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Effects of micro-bubbles on the nucleation and morphology of gas hydrate crystals.

Yangmin Kuang, Yu Feng, Lei Yang, Yongchen Song, Jiafei Zhao,

Gas hydrate is usually regarded as a huge potential energy resource that has promising industrial applications in gas separation, storage, and transportation. Previous research studies have shown that a gas hydrate phase transition is mainly controlled by heat and mass transfer, while there are limited works on the mass transfer ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(42):23401-23407]

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The predictive value of crescents in the disease progression of lupus nephritis based on the 2018 International Society of Nephrology/Renal Pathology Society Revision System: a large cohort study from China.

Juan Tao, Hui Wang, Su-Xia Wang, Feng Yu, Ming-Hui Zhao,

Objective: This study analyzed the associations of different crescents' fraction and clinical features in a Chinese lupus nephritis cohort based on the 2018 revision of ISN/RPS classification system.Methods: A total of 288 lupus nephritis patients with complete clinicopathological data and well follow-up was enrolled. The fraction of glomeruli with cellular ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):166-172]

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Circulating Exosomal MicroRNAs as Diagnostic and Prognostic Biomarkers in Patients with Diffuse Large B-cell Lymphoma

Di Cao, Yu Jiang, Xia Cao, Mao Li, Caixia Jing, Yu Feng, Juan Xu, Yuhuan Zheng, Deying Kang, Caigang Xu,

Abstract Background: Exosomal microRNAs (miRNAs) are potential biomarkers for a variety of tumors but have not yet been tested in diffuse large B-cell lymphoma (DLBCL). Here we sought to determine whether circulating exosomal miRNAs are differentially expressed in the blood of DLBCL patients compared with those in the blood of ... Read more >>

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Exploring the biomarkers associated with different host inflammation of acute respiratory distress syndrome (ARDS) from lung metabolomics in mice.

Feng Yu, Jing Zhu, Ming Lei, Chuan-Jiang Wang, Ke Xie, Fang Xu, Shi-Hui Lin,

RATIONALE:The aim of this study was to analyze the metabolomics of lung with different host inflammation of acute respiratory distress syndrome (ARDS) for the identification of biomarkers for predicting severity under different inflammatory conditions. METHODS:Cecal ligation and puncture (CLP) and lipopolysaccharide (LPS)-intratracheal injection induced acute lung injury (ALI). A mouse ... Read more >>

Rapid Commun Mass Spectrom (Rapid communications in mass spectrometry : RCM)
[2020, :e8971]

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Technical integrative approaches to cheese whey valorization towards sustainable environment.

Frank Peprah Addai, Feng Lin, Taotao Wang, Anthony A Kosiba, Pengcheng Sheng, Feng Yu, Jie Gu, Yang Zhou, Haifeng Shi,

Whey, a byproduct of cheese production, is often treated as an industrial dairy waste. A large volume of this product is disposed of annually due to inadequate bioconversion approaches. With its high pollutant load, disposal without pretreatment has raised a lot of environmental concerns alerting the need to seek optimal ... Read more >>

Food Funct (Food & function)
[2020, 11(10):8407-8423]

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Construction of chlorogenic acid-containing liposomes with prolonged antitumor immunity based on T cell regulation.

Yun Zhang, Yanfang Yang, Jun Ye, Yue Gao, Hengfeng Liao, Junzhuo Zhou, Yu Feng, Dongdong Liu, Yingying Meng, Xiaoguang Chen, Lili Gao, Yuling Liu,

As a potential cancer immunotherapeutic agent, chlorogenic acid (CHA) has entered phase II clinical trials in China as a lyophilized powder formulation for treating glioma. However, the in vivo instability of CHA necessitates daily intramuscular injections, resulting in patient noncompliance. In this study, CHA-phospholipid complex (PC)-containing PEGylated liposomes (CHA-PC PEG-Lipo, ... Read more >>

Sci China Life Sci (Science China. Life sciences)
[2020, :]

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Quantitative proteomics reveals Shexiang Baoxin Pill exerts cardioprotective effects by preserving energy metabolism in a rat model of myocardial infarction.

Feng Yu, Yue Yu, Saisai Tian, Yanting Zhou, Xiangling Chen, Ji Ye, Qian Liu, Xike Xu, Hu Zhou, Weidong Zhang,

ETHNOPHARMACOLOGICAL RELEVANCE:Shexiang Baoxin Pill (SBP) is a composite formula of traditional Chinese medicine used to treat cardiovascular disease (CVD) in the clinic. However, the mechanism of its therapeutic effect on CVD has not been clearly elucidated yet. AIM OF THE STUDY:The aim of this study was to investigate the potential ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 266:113460]

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The Epidemiology, Cause, and Prognosis of Painful Tic Convulsif Syndrome: An Individual Patient Data Analysis of 192 Cases

Zixiao Yin, Yuye Liu, Yutong Bai, Hua Zhang, Huanguang Liu, Feng Yu, Jianguo Zhang, Ruen Liu, Anchao Yang,

Abstract Background Characterized by the coexistence of trigeminal neuralgia and ipsilateral hemifacial spasm (HFS), painful tic convulsif (PTC) is a rare entity not yet been systematically studied.Objective To systematically explore the epidemiology, cause, prognosis, and prognosis predictors of PTC.Method We searched PubMed, Web of Science, and the Cochrane Library for ... Read more >>

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Therapeutic advances in cardiac targeted drug delivery: from theory to practice.

Cuican Li, Muhammad Naveed, Kashif Dar, Ziwei Liu, Mirza Muhammad Faran Ashraf Baig, Rundong Lv, Muhammad Saeed, Chen Dingding, Yu Feng, Zhou Xiaohui,

The most commonly used administration methods in clinics and life are oral administration, intravenous injection, and other systemic administration methods. Targeted administration must be an essential long-term development direction due to the limited availability and a high incidence of systemic side effects. Cardiovascular diseases (CVD) are the leading cause of ... Read more >>

J Drug Target (Journal of drug targeting)
[2020, :1-14]

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Emerging immunotherapy targets in lung cancer.

Hao-Hua Zhu, Yu Feng, Xing-Sheng Hu,

Immunotherapy has become the mainstay for lung cancer treatment, providing sustained therapeutic responses and improved prognosis compared with those obtained with surgery, chemotherapy, radiotherapy, and targeted therapy. It has the potential for anti-tumor treatment and killing tumor cells by activating human immunity and has moved the targets of anti-cancer therapy ... Read more >>

Chin Med J (Engl) (Chinese medical journal)
[2020, 133(20):2456-2465]

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CueR activates transcription through a DNA distortion mechanism.

Chengli Fang, Steven J Philips, Xiaoxian Wu, Kui Chen, Jing Shi, Liqiang Shen, Juncao Xu, Yu Feng, Thomas V O'Halloran, Yu Zhang,

The MerR-family transcription factors (TFs) are a large group of bacterial proteins responding to cellular metal ions and multiple antibiotics by binding within central RNA polymerase-binding regions of a promoter. While most TFs alter transcription through protein-protein interactions, MerR TFs are capable of reshaping promoter DNA. To address the question ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Development of chimeric antigen receptor-modified T cells for the treatment of esophageal cancer.

Feng Yu, Xiaoyan Wang, Hui Shi, Maorong Jiang, Jun Xu, Min Sun, Qinggang Xu, Frank Peprah Addai, Haifeng Shi, Jie Gu, Yang Zhou, Liqiong Liu,

BACKGROUND:Human epidermal growth factor receptor 2 (HER2) is an overexpressed antigen in esophageal squamous cell carcinomas (ESCCs) but with limited expression levels in normal esophageal tissues. Therefore, employing the adoptive transfer of T cells genetically modified to express chimeric antigen receptor (CAR) targeting HER2 could be a promising therapeutic strategy ... Read more >>

Tumori (Tumori)
[2020, :300891620960223]

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In Reply to the Letter to the Editor Regarding "Surgical Treatment of Secondary Trigeminal Neuralgia Induced by Cerebellopontine Angle Tumors: A Single-Center Experience".

Yong-Qiang Zhang, Feng Yu, Zhen-Yu Zhao, Xue-Zhong Men, Wei Shi,

World Neurosurg (World neurosurgery)
[2020, 142:550]

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A flexible Cellulose/Methylcellulose gel polymer electrolyte endowing superior Li+ conducting property for lithium ion battery

Feng Yu, Hongbing Zhang, Lingzhu Zhao, Zhipeng Sun, Yuli Li, Yan Mo, Yong Chen,

With the advent of gel polymer electrolyte (GPE), a series of safety problems of lithium ion batteries have been resolved. However, poor self-standing property, the low ionic conductivity and Li⁺ transference number are still the obstacles that impede the practical application of GPE. Herein, a flexible and eco-friendly GPE is ... Read more >>

(Carbohydrate polymers.)
[2020, 246:Not Available]

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Curcumin Promotes the Expression of IL-35 by Regulating Regulatory T Cell Differentiation and Restrains Uncontrolled Inflammation and Lung Injury in Mice.

Yan-Qing Chen, Yu-Sen Chai, Ke Xie, Feng Yu, Chuan-Jiang Wang, Shi-Hui Lin, Yuan-Zheng Yang, Fang Xu,

Interleukin (IL)-35, which has an anti-inflammatory role in acute respiratory distress syndrome (ARDS)/acute lung injury (ALI), is relatively promising as a drug target. Studies have shown that curcumin may play a therapeutic role in ALI and enhance the suppressive function of regulatory T cells (Tregs). To illustrate the effect of ... Read more >>

Inflammation (Inflammation)
[2020, 43(5):1913-1924]

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Precise Species Identification and Taxonomy Update for the Genus Kluyvera With Reporting Kluyvera sichuanensis sp. nov.

Lina Liu, Yu Feng, Li Wei, Fu Qiao, Zhiyong Zong,

Kluyvera is a genus within the family Enterobacteriaceae and can cause various human infections but remains poorly studied. A carbapenem-resistant bla NDM- 1-carrying Kluyvera strain 090646T was isolated from a hospital sink in Chengdu, Sichuan province, China. Whole genome sequencing of the strain revealed that it had 28.2 to 42.3% ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:579306]

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Prevalence and phylogenetic analysis of porcine deltacoronavirus in Sichuan province, China.

Yu Feng, Zhiwen Xu, Ling Zhu,

In order to understand the prevalence and genetic diversity of porcine deltacoronavirus (PDCoV) in diarrhoeal pigs in Sichuan province, 634 clinical samples were collected from individual pigs with diarrhoea in 13 regions of Sichuan province, China, from January 2017 and June 2019. The detection results showed that the infection rate ... Read more >>

Arch. Virol. (Archives of virology)
[2020, :]

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Dehydration-Induced Carotenoid Cleavage Dioxygenase 1 Reveals a Novel Route for β-Ionone Formation during Tea (Camellia sinensis) Withering.

Jingming Wang, Bin Wu, Na Zhang, Mingyue Zhao, Tingting Jing, Yi Wu, YunQing Hu, Feng Yu, Xiaochun Wan, Wilfried Schwab, Chuankui Song,

β-Ionone is a carotenoid-derived flavor and fragrance compound with a complex fruity and woody scent, known for its violet aroma. Due to the low odor threshold, β-ionone dramatically affects the aroma and quality of tea. Previous studies have shown that β-ionone increases during tea withering; however, its formation and regulation ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2020, 68(39):10815-10821]

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Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.

Lifeng Fu, Fei Ye, Yong Feng, Feng Yu, Qisheng Wang, Yan Wu, Cheng Zhao, Huan Sun, Baoying Huang, Peihua Niu, Hao Song, Yi Shi, Xuebing Li, Wenjie Tan, Jianxun Qi, George Fu Gao,

COVID-19 was declared a pandemic on March 11 by WHO, due to its great threat to global public health. The coronavirus main protease (Mpro, also called 3CLpro) is essential for processing and maturation of the viral polyprotein, therefore recognized as an attractive drug target. Here we show that a clinically ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4417]

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Intravenous Administration of Pyroglutamyl Apelin-13 Alleviates Murine Inflammatory Pain via the Kappa Opioid Receptor.

Shuangyu Lv, Xiaomei Zhang, Yu Feng, Yuchen Zhou, Binbin Cui, Yanjie Yang, Xinchun Wang,

Apelin is an endogenous neuropeptide, which has wide distribution in central nervous system and peripheral tissues. Pyroglutamyl apelin-13 [(pyr)apelin-13] is the major apelin isoform in human plasma. However, the role of peripheral (pyr)apelin-13 in pain regulation is unknown. The aim of this study was to investigate the effect of the ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:929]

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Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis.

Xuezhen Zeng, Jingying Zhou, Zhewen Xiong, Hanyong Sun, Weiqin Yang, Myth T S Mok, Jing Wang, Jingqing Li, Man Liu, Wenshu Tang, Yu Feng, Hector Kwong-Sang Wang, Shun-Wa Tsang, King-Lau Chow, Philip Chun Yeung, John Wong, Paul Bo-San Lai, Anthony Wing-Hung Chan, Ka Fai To, Stephen Lam Chan, Qiang Xia, Jing Xue, Xiao Chen, Jun Yu, Sui Peng, Joseph Jao-Yiu Sung, Ming Kuang, Alfred Sze-Lok Cheng,

The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types. Although a role for cancer cell invasion programs has been well characterized, whether and how liver-intrinsic factors drive metastatic spread is incompletely understood. Here, we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase (CCRK) ... Read more >>

Cell. Mol. Immunol. (Cellular & molecular immunology)
[2020, :]

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Mutations in PB2 and HA enhanced pathogenicity of H4N6 avian influenza virus in mice.

Guanlong Xu, Fang Wang, Qiuchen Li, Guoxia Bing, Shijie Xie, Shijing Sun, Zengjie Bian, HaoJie Sun, Yu Feng, Xiaowei Peng, Hui Jiang, Liangquan Zhu, Xuezheng Fan, Yuming Qin, Jiabo Ding,

The H4 subtype avian influenza virus (AIV) continues to circulate in both wild birds and poultry, and occasionally infects mammals (e.g. pigs). H4-specific antibodies have also been detected in poultry farm workers, which suggests that H4 AIV poses a potential threat to public health. However, the molecular mechanism by which ... Read more >>

J. Gen. Virol. (The Journal of general virology)
[2020, 101(9):910-920]

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Chemical Composition of a Supercritical Fluid (Sfe-CO2) Extract from Baeckea frutescens L. Leaves and Its Bioactivity Against Two Pathogenic Fungi Isolated from the Tea Plant (Camellia sinensis (L.) O. Kuntze).

Hao Jiang, Mengting Zhang, Li Qin, Dongxu Wang, Feng Yu, Wenhui Liang, Chuankui Song, Daniel Granato,

Colletotrichum gloeosporioides and Pseudopestalotiopsis camelliae-sinensis are the two most important tea plant (Camellia sinensis L.) pathogenic fungi. Interest in natural plant extracts as alternatives to synthetic chemical fungicides to control plant pathogens is growing. In this study, the volatile fraction of Baeckea frutescens L. was extracted by supercritical fluid extraction ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2020, 9(9):]

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Improved Energy Storage Performance of All-Organic Composite Dielectric via Constructing Sandwich Structure.

Mengjia Feng, Tiandong Zhang, Chunhui Song, Changhai Zhang, Yue Zhang, Yu Feng, Qingguo Chi, Qingguo Chen, Qingquan Lei,

Improving the energy storage density of dielectrics without sacrificing charge-discharge energy storage efficiency and reliability is crucial to the performance improvement of modern electrical and electronic systems, but traditional methods of doping high-dielectric ceramics cannot achieve high energy storage densities without sacrificing reliability and storage efficiency. Here, an all-organic energy ... Read more >>

Polymers (Basel) (Polymers)
[2020, 12(9):]

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Intrathecally Administered Apelin-13 Alleviated Complete Freund's Adjuvant-Induced Inflammatory Pain in Mice.

Shuangyu Lv, Xiaomei Zhang, Yuchen Zhou, Yu Feng, Yanjie Yang, Xinchun Wang,

Apelin is the endogenous ligand for APJ, a G-protein-coupled receptor. Apelin gene and protein are widely distributed in the central nervous system and peripheral tissues. The role of apelin in chronic inflammatory pain is still unclear. In the present study, a mouse model of complete Freund's adjuvant (CFA)-induced inflammatory pain ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1335]

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