A Gullen, Zhe Yu, Ying Wei, Lihui Wang, Caroline Zeiss, Amanda Beck, Ee-Chun Cheng, Chunfu Wu, Yung-Chi Cheng, Yixuan Zhang,

Malformin C, a fungal cyclic pentapeptide, has been claimed to have anti-cancer potential, but no in vivo study was available to substantiate this property. Therefore, we conducted in vitro and in vivo experiments to investigate its anti-cancer effects and toxicity. Our studies showed Malformin C inhibited Colon 38 and HCT ... Read more >>

PLoS ONE (PloS one)
[2015, 10(11):e0140069]

Cited: 7 times

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Disruption of the mevalonate pathway induces dNTP depletion and DNA damage.

Covadonga Martín Sánchez, José Manuel Pérez Martín, Jong-Sik Jin, Alberto Dávalos, Wei Zhang, Gema de la Peña, Javier Martínez-Botas, Sara Rodríguez-Acebes, Yajaira Suárez, María José Hazen, Diego Gómez-Coronado, Rebeca Busto, Yung-Chi Cheng, Miguel A Lasunción,

The mevalonate pathway is tightly linked to cell division. Mevalonate derived non-sterol isoprenoids and cholesterol are essential for cell cycle progression and mitosis completion respectively. In the present work, we studied the effects of fluoromevalonate, a competitive inhibitor of mevalonate diphosphate decarboxylase, on cell proliferation and cell cycle progression in ... Read more >>

Biochim. Biophys. Acta (Biochimica et biophysica acta)
[2015, 1851(9):1240-1253]

Cited: 5 times

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