Full Text Journal Articles by
Author Yuko Kai

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Dose-response relationships of accelerometer-measured sedentary behaviour and physical activity with non-alcoholic fatty liver disease.

Kenji Tsunoda, Naruki Kitano, Yuko Kai, Takashi Jindo, Ken Uchida, Takashi Arao,

<h4>Background</h4>Although a few studies have confirmed the association of accelerometer-measured sedentary behaviour (SB) and physical activity (PA) with non-alcoholic fatty liver disease (NAFLD), PA intensity and co-dependent daily time-use of movement behaviours are yet to be studied.<h4>Aims</h4>To cross-sectionally examine the dose-response relationship between accelerometer-measured SB or PA and NAFLD using ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

Cited: 0 times

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[Factors associated with behaviors to prevent COVID-19 infection during the declaration of emergency: A study among Tokyo residents].

Masataka Higuchi, Hirokazu Arai, Taku Ito, Nanako Nakamura, Yuko Kai,

Objectives The COVID-19 pandemic spread rapidly across the globe during the first half of 2020. In Japan, a state of emergency was declared on April 7, 2020, which had a significant impact on the life of citizens. This study focused on behaviors like avoiding going out or coming in contact with ... Read more >>

Nihon Koshu Eisei Zasshi ([Nihon koshu eisei zasshi] Japanese journal of public health)
[2021, 68(9):597-607]

Cited: 0 times

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Impact of Ergonomics on Cardiometabolic Risk in Office Workers: Transition to Activity-Based Working With Height-Adjustable Desk.

Takashi Jindo, Yuko Kai, Naruki Kitano, Mitsuru Makishima, Koji Takeda, Takashi Arao,

<h4>Objective</h4>Ergonomic office redesigning possibly improves physical activity (PA) and sedentary behavior (SB); however, its impact on cardiometabolic risk has not yet been determined. This study aimed to examine the effect of office relocation on cardiometabolic risk factors.<h4>Methods</h4>Annual health check-up data of 95 office workers from four offices in Tokyo, Japan, ... Read more >>

J Occup Environ Med (Journal of occupational and environmental medicine)
[2021, 63(5):e267-e275]

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Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications.

Eng Leng Saw, James T Pearson, Daryl O Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J A Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katare,

<h4>Background</h4>Acetylcholine (ACh) plays a crucial role in the function of the heart. Recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (NNCS) that comprises of choline acetyltransferase (ChAT), choline transporter 1 (CHT1), vesicular acetylcholine transporter (VAChT), acetylcholinesterase (AChE) and type-2 muscarinic ACh receptors (M<sub>2</sub>AChR) to synthesize, release, degrade ACh ... Read more >>

Cardiovasc Diabetol (Cardiovascular diabetology)
[2021, 20(1):50]

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Non-neuronal cardiac acetylcholine system playing indispensable roles in cardiac homeostasis confers resiliency to the heart.

Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Atsushi Kurabayashi, Masayuki Tsuda, Yoshihiko Kakinuma,

<h4>Background</h4>We previously established that the non-neuronal cardiac cholinergic system (NNCCS) is equipped with cardiomyocytes synthesizes acetylcholine (ACh), which is an indispensable endogenous system, sustaining cardiac homeostasis and regulating an inflammatory status, by transgenic mice overexpressing choline acetyltransferase (ChAT) gene in the heart. However, whole body biological significances of NNCCS remain to ... Read more >>

J Physiol Sci (The journal of physiological sciences : JPS)
[2021, 71(1):2]

Cited: 2 times

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Social participation and mortality according to company size of the longest-held job among older men in Japan: A 6-year follow-up study from the JAGES.

Satoru Kanamori, Naoki Kondo, Tomoko Takamiya, Hiroyuki Kikuchi, Shigeru Inoue, Taishi Tsuji, Yuko Kai, Go Muto, Katsunori Kondo,

<h4>Objectives</h4>The purpose of this study was to examine the relationship between social participation (type/pattern) and mortality according to company size of the longest-held job among older men in Japan who have worked in the company.<h4>Methods</h4>Longitudinal data from the Japan Gerontological Evaluation Study were used in this study. Functionally independent individuals ... Read more >>

J Occup Health (Journal of occupational health)
[2021, 63(1):e12216]

Cited: 1 time

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Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy, including FoxO1 and its targets.

Haruka Ajima, Yuko Kai, Junya Fujimaki, Shiori Akashi, Akihito Morita, Osamu Ezaki, Yasutomi Kamei, Shinji Miura,

Fibrates and statins have been widely used to reduce triglyceride and cholesterol levels, respectively. Besides its lipid-lowering effect, the side effect of muscle atrophy after fibrate administration to humans has been demonstrated in some studies. Combination therapy with fibrates and statins also increases the risk of rhabdomyolysis. FoxO1, a member ... Read more >>

J Toxicol Sci (The Journal of toxicological sciences)
[2021, 46(1):11-24]

Cited: 1 time

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Compositional data analysis of 24-hour movement behaviors and mental health in workers.

Naruki Kitano, Yuko Kai, Takashi Jindo, Kenji Tsunoda, Takashi Arao,

This cross-sectional study investigated the relationship between 24-hour movement behaviors and mental health among Japanese workers, accounting for the co-dependence of time spent in different behaviors during a single day. This research is part of a prospective cohort study called the Meiji Yasuda LifeStyle study. Participants were 1095 workers in ... Read more >>

Prev Med Rep (Preventive medicine reports)
[2020, 20:101213]

Cited: 1 time

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S-Nitroso-N-Pivaloyl-D-Penicillamine, a novel non-neuronal ACh system activator, modulates cardiac diastolic function to increase cardiac performance under pathophysiological conditions.

Shino Oikawa, Yuko Kai, Asuka Mano, Shigeo Nakamura, Yoshihiko Kakinuma,

We have previously reported the development of a novel chemical compound, S-Nitroso-N-Pivaloyl-D-Penicillamine (SNPiP), for the upregulation of the non-neuronal cardiac cholinergic system (NNCCS), a cardiac acetylcholine (ACh) synthesis system, which is different from the vagus nerve releasing of ACh as a neurotransmitter. However, it remains unclear how SNPiP could influence ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2020, 84:106459]

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Impact of Activity-Based Working and Height-Adjustable Desks on Physical Activity, Sedentary Behavior, and Space Utilization among Office Workers: A Natural Experiment.

Takashi Jindo, Yuko Kai, Naruki Kitano, Kyohsuke Wakaba, Mitsuru Makishima, Koji Takeda, Michitaka Iida, Kinji Igarashi, Takashi Arao,

It has been reported that office environment is an important determinant of physical activity (PA) and sedentary behavior (SB) in office workers. However, the effect of changes in office environment (office renovation) is unclear. The purpose of this study was to examine PA, SB, and space utilization changes among office ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 17(1):]

Cited: 1 time

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Size of company of the longest-held job and mortality in older Japanese adults: A 6-year follow-up study from the Japan Gerontological Evaluation Study.

Satoru Kanamori, Taishi Tsuji, Tomoko Takamiya, Hiroyuki Kikuchi, Shigeru Inoue, Daisuke Takagi, Yuko Kai, Mitsuya Yamakita, Yoshito Kameda, Katsunori Kondo,

<h4>Objectives</h4>Very few longitudinal studies have investigated the question of whether differences in company size may give rise to health inequalities. The aim of this study was to examine the relationship between company size of the longest-held job and mortality in older Japanese adults.<h4>Methods</h4>This study used longitudinal data from the Japan ... Read more >>

J Occup Health (Journal of occupational health)
[2020, 62(1):e12115]

Cited: 1 time

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Relationship of workplace exercise with work engagement and psychological distress in employees: A cross-sectional study from the MYLS study.

Takashi Jindo, Yuko Kai, Naruki Kitano, Kenji Tsunoda, Toshiya Nagamatsu, Takashi Arao,

We investigated the relationship between workplace exercise and psychological distress, and work engagement, both of which are factors related to the mental health and work productivity of employees. Data from the Meiji Yasuda Lifestyle study, collected from July 2017 through December 2017, were used. Data from an annual health checkup ... Read more >>

Prev Med Rep (Preventive medicine reports)
[2020, 17:101030]

Cited: 4 times

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Potentiating a non-neuronal cardiac cholinergic system reinforces the functional integrity of the blood brain barrier associated with systemic anti-inflammatory responses.

Shino Oikawa, Yuko Kai, Asuka Mano, Shuei Sugama, Naoko Mizoguchi, Masayuki Tsuda, Kazuyo Muramoto, Yoshihiko Kakinuma,

We previously reported that the heart-specific choline acetyltransferase (ChAT) gene overexpressing mice (ChAT tg) show specific phenotypes including ischemic tolerance and the CNS stress tolerance. In the current study, we focused on molecular mechanisms responsible for systemic and localized anti-inflammatory phenotypes of ChAT tg. ChAT tg were resistant to systemic ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2019, 81:122-137]

Cited: 2 times

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A Novel Nitric Oxide Donor, S-Nitroso-NPivaloyl-D-Penicillamine, Activates a Non-Neuronal Cardiac Cholinergic System to Synthesize Acetylcholine and Augments Cardiac Function.

Shino Oikawa, Yuko Kai, Asuka Mano, Shigeo Nakamura, Yoshihiko Kakinuma,

<h4>Background/aims</h4>In a previous study, we reported that cardiomyocytes were equipped with non-neuronal cardiac cholinergic system (NNCCS) to synthesize acetylcholine (ACh), which is indispensable for maintaining the basic physiological cardiac functions. The aim of this study was to identify and characterize a pharmacological inducer of NNCCS.<h4>Methods</h4>To identify a pharmacological inducer of ... Read more >>

Cell Physiol Biochem (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology)
[2019, 52(4):922-934]

Cited: 0 times

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Frequency and pattern of exercise and depression after two years in older Japanese adults: the JAGES longitudinal study.

Satoru Kanamori, Tomoko Takamiya, Shigeru Inoue, Yuko Kai, Taishi Tsuji, Katsunori Kondo,

Few have clarified what exercise frequencies and patterns (e.g. alone or with others) are effective for preventing depression in older adults. We examined the relationship between total frequency and/or pattern of exercise and the risk of depression after two years in older Japanese adults. We used a sub-sample of the ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):11224]

Cited: 14 times

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Erratum to: Various Regulatory Modes for Circadian Rhythmicity and Sexual Dimorphism in the Non-Neuronal Cardiac Cholinergic System.

Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Takahiro Nemoto, Yoshihiko Kakinuma,

J Cardiovasc Transl Res (Journal of cardiovascular translational research)
[2017, 10(4):435]

Cited: 0 times

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Various Regulatory Modes for Circadian Rhythmicity and Sexual Dimorphism in the Non-Neuronal Cardiac Cholinergic System.

Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Takahiro Nemoto, Yoshihiko Kakinuma,

Cardiomyocytes possess a non-neuronal cardiac cholinergic system (NNCCS) regulated by a positive feedback system; however, its other regulatory mechanisms remain to be elucidated, which include the epigenetic control or regulation by the female sex steroid, estrogen. Here, the NNCCS was shown to possess a circadian rhythm; its activity was upregulated ... Read more >>

J Cardiovasc Transl Res (Journal of cardiovascular translational research)
[2017, 10(4):411-422]

Cited: 3 times

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Effects of stretching on menopausal and depressive symptoms in middle-aged women: a randomized controlled trial.

Yuko Kai, Toshiya Nagamatsu, Yoshinori Kitabatake, Hiroomi Sensui,

<h4>Objective</h4>Exercise may help alleviate menopausal and depressive symptoms in middle-aged women, but sufficient evidence does not currently exist to fully support this theory. Whereas frequent moderate- to vigorous-intensity exercise may be associated with the risk of menopausal hot flashes, light-intensity exercise, such as stretching, is not likely to increase the ... Read more >>

Menopause (Menopause (New York, N.Y.))
[2016, 23(8):827-832]

Cited: 5 times

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Exercising alone versus with others and associations with subjective health status in older Japanese: The JAGES Cohort Study.

Satoru Kanamori, Tomoko Takamiya, Shigeru Inoue, Yuko Kai, Ichiro Kawachi, Katsunori Kondo,

Although exercising with others may have extra health benefits compared to exercising alone, few studies have examined the differences. We sought to examine whether the association of regular exercise to subjective health status differs according to whether people exercise alone and/or with others, adjusting for frequency of exercise. The study ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:39151]

Cited: 17 times

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Non-neuronal cardiac cholinergic system influences CNS via the vagus nerve to acquire a stress-refractory propensity.

Shino Oikawa, Yuko Kai, Masayuki Tsuda, Hisayuki Ohata, Asuka Mano, Naoko Mizoguchi, Shuei Sugama, Takahiro Nemoto, Kenji Suzuki, Atsushi Kurabayashi, Kazuyo Muramoto, Makoto Kaneda, Yoshihiko Kakinuma,

We previously developed cardiac ventricle-specific choline acetyltransferase (ChAT) gene-overexpressing transgenic mice (ChAT tgm), i.e. an in vivo model of the cardiac non-neuronal acetylcholine (NNA) system or non-neuronal cardiac cholinergic system (NNCCS). By using this murine model, we determined that this system was responsible for characteristics of resistance to ischaemia, or hypoxia, ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2016, 130(21):1913-1928]

Cited: 6 times

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Impact of physical activity on nonalcoholic steatohepatitis in people with nonalcoholic simple fatty liver: A prospective cohort study.

Kenji Tsunoda, Yuko Kai, Naruki Kitano, Ken Uchida, Tsutomu Kuchiki, Toshiya Nagamatsu,

Preventing nonalcoholic simple fatty liver (NASFL) from progressing to nonalcoholic steatohepatitis (NASH) is a key to avoiding cirrhosis. Physical activity (PA) may help manage fatty liver; however, there is a lack of prospective studies showing an association between PA and NASH. Our current prospective study investigated whether PA prevents NASFL ... Read more >>

Prev Med (Preventive medicine)
[2016, 88:237-240]

Cited: 8 times

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[The association between the presence of occupational health nurses at Japanese worksites and health promotion activities].

Satoru Kanamori, Yuko Kai, Kayo Kawamata, Mari Kusumoto, Tomoko Takamiya, Yumiko Ohya, Yuko Odagiri, Noritoshi Fukushima, Shigeru Inoue,

<h4>Objectives</h4>The purpose of this study was to determine the association between the presence of occupational health nurses and health promotion activities, relative to the number of employees, and the health promotion policies of the companies.<h4>Methods</h4>We investigated 3,266 companies with at least 50 employees listed on the Tokyo Stock Exchange. Questionnaires ... Read more >>

Sangyo Eiseigaku Zasshi (Sangyo eiseigaku zasshi = Journal of occupational health)
[2015, 57(6):297-305]

Cited: 2 times

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Prospective study of physical activity and sleep in middle-aged and older adults.

Kenji Tsunoda, Naruki Kitano, Yuko Kai, Ken Uchida, Tsutomu Kuchiki, Tomohiro Okura, Toshiya Nagamatsu,

<h4>Introduction</h4>Few prospective cohort studies have examined the association between physical activity (PA) and insomnia prevention, and the effective PA intensity remains unclear. This prospective study explores how PA intensity prevents incident short sleep duration and subjective insufficient sleep in middle-aged and older adults.<h4>Methods</h4>A self-reported questionnaire gathered data on sleep and ... Read more >>

Am J Prev Med (American journal of preventive medicine)
[2015, 48(6):662-673]

Cited: 18 times

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Social participation and the prevention of functional disability in older Japanese: the JAGES cohort study.

Satoru Kanamori, Yuko Kai, Jun Aida, Katsunori Kondo, Ichiro Kawachi, Hiroshi Hirai, Kokoro Shirai, Yoshiki Ishikawa, Kayo Suzuki, ,

<h4>Background</h4>We examined the relationship between incident functional disability and social participation from the perspective of number of types of organizations participated in and type of social participation in a prospective cohort study.<h4>Method</h4>The study was based on the Aichi Gerontological Evaluation Study (AGES) Cohort Study data. We followed 13,310 individuals aged ... Read more >>

PLoS One (PloS one)
[2014, 9(6):e99638]

Cited: 83 times

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Physical activity and risk of fatty liver in people with different levels of alcohol consumption: a prospective cohort study.

Kenji Tsunoda, Yuko Kai, Ken Uchida, Tsutomu Kuchiki, Toshiya Nagamatsu,

<h4>Objective</h4>To investigate whether physical activity affects the future incidence of fatty liver in people with never-moderate and heavy alcohol consumption.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Health check-up programme at Meiji Yasuda Shinjuku Medical Center in Shinjuku Ward, Tokyo, Japan.<h4>Population</h4>A total of 10,146 people aged 18 years or older without fatty liver enrolled through baseline surveys ... Read more >>

BMJ Open (BMJ open)
[2014, 4(8):e005824]

Cited: 6 times

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