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Author Yuki Ohta

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Wnt Signaling Shapes the Histological Variation in Diffuse Gastric Cancer.

Kazuhiro Togasaki, Shinya Sugimoto, Yuki Ohta, Kosaku Nanki, Mami Matano, Sirirat Takahashi, Masayuki Fujii, Takanori Kanai, Toshiro Sato,

BACKGROUND & AIMS:Diffuse type gastric cancer is currently subdivided into signet-ring cell carcinoma (SRCC) and non-SRCC referred to as poorly cohesive carcinoma not otherwise specified (PCC-NOS). Although these subtypes are considered to be independent, they often co-exist in the same tumors, raising a question whether they clonally differ or not. ... Read more >>

Gastroenterology (Gastroenterology)
[2020, :]

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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.

Kenta Kawasaki, Kohta Toshimitsu, Mami Matano, Masashi Fujita, Masayuki Fujii, Kazuhiro Togasaki, Toshiki Ebisudani, Mariko Shimokawa, Ai Takano, Sirirat Takahashi, Yuki Ohta, Kosaku Nanki, Ryo Igarashi, Kazuhiro Ishimaru, Hiroki Ishida, Yasutaka Sukawa, Shinya Sugimoto, Yoshimasa Saito, Kazuhiro Maejima, Shota Sasagawa, Hwajin Lee, Hong-Gee Kim, Kyungsik Ha, Junko Hamamoto, Koichi Fukunaga, Aya Maekawa, Minoru Tanabe, Soichiro Ishihara, Yasuo Hamamoto, Hiroyuki Yasuda, Shigeki Sekine, Atsushi Kudo, Yuko Kitagawa, Takanori Kanai, Hidewaki Nakagawa, Toshiro Sato,

Gastroenteropancreatic (GEP) neuroendocrine neoplasm (NEN) that consists of neuroendocrine tumor and neuroendocrine carcinoma (NEC) is a lethal but under-investigated disease owing to its rarity. To fill the scarcity of clinically relevant models of GEP-NEN, we here established 25 lines of NEN organoids and performed their comprehensive molecular characterization. GEP-NEN organoids ... Read more >>

Cell (Cell)
[2020, 183(5):1420-1435.e21]

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Linked color imaging can improve the visibility of superficial non-ampullary duodenal epithelial tumors.

Kenichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Mamoru Tokunaga, Tatsuya Kaneko, Hirotaka Oura, Naoki Akizue, Yuki Ohta, Keiko Saito, Makoto Arai, Jun Kato, Naoya Kato,

The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 44 consecutive patients diagnosed with SNADETs. Three trainees and three experts assessed the visibility scores of white light imaging (WLI), LCI, and blue ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20667]

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The Efficacy of Linked Color Imaging in the Endoscopic Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma.

Mamoru Tokunaga, Tomoaki Matsumura, Kentaro Ishikawa, Tatsuya Kaneko, Hirotaka Oura, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Kenichiro Okimoto, Naoki Akizue, Daisuke Maruoka, Yuki Ohta, Keiko Saito, Tomoo Nakagawa, Tetsuhiro Chiba, Makoto Arai, Jun Kato, Naoya Kato,

Background:The present study aimed to evaluate the efficacy of linked color imaging (LCI) in diagnosing Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Methods:A total of 112 and 12 consecutive patients with BE and EAC were analyzed. The visibility scores of BE and EAC ranging from 4 (excellent visibility) to 0 ... Read more >>

Gastroenterol Res Pract (Gastroenterology research and practice)
[2020, 2020:9604345]

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Comprehensive Analysis of Barrett's Esophagus: Focused on Carcinogenic Potential for Barrett's Cancer in Japanese Patients.

Kentaro Ishikawa, Kenichiro Okimoto, Tomoaki Matsumura, Yosuke Hirotsu, Kenji Amemiya, Takashi Kishimoto, Naoki Akizue, Yuki Ohta, Keiko Saito, Daisuke Maruoka, Motoi Nishimura, Kazuyuki Matsushita, Hitoshi Mochizuki, Makoto Arai, Jun Kato, Osamu Yokosuka, Masao Omata, Naoya Kato,

BACKGROUND/AIM:Barrett's esophagus (BE) is a precursor of esophageal adenocarcinoma (EAC). Therefore, an accurate diagnosis of BE is important for the subsequent follow-up and early detection of EAC. However, the definitions of BE have not been standardized worldwide; columnar-lined epithelium (CLE) without intestinal metaplasia (IM) and/or < 1 cm is not diagnosed as ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2020, :]

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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.

Rosalie T Zwiggelaar, Håvard T Lindholm, Madeleine Fosslie, Marianne Terndrup Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos R Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim B Jensen, Toshiro Sato, Menno J Oudhoff,

Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that lysine-specific demethylase ... Read more >>

Sci Adv (Science advances)
[2020, 6(37):]

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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium

Rosalie Zwiggelaar, Håvard Lindholm, Madeleine Fosslie, Marianne Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim Jensen, Toshiro Sato, Menno Oudhoff,

ABSTRACT Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify new regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that ... Read more >>

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Long-term use of proton pump inhibitors does not affect ectopic and metachronous recurrence of gastric cancer after endoscopic treatment.

Hirotaka Oura, Tomoaki Matsumura, Yohei Kawasaki, Kenichiro Okimoto, Kentaro Ishikawa, Tatsuya Kaneko, Mamoru Tokunaga, Tsubasa Oike, Yushi Imai, Yuya Yokoyama, Naoki Akizue, Daisuke Maruoka, Yuki Ohta, Keiko Saito, Tomoo Nakagawa, Makoto Arai, Jun Kato, Naoya Kato,

Objective: Long-term administration of proton pump inhibitors (PPIs) after eradication of Helicobacter pylori infection has been reported to increase the risk for development of gastric cancer (GC). We investigated whether long-term administration of PPI affects ectopic and metachronous recurrence of GC after endoscopic treatment.Methods: Participants were 687 patients who underwent ... Read more >>

Scand J Gastroenterol (Scandinavian journal of gastroenterology)
[2020, 55(2):209-215]

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Linked color imaging can improve the visibility of superficial non-ampullary duodenal epithelial tumors

Kenichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Mamoru Tokunaga, Tatsuya Kaneko, Hirotaka Oura, Naoki Akizue, Yuki Ohta, Keiko Saito, Makoto Arai, Jun Kato, Naoya Kato,

The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 44 consecutive patients diagnosed with SNADETs. Three trainees and three experts assessed the visibility scores of white light imaging (WLI), LCI, and blue ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):]

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Somatic inflammatory gene mutations in human ulcerative colitis epithelium.

Kosaku Nanki, Masayuki Fujii, Mariko Shimokawa, Mami Matano, Shingo Nishikori, Shoichi Date, Ai Takano, Kohta Toshimitsu, Yuki Ohta, Sirirat Takahashi, Shinya Sugimoto, Kazuhiro Ishimaru, Kenta Kawasaki, Yoko Nagai, Ryota Ishii, Kosuke Yoshida, Nobuo Sasaki, Toshifumi Hibi, Soichiro Ishihara, Takanori Kanai, Toshiro Sato,

With ageing, normal human tissues experience an expansion of somatic clones that carry cancer mutations1-7. However, whether such clonal expansion exists in the non-neoplastic intestine remains unknown. Here, using whole-exome sequencing data from 76 clonal human colon organoids, we identify a unique pattern of somatic mutagenesis in the inflamed epithelium ... Read more >>

Nature (Nature)
[2020, 577(7789):254-259]

Cited: 6 times

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Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma.

Kenta Kawasaki, Masayuki Fujii, Shinya Sugimoto, Keiko Ishikawa, Mami Matano, Yuki Ohta, Kohta Toshimitsu, Sirirat Takahashi, Naoki Hosoe, Shigeki Sekine, Takanori Kanai, Toshiro Sato,

BACKGROUND & AIMS:Traditional serrated adenomas (TSAs) are rare colorectal polyps with unique histologic features. Fusions in R-spondin genes have been found in TSAs, but it is not clear whether these are sufficient for TSA development, due to the lack of a chromosome engineering platform for human tissues. We studied the ... Read more >>

Gastroenterology (Gastroenterology)
[2020, 158(3):638-651.e8]

Cited: 1 time

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Underwater cold snare polypectomy for colorectal adenomas.

Daisuke Maruoka, Takashi Kishimoto, Tomoaki Matsumura, Makoto Arai, Naoki Akizue, Kentaro Ishikawa, Yuki Ohta, Shingo Kasamatsu, Takashi Taida, Hideaki Ishigami, Kenichiro Okimoto, Keiko Saito, Tomoo Nakagawa, Naoya Kato,

BACKGROUND AND AIM:Cold snare polypectomy (CSP) is a safe treatment for colorectal adenomas. However, the R0 resection rate is not sufficiently high because of inadequate resection of muscularis mucosa. We hypothesized that CSP in an underwater environment could improve this procedure by helping to safely achieve resection containing the muscularis ... Read more >>

Dig Endosc (Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society)
[2019, 31(6):662-671]

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Immunomodulator-associated Epstein-Barr virus-positive mucocutaneous ulcer in a patient with refractory Crohn's disease.

Shinsaku Hamanaka, Tomoo Nakagawa, Satoshi Ota, Mana Iida, Yuki Ohta, Yusuke Isshiki, Shingo Kasamatsu, Hideaki Ishigami, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoaki Matsumura, Chikako Ohwada, Masahiro Takeuchi, Emiko Sakaida, Makoto Arai, Tatsuro Katsuno, Chiaki Nakaseko, Yukio Nakatani, Naoya Kato,

Epstein-Barr virus (EBV)-positive mucocutaneous ulcer is a B-cell lymphoproliferative disorder occurring in elderly or iatrogenic immunocompromised patients. We report a 27-year-old male patient with Crohn's disease (CD) who developed immunomodulator-associated lymphoproliferative disorder. The patient was diagnosed with CD at the age of 17 and was treated with maintenance therapy including ... Read more >>

Clin J Gastroenterol (Clinical journal of gastroenterology)
[2019, 12(4):330-335]

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Exposure of immature rat heart to antenatal glucocorticoid results in cardiac proliferation.

Kenzo Sakurai, Yosuke Osada, Yuko Takeba, Masanori Mizuno, Yoshimitsu Tsuzuki, Yuki Ohta, Masanori Ootaki, Taro Iri, Kentaro Aso, Hitoshi Yamamoto, Naoki Matsumoto,

BACKGROUND:ATP synthesis and cardiac contraction-related protein production are accelerated in the immature fetal heart by antenatal glucocorticoids (GC). This study investigated the structural maturity of the myocardium and underlying signal pathway associated with cardiac growth in fetal rats that received antenatal GC. METHODS AND RESULTS:Dexamethasone (DEX) was given to pregnant ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, 61(1):31-42]

Cited: 0 times

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Long-Term Prognosis of Patients with Obscure Gastrointestinal Bleeding: A Retrospective Cohort Study.

Makoto Arai, Tomoaki Matsumura, Yuki Ohta, Soichiro Kiyono, Masahiro Hayashi, Takashi Taida, Keiko Saito, Kenichiro Okimoto, Daisuke Maruoka, Tomoo Nakagawa, Tatsuro Katsuno, Naoya Kato, Yuichi Takiguchi,

AIMS:We evaluated the long-term prognosis of patients with obscure gastrointestinal bleeding (OGIB) who underwent capsule endoscopy (CE). METHODS:In our hospital, 429 patients underwent CE between November 2007 and March 2012. Among them, 259 patients underwent CE as the first examination for OGIB and were then followed at 77 clinics and ... Read more >>

Digestion (Digestion)
[2019, 100(1):37-44]

Cited: 1 time

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Clinical characteristics and outcomes of primary sclerosing cholangitis and ulcerative colitis in Japanese patients.

Junichiro Kumagai, Takashi Taida, Sadahisa Ogasawara, Tomoo Nakagawa, Yotaro Iino, Ayako Shingyoji, Kentaro Ishikawa, Naoki Akizue, Mutsumi Yamato, Koji Takahashi, Yuki Ohta, Shinsaku Hamanaka, Kenichiro Okimoto, Masato Nakamura, Hiroshi Ohyama, Keiko Saito, Yuko Kusakabe, Daisuke Maruoka, Shin Yasui, Tomoaki Matsumura, Harutoshi Sugiyama, Yuji Sakai, Rintaro Mikata, Makoto Arai, Tatsuro Katsuno, Toshio Tsuyuguchi, Naoya Kato,

BACKGROUND:In Western countries, most patients with primary sclerosing cholangitis (PSC) have concurrent ulcerative colitis (UC). The number of patients with UC in East Asia has increased markedly over the past two decades. However, current clinical features of PSC and of PSC associated with UC (PSC-UC) have not yet been clarified ... Read more >>

PLoS One (PloS one)
[2018, 13(12):e0209352]

Cited: 3 times

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Real-time Endoscopy-Guided Measurement of Rectal Mucosal Admittance Is a Novel and Safe Method for Predicting Ulcerative Colitis Relapse.

Takashi Taida, Makoto Arai, Mai Fujie, Naoki Akizue, Kentaro Ishikawa, Yuki Ohta, Shinsaku Hamanaka, Hideaki Ishigami, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoaki Matsumura, Tomoo Nakagawa, Tatsuro Katsuno, Naoya Kato,

Background:There are known associations between inflammatory bowel disease (IBD) and changes in mucosal paracellular permeability. We recently developed a novel catheter that can measure mucosal admittance (MA). Methods:Patients with ulcerative colitis (UC) in clinical remission underwent real-time MA measurement during colonoscopy between June 2014 and July 2015 and were prospectively ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2018, 24(11):2360-2365]

Cited: 0 times

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Comparison of a novel predictor of venous thromboembolic complications in inflammatory bowel disease with current predictors.

Yuki Ohta, Makoto Arai, Tomoo Nakagawa, Naoki Akizue, Kentaro Ishikawa, Shinsaku Hamanaka, Hirotaka Koseki, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Sayuri Yoshihama, Daisuke Maruoka, Tomoaki Matsumura, Tatsuro Katsuno, Naoya Kato,

BACKGROUND AND AIM:Venous thromboembolism (VTE) is a common complication of inflammatory bowel disease (IBD). The aim of the present study was to identify predictors of VTE in hospitalized patients with IBD. METHODS:Patients with IBD who were hospitalized from February 2015 to March 2016 at the Chiba University Hospital were included. ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2019, 34(5):870-879]

Cited: 1 time

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Investigation of novel biomarkers for predicting the clinical course in patients with ulcerative colitis.

Shinsaku Hamanaka, Tomoo Nakagawa, Takaki Hiwasa, Yuki Ohta, Shingo Kasamatsu, Hideaki Ishigami, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoaki Matsumura, Hirotaka Takizawa, Koichi Kashiwado, Sohei Kobayashi, Kazuyuki Matsushita, Hisahiro Matsubara, Tatsuro Katsuno, Makoto Arai, Naoya Kato,

BACKGROUND:The clinical course of ulcerative colitis (UC) is characterized by repeated episodes of relapse and remission. We hypothesized that biomarkers that help distinguish refractory UC patients who are in remission using strong anti-immunotherapy could contribute in preventing the overuse of corticosteroids for treatment. Here, we clarified novel autoantibodies for UC ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2018, 33(12):1975-1983]

Cited: 1 time

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Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.

Kosaku Nanki, Kohta Toshimitsu, Ai Takano, Masayuki Fujii, Mariko Shimokawa, Yuki Ohta, Mami Matano, Takashi Seino, Shingo Nishikori, Keiko Ishikawa, Kenta Kawasaki, Kazuhiro Togasaki, Sirirat Takahashi, Yasutaka Sukawa, Hiroki Ishida, Shinya Sugimoto, Hirofumi Kawakubo, Jihoon Kim, Yuko Kitagawa, Shigeki Sekine, Bon-Kyoung Koo, Takanori Kanai, Toshiro Sato,

Recent sequencing analyses have shed light on heterogeneous patterns of genomic aberrations in human gastric cancers (GCs). To explore how individual genetic events translate into cancer phenotypes, we established a biological library consisting of genetically engineered gastric organoids carrying various GC mutations and 37 patient-derived organoid lines, including rare genomically ... Read more >>

Cell (Cell)
[2018, 174(4):856-869.e17]

Cited: 25 times

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Isolation of Adipose-Derived Stem/Stromal Cells from Cryopreserved Fat Tissue and Transplantation into Rats with Spinal Cord Injury.

Yuki Ohta, Mitsuko Takenaga, Akemi Hamaguchi, Masanori Ootaki, Yuko Takeba, Tsukasa Kobayashi, Minoru Watanabe, Taroh Iiri, Naoki Matsumoto,

Adipose tissue contains multipotent cells known as adipose-derived stem/stromal cells (ASCs), which have therapeutic potential for various diseases. Although the demand for adipose tissue for research use remains high, no adipose tissue bank exists. In this study, we attempted to isolate ASCs from cryopreserved adipose tissue with the aim of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(7):]

Cited: 2 times

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Long-Term Outcome of Endoscopic Balloon Dilatation for Strictures in Patients with Crohn's Disease.

Takashi Taida, Tomoo Nakagawa, Yuki Ohta, Shinsaku Hamanaka, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoaki Matsumura, Makoto Arai, Tatsuro Katsuno, Naoya Kato,

BACKGROUND/AIMS:Endoscopic balloon dilatation (EBD) is an alternative to surgery for strictures in patients with Crohn's disease (CD). The aim of the present study was to clarify the efficacy and safety of EBD for strictures in patients with CD. METHODS:Twenty-six patients with CD who underwent EBD for strictures from August 2008 ... Read more >>

Digestion (Digestion)
[2018, 98(1):26-32]

Cited: 1 time

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Characteristic glycopeptides associated with extreme human longevity identified through plasma glycoproteomics.

Yuri Miura, Noritaka Hashii, Yuki Ohta, Yoko Itakura, Hiroki Tsumoto, Junya Suzuki, Daisuke Takakura, Yukiko Abe, Yasumichi Arai, Masashi Toyoda, Nana Kawasaki, Nobuyoshi Hirose, Tamao Endo,

BACKGROUND:Glycosylation is highly susceptible to changes of the physiological conditions, and accordingly, is a potential biomarker associated with several diseases and/or longevity. Semi-supercentenarians (SSCs; older than 105 years) are thought to be a model of human longevity. Thus, we performed glycoproteomics using plasma samples of SSCs, and identified proteins and conjugated ... Read more >>

Biochim Biophys Acta Gen Subj (Biochimica et biophysica acta. General subjects)
[2018, 1862(6):1462-1471]

Cited: 1 time

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Evaluation of Esophageal Mucosal Integrity in Patients with Gastroesophageal Reflux Disease.

Tomoaki Matsumura, Makoto Arai, Hideaki Ishigami, Mai Fujie, Kentaro Ishikawa, Naoki Akizue, Takashi Taida, Yuki Ohta, Shinsaku Hamanaka, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoo Nakagawa, Naoya Kato,

Impaired esophageal mucosal integrity plays a role in causing symptoms of gastroesophageal reflux disease (GERD). Recently, the assessment of esophageal baseline impedance (BI) using the multichannel intraluminal impedance-pH (MII-pH) test was suggested as a surrogate technique for the study of esophageal mucosal integrity and was reported to be useful in ... Read more >>

Digestion (Digestion)
[2018, 97(1):31-37]

Cited: 0 times

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Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression.

Takashi Seino, Shintaro Kawasaki, Mariko Shimokawa, Hiroki Tamagawa, Kohta Toshimitsu, Masayuki Fujii, Yuki Ohta, Mami Matano, Kosaku Nanki, Kenta Kawasaki, Sirirat Takahashi, Shinya Sugimoto, Eisuke Iwasaki, Junichi Takagi, Takao Itoi, Minoru Kitago, Yuko Kitagawa, Takanori Kanai, Toshiro Sato,

Despite recent efforts to dissect the inter-tumor heterogeneity of pancreatic ductal adenocarcinoma (PDAC) by determining prognosis-predictive gene expression signatures for specific subtypes, their functional differences remain elusive. Here, we established a pancreatic tumor organoid library encompassing 39 patient-derived PDACs and identified 3 functional subtypes based on their stem cell niche ... Read more >>

Cell Stem Cell (Cell stem cell)
[2018, 22(3):454-467.e6]

Cited: 61 times

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