Full Text Journal Articles by
Author Yu Liu

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Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells.

Jia Liu, Xingwang Zhu, Liu Yu, Minghuan Mao,

<b>Aim:</b>A series of sulphonamide hybrids were designed, synthesised, and identified as potential lysine-specific demethylase 1 (LSD1) inhibitors.<b>Materials and methods:</b> Bladder cancer cell lines were cultured to evaluate the antiproliferative activity. Inhibitory evaluation of sulphonamide hybrids against LSD1 were performed.<b>Conclusion:</b> sulphonamide derivative <b>L8</b> exhibited the antiproliferative activity against HTB5, HTB3, HT1376, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2022, 37(1):866-875]

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Chitosan biguanide induced mitochondrial inhibition to amplify the efficacy of oxygen-sensitive tumor therapies

Zaigang Zhou, Chunjuan Zheng, Yu Liu, Wenjuan Luo, Hui Deng, Jianliang Shen,

At present, the tumor's poor oxygen perfusion and limited tumor drug permeation are the major bottlenecks that limit the therapeutic effectiveness of the oxygen-sensitive antitumor therapies, like doxorubicin (Dox)-mediated chemotherapy and photodynamic therapy (PDT). To our best knowledge, the abnormal tumor mitochondria oxidative phosphorylation (OXPHOS) was the vital cause of ... Read more >>

(Carbohydrate polymers.)
[2022, 295:Not Available]

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