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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Outcomes of critically ill patients according to the perception of intensivists on the appropriateness of intensive care unit admission.

Youjin Chang, Kyoung Ran Kim, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Chae-Man Lim,

<h4>Background</h4>It is important for intensivists to determine which patient may benefit from intensive care unit (ICU) admission. We aimed to assess the outcomes of patients perceived as non-beneficially or beneficially admitted to the ICU and evaluate whether their prognosis was consistent with the intensivists' perception.<h4>Methods</h4>A prospective observational study was conducted ... Read more >>

Acute Crit Care (Acute and critical care)
[2021, :]

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The story of critical care in Asia: a narrative review.

Jason Phua, Chae-Man Lim, Mohammad Omar Faruq, Khalid Mahmood Khan Nafees, Bin Du, Charles D Gomersall, Lowell Ling, Jigeeshu Vasishtha Divatia, Seyed Mohammad Reza Hashemian, Moritoki Egi, Aidos Konkayev, Mohd Basri Mat-Nor, Gentle Sunder Shrestha, Madiha Hashmi, Jose Emmanuel M Palo, Yaseen M Arabi, Hon Liang Tan, Rohan Dissanayake, Ming-Cheng Chan, Chairat Permpikul, Boonsong Patjanasoontorn, Do Ngoc Son, Masaji Nishimura, Younsuck Koh, ,

<h4>Background</h4>Asia has more critically ill people than any other part of our planet. The aim of this article is to review the development of critical care as a specialty, critical care societies and education and research, the epidemiology of critical illness as well as epidemics and pandemics, accessibility and cost ... Read more >>

J Intensive Care (Journal of intensive care)
[2021, 9(1):60]

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International Critical Care-From an Indulgence of the Best-Funded Healthcare Systems to a Core Need for the Provision of Equitable Care.

Philip D Lumb, Diane C Adler, Hussain Al Rahma, Pravin Amin, Jan Bakker, Satish Bhagwanjee, Bin Du, Christopher W Bryan-Brown, Geoffrey Dobb, Bruce Gingles, Judith Jacobi, Younsuck Koh, Assem Abdel Razek, Carol Peden, Gentle S Shrestha, Khalid Shukri, Mervyn Singer, Phil Taylor, Ged Williams,

Crit Care Med (Critical care medicine)
[2021, 49(10):1589-1605]

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Mechanical Ventilation Discontinuation Practices in Asia: A Multinational Survey.

Chi Hung Czarina Leung, Anna Lee, Yaseen M Arabi, Jason Phua, Jigeeshu V Divatia, Younsuck Koh, Bin Du, Cheng Cheng Tan, Jose Emmanuel M Palo, Karen E A Burns, Tae-Hyung Kim, Moritoki Egi, Mohammad Omar Faruq, Babu Raja Shrestha, Shih-Feng Liu, Tuan Dang Nguyen, Bambang Wahjuprajitno, Madiha Hashmi, Boonsong Patjanasoontorn, Zulaidi Latif, Kanishka Indraratna, Hussain N Al Rahma, Seyed Mohammad Reza Hashemian, Charles D Gomersall,

<b>Rationale:</b> There are limited data on mechanical discontinuation practices in Asia. <b>Objectives:</b> To document self-reported mechanical discontinuation practices and determine whether there is clinical equipoise regarding protocolized weaning among Asian Intensive Care specialists. <b>Methods:</b> A survey using a validated questionnaire, distributed using a snowball method to Asian Intensive Care specialists. ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(8):1352-1359]

Cited: 2 times

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Effects of high-flow nasal cannula in patients with mild to moderate hypercapnia: a prospective observational study.

Kyung Hun Nam, Hyung Koo Kang, Sung-Soon Lee, So-Hee Park, Sung Wook Kang, Jea Jun Hwang, So Young Park, Won Young Kim, Hee Jung Suh, Eun Young Kim, Ga Jin Seo, Younsuck Koh, Sang-Bum Hong, Jin Won Huh, Chae-Man Lim,

<h4>Background</h4>Evidence for using high-flow nasal cannula (HFNC) in hypercapnia is still limited. Most of the clinical studies had been conducted retrospectively, and there had been conflicting reports for the effects of HFNC on hypercapnia correction in prospective studies. Therefore, more evidence is needed to understand the effect of the HFNC ... Read more >>

Acute Crit Care (Acute and critical care)
[2021, 36(3):249-255]

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Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease.

Eva E Tejerina, Paolo Pelosi, Chiara Robba, Oscar Peñuelas, Alfonso Muriel, Deisy Barrios, Fernando Frutos-Vivar, Konstantinos Raymondos, Bin Du, Arnaud W Thille, Fernando Ríos, Marco González, Lorenzo Del-Sorbo, Maria Del Carmen Marín, Bruno Valle Pinheiro, Marco Antonio Soares, Nicolas Nin, Salvatore M Maggiore, Andrew Bersten, Pravin Amin, Nahit Cakar, Gee Young Suh, Fekri Abroug, Manuel Jibaja, Dimitros Matamis, Amine Ali Zeggwagh, Yuda Sutherasan, Antonio Anzueto, Andrés Esteban, ,

<h4>Objectives</h4>To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality.<h4>Design</h4>Secondary analysis of three prospective, observational, multicenter studies.<h4>Setting</h4>Cohort studies conducted in 2004, 2010, and 2016.<h4>Patients</h4>Adult patients who received mechanical ventilation for more than 12 hours.<h4>Interventions</h4>None.<h4>Measurements ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(7):1095-1106]

Cited: 0 times

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Dynamic inhomogeneity of aeration along the vertical axis of the lung may predict weaning failure regardless of diaphragm dysfunction.

Do Sik Moon, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Chae-Man Lim,

<h4>Purpose</h4>This study aimed to investigate dynamic changes of lung aeration during a spontaneous breathing trial (SBT) in patients with diaphragm dysfunction (DD) and to predict weaning failure using electrical impedance tomography (EIT).<h4>Materials and methods</h4>We enrolled 40 adult patients who received mechanical ventilation over 48 h and were eligible for SBT ... Read more >>

J Crit Care (Journal of critical care)
[2021, 65:186-191]

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Factors and Outcomes of Intensive Care Unit Readmission in Elderly Patients.

Song-I Lee, Younsuck Koh, Jin Won Huh, Sang-Bum Hong, Chae-Man Lim,

<h4>Introduction</h4>An increase in age has been observed among patients admitted to the intensive care unit (ICU). Age is a well-known risk factor for ICU readmission and mortality. However, clinical characteristics and risk factors of ICU readmission of elderly patients (≥65 years) have not been studied.<h4>Methods</h4>This retrospective single-center cohort study was ... Read more >>

Gerontology (Gerontology)
[2021, :1-9]

Cited: 0 times

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Erratum to "Global and regional ventilation during high flow nasal cannula in patients with hypoxia".

Dong Hyun Lee, Eun Young Kim, Ga Jin Seo, Hee Jung Suh, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Chae-Man Lim,

Acute Crit Care (Acute and critical care)
[2021, 36(2):173]

Cited: 0 times

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Possible respiratory syncytial virus infection presenting as diffuse alveolar hemorrhage in an elderly treated with systemic corticosteroid: A case report.

Kyung Hun Nam, Junho Kang, Younsuck Koh,

<h4>Introduction</h4>Respiratory syncytial virus infection is gaining interest in the elderly due to its growing morbidity and mortality. We present a Case of respiratory syncytial virus infection presenting as diffuse alveolar hemorrhage that was highly responsive to systemic corticosteroid in an elderly patient.<h4>Case presentation</h4>An 82-year old man was admitted to the ... Read more >>

Respir Med Case Rep (Respiratory medicine case reports)
[2021, 33:101399]

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Death in hospital following ICU discharge: insights from the LUNG SAFE study.

Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G Laffey, Giacomo Bellani, , ,

<h4>Background</h4>To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.<h4>Methods</h4>The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):144]

Cited: 0 times

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Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.

Prashant Nasa, Elie Azoulay, Ashish K Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M Arabi, Jan Bakker, Laurent J Brochard, Adam M Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M Galvagno, Claude Guérin, Samir Jaber, Gopi C Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R Machado, Manu L N G Malbrain, Jordi Mancebo, Michael T McCurdy, Brendan A McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K Park, Paolo Pelosi, John V Peter, Jason Phua, David V Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A Udy, Tobias Welte, Sheila N Myatra,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.<h4>Methods</h4>Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):106]

Cited: 6 times

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Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.

Waleed Alhazzani, Laura Evans, Fayez Alshamsi, Morten Hylander Møller, Marlies Ostermann, Hallie C Prescott, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Flavia Machado, Hannah Wunsch, Mark Crowther, Maurizio Cecconi, Younsuck Koh, Lisa Burry, Daniel S Chertow, Wojciech Szczeklik, Emilie Belley-Cote, Massimiliano Greco, Malgorzata Bala, Ryan Zarychanski, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Sheila Nainan Myatra, Amy Arrington, Ruth Kleinpell, Giuseppe Citerio, Kimberley Lewis, Elizabeth Bridges, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Muhammed Alshahrani, Zainab Al Duhailib, Greg S Martin, Lewis J Kaplan, Craig M Coopersmith, Massimo Antonelli, Andrew Rhodes,

<h4>Background</h4>The coronavirus disease 2019 pandemic continues to affect millions worldwide. Given the rapidly growing evidence base, we implemented a living guideline model to provide guidance on the management of patients with severe or critical coronavirus disease 2019 in the ICU.<h4>Methods</h4>The Surviving Sepsis Campaign Coronavirus Disease 2019 panel has expanded to ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):e219-e234]

Cited: 37 times

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The effectiveness of vitamin C for patients with severe viral pneumonia in respiratory failure.

Song-I Lee, Chae-Man Lim, Younsuck Koh, Jin-Won Huh, Jae Seung Lee, Sang-Bum Hong,

<h4>Background</h4>Vitamin C is a well-known antioxidant and essential cofactor for numerous biological reactions. Several studies reported that vitamin C can improve the symptoms and prognosis of patients with sepsis and respiratory infection. We aimed to examine the effect of vitamin C when used in viral pneumonia patients with severe respiratory ... Read more >>

J Thorac Dis (Journal of thoracic disease)
[2021, 13(2):632-641]

Cited: 1 time

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Severe Human Bocavirus-Associated Pneumonia in Adults at a Referral Hospital, Seoul, South Korea.

Sang-Ho Choi, Jin Won Huh, Sang-Bum Hong, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Heungsup Sung, Eun Jin Chae, Kyung-Hyun Do, Sang-Oh Lee, Chae-Man Lim, Yang Soo Kim, Jun Hee Woo, Younsuck Koh,

We report a case series of severe human bocavirus-associated pneumonia in adults in Seoul, South Korea. The virus accounted for 0.5% of all severe pneumonia cases. Structural lung disease and hematologic malignancy were common underlying diseases. Overall death rate was 54.5%. Higher death rates were associated with co-infection (83.3%) and ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(1):226-228]

Cited: 1 time

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Traitement des patients atteints d’une forme modérée ou grave de maladie à coronavirus 2019: Ligne directrice fondée sur des données probantes.

Zhikang Ye, Bram Rochwerg, Ying Wang, Neill K Adhikari, Srinivas Murthy, François Lamontagne, Robert A Fowler, Haibo Qiu, Li Wei, Ling Sang, Mark Loeb, Ning Shen, Minhua Huang, Zhaonan Jiang, Yaseen M Arabi, Luis Enrique Colunga-Lozano, Li Jiang, Younsuck Koh, Dong Liu, Fang Liu, Jason Phua, Aizong Shen, Tianyi Huo, Bin Du, Suodi Zhai, Gordon H Guyatt,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2020, 192(43):E1323-E1333]

Cited: 0 times

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Predictive powers of the Modified Early Warning Score and the National Early Warning Score in general ward patients who activated the medical emergency team.

Jee Hwan Ahn, Youn Kyung Jung, Ju-Ry Lee, You Na Oh, Dong Kyu Oh, Jin Won Huh, Chae-Man Lim, Younsuck Koh, Sang-Bum Hong,

BACKGROUND:The current early warning scores may be insufficient for medical emergency teams (METs) to use in assessing the severity and the prognosis of activated patients. We evaluated the predictive powers of the Modified Early Warning Score (MEWS) and the National Early Warning Score (NEWS) for 28-day mortality and to analyze ... Read more >>

PLoS One (PloS one)
[2020, 15(5):e0233078]

Cited: 2 times

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Iatrogenic Opioid Withdrawal Syndrome in Critically Ill Patients: a Retrospective Cohort Study.

Dong Gon Hyun, Jin Won Huh, Sang Bum Hong, Younsuck Koh, Chae Man Lim,

<h4>Background</h4>Opioid withdrawal syndrome (OWS) may occur following the reduction or discontinuation of opioid analgesics. In critically ill pediatric patients, OWS is a common and clinically significant condition. However, OWS in adult patients has not been assessed in detail. Therefore, we aimed to investigate the incidence, risk factors, and clinical features ... Read more >>

J Korean Med Sci (Journal of Korean medical science)
[2020, 35(15):e106]

Cited: 1 time

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Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline.

Zhikang Ye, Bram Rochwerg, Ying Wang, Neill K Adhikari, Srinivas Murthy, François Lamontagne, Robert A Fowler, Haibo Qiu, Li Wei, Ling Sang, Mark Loeb, Ning Shen, Minhua Huang, Zhaonan Jiang, Yaseen M Arabi, Luis Enrique Colunga-Lozano, Li Jiang, Younsuck Koh, Dong Liu, Fang Liu, Jason Phua, Aizong Shen, Tianyi Huo, Bin Du, Suodi Zhai, Gordon H Guyatt,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2020, 192(20):E536-E545]

Cited: 18 times

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Usefulness of ICU criteria for diagnosis of invasive pulmonary aspergillosis in nonhematologic critically ill patients.

Song-I Lee, Heungsup Sung, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin-Won Huh,

Invasive pulmonary aspergillosis (IPA) is a life-threatening disease in the intensive care unit (ICU). The ICU criteria were proposed to diagnose IPA in critically ill patients. This study aims to evaluate the usefulness of ICU criteria for diagnosis and treatment of IPA in nonhematologic patients in the ICU. We retrospectively ... Read more >>

Med Mycol (Medical mycology)
[2020, 58(3):275-281]

Cited: 0 times

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Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations.

Jason Phua, Li Weng, Lowell Ling, Moritoki Egi, Chae-Man Lim, Jigeeshu Vasishtha Divatia, Babu Raja Shrestha, Yaseen M Arabi, Jensen Ng, Charles D Gomersall, Masaji Nishimura, Younsuck Koh, Bin Du, ,

As coronavirus disease 2019 (COVID-19) spreads across the world, the intensive care unit (ICU) community must prepare for the challenges associated with this pandemic. Streamlining of workflows for rapid diagnosis and isolation, clinical management, and infection prevention will matter not only to patients with COVID-19, but also to health-care workers ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, 8(5):506-517]

Cited: 409 times

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Effect of corticosteroid therapy in the early phase of acute respiratory distress syndrome: a propensity-matched cohort study.

Moon Seong Baek, Yunkyoung Lee, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh,

<h4>Background/aims</h4>It is unclear whether corticosteroid use in patients with acute respiratory distress syndrome (ARDS) improves survival. This study aimed to investigate whether the administration of corticosteroids to patients in the early phase of moderate to severe ARDS is associated with improved outcomes.<h4>Methods</h4>We analyzed the data of patients who received corticosteroids ... Read more >>

Korean J Intern Med (The Korean journal of internal medicine)
[2021, 36(1):145-153]

Cited: 4 times

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