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Author Yuehong Wang

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Cystathionine gamma-lyase/H2 S signaling facilitates myogenesis under aging and injury condition.

Yanjie Zhang, Laura Masters, Yuehong Wang, Lingyun Wu, Yanxi Pei, Baoqing Guo, Amadeo Parissenti, Simon J Lees, Rui Wang, Guangdong Yang,

Hydrogen sulfide (H<sub>2</sub> S) can be endogenously produced and belongs to the class of signaling molecules known as gasotransmitters. Cystathionine gamma-lyase (CSE)-derived H<sub>2</sub> S is implicated in the regulation of cell differentiation and the aging process, but the involvements of the CSE/H<sub>2</sub> S system in myogenesis upon aging and injury ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21511]

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Risk Factors of Coronavirus Disease 2019-Related Mortality and Optimal Treatment Regimens: A Retrospective Study.

Yuehong Wang, Shuang Yao, Xiaoling Liu, Yinghao Cao, Yaling Wang, Mao Xie,

BACKGROUND Coronavirus disease 2019 (COVID-19) is spreading rapidly worldwide, and scientists are trying to find a way to overcome the disease. We explored the risk factors that influence patient outcomes, including treatment regimens, which can provide a reference for further treatment. MATERIAL AND METHODS A retrospective cohort study analysis was ... Read more >>

Med Sci Monit (Medical science monitor : international medical journal of experimental and clinical research)
[2021, 27:e926751]

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Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) combined with bevacizumab for advanced non-squamous non-small-cell lung cancer patients with gradual progression on EGFR-TKI treatment: A cohort study.

Yuman Yu, Yuehong Wang, Linying Wu, Xuanli Xu, Hua Zhou, Qing Wang, Jianying Zhou,

<h4>Abstract</h4>Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) significantly improve outcomes of patients with EGFR-mutated non-small-cell lung cancer (NSCLC). However, acquired resistance inevitably emerges and remains a major challenge. The present study aimed to evaluate the efficacy of EGFR-TKIs plus bevacizumab in advanced non-squamous NSCLC patients with gradual progression on ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(5):e23712]

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Gasotransmitter signaling in energy homeostasis and metabolic disorders.

Amr Ali, Yuehong Wang, Lingyun Wu, Guangdong Yang,

Gasotransmitters are small molecules of gases, including nitric oxide (NO), hydrogen sulfide (H<sub>2</sub>S), and carbon monoxide (CO). These three gasotransmitters can be endogenously produced and regulate a wide range of pathophysiological processes by interacting with specific targets upon diffusion in the biological media. By redox and epigenetic regulation of various ... Read more >>

Free Radic Res (Free radical research)
[2020, :1-23]

Cited: 1 time

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Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation.

Yuehong Wang, Ruihuan Yu, Lingyun Wu, Guangdong Yang,

Recognized as a novel and important gasotransmitter, hydrogen sulfide (H<sub>2</sub>S) is widely present in various tissues and organs. Cystathionine gamma-lyase (CSE)-derived H<sub>2</sub>S has been shown to regulate oxidative stress and lipid metabolism. The aim of the present study is to examine the role of H<sub>2</sub>S in ferroptosis and lipid peroxidation ... Read more >>

Cell Signal (Cellular signalling)
[2021, 78:109870]

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Correction: Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.

Yuehong Wang, Ping Gao, Can Wei, Hongzhu Li, Li Zhang, Yajun Zhao, Bo Wu, Ye Tian, Weihua Zhang, Lingyun Wu, Rui Wang, Changqing Xu,

Since online publication of this article, the authors noticed that there was an error in Figs. 2 and 4. In Fig. 2c the samples were mislabelled, the correct labelling order is 'Control, HG, HG + NPS R568, HG + Calhex231'. In Fig. 4c, an incorrect image was used to compile the HG + NPS R568 group, ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(9):784]

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Spermine Protects Cardiomyocytes from High Glucose-Induced Energy Disturbance by Targeting the CaSR-gp78-Ubiquitin Proteasome System.

Yuehong Wang, Yuwen Wang, Fadong Li, Xinying Zhang, Hongzhu Li, Guangdong Yang, Changqing Xu, Can Wei,

<h4>Purpose</h4>To determine the mediation of spermine on energy metabolism disorder and diabetic cardiomyopathy (DCM) development as well as the underlying mechanisms.<h4>Methods</h4>An in vitro model of DCM was established by incubating primary cultured neonatal rat cardiomyocytes with high glucose (HG). Spermine content was assessed by RP-HPLC. The protein levels were detected ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, 35(1):73-85]

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Hydrogen sulfide signaling in regulation of cell behaviors.

Yuehong Wang, Ruihuan Yu, Lingyun Wu, Guangdong Yang,

Recent advances in the biomedical importance of H<sub>2</sub>S have help us understand various cellular functions and pathophysiological processes from a new aspect. Specially, H<sub>2</sub>S has been demonstrated to play multiple roles in regulating cell behaviors, including cell survival, cell differentiation, cell senescence, cell hypertrophy, cell atrophy, cell metaplasia, and cell ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 103:9-19]

Cited: 3 times

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Mechanism of acquired resistance to nivolumab in lung squamous cell carcinoma: case report and review of the literature.

Linying Wu, Yuman Yu, Jianying Zhou, Xiaoling Wang, Jingjie Li, Yuehong Wang,

<b>Background:</b> Immune checkpoint inhibitors targeting PD-1 and PD-L1 have noticeably improved the treatment landscape of advanced non-small-cell lung cancer, including lung squamous cell carcinoma (SCC). Although patients with immune checkpoint therapy can achieve long-term survival, acquired resistance has been recognized more frequently, while the underlying mechanisms are currently poorly understood. ... Read more >>

Immunotherapy (Immunotherapy)
[2020, 12(13):957-964]

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Content and health risk assessment of heavy metals and polybrominated diphenyl ethers in fish from Songhua Lake (Jilin City), China.

Mengnan Shen, Chunyu Kang, Tiehong Song, Hai Lu, Yuehong Wang, Bowen Yu, Ru Wang, Jie Cheng,

Levels of heavy metals and polybrominated diphenyl ethers (PBDEs) were determined in fishes sampled in Jilin Songhua Lake, China. Concentrations and congener profiles of these contaminants varied by fish type. The highest concentrations of Zn, Cu, Mn, and Cd were found in three omnivorous fish (Carassius carassius, Hypomesus olidus, and ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, 27(32):40848-40856]

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Investigation on the prognostic impact of concurrent genomic alterations in crizotinib-treated EML4-ALK-rearranged advanced non-small cell lung cancer patients.

Jing Zheng, Yanping Zhu, Ke Sun, Qian Shen, Yuehong Wang, He Cao, Analyn Lizaso, Bing Yu, Jing Lin, Songan Chen, Jianya Zhou, Jianying Zhou,

<h4>Background</h4>Despite the efficacy of crizotinib in non-small cell lung cancer (NSCLC) with genomic rearrangement between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK), clinical outcomes are heterogeneous among these patients. In our study, we investigated concurrent molecular factors that could contribute to the heterogeneity of their clinical outcomes ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2020, 146:209-216]

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Extracellular vesicle encapsulated microRNA-320a inhibits endometrial cancer by suppression of the HIF1α/VEGFA axis.

Na Zhang, Yuehong Wang, Hongbo Liu, Wenjing Shen,

Accumulating evidence indicates that cancer-associated fibroblasts (CAFs) play a crucial role in endometrial cancer (EC) pathogenesis. The present study investigated the clinical significance and biological function of extracellular vesicle (EV) encapsulated miR-320a released from CAFs in EC. EC-related microarray data was obtained from the GSE25405 database and differential analysis was ... Read more >>

Exp Cell Res (Experimental cell research)
[2020, 394(2):112113]

Cited: 4 times

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Recurrent eosinophilic pleuritis caused by sparganum infection: A case report and review of the literature.

Liangjie Fang, Yuehong Wang, Qiqi Gao, Bing Yan, Jianying Zhou,

<h4>Rationale</h4>Sparganosis is an infectious disease caused by a larval tapeworm of the genus Spirometra, which commonly invades subcutaneous tissues. Pulmonary and pleural involvement due to sparganum has been rarely reported previously.<h4>Patient concerns</h4>We herein described a case of recurrent eosinophilic pleuritis in a 24-year-old woman. She was admitted with persistent cough ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(22):e20226]

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A practice of anesthesia scenario design for emergency cesarean section in patients with COVID-19 infection based on the role of standard patient.

Yin Kang, Longjiao Deng, Dengwen Zhang, Yuehong Wang, Gang Wang, Li Mei, Guobin Zhou, Haihua Shu,

The new coronavirus (COVID-19) has been characterized as a world pandemic by WHO since March 11, 2020. Although it is likely that COVID-19 transmission is primarily via droplets and close contact, airborne transmission and fecal-oral route remains a possibility. The medical staff working in the operating room, such as anesthesiologists, ... Read more >>

Biosci Trends (Bioscience trends)
[2020, 14(3):222-226]

Cited: 1 time

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Exogenous spermine attenuates myocardial fibrosis in diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress and the canonical Wnt signaling pathway.

Jing Hu, Xiaoxiao Lu, Xinying Zhang, Xiaoting Shao, Yuehong Wang, Junting Chen, Bingbing Zhao, Siwei Li, Changqing Xu, Can Wei,

Myocardial fibrosis is one of the main pathological manifestations of diabetic cardiomyopathy (DCM). Spermine (SPM), a product of polyamine metabolism, plays an important role in many cardiac diseases including hypertrophy, ischemia, and infarction, but its role in diabetic myocardial fibrosis has not been clarified. This study aimed to investigate the ... Read more >>

Cell Biol Int (Cell biology international)
[2020, 44(8):1660-1670]

Cited: 2 times

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Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.

Yuehong Wang, Junting Chen, Siwei Li, Xinying Zhang, Zuoming Guo, Jing Hu, Xiaoting Shao, Ningyang Song, Yajun Zhao, Hongzhu Li, Guangdong Yang, Changqing Xu, Can Wei,

Diabetic cardiomyopathy (DCM) is a severe complication of type 1 diabetic (T1D) patients, manifested as combined diastolic and systolic dysfunction. DCM is associated with impaired calcium homeostasis secondary to decreased calcium-sensitive receptor (CaSR) expression. Spermine, a direct agonist of CaSR, was found deficient in cardiomyocytes of T1D rats. However, the ... Read more >>

Redox Biol (Redox biology)
[2020, 32:101514]

Cited: 3 times

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Golgi Stress Response, Hydrogen Sulfide Metabolism, and Intracellular Calcium Homeostasis.

Yanjie Zhang, Yuehong Wang, Ethan Read, Ming Fu, Yanxi Pei, Lingyun Wu, Rui Wang, Guangdong Yang,

<b><i>Aims:</i></b> The physiological and pathological importance of hydrogen sulfide (H<sub>2</sub>S) as a novel gasotransmitter has been widely recognized. Cystathionine gamma-lyase (CSE) is one of the major H<sub>2</sub>S-producing enzymes and it regulates diverse functions in connection with intracellular calcium (Ca<sup>2+</sup>). The aim of this study is to examine the role of ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2020, 32(9):583-601]

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Chinese experts’ consensus on the Internet of Things-aided diagnosis and treatment of coronavirus disease 2019 (COVID-19)

Li Bai, Dawei Yang, Xun Wang, Lin Tong, Xiaodan Zhu, Nanshan Zhong, Chunxue Bai, Charles A. Powell, Rongchang Chen, Jian Zhou, Yuanlin Song, Xin Zhou, Huili Zhu, Baohui Han, Qiang Li, Guochao Shi, Shengqing Li, Changhui Wang, Zhongmin Qiu, Yong Zhang, Yu Xu, Jie Liu, Ding Zhang, Chaomin Wu, Jing Li, Jinming Yu, Jiwei Wang, Chunling Dong, Yaoli Wang, Qi Wang, Lichuan Zhang, Min Zhang, Xia Ma, Lin Zhao, Wencheng Yu, Tao Xu, Yang Jin, Xiongbiao Wang, Yuehong Wang, Yan Jiang, Hong Chen, Kui Xiao, Xiaoju Zhang, Zhenju Song, Ziqiang Zhang, Xueling Wu, Jiayuan Sun, Yao Shen, Maosong Ye, Chunlin Tu, Jinjun Jiang, Hai Yu, Fei Tan,

The aim is to diagnose COVID-19 earlier and to improve its treatment by applying medical technology, the “COVID-19 Intelligent Diagnosis and Treatment Assistant Program (nCapp)” based on the Internet of Things. Terminal eight functions can be implemented in real-time online communication with the “cloud” through the page selection key. According ... Read more >>

(Clinical eHealth)
[2020, 3:7-15]

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Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screening.

Edyta M Grzelak, Mary P Choules, Wei Gao, Geping Cai, Baojie Wan, Yuehong Wang, James B McAlpine, Jinhua Cheng, Yingyu Jin, Hanki Lee, Joo-Won Suh, Guido F Pauli, Scott G Franzblau, Birgit U Jaki, Sanghyun Cho,

The rise of multi- and extensively drug-resistant Mycobacterium tuberculosis (M. tb) strains and co-infection with human immunodeficiency virus has escalated the need for new anti-M. tb drugs. Numerous challenges associated with the M. tb, in particular slow growth and pathogenicity level 3, discouraged use of this organism in past primary ... Read more >>

J Antibiot (Tokyo) (The Journal of antibiotics)
[2019, 72(10):719-728]

Cited: 3 times

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Oral submucous fibrosis in Asian countries.

Qian Peng, Hongyuan Li, Juan Chen, Yuehong Wang, Zhangui Tang,

Oral submucous fibrosis (OSF) is a chronic, insidious, and progressive oral mucosal disease that affects entire oral cavity and sometimes pharynx. This oral potentially malignant disorder has a high rate of malignant transformation (7%-30%) to oral squamous cell carcinoma (OSCC), posing global problems for public health. Due to enormous efforts ... Read more >>

J Oral Pathol Med (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology)
[2020, 49(4):294-304]

Cited: 1 time

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Calhex231 Alleviates High Glucose-Induced Myocardial Fibrosis via Inhibiting Itch-Ubiquitin Proteasome Pathway in Vitro.

Hui Yuan, Jiyu Xu, Xiaoyi Xu, Tielei Gao, Yuehong Wang, Yuqi Fan, Jing Hu, Yiying Shao, Bingbing Zhao, Hongzhu Li, Jian Sun, Changqing Xu,

Diabetic cardiomyopathy (DCM) is a major complication of diabetes, and features myocardial fibrosis as its main pathological feature. Calcium sensing receptor (CaSR) is a G protein-coupled receptor, which involves in myocardial fibrosis by regulation of calcium homeostasis. Calhex<sub>231</sub>, the CaSR inhibitor, is not clear whether it regulates myocardial fibrosis in ... Read more >>

Biol Pharm Bull (Biological & pharmaceutical bulletin)
[2019, 42(8):1337-1344]

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Calcium‑sensing receptor promotes high glucose‑induced myocardial fibrosis via upregulation of the TGF‑β1/Smads pathway in cardiac fibroblasts.

Hui Yuan, Yuqi Fan, Yuehong Wang, Tielei Gao, Yiying Shao, Bingbing Zhao, Hongzhu Li, Changqing Xu, Can Wei,

Diabetic cardiomyopathy (DCM) is a major complication of diabetes and myocardial fibrosis is its major pathological feature. Calcium‑sensing receptor (CaSR) is a G protein‑coupled receptor and participates in the regulation of calcium homeostasis; it is implicated in a range of diseases, including myocardial ischemia/reperfusion injury, myocardial infarction and pulmonary hypertension. However, ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2019, 20(2):1093-1102]

Cited: 2 times

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H2S restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF/EGFR signaling.

Yuanzhou Zhang, Jun Gao, Weiming Sun, Xin Wen, Yuxin Xi, Yuehong Wang, Can Wei, Changqing Xu, Hongzhu Li,

Hydrogen sulfide (H2S) reduces ischemia/reperfusion (I/R) injury and apoptosis and restores the cardioprotective effects of ischemic post-conditioning (PC) in aged cardiomyocytes by inhibiting oxidative stress and endoplasmic reticulum stress and increasing autophagy. However, the mechanism is unclear. In the present study, we observed a loss of PC-mediated cardioprotection of aged ... Read more >>

Aging (Albany NY) (Aging)
[2019, 11(6):1745-1758]

Cited: 1 time

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Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Antituberculosis Agents.

Elda Meta, Chiara Brullo, Michele Tonelli, Scott G Franzblau, Yuehong Wang, Rui Ma, Wan Baojie, Beatrice S Orena, Maria R Pasca, Olga Bruno,

BACKGROUND:We screened a large library of differently decorated imidazo-pyrazole and pyrazole derivatives as possible new antitubercular agents and this preliminary screening showed that many compounds are able to totally inhibit Mycobacterium growth (>90 %). Among the most active compounds, we selected some new possible hits based on their similarities and, ... Read more >>

Med Chem (Medicinal chemistry (Shariqah (United Arab Emirates)))
[2019, 15(1):17-27]

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An antimycobacterial pleuromutilin analogue effective against dormant bacilli.

Maddie R Lemieux, Shajila Siricilla, Katsuhiko Mitachi, Shakiba Eslamimehr, Yuehong Wang, Dong Yang, Jeffrey D Pressly, Ying Kong, Frank Park, Scott G Franzblau, Michio Kurosu,

Pleuromutilin is a promising pharmacophore to design new antibacterial agents for Gram-positive bacteria. However, there are limited studies on the development of pleuromutilin analogues that inhibit growth of Mycobacterium tuberculosis (Mtb). In screening of our library of pleuromutilin derivatives, UT-800 (1) was identified to kill replicating- and non-replicating Mtb with ... Read more >>

Bioorg Med Chem (Bioorganic & medicinal chemistry)
[2018, 26(17):4787-4796]

Cited: 2 times

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