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Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain.

Victor K Outlaw, Francesca T Bovier, Megan C Mears, Maria N Cajimat, Yun Zhu, Michelle J Lin, Amin Addetia, Nicole A P Lieberman, Vikas Peddu, Xuping Xie, Pei-Yong Shi, Alexander L Greninger, Samuel H Gellman, Dennis A Bente, Anne Moscona, Matteo Porotto,

The emergence of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the etiological agent of the 2019 coronavirus disease (COVID-19), has erupted into a global pandemic that has led to tens of millions of infections and hundreds of thousands of deaths worldwide. The development of therapeutics to treat infection or ... Read more >>

mBio (mBio)
[2020, 11(5):]

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Optimization of Solid-State Fermentation Conditions of Astragali Radix Residues and Changes of Its Nine Constituents Content Before and After Fermentation

Cuiyan Liu, Yun Zhu, Guangtai Fan, Jingang Gu, Chunyang Han,

Abstract Background: For the last few years huge quantity of herb residues are discharged in China, and so far there is not a good solution. The current methods of disposal and utilization of herb residues (stacking, incineration, and landfill) were not only great harmful to the ecological environment, but also ... Read more >>

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Analyses and identification of the chemical constituents of the Uighur formulation Baixuan Xiatare using three-stage infrared spectroscopy.

Aibibula Litipijiang, Xiaobo Pang, Yun Zhu, Jian Huang, Hangyu Wang, Le Gao, Xu Liang, Long Chen, Ke Zhang, Jinhui Wang,

OBJECTIVE:To identify, rapidly and accurately, the chemical composition of the traditional Uighur formulation Baixuan Xiatare (BXXTR-FU). METHODS:We investigated if application of three-stage infrared (IR) spectroscopy enabled identification of the main chemical constituents (and their origins) in BXXTR-FU. RESULTS:The characteristic peaks of herbal material(s) and BXXTR-FU were assigned. In Fourier transform-IR ... Read more >>

J Tradit Chin Med (Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan)
[2020, 40(5):875-882]

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Clinical Efficacy and Safety of Eight Traditional Chinese Medicine Combined with Entecavir in the Treatment of Chronic Hepatitis B Liver Fibrosis in Adults: A Network Meta-Analysis.

Tao Wang, Wei Jin, Qianqian Huang, Haotian Li, Yun Zhu, Honghong Liu, Huadan Cai, Jiabo Wang, Ruilin Wang, Xiaohe Xiao, Yanling Zhao, Wenjun Zou,

Background:Traditional Chinese medicine (TCM) is used as an adjuvant drug for the treatment of chronic hepatitis B liver fibrosis and is used frequently. We still do not know which TCM has the best curative effect as an adjuvant drug. Therefore, we decided to use network meta-analysis to solve this problem. ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2020, 2020:7603410]

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Epstein-Barr virus-related hemophagocytic lymphohistiocytosis complicated with coronary artery dilation and acute renal injury in a boy with a novel X-linked inhibitor of apoptosis protein (XIAP) variant: a case report.

Ru-Yue Chen, Xiao-Zhong Li, Qiang Lin, Yun Zhu, Yun-Yan Shen, Qin-Ying Xu, Xue-Ming Zhu, Zhen-Jiang Bai, Ying Li,

BACKGROUND:X-linked lymphoproliferative disease (XLP) is a rare inherited X-linked primary immunodeficiency diseases (PID). One such disease, X-linked inhibitor of apoptosis protein (XIAP) deficiency, is characterized by Epstein-Barr virus-related hemophagocytic lymphohistiocytosis (EBV-HLH). However, EBV-HLH with coronary artery dilation and acute renal injury (AKI) in children is unusual. CASE PRESENTATION:We report the ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):456]

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Selective regulation of human TRAAK channels by biologically active phospholipids.

Samantha Schrecke, Yun Zhu, Jacob W McCabe, Mariah Bartz, Charles Packianathan, Minglei Zhao, Ming Zhou, David Russell, Arthur Laganowsky,

TRAAK is an ion channel from the two-pore domain potassium (K2P) channel family with roles in maintaining the resting membrane potential and fast action potential conduction. Regulated by a wide range of physical and chemical stimuli, the affinity and selectivity of K2P4.1 toward lipids remains poorly understood. Here we show ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Dexmedetomidine versus midazolam on cough and recovery quality after partial and total laryngectomy - a randomized controlled trial.

Rui Xu, Yun Zhu, Yi Lu, Wenxian Li, Jie Jia,

BACKGROUND:During emergence from anesthesia after partial and total laryngectomy, excessive airway reflex and systemic hypertension may lead to subcutaneous emphysema, hemorrhage or pneumothorax. METHODS:American Society of Anesthesiologist physical status III and IV male adults undergoing elective laryngectomy were recruited and randomly allocated to receive either dexmedetomidine (group D) or midazolam ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2020, 20(1):249]

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Poly-γ-glutamic acid derived nanopolyplexes for up-regulation of gamma-glutamyl transpeptidase to augment tumor active targeting and enhance synergistic antitumor therapy by regulating intracellular redox homeostasis.

Fangying Yu, Yun Zhu, Yupeng Liu, Guoxi Qiu, Xuwei Shang, Tingting Meng, Hong Yuan, Fuqiang Hu,

The active targeting strategy has achieved inspiring progress for drug accumulation in tumor therapy; however, the insufficient expression level of many potential receptors poses challenges for drug delivery. Poly-γ-glutamic acid (γ-pGluA), a naturally occurring anionic biopolymer, showed high affinity with tumor-associated gamma-glutamyl transpeptidase (GGT), which localized on the cell surface ... Read more >>

Biomater Sci (Biomaterials science)
[2020, :]

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Proteinuria as a presenting sign of combined methylmalonic acidemia and homocysteinemia: case report.

Ru-Yue Chen, Xiao-Zhong Li, Qiang Lin, Yun Zhu, Yun-Yan Shen, Qin-Ying Xu, Xue-Ming Zhu, Lin-Qi Chen, Hai-Ying Wu, Xu-Qin Chen,

BACKGROUND:Disorders of the metabolism and absorption of vitamin B12 can lead to decrease in activity of methionine synthetase and methylmalonate coenzyme A mutase (MMUT), which results in increased levels of methylmalonic acid and homocysteine in blood and urine. Often, combined methylmalonic acidemia (MMA) and homocysteinemia is misdiagnosed due to a ... Read more >>

BMC Med Genet (BMC medical genetics)
[2020, 21(1):183]

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Erratum to: Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum.

Chunyu Li, Ming Niu, Zhaofang Bai, Congen Zhang, Yanling Zhao, Ruiyu Li, Can Tu, Huifang Li, Jing Jing, Yakun Meng, Zhijie Ma, Wuwen Feng, Jinfa Tang, Yun Zhu, Jinjie Li, Xiaoya Shang, Zhengsheng Zou, Xiaohe Xiao, Jiabo Wang,

The original version of this article unfortunately contained some mistakes.The panel of "LPS-/drug-" in Fig. 3B (Page 259), the panels of "LPS-/EtoAc+" and "LPS-/Residue+" in Supplementary Fig. 3 (Page 7 in the online supplementary materials) should be corrected. The authors apologize for this error and state that this does not ... Read more >>

Front Med (Frontiers of medicine)
[2020, :]

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Dexmedetomidine versus midazolam on cough and recovery quality after partial and total laryngectomy – a randomized controlled trial.

Rui Xu, Yun Zhu, Yi Lu, Wen Xian Li, Jie Jia,

Abstract Background ː During emergence from anesthesia after partial and total laryngectomy, excessive airway reflex and systemic hypertension may lead to subcutaneous emphysema, hemorrhage or pneumothorax. Methods ː American Society of Anesthesiologist physical status III and IV male adults undergoing elective laryngectomy were recruited and randomly allocated to receive either ... Read more >>

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Microscopic anatomy and ultrastructure of the resin ducts of Ferula ferulaeoides (Steud.) Korov. in Xinjiang.

Meng-Meng Liu, Si-Wei Zhang, Qing-Guang Liu, Meng-Meng Guo, Sheng-Hui Liang, Li-Xia Luo, Wen-Xia Liu, Yun Zhu, Kai Liao,

Ferula ferulaeoides (Steud.) Korov. is a perennial herb that belongs to Umbelliferae (Apiaceae). Its resin and roots have extensive commercial and medicinal value in the Xinjiang region. However, the resin-secreting resin ducts (RDs) of F. ferulaeoides have not been studied in detail. This study used optical and transmission electron microscopy ... Read more >>

Microsc. Res. Tech. (Microscopy research and technique)
[2020, :]

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A role of color vision in emmetropization in C57BL/6J mice.

Jinglei Yang, Li Yang, Rongfang Chen, Yun Zhu, Siyao Wang, Xueqin Hou, Bei Wei, Qiongsi Wang, Yue Liu, Jia Qu, Xiangtian Zhou,

Spectral composition affects emmetropization in both humans and animal models. Because color vision interacts the effects of chromatic defocus, we developed a method to bypass the effects of longitudinal chromatic aberration by placing a spectral filter behind the optics of the eye, using genetic tools. Newborn C57BL/6J (B6) mice were ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):14895]

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Effect of intrathecal lipophilic opioids on the incidence of shivering in women undergoing cesarean delivery after spinal anesthesia: a systematic review and bayesian network meta- analysis of randomized controlled trials.

Yamini Subramani, Mahesh Nagappa, Kamal Kumar, Lee-Anne Fochesato, Moaz Bin Yunus Chohan, Yun Fei Zhu, Kevin Armstrong, Sudha Indu Singh,

BACKGROUND:Shivering is a common side effect in women having cesarean delivery (CD) under spinal anesthesia, which can be bothersome to the patient, and it can also interfere with perioperative monitoring. In several studies, the intrathecal (IT) addition of a lipophilic opioid to local anesthetics has been shown to decrease the ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2020, 20(1):214]

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An epidemiological cross-sectional study of prevalence of mental disorders in Dulong nationality of Southwest China.

Jinsheng Zhi, Yunqiao Zhang, Xu You, Qing Long, Yun Zhu, Jianping Liu, Jie Wu, JinTao Zhang, TingTing Wang, Zhaowei Teng, Yong Zeng,

The Dulong nationality is one of the 5 smallest ethnic minorities in China. The suicide rate among people of the Dulong nationality is very serious. To address this issue, we conducted cross-sectional epidemiological studies on the prevalence of mental disorders in ethnic groups. Studying the unique situation of ethnic minorities ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(38):e21884]

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Maternal Folic Acid Impacts DNA Methylation Profile in Male Rat Offspring Associated With Neurodevelopment and Learning/Memory Abilities

Xinyan Wang, Zhenshu Li, Yun Zhu, Jing Yan, Huan Liu, Guowei Huang, Wen Li,

Abstract Background: Periconceptional folic acid (FA) supplementation not only reduces the incidence of neural tube defects, but also improves cognitive performances in offspring. However, the genes or pathways that are epigenetically regulated by FA in neurodevelopment were rarely reported. Methods: To elucidate the underlying mechanism, the effect of FA on ... Read more >>

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Cytologic diagnosis of medullary thyroid carcinoma in the Asia-Pacific region.

Chih-Yi Liu, Andrey Bychkov, Shipra Agarwal, Yun Zhu, Jen-Fan Hang, Chiung-Ru Lai, Hee Young Na, Weiwei Li, Zhiyan Liu, Deepali Jain, Ayana Suzuki, Mitsuyoshi Hirokawa, Noel Chia, Min En Nga, Tikamporn Jitpasutham, Somboon Keelawat, So Yeon Park, Shinya Satoh, Chien-Chin Chen, Dilini Gunawardena, Priyanthi Kumarasinghe, Chan Kwon Jung, Kennichi Kakudo,

BACKGROUND:The accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to the rarity of tumor and variable cytologic appearance. The Asian experience with diagnosing MTC by fine-needle aspiration (FNA) was scarcely reported. METHODS:Cases of MTC with available FNA slides were enrolled from 13 hospitals representing 8 Asia-Pacific countries. ... Read more >>

Diagn Cytopathol (Diagnostic cytopathology)
[2020, :]

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miR-100 rs1834306 A>G Increases the Risk of Hirschsprung Disease in Southern Chinese Children.

Yun Zhu, Ao Lin, Yi Zheng, Xiaoli Xie, Qiuming He, Wei Zhong,

Background:Hirschsprung disease (HSCR) is a rare congenital gastrointestinal disease characterized by the absence of intestinal submucosal and myometrial ganglion cells. Recently, researches indicated that miR-100 regulated the growth, differentiation and apoptosis of neurons, and affected the functions of HSCR-associated pathways. While miR-100 rs1834306 A>G polymorphism was shown to modify the ... Read more >>

Pharmgenomics Pers Med (Pharmacogenomics and personalized medicine)
[2020, 13:283-288]

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CALCIUM-DEPENDENT PROTEIN KINASE 32-mediated phosphorylation is essential for the ammonium transport activity of AMT1;1 in Arabidopsis roots.

De-Bin Qin, Meng-Yuan Liu, Lixing Yuan, Yun Zhu, Xi-Dong Li, Li-Mei Chen, Yi Wang, Yi-Fang Chen, Wei-Hua Wu, Yang Wang,

Protein kinase-mediated phosphorylation modulates the absorption of many nutrients in plants. CALCIUM-DEPENDENT PROTEIN KINASES (CPKs) are key players in plant signaling to translate calcium signals into diverse physiological responses. However, the regulatory role of CPKs in ammonium uptake remains largely unknown. Here, using methylammonium (MeA) toxicity screening, CPK32 was identified ... Read more >>

J. Exp. Bot. (Journal of experimental botany)
[2020, 71(16):5087-5097]

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Perspectives on ENCODE.

, Michael P Snyder, Thomas R Gingeras, Jill E Moore, Zhiping Weng, Mark B Gerstein, Bing Ren, Ross C Hardison, John A Stamatoyannopoulos, Brenton R Graveley, Elise A Feingold, Michael J Pazin, Michael Pagan, Daniel A Gilchrist, Benjamin C Hitz, J Michael Cherry, Bradley E Bernstein, Eric M Mendenhall, Daniel R Zerbino, Adam Frankish, Paul Flicek, Richard M Myers,

The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The ... Read more >>

Nature (Nature)
[2020, 583(7818):693-698]

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Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19

Stuart Weisberg, Thomas Connors, Yun Zhu, Matthew Baldwin, Wen-Hsuan Lin, Sandeep Wontakal, Peter Szabo, Steven Wells, Pranay Dogra, Joshua Gray, Emma Idzikowski, Francesca Bovier, Julia Davis-Porada, Rei Matsumoto, Maya Meimei Li Poon, Michael Chait, Cyrille Mathieu, Branka Horvat, Didier Decimo, Zachary Bitan, Francesca La Carpia, Stephen Ferrara, Emily Mace, Joshua Milner, Anne Moscona, Eldad Hod, Matteo Porotto, Donna Farber,

Clinical manifestations of COVID-19 caused by the novel coronavirus SARS-CoV-2 are associated with age. While children are largely spared from severe respiratory disease, they can present with a SARS-CoV-2-associated multisystem inflammatory syndrome (MIS-C) similar to Kawasaki's disease. Here, we show distinct antibody (Ab) responses in children with MIS-C compared to ... Read more >>

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Correction to: White-coat hypertension and incident end‑stage renal disease in patients with non‑dialysis chronic kidney disease: results from the C‑STRIDE Study.

Qin Wang, Yu Wang, Jinwei Wang, Luxia Zhang, Ming-Hui Zhao, ,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):282]

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Prevalence and diagnostic challenges of thyroid lymphoma: a multi-institutional study in non-Western countries.

Mitsuyoshi Hirokawa, Ayana Suzuki, Yuko Hashimoto, Shinya Satoh, Sule Canberk, Jie Yang Jhuang, Chan Kwon Jung, Nichthida Tangnuntachai, Bozidar Kovacevic, Yun Zhu, Shipra Agarwal, Kennichi Kakudo,

Research on the primary thyroid lymphoma (PTL) diagnosis is limited, with only a few large sample size studies, reported from Asian countries. The aim of the present study was to clarify the current prevalence and challenges in PTL diagnosis, and recommended ancillary studies for PTL in non-Western countries. PTL (n ... Read more >>

Endocr. J. (Endocrine journal)
[2020, :]

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Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis.

Fei Zhao, Dake Zhang, Qingyi Zhou, Fuxin Zhao, Mingguang He, Zhenglin Yang, Yongchao Su, Ying Zhai, Jiaofeng Yan, Guoyun Zhang, Anquan Xue, Jing Tang, Xiaotong Han, Yi Shi, Yun Zhu, Tianzi Liu, Wenjuan Zhuang, Lulin Huang, Yaqiang Hong, Deng Wu, Yingxiang Li, Qinkang Lu, Wei Chen, Shiming Jiao, Qiongsi Wang, Nethrajeith Srinivasalu, Yingying Wen, Changqing Zeng, Jia Qu, Xiangtian Zhou,

BACKGROUND:Myopia is a good model for understanding the interaction between genetics and environmental stimuli. Here we dissect the biological processes affecting myopia progression. METHODS:Human Genetic Analyses: (1) gene set analysis (GSA) of new genome wide association study (GWAS) data for 593 individuals with high myopia (refraction ≤ -6 diopters [D]); ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 57:102878]

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PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway.

Xuming Tang, Tingting Cao, Yun Zhu, Liyi Zhang, Jinna Chen, Tengfei Liu, Xiaoyan Ming, Shuo Fang, Yun-Fei Yuan, Lingxi Jiang, Jian-Dong Huang, Xin-Yuan Guan,

Inflammatory factors and activation of oncogenes both played critical roles in the development and progression of human hepatocellular carcinoma (HCC). However, the interplay between these two has not been well studied. In this study, we found that regulated by TNFα, Pim-2 proto-oncogene, serine/threonine kinase (PIM2) was highly expressed in HCC ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(7):510]

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