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Erratum to: Implication of Small Vessel Disease MRI Markers in Alzheimer's Disease and Lewy Body Disease.

Mincheol Park, Kyoungwon Baik, Young-Gun Lee, Sung Woo Kang, Jin Ho Jung, Seong Ho Jeong, Phil Hyu Lee, Young H Sohn, Byoung Seok Ye,

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2022, :]

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Association of β-Amyloid and Basal Forebrain With Cortical Thickness and Cognition in Alzheimer and Lewy Body Disease Spectra.

Han Soo Yoo, Seun Jeon, Enrica Cavedo, MinJin Ko, Mijin Yun, Phil Hyu Lee, Young H Sohn, Michel J Grothe, Stefan Teipel, Harald Hampel, Alan C Evans, Byoung Seok Ye,

<h4>Objective</h4>Cholinergic degeneration and β-amyloid contribute to brain atrophy and cognitive dysfunction in Alzheimer's disease (AD) and Lewy body disease (LBD), but their relationship has not been comparatively evaluated.<h4>Methods</h4>In this cross-sectional study, we recruited 28 normal controls (NC), 55 patients with AD mild cognitive impairment (MCI), 34 patients with AD dementia, ... Read more >>

Neurology (Neurology)
[2021, :]

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White matter connectivity networks predict levodopa-induced dyskinesia in Parkinson's disease.

Jin Ho Jung, Yae Ji Kim, Seok Jong Chung, Han Soo Yoo, Yang Hyun Lee, Kyoungwon Baik, Seong Ho Jeong, Young Gun Lee, Hye Sun Lee, Byoung Seok Ye, Young H Sohn, Yong Jeong, Phil Hyu Lee,

<h4>Background</h4>Although levodopa-induced dyskinesia-relevant white matter change has been evaluated, it is uncertain whether these changes may reflect the underlying predisposing conditions leading to the development of levodopa-induced dyskinesia.<h4>Objective</h4>To elucidate the role of white matter connectivity networks in the development of levodopa-induced dyskinesia in drug-naïve Parkinson's disease.<h4>Methods</h4>We recruited 30 patients who developed ... Read more >>

J Neurol (Journal of neurology)
[2021, :]

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Temporalis Muscle Thickness as an Indicator of Sarcopenia Is Associated With Long-term Motor Outcomes in Parkinson's Disease.

Seok Jong Chung, Yun Joong Kim, Han Soo Yoo, Jin Ho Jung, KyoungWon Baik, Hye Sun Lee, Yang Hyun Lee, Ji-Man Hong, Young H Sohn, Phil Hyu Lee,

<h4>Background</h4>To investigate the relationship between temporalis muscle thickness (TMT) at baseline as a surrogate marker for sarcopenia and long-term motor outcomes in patients with Parkinson's disease (PD).<h4>Methods</h4>We enrolled 249 patients with drug-naïve early-stage PD (119 males and 130 females, follow-up > 3 years). Baseline TMT of each patient was measured ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2021, 76(12):2242-2248]

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Effects of statins on dopamine loss and prognosis in Parkinson's disease.

Seong Ho Jeong, Hye Sun Lee, Seok Jong Chung, Han Soo Yoo, Jin Ho Jung, Kyoungwon Baik, Yang Hyun Lee, Young H Sohn, Phil Hyu Lee,

Statins are more widely used not only for the primary and secondary prevention of cardiovascular disease by blocking cholesterol biosynthesis but also for the potential neuroprotective agents during neurological disorders due to their pleiotropic effects. In this study, we investigate whether the previous use of statins affect baseline nigrostriatal dopamine ... Read more >>

Brain (Brain : a journal of neurology)
[2021, 144(10):3191-3200]

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Premorbid Educational Attainment and Long-Term Motor Prognosis in Parkinson's Disease.

Seong Ho Jeong, Seok Jong Chung, Han Soo Yoo, Jin Ho Jung, Kyoungwon Baik, Yang Hyun Lee, Phil Hyu Lee, Young H Sohn,

<h4>Background</h4>Premorbid educational attainment is a well-known proxy of reserve, not only with regard to cognition, but also to motor symptoms.<h4>Objective</h4>In the present study, we investigated the relationship between educational attainment and long-term motor prognosis in patients with Parkinson's disease (PD).<h4>Methods</h4>We analyzed 466 patients with de novo PD without dementia who ... Read more >>

J Parkinsons Dis (Journal of Parkinson's disease)
[2021, :]

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Neural correlates of self-awareness of cognitive deficits in non-demented patients with Parkinson's disease.

Han Soo Yoo, Hyeokjin Kwon, Seok Jong Chung, Young H Sohn, Jong-Min Lee, Phil Hyu Lee,

<h4>Background and purpose</h4>The aim was to investigate the neural correlates of impaired self-awareness of cognitive deficits (IACd) in non-demented patients with Parkinson's disease (PD).<h4>Methods</h4>This cross-sectional study enrolled 153 drug-naïve and non-demented PD patients who underwent brain magnetic resonance imaging, dopamine transporter (DAT) positron emission tomography, detailed neuropsychological testing, and the ... Read more >>

Eur J Neurol (European journal of neurology)
[2021, 28(12):4022-4030]

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Diffusion tensor imaging-based pontine damage as a degeneration marker in synucleinopathy.

Seok Jong Chung, Kyoo Ho Cho, Yang Hyun Lee, Han Soo Yoo, KyoungWon Baik, Jin Ho Jung, Byoung Seok Ye, Young H Sohn, Jungho Cha, Phil Hyu Lee,

The pons is one of the earliest affected regions in patients with synucleinopathies. We aimed to investigate the diagnostic value of measuring pontine damage using diffusion tensor imaging (DTI) in these patients. We enrolled 49 patients with Parkinson's disease (PD), 16 patients with idiopathic rapid eye movement sleep behavior disorder ... Read more >>

J Neurosci Res (Journal of neuroscience research)
[2021, 99(11):2922-2931]

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Association of Dipeptidyl Peptidase-4 Inhibitor Use and Amyloid Burden in Patients With Diabetes and AD-Related Cognitive Impairment.

Seong Ho Jeong, Hye Ryun Kim, Jeonghun Kim, Hankyeol Kim, Namki Hong, Jin Ho Jung, Kyoungwon Baik, Hanna Cho, Chul Hyoung Lyoo, Byoung Seok Ye, Young H Sohn, Joon-Kyung Seong, Phil Hyu Lee,

<h4>Background and objective</h4>To investigate whether dipeptidyl peptidase-4 inhibitors (DPP-4i) have beneficial effects on amyloid aggregation and longitudinal cognitive outcome in diabetic Alzheimer disease-related cognitive impairment (ADCI).<h4>Methods</h4>We retrospectively reviewed 282 patients with ADCI with positive <sup>18</sup>F-florbetaben amyloid PET images. Patients were classified into 3 groups according to prior diagnosis of diabetes ... Read more >>

Neurology (Neurology)
[2021, 97(11):e1110-e1122]

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Erratum: Validation Study of the Official Korean Version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale.

Jinse Park, Seong Beom Koh, Kyum Yil Kwon, Sang Jin Kim, Jae Woo Kim, Joong Seok Kim, Kun Woo Park, Jong Sam Paik, Young H Sohn, Jin Young Ahn, Tae Beom Ahn, Eungseok Oh, Jinyoung Youn, Ji Young Lee, Phil Hyu Lee, Wooyoung Jang, Han Joon Kim, Beom Seok Jeon, Sun Ju Chung, Jin Whan Cho, Sang Myung Cheon, Suk Yun Kang, Mee Young Park, Seongho Park, Young Eun Huh, Seok Jae Kang, Hee Tae Kim,

This corrects the article on p. 633 in vol. 16, PMID: 33029970. ... Read more >>

J Clin Neurol (Journal of clinical neurology (Seoul, Korea))
[2021, 17(3):501]

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Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies.

Sung Woo Kang, Seun Jeon, Young-Gun Lee, Mincheol Park, Kyoungwon Baik, Jin Ho Jung, Seok Jong Chung, Han Soo Yoo, Seong Ho Jeong, Mijin Yun, Phil Hyu Lee, Young H Sohn, Alan C Evans, Byoung Seok Ye,

To evaluate the implication of <sup>18</sup>F-fluorodeoxyglucose (FDG)- and dopamine transporter (DAT)-positron emission tomography (PET) in the diagnosis and clinical symptoms of dementia with Lewy bodies (DLB), 55 DLB patients and 49 controls underwent neuropsychological evaluation and FDG-, DAT-, and <sup>18</sup>F-Florbetaben (FBB) PET. DAT- and FDG-uptake and FDG/DAT ratio were measured ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):14394]

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Apolipoprotein E4, amyloid, and cognition in Alzheimer's and Lewy body disease.

Jin Ho Jung, Seun Jeon, Kyoungwon Baik, Yang Hyun Lee, Seok Jong Chung, Han Soo Yoo, Seong Ho Jeong, Young H Sohn, Phil Hyu Lee, Byoung Seok Ye,

The role of apolipoprotein E4 (APOE4) in the risk of Alzheimer's disease (AD) and Lewy body disease (LBD), and their relationship with β-amyloid deposition and cognitive dysfunction, remain unclear. Using amyloid and dopamine transporter imaging, we enrolled 126 controls and 208 patients with typical AD (pure AD and Lewy body ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2021, 106:45-54]

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Baseline cognitive profile is closely associated with long-term motor prognosis in newly diagnosed Parkinson's disease.

Seok Jong Chung, Han Soo Yoo, Hye Sun Lee, Yang Hyun Lee, KyoungWon Baik, Jin Ho Jung, Byoung Seok Ye, Young H Sohn, Phil Hyu Lee,

<h4>Objectives</h4>To investigate the association between cognitive function at baseline and the progression of motor disability in Parkinson's disease (PD).<h4>Methods</h4>We consecutively enrolled 257 drug-naïve patients with early-stage PD (follow-up > 2 years) who underwent a detailed neuropsychological test at initial assessment. Factor analysis was conducted to yield four cognitive function factors and composite scores ... Read more >>

J Neurol (Journal of neurology)
[2021, 268(11):4203-4212]

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Beneficial effects of dipeptidyl peptidase-4 inhibitors in diabetic Parkinson's disease.

Seong Ho Jeong, Seok Jong Chung, Han Soo Yoo, Namki Hong, Jin Ho Jung, Kyoungwon Baik, Yang Hyun Lee, Young H Sohn, Phil Hyu Lee,

Dipeptidyl peptidase 4 (DPP4) inhibitors are widely used hypoglycaemic agents and improve glucose metabolism by enhancing the bioavailability of active glucagon-like peptide-1. In this study, we hypothesized that treatment with DPP4 inhibitors may have beneficial effects on nigrostriatal dopamine and longitudinal motor performance in diabetic patients with Parkinson's disease. We ... Read more >>

Brain (Brain : a journal of neurology)
[2021, 144(4):1127-1137]

Cited: 3 times

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Structural connectivity networks in Alzheimer's disease and Lewy body disease.

Kyoungwon Baik, Jin-Ju Yang, Jin Ho Jung, Yang Hyun Lee, Seok Jong Chung, Han Soo Yoo, Young H Sohn, Phil Hyu Lee, Jong-Min Lee, Byoung Seok Ye,

<h4>Objective</h4>We evaluated disruption of the white matter (WM) network related with Alzheimer's disease (AD) and Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies.<h4>Methods</h4>We consecutively recruited 37 controls and 77 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI). Diagnoses of ADCI and LBCI ... Read more >>

Brain Behav (Brain and behavior)
[2021, 11(5):e02112]

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Donepezil for mild cognitive impairment in Parkinson's disease.

Kyoungwon Baik, Seon Myeong Kim, Jin Ho Jung, Yang Hyun Lee, Seok Jong Chung, Han Soo Yoo, Byoung Seok Ye, Phil Hyu Lee, Young H Sohn, Seung Wan Kang, Suk Yun Kang,

We investigated the efficacy of donepezil for mild cognitive impairment in Parkinson's disease (PD-MCI). This was a prospective, non-randomized, open-label, two-arm study. Eighty PD-MCI patients were assigned to either a treatment or control group. The treatment group received donepezil for 48 weeks. The primary outcome measures were the Korean version of ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):4734]

Cited: 2 times

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Different patterns of β-amyloid deposition in patients with Alzheimer's disease according to the presence of mild parkinsonism.

Seok Jong Chung, Sangwon Lee, Han Soo Yoo, KyoungWon Baik, Hye Sun Lee, Jin Ho Jung, Yonghoon Choi, Ji-Man Hong, Yun Joong Kim, Byoung Seok Ye, Young H Sohn, Mijin Yun, Phil Hyu Lee,

This study aimed to compare the patterns of β-amyloid deposition between patients with early-stage Alzheimer's disease (AD) with mild parkinsonism and those without parkinsonism. Sixty-one patients with early-stage AD (Clinical Dementia Rating [CDR], 0.5 or 1) who underwent <sup>18</sup>F-florbetaben (<sup>18</sup>F-FBB) PET scans were enrolled. We performed comparative analyses of regional ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2021, 101:199-206]

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Perivascular Spaces in the Basal Ganglia and Long-term Motor Prognosis in Newly Diagnosed Parkinson Disease.

Seok Jong Chung, Han Soo Yoo, Na-Young Shin, Yae Won Park, Hye Sun Lee, Ji-Man Hong, Yun Joong Kim, Seung-Koo Lee, Phil Hyu Lee, Young H Sohn,

<h4>Objective</h4>To investigate the association between enlarged perivascular spaces (PVS) in the basal ganglia (BG-PVS) and long-term motor outcomes in Parkinson disease (PD).<h4>Methods</h4>We reviewed the medical records of 248 patients with drug-naive early-stage PD (follow-up >3 years, mean age 67.44 ± 8.46 years, 130 female) who underwent brain MRI and dopamine ... Read more >>

Neurology (Neurology)
[2021, 96(16):e2121-e2131]

Cited: 1 time

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Neuropsychiatric Burden Is a Predictor of Early Freezing and Motor Progression in Drug-Naïve Parkinson's Disease.

Seong Ho Jeong, Han Soo Yoo, Seok Jong Chung, Jin Ho Jung, Yang Hyun Lee, Kyoungwon Baik, Young H Sohn, Phil Hyu Lee,

<h4>Background</h4>Neuropsychiatric symptoms (NPS) are the most common non-motor symptom in Parkinson's disease (PD).<h4>Objective</h4>To investigate the association between the burden of NPS and motor prognosis in patients with PD.<h4>Methods</h4>We enrolled 329 drug-naïve patients with PD, who was non-demented and followed-up≥2 years after their first visit to the clinic with baseline dopamine ... Read more >>

J Parkinsons Dis (Journal of Parkinson's disease)
[2021, 11(4):1947-1956]

Cited: 1 time

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White Matter Hyperintensities, Dopamine Loss, and Motor Deficits in De Novo Parkinson's Disease.

Seong Ho Jeong, Hye Sun Lee, Jin Ho Jung, Kyoungwon Baik, Yang Hyun Lee, Han Soo Yoo, Young H Sohn, Seok Jong Chung, Phil Hyu Lee,

<h4>Background</h4>White matter hyperintensities, prevalent in patients with Parkinson's disease (PD), significantly affect parkinsonian motor symptoms. The objective of this study was to investigate the relationship between white matter hyperintensities and nigrostriatal dopamine depletion and their interaction or mediating effects on motor symptoms in patients with drug-naive early-stage PD.<h4>Methods</h4>This cross-sectional study ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2021, 36(6):1411-1419]

Cited: 1 time

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Glucocerebrosidase Mutations and Motor Reserve in Parkinson's Disease.

Seok Jong Chung, Phil Hyu Lee, Young H Sohn, Yun Joong Kim,

<h4>Background</h4>The concept of motor reserve explains the individual differences in motor deficits despite similar degrees of nigrostriatal dopamine depletion in Parkinson's disease (PD).<h4>Objective</h4>To investigate glucocerebrosidase (GBA) variants as potential determinants of motor reserve for exploratory purposes.<h4>Methods</h4>A total of 408 patients with drug-naïve PD were enrolled from the Parkinson's Progression Markers ... Read more >>

J Parkinsons Dis (Journal of Parkinson's disease)
[2021, 11(4):1715-1724]

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Clinical and Dopamine Depletion Patterns in Hyposmia- and Dysautonomia-Dominant Parkinson's Disease.

Han Soo Yoo, Sangwon Lee, Seong Ho Jeong, Byoung Seok Ye, Young H Sohn, Mijin Yun, Phil Hyu Lee,

<h4>Background</h4>Olfactory or autonomic dysfunction is one of the earliest prodromal symptoms of Parkinson's disease (PD). It has not been investigated whether PD patients have different phenotypes depending on the presence of these prodromal symptoms.<h4>Objective</h4>To investigate whether hyposmia-dominant and dysautonomia-dominant patients with early PD have different clinical manifestations and nigrostriatal degeneration.<h4>Methods</h4>This ... Read more >>

J Parkinsons Dis (Journal of Parkinson's disease)
[2021, 11(4):1703-1713]

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Effect of Alzheimer's Disease and Lewy Body Disease on Metabolic Changes.

Yang Hyun Lee, Seun Jeon, Han Soo Yoo, Seok Jong Chung, Jin Ho Jung, Kyoungwon Baik, Young H Sohn, Phil Hyu Lee, Mijin Yun, Alan C Evans, Byoung Seok Ye,

<h4>Background</h4>The relationship among amyloid-β (Aβ) deposition on amyloid positron emission tomography (PET), cortical metabolism on 18F-fluoro-2-deoxy-D-glucose (FDG)-PET, and clinical diagnosis has not been elucidated for both Alzheimer's disease (AD) and Lewy body disease (LBD).<h4>Objective</h4>We investigated the patterns of cerebral metabolism according to the presence of AD and LBD.<h4>Methods</h4>A total of ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, 79(4):1471-1487]

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Microstructural Connectivity is More Related to Cognition than Conventional MRI in Parkinson's Disease.

Yang Hyun Lee, Wha Jin Lee, Seok Jong Chung, Han Soo Yoo, Jin Ho Jung, Kyoungwon Baik, Young H Sohn, Joon-Kyung Seong, Phil Hyu Lee,

<h4>Background</h4>The different effects of white matter hyperintensity (WMH) severity and WMH-associated microstructural connectivity on cognition in the early stages of Parkinson's disease (PD) have not been investigated.<h4>Objective</h4>To investigate the differential effect of WMH severity and WMH-associated microstructural connectivity on cognition in early stages of PD.<h4>Methods</h4>A total of 136 de novo ... Read more >>

J Parkinsons Dis (Journal of Parkinson's disease)
[2021, 11(1):239-249]

Cited: 1 time

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Implication of Small Vessel Disease MRI Markers in Alzheimer's Disease and Lewy Body Disease.

Mincheol Park, Kyoungwon Baik, Young-Gun Lee, Sung Woo Kang, Jin Ho Jung, Seong Ho Jeong, Phil Hyu Lee, Young H Sohn, Byoung Seok Ye,

<h4>Background</h4>Small vessel disease (SVD) magnetic resonance imaging (MRI) markers including deep and periventricular white matter hyperintensities (PWMH), lacunes, and microbleeds are frequently observed in Alzheimer's disease (AD) and Lewy body disease (LBD), but their implication has not been clearly elucidated.<h4>Objective</h4>To investigate the implication of SVD MRI markers in cognitively impaired ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, 83(2):545-556]

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