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Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue.

Yanming Li, Pingping Ren, Ashley Dawson, Hernan G Vasquez, Waleed Ageedi, Chen Zhang, Wei Luo, Rui Chen, Yumei Li, Sangbae Kim, Hong S Lu, Lisa A Cassis, Joseph S Coselli, Alan Daugherty, Ying H Shen, Scott A LeMaire,

BACKGROUND:Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and other life-threatening complications. To improve our understanding of ATAA pathogenesis, we aimed to comprehensively characterize the cellular composition of the ascending aortic wall and to ... Read more >>

Circulation (Circulation)
[2020, 142(14):1374-1388]

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Nucleolar protein 7 facilitates melanoma progression and metastasis via HIF-1ɑ/PI3K/AKT/ERK axis

Yumei Li, Fan Chen, Weiyu Shen, Bifei Li, Ning Zheng, Yusheng Lu, Vladimir Katanaev, Lee Jia,

Abstract Background Metastasis is the cause of most fatalities in cancer patients and is poorly understood. Discovery of the underlying determinant and regulatory networks implicated in the cancer cell metastasis is urgently needed. Methods The expression pattern of nucleolar protein 7 (NOL7) was examined by IHC in clinic melanoma samples. ... Read more >>

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S-nitrosylation of CYR61 protein reduces triple-negative breast cancer metastasis ability

Lee Jia, Yusheng Lu, Sudan He, Huanzhang Xie, Chunlian Zhong, Xingtian Yang, Suhong Yu, Shu Lian, Yumei Li, Guoxing Lin, Chen Zhang,

Abstract Background Triple-negative breast cancer (TNBC) is the most difficult cancer to be treated. TNBC expresses high level of matricellular cysteine-rich protein CYR61/CCN1 that plays a key role in producing cancer metastases and is an important target for metastasis chemoprevention. Nitric oxide (NO) can covalently bind to the thiol group ... Read more >>

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Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.

Li-Wa Shao, Qi Peng, Mingyue Dong, Kaiyu Gao, Yumei Li, Yi Li, Chuan-Yun Li, Ying Liu,

The ability to detect, respond and adapt to mitochondrial stress ensures the development and survival of organisms. Caenorhabditis elegans responds to mitochondrial stress by activating the mitochondrial unfolded protein response (UPRmt) to buffer the mitochondrial folding environment, rewire the metabolic state, and promote innate immunity and lifespan extension. Here we ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4639]

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Enhancement of angucycline production by combined UV mutagenesis and ribosome engineering and fermentation optimization in Streptomyces dengpaensis XZHG99T.

Yumei Li, Jiyu Li, Zhengmao Ye, Lingchao Lu,

Strain improvement of Streptomyces dengpaensis XZHG99T was performed by combined UV mutagenesis and ribosome engineering, as well as fermentation optimization for enhanced angucycline production (rabelomycin and saquayamycin B1). First, four streptomycin-resistant mutants were obtained after screening of UV mutagenesis and ribosome engineering. Then a rpsL mutant (HTT7) with higher productivity ... Read more >>

Prep. Biochem. Biotechnol. (Preparative biochemistry & biotechnology)
[2020, :1-10]

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A boy with refractory cyanosis: pediatric pulmonary arteriovenous malformation case report and literature review

Chuqiao Sheng, Chunfeng Yang, Yu Ao, Yumei LI,

Abstract Background : Pulmonary arteriovenous malformation is rare and is defined as the presence of an abnormal connection between the pulmonary artery and vein. Pulmonary arteriovenous malformation can manifest with no obvious clinical symptoms and is only found incidentally on pulmonary imaging examinations. The clinical signs vary according to the ... Read more >>

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The safety and clinical effects of administering a multiantigen-targeted T cell therapy to patients with multiple myeloma.

Premal D Lulla, Ifigeneia Tzannou, Spyridoula Vasileiou, George Carrum, Carlos A Ramos, Rammurti Kamble, Tao Wang, Mengfen Wu, Mrinalini Bilgi, Adrian P Gee, Shivani Mukhi, Betty Chung, Linghua Wang, Ayumi Watanabe, Manik Kuvalekar, Mira Jeong, Yumei Li, Shamika Ketkar, Matthew French-Kim, Bambi Grilley, Malcolm K Brenner, Helen E Heslop, Juan F Vera, Ann M Leen,

Multiple myeloma (MM) is an almost always incurable malignancy of plasma cells. Despite the advent of new therapies, most patients eventually relapse or become treatment-refractory. Consequently, therapies with nonoverlapping mechanisms of action that are nontoxic and provide long-term benefit to patients with MM are greatly needed. To this end, we ... Read more >>

Sci Transl Med (Science translational medicine)
[2020, 12(554):]

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Extension of cell membrane boosting squalene production in the engineered Escherichia coli.

Yunhe Meng, Xixi Shao, Yan Wang, Yumei Li, Xiaojian Zheng, Gongyuan Wei, Seon-Won Kim, Chonglong Wang,

Squalene is a lipophilic and non-volatile triterpene with many industrial applications for food, pharmaceuticals and cosmetics. Metabolic engineering focused on optimization of the production pathway suffer from little success in improving titers because of a limited space of the cell membrane accommodating the lipophilic product. Extension of cell membrane would ... Read more >>

Biotechnol Bioeng (Biotechnology and bioengineering)
[2020, :]

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Speciation of antimony in representative sulfidic hot springs in the YST Geothermal Province (China) and its immobilization by spring sediments.

Qinghai Guo, Britta Planer-Friedrich, Li Luo, Mingliang Liu, Geng Wu, Yumei Li, Qian Zhao,

As a well-known toxic element, antimony occurred in a wide range of concentrations in the geothermal waters discharging from Rehai and Daggyai, two representative hydrothermal areas in the Yunnan-Sichuan-Tibet Geothermal Province of China. Antimony speciation in different types of the hot springs in Rehai and Daggyai varied greatly as well, ... Read more >>

Environ Pollut (Environmental pollution (Barking, Essex : 1987))
[2020, 266(Pt 1):115221]

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Amplitude of low-frequency fluctuations on Alzheimer's disease with depression: evidence from resting-state fMRI.

Yuzhu Mu, Yumei Li, Qi Zhang, Zhongxiang Ding, Mei Wang, Xingguang Luo, Xiaoyun Guo, Maosheng Xu,

Background:The prevalence of Alzheimer's disease (AD) comorbid with depression is common. However, the mechanisms of AD with depression remain unclear. Aims:To investigate the regional alterations of brain activity of AD with depression in resting-state functional magnetic resonance imaging (rs-fMRI). Methods:154 patients with AD who met the inclusion criteria were recruited ... Read more >>

(General psychiatry)
[2020, 33(4):e100147]

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Latent profiles of the comorbidity of the symptoms for posttraumatic stress disorder and generalized anxiety disorder among children and adolescents who are susceptible to COVID-19.

Yumei Li, Wenjie Duan, Zheng Chen,

The present study aims to examine the comorbidity patterns of the symptoms (intrusion and avoidance) for posttraumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) and the role of perceived threat and courtesy stigma in distinguishing specific patterns of the symptoms for PTSD and GAD among children and adolescents who ... Read more >>

Child Youth Serv Rev (Children and youth services review)
[2020, 116:105235]

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Prediction of Malignant Acute Middle Cerebral Artery Infarction via Computed Tomography Radiomics.

Xuehua Wen, Yumei Li, Xiaodong He, Yuyun Xu, Zhenyu Shu, Xingfei Hu, Junfa Chen, Hongyang Jiang, Xiangyang Gong,

Malignant middle cerebral artery infarction (mMCAi) is a serious complication of cerebral infarction usually associated with poor patient prognosis. In this retrospective study, we analyzed clinical information as well as non-contrast computed tomography (NCCT) and computed tomography angiography (CTA) data from patients with cerebral infarction in the middle cerebral artery ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:708]

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Identification of core genes and pathways in melanoma metastasis via bioinformatics analysis

Yumei Li, Bifei Li, Fan Chen, Weiyu Shen, Vladimir Katanaev, lee jia,

Abstract Background Metastasis is the leading cause of melanoma mortality. Current therapies are rarely curative for metastatic melanoma, revealing the urgent need to identify more effective preventive and therapeutic targets. This study aimed to screen for the key core genes and molecular mechanisms related to the metastasis of melanoma. ... Read more >>

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Natural variations in SlSOS1 contribute to the loss of salt tolerance during tomato domestication.

Zhen Wang, Yechun Hong, Yumei Li, Huazhong Shi, Juanjuan Yao, Xue Liu, Fuxing Wang, Sanwen Huang, Guangtao Zhu, Jian-Kang Zhu,

Soil salinity is a major constraint on crop cultivability and productivity worldwide (Shabala 2013). The ion toxicity caused by high salinity is alleviated by the adjustment of cellular Na+ and K+ homeostasis through the functions of ion transporters such as SOS1 (Salt Overly Sensitive 1) and HKT1 (High-Affinity Potassium Transporter ... Read more >>

Plant Biotechnol. J. (Plant biotechnology journal)
[2020, :]

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Modelling spatio-temporal patterns of soil carbon and greenhouse gas emissions in grazing lands: Current status and prospects.

Junye Wang, Yumei Li, Edward W Bork, Goetz M Richter, Hyung-Il Eum, Changchun Chen, Syed Hamid Hussain Shah, Symon Mezbahuddin,

The sustainability of grazing lands lies in the nexus of human consumption behavior, livestock productivity, and environmental footprint. Due to fast growing global food demands, many grazing lands have suffered from overgrazing, leading to soil degradation, air and water pollution, and biodiversity losses. Multidisciplinary efforts are required to understand how ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 739:139092]

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OSW-1 inhibits tumor growth and metastasis by NFATc2 on triple-negative breast cancer.

Xiaorong Ding, Yumei Li, Jun Li, Yongmei Yin,

OSW-1 is a natural compound extracted from the bulbs of Ornithogalum saundersiae in 1992. It has been shown strong antitumor activities in various cancer cells. However, the effects of OSW-1 on tumor growth and metastasis in breast cancer are still poorly understood. In our research, we showed that OSW-1 had ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(15):5558-5569]

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Assessing the chromium mobility in ashes through SiO2-Al2O3-Fe2O3-CaO system: The role of composition.

Zhe Yang, Changxiang Wang, Yumei Li, Sen Yang, Wei Zhang, Yilian Li,

Given the millions of coal-fired power stations worldwide and the generalization of co-firing technologies in the near future, the aqueous extraction experiments were taken to study the effects of oxides on Cr mobility in ashes through SiO2-Al2O3-Fe2O3-CaO system. The results identify that both the component and the species of Cr ... Read more >>

Chemosphere (Chemosphere)
[2020, 257:127112]

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A unique and evolutionarily conserved retinal interneuron relays rod and cone input to the inner plexiform layer

Brent Young, Charu Ramakrishnan, Tushar Ganjawala, Yumei Li, Sangbae Kim, Ping Wang, Rui Chen, Karl Deisseroth, Ning Tian,

Abstract Neurons in the CNS are distinguished from each other by their morphology, the types of the neurotransmitter they release, their synaptic connections, and their genetic profiles. While attempting to characterize the retinal bipolar cell (BC) input to retinal ganglion cells (RGCs), we discovered a previously undescribed type of interneuron ... Read more >>

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Non-destructive estimation of field maize biomass using terrestrial lidar: an evaluation from plot level to individual leaf level.

Shichao Jin, Yanjun Su, Shilin Song, Kexin Xu, Tianyu Hu, Qiuli Yang, Fangfang Wu, Guangcai Xu, Qin Ma, Hongcan Guan, Shuxin Pang, Yumei Li, Qinghua Guo,

Background:Precision agriculture is an emerging research field that relies on monitoring and managing field variability in phenotypic traits. An important phenotypic trait is biomass, a comprehensive indicator that can reflect crop yields. However, non-destructive biomass estimation at fine levels is unknown and challenging due to the lack of accurate and ... Read more >>

Plant Methods (Plant methods)
[2020, 16:69]

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Physicochemical parameter based estimation of discarding points for frying oil using data interpolation and principal component transformation.

Yumei Li, Xianbing Cao, Yanping Cao, Yuxu Feng, Jingjun Ji, Jiuying Xie, Xin Wang,

Data interpolation and principal component transformation (PCT) were used to compute the discarding points of a frying oil by measuring the physicochemical parameters-acid value, carbonyl value, and total polar compounds. Herein, the discarding point refers to the time point (associated with the value of each physicochemical parameter) at which the ... Read more >>

Food Sci Nutr (Food science & nutrition)
[2020, 8(5):2360-2372]

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How Could Peers in Online Health Community Help Improve Health Behavior.

Yumei Li, Xiangbin Yan,

Human behavior is the largest source of variance in health-related outcomes, and the increasingly popular online health communities (OHC) can be used to promote healthy behavior and outcomes. We explored how the social influence (social integration, descriptive norms and social support) exerted by online social relationships does affect the health ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(9):]

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Prognostic Significance of β-Catenin Expression in Osteosarcoma: A Meta-Analysis.

Xiaoliang Xie, Yumei Li, Haixia Zhu, Zhixing Kuang, Deta Chen, Tianyou Fan,

Background: β-catenin plays a crucial role in the progression of osteosarcoma. However, the clinical significance of β-catenin over-expression in osteosarcoma still remains unclear. Thus, we performed a meta-analysis of studies that evaluated the impact of β-catenin on metastasis and overall survival (OS) in osteosarcoma. Methods: We searched PubMed, The Cochrane ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:402]

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Loss of salt tolerance during tomato domestication conferred by variation in a Na+ /K+ transporter.

Zhen Wang, Yechun Hong, Guangtao Zhu, Yumei Li, Qingfeng Niu, Juanjuan Yao, Kai Hua, Jinjuan Bai, Yingfang Zhu, Huazhong Shi, Sanwen Huang, Jian-Kang Zhu,

Domestication has resulted in reduced salt tolerance in tomato. To identify the genetic components causing this deficiency, we performed a genome-wide association study (GWAS) for root Na+ /K+ ratio in a population consisting of 369 tomato accessions with large natural variations. The most significant variations associated with root Na+ /K+ ... Read more >>

EMBO J. (The EMBO journal)
[2020, 39(10):e103256]

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Efficacy of Local Control Strategies for Ewing Sarcoma After Neoadjuvant Chemotherapy: A Network Meta-analysis.

Haixia Zhu, Yumei Li, Xiaoliang Xie, Shichao Zhang, Yuntao Xue, Tianyou Fan,

OBJECTIVE:This network meta-analysis aimed at comparing the efficacy of local control strategies after neoadjuvant chemotherapy in patients with Ewing sarcoma. DESIGN:Network meta-analysis was used to synthesize direct and indirect evidence in a network of trials that compare multiple interventions and has the potential to rank the competing treatments according to ... Read more >>

Indian Pediatr (Indian pediatrics)
[2020, 57(6):527-532]

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Purinergic Signaling in Neutrophils During Inflammatory Diseases

Hui Sun, Gang Xu, Pingsong Li, Yumei Li, Bingwei Sun,

Purinergic signaling is that nucleotides (especially ATP) and adenosine are utilized as transmitter molecules, which play an important role in the immune system. In the extracellular ventricle, ATP plays a significant role of pro-inflammatory molecules mainly through activating P2 receptors, while adenosine plays the role of anti-inflammatory molecules mainly through ... Read more >>

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