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Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis.

Jiawei Zhao, Kai Liu, Shen Li, Yuan Gao, Lu Zhao, Hongbing Liu, Hui Fang, Bo Song, Yuming Xu,

<h4>Background</h4>Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.<h4>Methods</h4>Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor ... Read more >>

Curr Neurovasc Res (Current neurovascular research)
[2021, :]

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Retraction Note to: Treatment with a brain-selective prodrug of 17β-estradiol improves cognitive function in Alzheimer's disease mice by regulating klf5-NF-κB pathway.

Wenhao Yan, Jun Wu, Bo Song, Qiang Luo, Yuming Xu,

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2021, :]

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Generation of induced pluripotent stem cell line (ZZUi027-A) derived from skin fibroblasts from a Parkinson's disease patient with RAB39B gene mutation.

Huifang Sun, Zhuoya Wang, Qi Zhang, Yutao Liu, Jing Yang, Han Liu, Changhe Shi, Yanlin Wang, Yuming Xu,

Parkinson's disease is a common neurogenetic degenerative disease that can be caused by a variety of genetic mutations. RAB39B gene mutations have recently been identified as a cause of Parkinson's disease. We collected skin tissue samples from a family with mutations in RAB39B for our clinical study. Additionally, we constructed ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 55:102454]

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Serum Immunoglobulin G level and Neutrophils to Lymphocytes Ratio Associated with the Prognosis of Neuromyelitis Optica Spectrum Disorder.

Ying Tong, Li Wang, Kai Liu, Weishi Liu, Shen Li, Bo Song, Zongping Xia, Yuming Xu, Rui Zhang,

<h4>Objective</h4>To investigate the factors related to the prognosis of neuromyelitis optica spectrum disorder (NMOSD) in cerebrospinal fluid and peripheral blood examination.<h4>Methods</h4>In this study, we collected 111 patients who were admitted to the First Affiliated Hospital of Zhengzhou University between January 2016 and January 2018 and diagnosed with NMOSD. The patients ... Read more >>

Curr Neurovasc Res (Current neurovascular research)
[2021, :]

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IL-17 Inhibits Oligodendrocyte Progenitor Cell Proliferation and Differentiation by Increasing K+ Channel Kv1.3.

Han Liu, Xueke Yang, Jing Yang, Yanpeng Yuan, Yanlin Wang, Rui Zhang, Huangui Xiong, Yuming Xu,

Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. IL-17 level is significantly increased in inflammatory conditions of the CNS, including but not limited to post-stroke and multiple sclerosis. IL-17 has been detected direct toxicity on oligodendrocyte (Ol) lineage cells and inhibition on oligodendrocyte progenitor cell (OPC) differentiation, and ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:679413]

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Autologous Transplantation for Parkinson's Disease Patients: Feasibility and Challenge.

Qi Zhang, Yanlin Wang, Yukai Wang, Han Liu, Huifang Sun, Zhuoya Wang, Changhe Shi, Jing Yang, Yuming Xu,

Neurosci Bull (Neuroscience bulletin)
[2021, 37(7):1085-1086]

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Generation of induced pluripotent stem cell line (ZZUi028-A) from a 52-year-old Chinese Han healthy female individual.

Yanlin Wang, Zhuoya Wang, Huifang Sun, Qi Zhang, Jing Yang, Yutao Liu, Han Liu, Changhe Shi, Rui Zhang, Yuming Xu,

Skin fibroblasts were donated by a healthy 52-year-old Han Chinese woman. The induced pluripotent stem cell (iPSC) line was constructed using an episomal reprogramming method that made the generated iPSCs integration-free. This iPSC line expressed the common pluripotency markers, could be differentiated into three germ layers, and showed normal karyotype ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 53:102381]

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The Value of NOTCH2NLC Gene Detection and Skin Biopsy in the Diagnosis of Neuronal Intranuclear Inclusion Disease.

Jie Pang, Jing Yang, Yanpeng Yuan, Yuan Gao, Changhe Shi, Shiheng Fan, Yuming Xu,

The clinical manifestations of neuronal intranuclear inclusion disease (NIID) are heterogeneous, and the premortem diagnosis is mainly based on skin biopsy findings. Abnormal GGC repeat expansions in <i>NOTCH2NLC</i> was recently identified in familial and sporadic NIID. The comparison of diagnostic value between abnormal GGC repeat expansions of <i>NOTCH2NLC</i> and skin ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:624321]

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Metabolically healthy obesity increases the prevalence of stroke in adults aged 40 years or older: Result from the China National Stroke Screening survey.

Ningning Zhang, Ge Liang, Mengying Liu, Guowei Zheng, Hailan Yu, Yage Shi, Yihe Zhang, Hao Wang, Yapeng Li, Yuming Xu, Jie Lu,

Debate over the cardio-cerebrovascular risk associated with metabolically healthy obesity (MHO) continues. In this study we investigated the association of MHO with the risk of stroke among 221,114 individuals aged 40 years or older based on data from the China National Stroke Screening and Prevention Project (CNSSPP), a nationally representative cross-sectional ... Read more >>

Prev Med (Preventive medicine)
[2021, 148:106551]

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Effectiveness of intravenous r-tPA versus UK for acute ischaemic stroke: a nationwide prospective Chinese registry study.

Xinhong Wang, Xiaoqiu Li, Yuming Xu, Runhui Li, Qingcheng Yang, Yong Zhao, Fengyun Wang, Baoying Sheng, Runqing Wang, Shaoyuan Chen, Lihua Wang, Liying Shen, Xiaowen Hou, Yu Cui, Duolao Wang, Bin Peng, Craig S Anderson, Huisheng Chen, ,

<h4>Background</h4>Intravenous recombinant tissue plasminogen activator (r-tPA) and urokinase (UK) are both recommended for the treatment of acute ischaemic stroke (AIS) in China, but with few comparative outcome data being available. We aimed to compare the outcomes of these two thrombolytic agents for the treatment of patients within 4.5 hours of onset ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2021, :]

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Rationale and design of a phase 3b, prospective, randomized, open label, blinded-endpoint, multicenter trial of the efficacy and safety of urokinase thrombolysis comparing with antiplatelet agents for patients with minor stroke.

Lu Zhao, Chenyang Jiang, Yongli Tao, Yuan Gao, Yafang Xu, Rui Zhang, Kai Liu, Hongqiu Gu, Yilong Wang, Yuming Xu, Bo Song,

<h4>Rationale</h4>Minor ischemic stroke attack has taken a significant part of cerebrovascular disease burden. Benefits of thrombolysis in minor stroke is under debates and the use of urokinase in developing countries needs to be further explored.<h4>Aim</h4>TRUST (ThRombolysis of Urokinase for minor STroke) trial was designed to evaluate the efficacy and safety ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2021, :17474930211014344]

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Femoral artery-nourished anteromedial thigh flap: A new perspective in oral and maxillofacial defect reconstruction.

Zhaojian Gong, Shanshan Zhang, Panchun Li, Jiang Liu, Yuming Xu,

<h4>Objectives</h4>The aim of this study was to evaluate the feasibility and efficacy of the femoral artery (FA)-nourished anteromedial thigh (AMT) flap for reconstructing oral and maxillofacial defects.<h4>Patients and methods</h4>The authors analyzed a retrospective case series of 13 patients who underwent the reconstruction of oral and maxillofacial defects with the FA-nourished ... Read more >>

Oral Oncol (Oral oncology)
[2021, 117:105295]

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Analysis of 12 GWAS-Linked Loci With Parkinson's Disease in the Chinese Han Population.

Liyuan Fan, Changhe Shi, Xinchao Hu, Zhongxian Zhang, Huimin Zheng, Haiyang Luo, Yu Fan, Shuo Zhang, Zhengwei Hu, Jing Yang, Chengyuan Mao, Yuming Xu,

A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:623913]

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Generation of induced pluripotent stem cell line (ZZUi0021-A) from a patient with spinocerebellar ataxia type 19.

Fen Liu, Yu Fan, Liyuan Fan, Mengjie Li, Qimeng Zhang, Chengyuan Mao, Jun Wu, Shuo Zhang, Zhengwei Hu, Changhe Shi, Yuming Xu,

Spinocerebellar ataxia type 19 (SCA19) is an extremely rare autosomal dominant cerebellar ataxia hereditary that caused by the KCND3 gene mutation. And has a complex pathogenesis. At present, its pathogenesis is still unclear, and there is no effective treatment for SCA19. So, to study its pathogenesis and find effective treatments, ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 53:102320]

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A Mendelian Randomization Study of Plasma Homocysteine Levels and Cerebrovascular and Neurodegenerative Diseases.

Weishi Liu, Luyang Zhang, Shen Li, Chen Liu, Ying Tong, Hui Fang, Rui Zhang, Bo Song, Zongping Xia, Yuming Xu,

<b>Background</b>: Homocysteine (Hcy) is a toxic amino acid and hyperhomocysteinemia (HHcy) was reported to be associated with both cerebrovascular disease and neurodegenerative disease. Our aim was to assess the causal link between plasma Hcy level and cerebrovascular and neurodegenerative diseases through a Mendelian randomization (MR) study. <b>Methods</b>: A two-sample MR ... Read more >>

Front Genet (Frontiers in genetics)
[2021, 12:653032]

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Generation of induced pluripotent stem cell line (ZZUi019-A) derived from skin fibroblasts from a healthy volunteer.

Yanlin Wang, Huifang Sun, Zhuoya Wang, Qi Zhang, Jing Yang, Yutao Liu, Han Liu, Changhe Shi, Yanlin Wang, Yuming Xu,

The research on nervous system diseases is limited by the difficulty in obtaining nerve cells from humans. The development of induced pluripotent stem cells (iPSCs) technology and the experimental system provide a feasible method for directional induced differentiation of nerve cells in vitro. In this project, we recruited a 50-year-old ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 53:102285]

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Reply: Shouldn't Patients With Paradoxical Emboli and Thrombophilia Be Given Anticoagulant Agents?

Kai Liu, Bo Song, Igor F Palacios, Ignacio Inglessis-Azuaje, Eng H Lo, YuMing Xu, Ferdinando S Buonanno, MingMing Ning,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2021, 14(5):583-584]

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Generation of induced pluripotent stem cell line (ZZUi0024-A) from a 51-year-old patient with APP gene mutation in Alzheimer' s disease.

Zhuoya Wang, Huifang Sun, Qi Zhang, Jing Yang, Yutao Liu, Han Liu, Changhe Shi, Yanlin Wang, Yuming Xu,

Alzheimer's disease (AD) is a neurodegenerative disease that manifests mainly as cognitive, behavioral, and neuropsychiatric changes and impairs social functions and activities of daily living. The β-amyloid precursor protein (APP) gene is one of the most common pathogenic genes associated with AD. We isolated dermal fibroblasts from a 51-year-old woman ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 53:102267]

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Zinc monotherapy for young patients with oligosymptomatic Wilson disease: A single center, retrospective study.

Haiman Hou, Dingbang Chen, Junxiu Liu, Li Feng, Jiwei Zhang, Xiuling Liang, Yuming Xu, Xunhua Li,

<h4>Background and aims</h4>Few studies have focused on the treatment failure of zinc monotherapy for oligosymptomatic Wilson disease (WD) patients. Therefore, we aimed to evaluate the long-term efficacy of zinc monotherapy in oligosymptomatic patients and to analyze the possible factors that may influence the outcome of this treatment.<h4>Methods</h4>We retrospectively reviewed the ... Read more >>

Clin Res Hepatol Gastroenterol (Clinics and research in hepatology and gastroenterology)
[2021, 45(6):101623]

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Multiple myeloma with Echinococcus granulosus infection diagnosed by detection of oligoclonal bands: A case report.

Jinghong Li, Xiaoyun Zhang, Hongjun Hao, Shiheng Fan, Yuming Xu,

<h4>Rationale</h4>Isoelectric focusing electrophoresis (IFE) is currently recognized as the gold standard for detecting oligoclonal bands (OCBs) in cerebrospinal fluid (CSF). To the best of our knowledge, however, no study has reported on type III OCBs using IFE. In this paper, we report on a rare case of multiple myeloma (MM) ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(9):e24709]

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Neuroinflammation in Parkinson's Disease: Triggers, Mechanisms, and Immunotherapies.

Tai Wang, Changhe Shi, Haiyang Luo, Huimin Zheng, Liyuan Fan, Mibo Tang, Yun Su, Jing Yang, Chengyuan Mao, Yuming Xu,

Parkinson's disease (PD) is a heterogeneous neurodegenerative disease involving multiple etiologies and pathogenesis, in which neuroinflammation is a common factor. Both preclinical experiments and clinical studies provide evidence for the involvement of neuroinflammation in the pathophysiology of PD, although there are a number of key issues related to neuroinflammatory processes ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421991066]

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Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3.

Jing Fang, Yanlin Wang, Zhuoya Wang, Huifang Sun, Qi Zhang, Jing Yang, Yutao Liu, Han Liu, Changhe Shi, Yuming Xu, Xinzhong Zhang, Quancheng Kan,

Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disease caused by CAG repeat expansion of the ATXN3 gene encoding ataxin-3 protein and is mainly manifested by motor symptoms such as ataxia and non-motor symptoms such as cognitive dysfunction. In this study, we obtained skin fibroblasts from a SCA3 patient ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 53:102205]

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Evolutionary selection on synonymous codons in RNA G-quadruplex structural region

Yuming Xu, Ting Qi, Zuhong Lu, Tong Zhou, Wanjun Gu,

<h4>ABSTRACT</h4> In addition to the amino acid sequence information, synonymous codons can encode multiple regulatory and structural signals in protein coding region. In this study, we investigated how synonymous codons have been adapted to the formation of RNA G-quadruplex (rG4) structure. We found a universal selective pressure acting on synonymous ... Read more >>

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Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants.

Jing Yang, Hao Wang, Yanpeng Yuan, Shiheng Fan, Lanjun Li, Chenyang Jiang, Chengyuan Mao, Changhe Shi, Yuming Xu,

<h4>Objective</h4>Recent studies demonstrated cutaneous phosphorylated α synuclein (p-syn) deposition in idiopathic and some monogenetic Parkinson disease (PD) patients, suggesting synucleinopathy identical to that in the brain. Although the LRRK2 Gly2385Arg (G2385R) variant is a common PD risk factor in the Chinese population, the pathogenesis of PD with G2385R variant has ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2021, 8(3):592-602]

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Prognostic Nutritional Index Predicts Clinical Outcome in Patients with Cerebral Venous Sinus Thrombosis

Jiawei Zhao, Kai Liu, Shen Li, Yuan Gao, Lu Zhao, Hongbing Liu, Hui Fang, Jun Wu, Shilei Sun, Yusheng Li, Bo Song, Yuming Xu,

<h4>Background: </h4> Lower prognostic nutritional index (PNI) is related to poor prognosis of cardiovascular disease. However, little is known about PNI and its relationship with prognosis in cerebral venous sinus thrombosis (CVST). <h4>Methods: </h4>: From January 2013 to June 2019, we retrospectively identified consecutive CVST patients. We selected patients in ... Read more >>

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