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A two-dimensional MXene potentiates a therapeutic microneedle patch for photonic implantable medicine in the second NIR biowindow.

Shiyang Lin, Han Lin, Mai Yang, Min Ge, Yu Chen, Yufang Zhu,

Due to the refractory nature and recurrence of cancer, the related treatments are continuously updated and improved. Here, we designed a soluble polyvinylpyrrolidone (PVP) microneedle system loaded with a two-dimensional (2D) MXene (Nb2C nanosheets) for medical implantation and photothermal ablation of superficial tumors in the second near infrared biological window ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(18):10265-10276]

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Defect engineering of 2D BiOCl nanosheets for photonic tumor ablation.

Chen Dai, Ruizhi Hu, Chunmei Wang, Zhuang Liu, Shengjian Zhang, Luodan Yu, Yu Chen, Bo Zhang,

Photothermal therapy (PTT) is an emerging technology as a noninvasive therapeutic modality for inducing photonic cancer hyperthermia. However, current photothermal conversion agents suffer from low therapeutic efficiency and single functionality. Engineering crystal defects on the surface or substrate of semiconductors can substantially enhance their optical absorption capability as well as ... Read more >>

Nanoscale Horiz (Nanoscale horizons)
[2020, 5(5):857-868]

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Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Chen,

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):761-770]

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Selenium alleviates lipopolysaccharide-induced endometritis via regulating the recruitment of TLR4 into lipid rafts in mice.

Yu Chen, Yi-Fan Zhao, Jing Yang, Hong-Yuan Jing, Wan Liang, Miao-Yu Chen, Mei Yang, Ying Wang, Meng-Yao Guo,

Selenium (Se) is an essential trace element for living organisms and plays diverse biological roles. Endometritis is a common reproductive disorder in dairy cows, causing huge economic losses. In this study, we explored the effects of Se on lipopolysaccharide (LPS)-induced endometritis in mice and expounded its underlying mechanism of action. ... Read more >>

Food Funct (Food & function)
[2020, 11(1):200-210]

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A biotinylated ruthenium(ii) photosensitizer for tumor-targeted two-photon photodynamic therapy.

Jia Li, Leli Zeng, Kai Xiong, Thomas W Rees, Chengzhi Jin, Weijun Wu, Yu Chen, Liangnian Ji, Hui Chao,

Platinum-resistant cancer cells are sensitive to changes in the levels of reactive oxidative species (ROS). Herein, we design a biotin-modified Ru(ii) complex as a photosensitizer (denoted as Ru-Biotin). Ru-Biotin can selectively target cancer cells and produce vast amounts of singlet oxygen under two-photon excitation at 820 nm leading to cell ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(73):10972-10975]

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Mitochondria-targeted [email protected] as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy.

Libing Ke, Cheng Zhang, Xinxing Liao, Kangqiang Qiu, Thomas W Rees, Yu Chen, Zizhuo Zhao, Liangnian Ji, Hui Chao,

Ir(iii) complex modified gold nanorods, [email protected], were developed as mitochondria-targeted theranostic nanoagents. Their hypoxia imaging and photothermal therapeutic properties were demonstrated in vitro and in vivo. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(69):10273-10276]

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Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China.

Yang Li, Ruihong Zhao, Shufa Zheng, Xu Chen, Jinxi Wang, Xiaoli Sheng, Jianying Zhou, Hongliu Cai, Qiang Fang, Fei Yu, Jian Fan, Kaijin Xu, Yu Chen, Jifang Sheng,

A woman with coronavirus disease in her 35th week of pregnancy delivered an infant by cesarean section in a negative-pressure operating room. The infant was negative for severe acute respiratory coronavirus 2. This case suggests that mother-to-child transmission is unlikely for this virus. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(6):1335-1336]

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Ultrathin Rh nanosheets as a highly efficient bifunctional electrocatalyst for isopropanol-assisted overall water splitting.

Yue Zhao, Shihui Xing, Xinying Meng, Jinghui Zeng, Shibin Yin, Xifei Li, Yu Chen,

In this work, we synthesized ultrathin Rh nanosheets (Rh-NSs) with atomic thickness, which revealed excellent activity for the hydrogen evolution reaction (HER) and super activity and extraordinary selectivity for the isopropanol oxidation reaction (IOR) in alkaline medium. When using Rh-NSs as a bifunctional electrocatalyst for water electrolysis in the presence ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(19):9319-9326]

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Postintubation Tracheal Stenosis Evaluated by Endobronchial Optical Coherence Tomography: A Canine Model Study.

Zi-Qing Zhou, Zhu-Quan Su, Wan Sun, Ming-Lu Zhong, Yu Chen, Chang-Hao Zhong, Huan-Jie Chen, Shi-Yue Li,

BACKGROUND:The predictors and airway morphological changes during the development of postintubation tracheal stenosis (PITS) have not been well elucidated. OBJECTIVES:To elucidate the validation of endobronchial optical coherence tomography (EB-OCT) in assessing the airway morphological changes in PITS. METHODS:We performed oral endotracheal intubation in 12 beagles to establish the PITS model. ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2020, :1-8]

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Correction to "A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows".

Han Lin, Shanshan Gao, Chen Dai, Yu Chen, Jianlin Shi,

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, :]

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CAG regimen for refractory or relapsed adult T-cell acute lymphoblastic leukemia: A retrospective, multicenter, cohort study.

Jie-Jing Qian, Xiaoxia Hu, Ying Wang, Yi Zhang, Juan Du, Min Yang, Hongyan Tong, Wen-Bin Qian, Juying Wei, Wenjun Yu, Yin-Jun Lou, Liping Mao, Hai Tao Meng, Liang-Shun You, Libing Wang, Xia Li, Xin Huang, Li-Hong Cao, Jian-Zhi Zhao, Xiao Yan Yan, Yu-Bao Chen, Yu Chen, Su-Jiang Zhang, Jie Jin, Jiong Hu, Hong-Hu Zhu,

Adult patients with relapsed or refractory T-cell acute lymphoblastic leukemia (R/R-T-ALL) have extremely poor prognosis, representing an urgent unmet medical need. Finding an optimal salvage regimen to bridge transplantation is a priority. The CAG (cytarabine, aclarubicin, and G-CSF) regimen was initially used by one group in China, showing unexpectedly promising ... Read more >>

Cancer Med (Cancer medicine)
[2020, :]

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Contemporary management of brain arteriovenous malformations in mainland China: a web-based nationwide questionnaire survey

Chen Yu, Xiangyu Meng, Li Ma, Yang Zhao, Ye Gu, Hengwei Jin, Dezhi Gao, Youxiang Li, Shibin Sun, Ali Liu, Yuanli Zhao, Xiaolin Chen, Shuo Wang,

Abstract Background: In the benefit of the large population and rapid economic growth, the interventional techniques and equipment for brain arteriovenous malformations (bAVMs) in mainland China have been rapidly improved. Chinese neurosurgical cerebrovascular physicians have accumulated rich experience and made pioneering explorations. This study aims to summarize the experience and ... Read more >>

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Decreased B cells on admission was associated with prolonged viral RNA shedding from respiratory tract in Coronavirus Disease 2019: a case control study.

Shaorui Hao, Jiangshan Lian, Yingfeng Lu, Hongyu Jia, Jianhua Hu, Guodong Yu, Xiaoyan Wang, Kaijin Xu, Qin Ni, Yongtao Li, Jun Liu, Hong Zhao, Xuan Zhang, Liang Yu, Xiaopeng Yu, Dairong Xiang, Yu Chen, Shufa Zheng, Yunqing Qiu, Lanjuan Li, Tingbo Liang, Yida Yang, Jifang Sheng,

The viral RNA shedding time of SARS-CoV-2 has not been well characterized. Clinical data were collected and compared between patients with short and long viral RNA shedding (in the first and last quarter). The probability of recurrent positive RT-PCR results decreased sharply to 4.8% after three consecutive negatives. At least ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, :]

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Immunization with Bovine Serum Albumin (BSA) in Oil-Adjuvant Elicits IgM Antibody Response in Chinese Soft-Shelled Turtle (Pelodiscus Sinensis).

Cheng Xu, Jiehao Xu, Yu Chen, Øystein Evensen, Hetron Mweemba Munang'andu, Guoying Qian,

Immunoassays are among the frontline methods used for disease diagnosis and surveillance. Despite this, there are no immunoassays developed for the Chinese soft-shelled turtle (Pelodiscus sinensis), which has expanded into large scale commercial production in several Asian countries. One of the critical factors delaying the development of immunoassays is the ... Read more >>

Vaccines (Basel) (Vaccines)
[2020, 8(2):]

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Identified and Validated the Characterization of the Colorectal Cancer Tumor Immune Microenvironment

Peng Han, yu De Chen, Feng Yang,

Abstract Background While the administration of immunotherapy can facilitate the development of durable anti-tumor immunity in certain colorectal cancer (CRC) patients.This study was therefore designed to conduct a robust analysis of the CRC immune microenvironment to identify specific genes and pathways that can be targeted in an effort to ... Read more >>

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PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/β-catenin signalling pathway.

Yu Chen, Xin Chen, Ya-Ru Ji, Sai Zhu, Fang-Tian Bu, Xiao-Sa Du, Xiao-Ming Meng, Cheng Huang, Jun Li,

As an outcome of chronic liver disease, liver fibrosis involves the activation of hepatic stellate cells (HSCs) caused by a variety of chronic liver injuries. It is important to explore approaches to inhibit the activation and proliferation of HSCs for the treatment of liver fibrosis. PLK1 is overexpressed in many ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, :]

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Evaluation of the processing quality of noodle dough containing a high Tartary buckwheat flour content through texture analysis.

Yu Chen, Mohammed Obadi, Shuyi Liu, Yajing Qi, Zhongwei Chen, Song Jiang, Bin Xu,

A texture analysis method for evaluating the processing quality of noodle dough with a high Tartary buckwheat flour (BF) content was established. And then the improvement of wheat flour (WF), wheat gluten (WG) and pre-gelatinized Tartary buckwheat flour (PBF) for the processing quality of buckwheat noodle dough was compared quantitatively, ... Read more >>

J Texture Stud (Journal of texture studies)
[2020, :]

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DZIP1 Promotes Proliferation, Migration, and Invasion of Oral Squamous Carcinoma Through the GLI1/3 Pathway.

Wangxiang Yan, Yun Deng, Yuhang Zhang, Jing Luo, Dunlang Lu, Quan Wan, Lijuan Mao, Yu Chen,

BACKGROUND:DZIP1 is an oncogene involved in the progression and stemness of carcinoma through the Wnt/β-catenin pathway, and the potential mechanism of DZIP1 in oral squamous cancer remains unknown. The aim of this study was to uncover the effect and mechanism of DZIP1 in the progression of oral squamous carcinoma. METHODS:TCGA ... Read more >>

Transl Oncol (Translational oncology)
[2019, 12(11):1504-1515]

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Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir

Ho Sing Lo, Kenrie Hui, Hei-Ming Lai, Khadija Shahed Khan, Simranjeet Kaur, Zhongqi Li, Anthony Chan, Hayley Hei-Yin Cheung, Ka Chun Ng, John Chi Wang Ho, Yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Kuen-Phon Wu, Ivan Dikic, Po-Huang Liang, Zhong Zuo, Francis Chan, David Hui, Vincent Mok, Kam-Bo Wong, Ho Ko, Wei Shen Aik, Michael Chan, Wai-Lung Ng,

Abstract The recent outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, is a global threat to human health. By in vitro screening and biochemical characterization, we identified the hepatitis C virus (HCV) protease inhibitor simeprevir as an especially promising repurposable drug ... Read more >>

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An artificially engineered "tumor bio-magnet" for collecting blood-circulating nanoparticles and magnetic hyperthermia.

Bing Liang, Kexiao Yu, Yi Ling, Micheal Kolios, Agata Exner, Zhigang Wang, Bing Hu, Guoqing Zuo, Yu Chen, Yuanyi Zheng,

It is a great challenge to directly endow a tumor with specific functions for theranostic treatment. In this study, we report on a novel approach to transform a tumor into a "bio-magnet", to be magnetized on demand, in order to create an intrinsic tumor magnetic field that would collect magnetic ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(5):1815-1824]

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FAM172A suppresses polymerization of tubulin and development of HCC (Hepatocellular Carcinoma)

Jin-qian Zhang, Zheng-lin Xia, Li Li, Dao-wei Li, Yu Chen, Jinglong Chen, Guo-an Xiang,

Abstract BackgroundThe polymerization of tubulin play the vital role in development and pathogenesis of cancer. Our study will explain the role of FAM172A in tubulin polymerization of HCC cell line.MethodsFAM172A-interacting proteins were screened from cDNA library of human liver with the system of yeast two-hybrid, the combined protein of FAM172A ... Read more >>

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ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens.

Tao Suo, Xinjin Liu, Jiangpeng Feng, Ming Guo, Wenjia Hu, Dong Guo, Hafiz Ullah, Yang Yang, Qiuhan Zhang, Xin Wang, Muhanmmad Sajid, Zhixiang Huang, Liping Deng, Tielong Chen, Fang Liu, Ke Xu, Yuan Liu, Qi Zhang, Yingle Liu, Yong Xiong, Guozhong Chen, Ke Lan, Yu Chen,

Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load specimens and the limitations of RT-PCR, significant numbers of false negative reports are inevitable, which results in failure to timely diagnose, early treat, cut off transmission, ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, :1-30]

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The role of gastric microbiota in gastric cancer.

Oliver A Stewart, Fen Wu, Yu Chen,

Gastric cancer represents one of the leading causes of cancer deaths worldwide. Helicobacter pylori (H. pylori) infection is the strongest risk factor associated with gastric cancer. Due to new molecular techniques allowing greater identification of stomach microbes, investigators are beginning to examine the role that bacteria other than H. pylori ... Read more >>

Gut Microbes (Gut microbes)
[2020, :1-11]

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Clinical features of rheumatic patients infected with COVID-19 in Wuhan, China.

Cong Ye, Shaozhe Cai, Guifen Shen, Hanxiong Guan, Liling Zhou, Yangyang Hu, Wei Tu, Yu Chen, Yikai Yu, Xuefen Wu, Yuxue Chen, Jixin Zhong, Lingli Dong,

OBJECTIVE:The clinical features of rheumatic patients with coronavirus disease 2019 (COVID-19) have not been reported. This study aimed to describe the clinical features of COVID-19 in rheumatic patients and provide information for handling this situation in clinical practice. METHODS:This is a retrospective case series study. Deidentified data, including gender, age, ... Read more >>

Ann. Rheum. Dis. (Annals of the rheumatic diseases)
[2020, :]

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Ir-catalyzed selective dehydrogenative cross-coupling of aryls with o-carboranes via a mixed directing-group strategy.

Yu Chen, Yangjian Quan, Zuowei Xie,

An efficient Ir-catalyzed selective B-H/C-H dehydrocoupling between o-carboranes and (hetero)aryls has been achieved based on a mixed directing-group strategy, leading to a wide variety of carborane-(hetero)arene combinations. Control experiments indicate that aryl C-H activation proceeds preferentially over the B-H one. Thus, a plausible reaction pathway for dehydrogenative cross-coupling is proposed ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, :]

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