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Author Yu Lei

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Superconductivity enhancement in phase-engineered molybdenum carbide/disulfide vertical heterostructures.

Fu Zhang, Wenkai Zheng, Yanfu Lu, Lavish Pabbi, Kazunori Fujisawa, Ana Laura Elías, Anna R Binion, Tomotaroh Granzier-Nakajima, Tianyi Zhang, Yu Lei, Zhong Lin, Eric W Hudson, Susan B Sinnott, Luis Balicas, Mauricio Terrones,

Stacking layers of atomically thin transition-metal carbides and two-dimensional (2D) semiconducting transition-metal dichalcogenides, could lead to nontrivial superconductivity and other unprecedented phenomena yet to be studied. In this work, superconducting α-phase thin molybdenum carbide flakes were first synthesized, and a subsequent sulfurization treatment induced the formation of vertical heterolayer systems ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, :]

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Person-specific contributions of brain pathologies to progressive parkinsonism in older adults.

Aron S Buchman, Lei Yu, Shahram Oveisgharan, Jose M Farfel, Julie A Schneider, David A Bennett,

OBJECTIVE:Mixed-brain pathologies are the most common cause of progressive parkinsonism in older adults. We tested the hypothesis that the impact of individual pathologies associated with progressive parkinsonism, differ among older adults. METHODS:Data was from 1089 decedents who had undergone annual clinical testing and autopsy. Parkinsonism was based on a modified ... Read more >>

J. Gerontol. A Biol. Sci. Med. Sci. (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2020, :]

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HDAC inhibition reduces white matter injury after intracerebral hemorrhage.

Heng Yang, Wei Ni, Pengju Wei, Sicheng Li, Xinjie Gao, Jiabin Su, Hanqiang Jiang, Yu Lei, Liangfu Zhou, Yuxiang Gu,

Inhibition of histone deacetylases (HDACs) has been shown to reduce inflammation and white matter damage after various forms of brain injury via modulation of microglia/macrophage polarization. Previously we showed that the HDAC inhibitor scriptaid could attenuate white matter injury (WMI) after ICH. To access whether modulation of microglia/macrophage polarization might ... Read more >>

J. Cereb. Blood Flow Metab. (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2020, :271678X20942613]

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CAR-T therapy bridging to allogeneic HSCT provides durable molecular remission of Ph+ mixed phenotype acute leukaemia with minimal residual disease.

Danqing Kong, Changju Qu, Haiping Dai, Zheng Li, Jia Yin, Suning Chen, Liqing Kang, Guanghua Chen, Mingqing Zhu, Lei Yu, Depei Wu, Xiaowen Tang,

Br. J. Haematol. (British journal of haematology)
[2020, :]

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Long non-coding RNA MILNR1 retards colorectal cancer growth by inhibiting c-Myc.

Hao Gu, Yang Xia, Lili Guo, Zifei Wang, Shuang Wu, Yuan Xu, Yaqin Zhang, Jing Huang, Yu Lei, Wanglai Hu,

Cancer Commun (Lond) (Cancer communications (London, England))
[2020, :]

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Copper Inhibition of Triplet-sensitized Phototranformation of Phenolic and Amine Contaminants.

Yanheng Pan, Xiaoxue Ruan, Shikha Garg, T David Waite, Yu Lei, Xin Yang,

Excited triplet states of natural organic matter (3NOM*) are important reactive intermediates in phototransformation of organic contaminants in sunlit waters. The main goal of this study was to explore the influence of Cu on triplet-sensitized transformation rates of twenty selected phenolic and amine contaminants. Fourteen of the compounds examined exhibited ... Read more >>

Environ. Sci. Technol. (Environmental science & technology)
[2020, :]

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Establishment and internal validation of preoperative nomograms for predicting the possibility of testicular salvage in patients with testicular torsion.

Wan-Xiang Zheng, Guang-Dong Hou, Wei Zhang, Di Wei, Xue-Lin Gao, Mei-Hong Chen, Lu-Guang Huang, Fei Yan, Geng Zhang, Lei Yu, Fei Liu, Bo Zhang, Jian-Lin Yuan,

This study aimed to establish nomograms to preoperatively predict the possibility of testicular salvage (TS) in patients with testicular torsion. The clinical data of 204 patients with testicular torsion diagnosed at Xijing Hospital and Tangdu Hospital (Xi'an, China) between August 2008 and November 2019 were retrospectively analyzed. Univariate and multivariate ... Read more >>

Asian J. Androl. (Asian journal of andrology)
[2020, :]

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Interlaboratory method validation of imaged capillary isoelectric focusing methodology for analysis of recombinant human erythropoietin.

Xiang Li, Xingchang Shi, Xi Qin, Lei Yu, Yong Zhou, Chunming Rao,

Recombinant human erythropoietin (rhEPO) is one of the most important biopharmaceuticals worldwide, with global sales expected to reach US$11.9 billion in 2020. The charge heterogeneity of rhEPO must be monitored throughout the entire production process. Imaged capillary isoelectric focusing (icIEF) is a promising method for monitoring rhEPO charge heterogeneity, but ... Read more >>

Anal Methods (Analytical methods : advancing methods and applications)
[2020, :]

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Bedtime procrastination predicts the prevalence and severity of poor sleep quality of Chinese undergraduate students.

Xiaohan Ma, Dexin Meng, Liwei Zhu, Huiying Xu, Jing Guo, Limin Yang, Lei Yu, Yiming Fu, Li Mu,

Objective: Bedtime procrastination is a type of unhealthy sleep behavior, but whether it affects sleep quality remains unknown. The current study aimed to examine the relationship between bedtime procrastination and poor sleep quality among Chinese college students. Participants: A total of 1550 Chinese undergraduates participated and effectively completed the study. ... Read more >>

J Am Coll Health (Journal of American college health : J of ACH)
[2020, :1-8]

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Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.

Ying-Wooi Wan, Rami Al-Ouran, Carl G Mangleburg, Thanneer M Perumal, Tom V Lee, Katherine Allison, Vivek Swarup, Cory C Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M Neuner, Catherine C Kaczorowski, Vivek M Philip, Gareth R Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L Dawson, Ted M Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K Sieberts, Larsson Omberg, Kristen D Dang, James A Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J Ebert, David C Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, , Gregory W Carter, David A Collier, Todd E Golde, Allan I Levey, David A Bennett, Karol Estrada, T Matthew Townsend, Bin Zhang, Eric Schadt, Philip L De Jager, Nathan D Price, Nilüfer Ertekin-Taner, Zhandong Liu, Joshua M Shulman, Lara M Mangravite, Benjamin A Logsdon,

We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples. We discover 30 brain coexpression modules from seven regions as the major source of AD transcriptional perturbations. We next examine overlap with 251 brain differentially ... Read more >>

Cell Rep (Cell reports)
[2020, 32(2):107908]

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Loneliness Interacts With Cognition in Relation to Healthcare and Financial Decision Making Among Community-Dwelling Older Adults.

Christopher C Stewart, Lei Yu, Crystal M Glover, Gary Mottola, David A Bennett, Robert S Wilson, Patricia A Boyle,

BACKGROUND AND OBJECTIVES:Cognition is a known determinant of healthcare and financial decision making in old age. Social vulnerabilities also might play a role in such decisions; however, the evidence for this is less clear. Here, we examined the association of loneliness with decision making and tested the hypothesis that loneliness ... Read more >>

Gerontologist (The Gerontologist)
[2020, :]

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Older People’s Needs and Opportunities for Assistive Technologies.

Jeffrey Soar, Lei Yu, Latif Al-Hakim,

Older adults experience a disconnect between their needs and adoption of technologies that have potential to assist and to support more independent living. This paper reviewed research that links people’s needs with opportunities for assistive technologies. It searched 13 databases identifying 923 papers with 34 papers finally included for detailed ... Read more >>

(The Impact of Digital Technologies on Public Health in Developed and Developing Countries)
[0, 12157:404-414]

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Clinical Features and Short-term Outcomes of 102 Patients with Coronavirus Disease 2019 in Wuhan, China.

Jianlei Cao, Wen-Jun Tu, Wenlin Cheng, Lei Yu, Ya-Kun Liu, Xiaorong Hu, Qiang Liu,

BACKGROUND:In December 2019, a series of pneumonia cases of unknown cause emerged in Wuhan, Hubei, China. In this study, we investigate the clinical and laboratory features and short-term outcomes of patients with coronavirus disease 2019 (COVID-19). METHODS:All patients with COVID-19 admitted to Wuhan University Zhongnan Hospital in Wuhan, China, between ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(15):748-755]

Cited: 14 times

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PD-L1+ exosomes from bone marrow-derived cells of tumor-bearing mice inhibit antitumor immunity.

Yan Sun, Jufeng Guo, Lei Yu, Tianxin Guo, Jiaoli Wang, Xian Wang, Yinghu Chen,

Tumors escape immune attack by upregulating the surface expression of PD-L1, which interacts with PD-1 on T cells to activate immune inhibitory signaling. Anti-PD-1 treatments can effectively block this inhibitory signaling and activate antitumor immune responses. However, anti-PD-1 treatment also has a tumor suppressive effect in patients whose tumor cells ... Read more >>

Cell. Mol. Immunol. (Cellular & molecular immunology)
[2020, :]

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Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons.

Lei Yu, Shinya Tasaki, Julie A Schneider, Konstantinos Arfanakis, Duc M Duong, Aliza P Wingo, Thomas S Wingo, Nicola Kearns, Gregory R J Thatcher, Nicholas T Seyfried, Allan I Levey, Philip L De Jager, David A Bennett,

Importance:Identifying genes and proteins for cognitive resilience (ie, targets that may be associated with slowing or preventing cognitive decline regardless of the presence, number, or combination of common neuropathologic conditions) provides a complementary approach to developing novel therapeutics for the treatment and prevention of Alzheimer disease and related dementias. Objective:To ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2020, :]

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Association of Early-Life Cognitive Enrichment With Alzheimer Disease Pathological Changes and Cognitive Decline.

Shahram Oveisgharan, Robert S Wilson, Lei Yu, Julie A Schneider, David A Bennett,

Importance:Indicators of early-life cognitive enrichment (ELCE) have been associated with slower cognitive decline and decreased dementia in late life. However, the mechanisms underlying this association have not been elucidated. Objective:To examine the association of ELCE with late-life Alzheimer disease (AD) and other common dementia-related pathological changes. Design, Setting, and Participants:This ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, :]

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An Avirulence Gene Cluster in the Wheat Stripe Rust Pathogen (Puccinia striiformis f. sp. tritici) Identified through Genetic Mapping and Whole-Genome Sequencing of a Sexual Population.

Chongjing Xia, Yu Lei, Meinan Wang, Wanquan Chen, Xianming Chen,

Puccinia striiformis f. sp. tritici, the causal agent of wheat stripe (yellow) rust, is an obligate, biotrophic fungus. It was difficult to study the genetics of the pathogen due to the lack of sexual reproduction. The recent discovery of alternate hosts for P. striiformis f. sp. tritici makes it possible ... Read more >>

mSphere (mSphere)
[2020, 5(3):]

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Deficiency of Nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 reduces atherosclerosis.

Ann-Kathrin Vlacil, Jutta Schuett, Volker Ruppert, Muhidien Soufi, Raghav Oberoi, Kinan Shahin, Christian Wächter, Thomas Tschernig, Yu Lei, Fan Liu, Uwe J F Tietge, Bernhard Schieffer, Harald Schuett, Karsten Grote,

Atherosclerosis is crucially fueled by inflammatory pathways including pattern recognition receptor (PRR)-related signaling of the innate immune system. Currently, the impact of the cytoplasmic PRRs nucleotide-binding oligomerization domain-containing protein (NOD) 1 and 2 is incompletely characterized. We, therefore, generated Nod1/Nod2 double knockout mice on a low-density lipoprotein receptor (Ldlr)-deficient background ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2020, 115(4):47]

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Allogeneic haematopoietic stem cell transplantation improves outcome of adults with relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia entering remission following CD19 chimeric antigen receptor T cells.

Bin Gu, Bing-Yu Shi, Xiang Zhang, Shi-Yuan Zhou, Jian-Hong Chu, Xiao-Jin Wu, Cheng-Cheng Fu, Hui-Ying Qiu, Yue Han, Su-Ning Chen, Lei Yu, Xiao Ma, De-Pei Wu,

Relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (r/r Ph+ ALL) has an extremely poor prognosis. Chimeric antigen receptor T-cell (CART) therapy has acquired unprecedented efficacy in B-cell malignancies, but its role in the long-term survival of r/r Ph+ ALL patients is unclear. We analyzed the effect of CART on 56 adults ... Read more >>

Bone Marrow Transplant. (Bone marrow transplantation)
[2020, :]

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Selective Synthesis of Bi2Te3/WS2 Heterostructures with Strong Interlayer Coupling.

Ethan Kahn, Michael Lucking, Fu Zhang, Yu Lei, Tomotaroh Granzier-Nakajima, Daniel Grasseschi, Kory Beach, William Murray, Yin-Ting Yeh, Ana Laura Elias, Zhiwen Liu, Humberto Terrones, Mauricio Terrones,

The vertical integration of atomically thin-layered materials to create van der Waals heterostructures (vdWHs) has been proposed as a method to design nanostructures with emergent properties. In this work, epitaxial Bi2Te3/WS2 vdWHs are synthesized via a two-step vapor deposition process. It is calculated that the vdWH has an indirect band ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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Characterization of lncRNA-Perturbed TLR-Signaling Network Identifies Novel lncRNA Prognostic Biomarkers in Colorectal Cancer.

Yanjie Chu, Zhiqiang Liu, Jing Liu, Lei Yu, Dekai Zhang, Fenghua Pei,

Increasing evidence has suggested that long non-coding RNAs (lncRNAs) are critical regulators in the Toll-like receptors (TLR)-signaling network to modulate colorectal cancer (CRC) development and progression. However, the mechanism and clinical significance for lncRNAs regulating TLR signaling pathways in CRC remained largely unknown. In this study, we performed an integrative ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:503]

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Venous thromboembolism after adult thymus or thymic tumor resection: A single-center experience.

Xingguo Yang, Lei Yu, Tao Yu, Fei Li, Yunfeng Zhang, Zhen Yu, Baoxun Zhang, Ji Ke, Hui Li,

BACKGROUND:Venous thromboembolism (VTE) is a common postoperative complication. Previous studies have shown that the VTE incidence after major thoracic surgery is high. However, there have been no exclusive data after thymectomy thus far. To investigate the incidence of postoperative VTE, we conducted a single-center, prospective cohort study. METHODS:Patients who underwent ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, :]

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The Association of Late Life Cognitive Activity with Healthcare and Financial Decision-Making in Community-Dwelling, Nondemented Older Adults.

Crystal M Glover, Lei Yu, Christopher C Stewart, Robert S Wilson, David A Bennett, Patricia A Boyle,

OBJECTIVE:The purpose of this study was to test the hypothesis that late life cognitive activity is associated with decision-making in older adults and to examine whether this association varies by level of cognitive function. DESIGN:This study employed a cross-sectional design. SETTING:All data were collected in participants' community-based residences. PARTICIPANTS:Participants were ... Read more >>

Am J Geriatr Psychiatry (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
[2020, :]

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Gray Matter Atrophy in Parkinson's Disease and the Parkinsonian Variant of Multiple System Atrophy: A Combined ROI- and Voxel-Based Morphometric Study.

Xiaorui Cui, Lan Li, Lei Yu, Huijuan Xing, Hong Chang, Li Zhao, Jin Qian, Qingwei Song, Shiyu Zhou, Chunbo Dong,

OBJECTIVES:Parkinson's disease (PD) and the parkinsonian variant of multiple system atrophy (MSA-P) are distinct neurodegenerative disorders that share similar clinical features of parkinsonism. The morphological alterations of these diseases have yet to be understood. The purpose of this study was to evaluate gray matter atrophy in PD and MSA-P using ... Read more >>

Clinics (Sao Paulo) (Clinics (Sao Paulo, Brazil))
[2020, 75:e1505]

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Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.

Hyun-Sik Yang, Charles C White, Hans-Ulrich Klein, Lei Yu, Christopher Gaiteri, Yiyi Ma, Daniel Felsky, Sara Mostafavi, Vladislav A Petyuk, Reisa A Sperling, Nilüfer Ertekin-Taner, Julie A Schneider, David A Bennett, Philip L De Jager,

Here, we perform a genome-wide screen for variants that regulate the expression of gene co-expression modules in the aging human brain; we discover and replicate such variants in the TMEM106B and RBFOX1 loci. The TMEM106B haplotype is known to influence the accumulation of TAR DNA-binding protein 43 kDa (TDP-43) proteinopathy, and ... Read more >>

Neuron (Neuron)
[2020, :]

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