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Author Yue Chun Li

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MG-132 attenuates cardiac deterioration of viral myocarditis via AMPK pathway.

Xin-Min Zhang, Yue-Chun Li, Peng Chen, Sheng Ye, Shang-He Xie, Wu-Jie Xia, Jun-Hua Yang,

BACKGROUND:Coxsackievirus B3 (CVB3) is the primary cause of infectious myocarditis. Aggressive immunological activation and apoptosis of myocytes contributes to progressive dysfunction of cardiac contraction and poor prognosis. MG-132, a proteasome inhibitor, regulates mitochondrial-mediated intrinsic myocardial apoptosis and downregulates NF-κB-mediated inflammation. Here, we determined whether AMPK pathway participates in MG-132-mediated myocardial ... Read more >>

Biomed. Pharmacother. (Biomedicine & Pharmacotherapy)
[2020, 126:110091]

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An electrocardiographic sign of idiopathic ventricular tachycardia ablatable from the distal great cardiac vein.

Yuan-Nan Lin, Jing Xu, Yang-Qi Pan, Cheng Zheng, Jia-Xuan Lin, Jin Li, Jia Li, Jia-Feng Lin, Yue-Chun Li,

BACKGROUND:Idiopathic ventricular arrhythmias (IVAs) can originate from the distal great cardiac vein (DGCV). However, inadequate distinction sometimes occurs when electrocardiographic (ECG) characteristics are used to distinguish ventricular arrhythmias (VAs) arising from the DGCV from those arising from the adjacent left ventricular endocardium (LV ENDO). OBJECTIVE:The purpose of this study was ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(6):905-914]

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Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients.

Xue-Qiang Guan, Yang-Jing Xue, Jie Wang, Jun Ma, Yue-Chun Li, Cheng Zheng, Sai-Zhu Wu,

Background:Accelerated atherosclerosis is considered to be the linking factor between low bone mineral density (BMD) and increased cardiovascular events and mortality, while some coronary angiographic studies do not support this point. In this study, we attempt to provide a distinct comprehensive view of the relationship between BMD and the angiographically ... Read more >>

Clin Interv Aging (Clinical interventions in aging)
[2018, 13:1475-1483]

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Corrigendum: Ivabradine Treatment Reduces Cardiomyocyte Apoptosis in a Murine Model of Chronic Viral Myocarditis.

Ge Li-Sha, Liu Li, Zhou De-Pu, Shi Zhe-Wei, Gu Xiaohong, Chen Guang-Yi, Li Jia, Lin Jia-Feng, Chu Maoping, Li Yue-Chun,

[This corrects the article DOI: 10.3389/fphar.2018.00182.]. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1126]

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Eliciting α7-nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling.

Zhong-Hao Lin, Yue-Chun Li, Shu-Jie Wu, Cheng Zheng, Yuan-Zheng Lin, Hao Lian, Wei-Qian Lin, Jia-Feng Lin,

Our previous studies have reported that agonist of α7 nicotinic acetylcholine receptors prevented electrophysiological dysfunction of rats with ischaemic cardiomyopathy (ICM) by eliciting the cholinergic anti-inflammatory pathway (CAP). Adenosine monophosphate-activated protein kinase (AMPK) signalling is widely recognized exerting cardioprotective effect in various cardiomyopathy. Here, we aimed to investigate whether the ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2019, 23(7):4746-4758]

Cited: 2 times

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Elderly Woman With Severe Dyspnea.

Li Yue-Chun, Zhang Wen-Wu, Lin Jia-Feng,

Ann Emerg Med (Annals of emergency medicine)
[2018, 72(5):562-566]

Cited: 0 times

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The Role of Necroptosis in Cardiovascular Disease.

Shi Zhe-Wei, Ge Li-Sha, Li Yue-Chun,

A newly discovered mechanism of cell death, programmed necrosis (necroptosis), combines features of both necrosis and apoptosis. Necroptosis is tightly modulated by a series of characteristic signaling pathways. Activating necroptosis by ligands of death receptors requires the kinase activity of receptor-interacting protein 1 (RIP1), which mediates the activation of receptor-interacting ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2018, 9:721]

Cited: 9 times

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Common and distinctive electrocardiographic characteristics and effective catheter ablation of idiopathic ventricular arrhythmias originating from different areas of ventricular septum adjacent to atrioventricular annulus.

Su-Qin Zhang, Cheng Zheng, Yue-Chun Li, Kang-Ting Ji, Ri-Peng Yin, Jia-Feng Lin, Jia Li,

OBJECTIVE:To investigate electrocardiographic (ECG) characteristics and radiofrequency catheter ablation (RFCA) efficacy for premature ventricular complexes (PVCs) and idiopathic ventricular tachycardias (IVTs) originating from ventricular septum areas adjacent to atrioventricular annulus (VS-AVA). METHODS:Among 1,505 consecutive PVCs/IVTs cases, 106 (7.04%) were confirmed as origin of VS-AVA guided by both fluoroscopy and three-dimensional ... Read more >>

J. Cardiovasc. Electrophysiol. (Journal of cardiovascular electrophysiology)
[2018, 29(8):1104-1112]

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Ivabradine Treatment Reduces Cardiomyocyte Apoptosis in a Murine Model of Chronic Viral Myocarditis.

Ge Li-Sha, Liu Li, Zhou De-Pu, Shi Zhe-Wei, Gu Xiaohong, Chen Guang-Yi, Li Jia, Lin Jia-Feng, Chu Maoping, Li Yue-Chun,

This study was designed to explore the effects of ivabradine on cardiomyocyte apoptosis in a murine model of chronic viral myocarditis (CVMC). Mice were inoculated intraperitoneally with Coxsackievirus B3 at days 1, 14, and 28, respectively. On day 42, the mice were gavaged with ivabradine for 30 days until the ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:182]

Cited: 1 time

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The cholinergic anti-inflammatory pathway ameliorates acute viral myocarditis in mice by regulating CD4+ T cell differentiation.

Zhou De-Pu, Ge Li-Sha, Chen Guang-Yi, Gu Xiaohong, Xing Chao, Zheng Cheng, Zhang Wen-Wu, Li Jia, Lin Jia-Feng, Chu Maoping, Li Yue-Chun,

Many studies have found that abnormalities in the proportion and differentiation of CD4+ T cells (Th cells) are closely related to the pathogenesis of viral myocarditis (VMC). Our previous research indicates that the cholinergic anti-inflammatory pathway (CAP) attenuates the inflammatory response of VMC and downregulates the expression of cytokines in ... Read more >>

Virulence (Virulence)
[2018, 9(1):1364-1376]

Cited: 1 time

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Role of Heart Rate Reduction in the Management of Myocarditis.

Chen Guang-Yi, Ge Li-Sha, Li Yue-Chun,

The morbidity of myocarditis demonstrates an upward tendency by years, is commonly defined as the inflammation of myocytes and is caused by multiple factors. With the development of the molecular biological technique, great breakthroughs in the diagnosis and understanding of pathophysiological mechanisms of myocarditis have recently been achieved. Several questions ... Read more >>

Curr. Pharm. Des. (Current pharmaceutical design)
[2018, 24(3):365-378]

Cited: 1 time

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Editorial: Inflammation and Heart Diseases.

Li Yue-Chun,

Curr. Pharm. Des. (Current pharmaceutical design)
[2018, 24(3):259-261]

Cited: 0 times

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Alteration of Cholinergic Anti-Inflammatory Pathway in Rat With Ischemic Cardiomyopathy-Modified Electrophysiological Function of Heart.

Shu-Jie Wu, Yue-Chun Li, Zhe-Wei Shi, Zhong-Hao Lin, Zhi-Heng Rao, Si-Chao Tai, Mao-Ping Chu, Lei Li, Jia-Feng Lin,

With chronic ischemia after myocardial infarction, the resulting scar tissue result in electrical and structural remodeling vulnerable to an arrhythmogenic substrate. The cholinergic anti-inflammatory pathway elicited by vagal nerve via α7 nicotinic acetylcholine receptors (α7-nAChR) can modulate local and systemic inflammatory responses. Here, we aimed to clarify a novel mechanism ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(9):]

Cited: 4 times

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Right Cervical Vagotomy Aggravates Viral Myocarditis in Mice Via the Cholinergic Anti-inflammatory Pathway.

Ge Li-Sha, Chen Xing-Xing, Wu Lian-Pin, Zhou De-Pu, Li Xiao-Wei, Lin Jia-Feng, Li Yue-Chun,

The autonomic nervous system dysfunction with increased sympathetic activity and withdrawal of vagal activity may play an important role in the pathogenesis of viral myocarditis. The vagus nerve can modulate the immune response and control inflammation through a 'cholinergic anti-inflammatory pathway' dependent on the α7-nicotinic acetylcholine receptor (α7nAChR). Although the ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2017, 8:25]

Cited: 9 times

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The Protective Effects of Ivabradine in Preventing Progression from Viral Myocarditis to Dilated Cardiomyopathy.

Li Yue-Chun, Chen Guang-Yi, Ge Li-Sha, Xing Chao, Tian Xinqiao, Lin Cong, Dai Xiao-Ya, Yang Xiangjun,

To study the beneficial effects of ivabradine in dilated cardiomyopathy (DCM) mice, which evolved from coxsackievirus B3-induced chronic viral myocarditis. Four-to-five-week-old male balb/c mice were inoculated intraperitoneally with coxsackievirus B3 (Strain Nancy) on days 1, 14, and 28. The day of the first virus inoculation was defined as day 1. ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2016, 7:408]

Cited: 9 times

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An Unusually Wide QRS Complex Tachycardia in a Patient With Hemodynamic Instability.

Yue-Chun Li, Jia-Feng Lin, Peng Chen,

JAMA Intern Med (JAMA internal medicine)
[2016, 176(12):1857-1859]

Cited: 0 times

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Chronic Left Coronary Artery Stenosis After Radiofrequency Ablation of Idiopathic Premature Ventricular Contraction Originating From Left Coronary Sinus Cusp.

Li Yue-Chun, Lin Jia-Feng, Guan Xue-Qiang, Chen Peng,

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2016, 9(8):e004353]

Cited: 0 times

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Autonomic Nervous System in Viral Myocarditis: Pathophysiology and Therapy.

Zheng Cheng, Ge Li-Sha, Li Yue-Chun,

Myocarditis, which is caused by viral infection, can lead to heart failure, malignant arrhythmias, and even sudden cardiac death in young patients. It is also one of the most important causes of dilated cardiomyopathy worldwide. Although remarkable advances in diagnosis and understanding of pathophysiological mechanisms of viral myocarditis have been ... Read more >>

Curr. Pharm. Des. (Current pharmaceutical design)
[2016, 22(4):485-498]

Cited: 5 times

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Nicotine inhibits the production of proinflammatory cytokines of mice infected with coxsackievirus B3.

Ge Li-Sha, Zhao Jing-Lin, Liu Li, Chen Guang-Yi, Li Xiao-Wei, Li Yue-Chun,

Although excessive sympathetic activation in viral myocarditis and the protective effects of sympathetic inhibition with β-blockers are clear, the effects of enhancing vagal tone on viral myocarditis remain unclear. In several models, vagus nerve activation with the α7 nicotinic acetylcholine receptor (α7-nAChR) agonists has been demonstrated to ameliorate inflammation. This ... Read more >>

Life Sci. (Life sciences)
[2016, 148:9-16]

Cited: 7 times

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Recent Advances in Management of Myocarditis.

Li Yue-Chun,

Curr. Pharm. Des. (Current pharmaceutical design)
[2016, 22(4):405-407]

Cited: 2 times

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Dose-dependent protective effect of nicotine in a murine model of viral myocarditis induced by coxsackievirus B3.

Ge Li-Sha, Zhao Jing-Lin, Chen Guang-Yi, Liu Li, Zhou De-Pu, Li Yue-Chun,

The alpha 7 nicotinic acetylcholine receptor (alpha7 nAChR) was recently described as an anti-inflammatory target in various inflammatory diseases. The aim of this study was to investigate the dose-related effects of nicotine, an alpha7 nAChR agonist, in murine model of viral myocarditis. BALB/C mice were infected by an intraperitoneally injection ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:15895]

Cited: 9 times

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Recurrent acute coronary syndrome and restenosis after percutaneous coronary intervention in a patient with idiopathic thrombocytopenic purpura: a case report and literature review.

Ge Li-Sha, Chen Peng, Li Yue-Chun,

Platelets play a pivotal role in the pathogenesis of acute coronary syndrome (ACS) and acute and chronic complications following percutaneous coronary intervention (PCI). Platelet inhibition is a cornerstone in the management of these patients. Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder characterized by premature platelet destruction mediated by autoantibodies. ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2015, 15:101]

Cited: 3 times

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Erratum: Dose-dependent protective effect of nicotine in a murine model of viral myocarditis induced by coxsackievirus B3.

Ge Li-Sha, Zhao Jing-Lin, Chen Guang-Yi, Liu Li, Zhou De-Pu, Li Yue-Chun,

Sci Rep (Scientific reports)
[2015, 5:17247]

Cited: 1 time

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Dynamic Changes of QRS Morphology of Premature Ventricular Contractions During Ablation in the Right Ventricular Outflow Tract: A Case Report.

Li Yue-Chun, Lin Jia-Feng, Lin Jia-Xuan,

Electrocardiographic characteristics can be useful in differentiating between right ventricular outflow tract (RVOT) and aortic sinus cusp (ASC) ventricular arrhythmias. Ventricular arrhythmias originating from ASC, however, show preferential conduction to RVOT that may render the algorithms of electrocardiographic characteristics less reliable. Even though there are few reports describing ventricular arrhythmias ... Read more >>

Medicine (Madr) (Medicine)
[2015, 94(42):e1885]

Cited: 0 times

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Clinical Features of Acute Massive Pulmonary Embolism Complicated by Radiofrequency Ablation: An Observational Study.

Yue-Chun Li, Jiafeng Lin, Lianpin Wu, Jia Li, Peng Chen, Xue-Qiang Guang,

Although pulmonary embolism (PE) complicated by radiofrequency catheter ablation (RFCA) is rare, it can be life-threatening. Our goal was to elucidate the clinical features of acute massive PE after RFCA. Of 2386 patients who underwent RFCA for supraventricular tachycardia or idiopathic ventricular arrhythmia, 4 patients (0.16%) whose cases were complicated ... Read more >>

Medicine (Madr) (Medicine)
[2015, 94(40):e1711]

Cited: 3 times

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