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Heterologous redox partners supporting the efficient catalysis of epothilone B biosynthesis by EpoK in Schlegelella brevitalea.

Junheng Liang, Huimin Wang, Xiaoying Bian, Youming Zhang, Guoping Zhao, Xiaoming Ding,

BACKGROUND:Epothilone B is a natural product that stabilizes microtubules, similar to paclitaxel (Taxol); therefore, epothilone B and several derivatives have shown obvious antitumour activities. Some of these products are in clinical trials, and one (ixabepilone, BMS) is already on the market, having been approved by the FDA in 2007. The ... Read more >>

Microb. Cell Fact. (Microbial cell factories)
[2020, 19(1):180]

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Biallelic intronic AAGGG expansion of RFC1 is related to multiple system atrophy.

Linlin Wan, Zhao Chen, Na Wan, Mingjie Liu, Jin Xue, Hongsheng Chen, Youming Zhang, Yun Peng, Zhichao Tang, Yiqing Gong, Hongyu Yuan, Shang Wang, Qi Deng, Xuan Hou, Chunrong Wang, Huirong Peng, Yuting Shi, Linliu Peng, Lijing Lei, Ranhui Duan, Kun Xia, Rong Qiu, Lu Shen, Beisha Tang, Tetsuo Ashizawa, Hong Jiang,

OBJECTIVE:A recessive biallelic repeat expansion, (AAGGG)exp , in the RFC1 gene has been reported to be a frequent cause of late-onset ataxia. For cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS), the recessive biallelic (AAGGG)exp genotype was present in approximately 92% of cases. This study aimed to examine whether the ... Read more >>

Ann. Neurol. (Annals of neurology)
[2020, :]

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Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy.

Wei Zhao, Ying Cong, Hong-Mei Li, Shengying Li, Yuemao Shen, Qingsheng Qi, Youming Zhang, Yue-Zhong Li, Ya-Jie Tang,

Covering: up to 2020As a main bioactive component of the Chinese, Indian, and American Podophyllum species, the herbal medicine, podophyllotoxin (PTOX) exhibits broad spectrum pharmacological activity, such as superior antitumor activity and against multiple viruses. PTOX derivatives (PTOXs) could arrest the cell cycle, block the transitorily generated DNA/RNA breaks, and ... Read more >>

Nat Prod Rep (Natural product reports)
[2020, :]

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Association of serum neurofilament light (sNfL) and disease severity in patients with spinocerebellar ataxia type 3.

Yun Peng, Youming Zhang, Zhao Chen, Huirong Peng, Na Wan, Jennifer Zhang, Jingyi Tang, Puzhi Wang, Yue Xie, Qiyong Cai, Shaohui Liu, Xuewei Zhang, Chunrong Wang, Hongyu Yuan, Tianjiao Li, Linlin Wan, Yuting Shi, Rong Qiu, Thomas Klockgether, Beisha Tang, Weihua Liao, Hong Jiang,

OBJECTIVE:To investigate serum neurofilament light protein (sNfL) levels in patients with spinocerebellar ataxia type 3 (SCA3) and to determine whether they are associated with disease severity. METHODS:This cross-sectional study enrolled 185 healthy controls and 235 ATXN3 mutation carriers (17 asymptomatic stage, 20 preclinical stage, and 198 ataxic stage). We measured ... Read more >>

Neurology (Neurology)
[2020, :]

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Applications of radiomics in genitourinary tumors.

Longfei Liu, Xiaoping Yi, Can Lu, Lin Qi, Youming Zhang, Minghao Li, Qiao Xiao, Cikui Wang, Liang Zhang, Yingxian Pang, Yong Wang, Xiao Guan,

Genitourinary tumors are heterogeneous groups of tumors with high morbidity and mortality rates. Confronted with existing problems in the management of genitourinary tumors, a personalized imaging method called radiomics shows great potential in areas including detection, grading, and treatment response assessment. Radiomics is characterized by extraction of quantitative imaging features ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2020, 10(8):2293-2308]

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Antagonistic Interaction between Auxin and SA Signaling Pathways Regulates Bacterial Infection through Lateral Root in Arabidopsis.

Xiangpei Kong, Chunlei Zhang, Huihui Zheng, Min Sun, Feng Zhang, Mengyue Zhang, Fuhao Cui, Dongping Lv, Lijing Liu, Siyi Guo, Youming Zhang, Xianzheng Yuan, Shan Zhao, Huiyu Tian, Zhaojun Ding,

Pathogen entry into host tissues is a critical and first step in infections. In plants, the lateral roots (LRs) are a potential entry and colonization site for pathogens. Here, using a GFP-labeled pathogenic bacterium Pseudomonas syringae pv. tomato strain DC3000 (Pto DC3000), we observe that virulent Pto DC3000 invades plants through emerged ... Read more >>

Cell Rep (Cell reports)
[2020, 32(8):108060]

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SenX3-RegX3, an Important Two-Component System, Regulates Strain Growth and Butenyl-spinosyn Biosynthesis in Saccharopolyspora pogona.

Jie Rang, Haocheng He, Jianming Chen, Jinjuan Hu, Jianli Tang, Zhudong Liu, Ziyuan Xia, Xuezhi Ding, Youming Zhang, Liqiu Xia,

Butenyl-spinosyn produced by Saccharopolyspora pogona exhibits strong insecticidal activity and a broad pesticidal spectrum. Currently, important functional genes involved in butenyl-spinosyn biosynthesis remain unknown, which leads to difficulty in efficient understanding of its regulatory mechanism and improving its production by metabolic engineering. Here, we present data supporting a role of ... Read more >>

iScience (iScience)
[2020, 23(8):101398]

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Reassembly of the Biosynthetic Gene Cluster Enables High Epothilone Yield in Engineered Schlegelella brevitalea.

Yucong Yu, Huimin Wang, Biao Tang, Junheng Liang, Lin Zhang, Hongkuan Wang, Xiaoying Bian, Yue-Zhong Li, Youming Zhang, Guo-Ping Zhao, Xiaoming Ding,

Epothilones, as a new class of microtubule-stabilizing anticancer drugs, exhibit strong bioactivity against taxane-resistant cells and show clinical activity for the treatment of advanced breast cancer. Additionally, they also show great potential for a central nervous system injury and Alzheimer's disease. However, due to the long fermentation period of the ... Read more >>

ACS Synth Biol (ACS synthetic biology)
[2020, 9(8):2009-2022]

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Y disruption, autosomal hypomethylation and poor male lung cancer survival

Saffron Willis-Owen, Clara Domingo Sabugo, Elizabeth Starren, Liming Liang, Maxim Freydin, Madeleine Arseneault, Youming Zhang, Lu Shir Kiong, Sanjay Popat, Eric Lim, Andrew Nicholson, Yasser Riazalhosseini, Mark Lathrop, William Osmond Cookson, Miriam Moffatt,

Lung cancer is the most frequent cause of cancer death worldwide1. It is male predominant and for reasons that are unknown also associated with significantly worse outcomes in men2. Here we compared gene co-expression networks in affected and unaffected pulmonary tissue derived from 126 patients with Stage IA-IV lung cancer. ... Read more >>

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Use of a paraprobiotic and postbiotic feed supplement (HWF™) improves the growth performance, composition and function of gut microbiota in hybrid sturgeon (Acipenser baerii x Acipenser schrenckii).

Xuexiang Wu, Tsegay Teame, Qiang Hao, Qianwen Ding, Hongliang Liu, Chao Ran, Yalin Yang, Youming Zhang, Zhigang Zhou, Ming Duan, Zhen Zhang,

The contribution of cold water aquaculture for the world fish production is significant. Although sturgeon farming is an important part of China's cold water aquaculture industry, its production is less compared with the current potentiality of the country. There are many reasons for the lower production of cold water fish ... Read more >>

Fish Shellfish Immunol. (Fish & shellfish immunology)
[2020, 104:36-45]

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Attenuation of Pseudomonas aeruginosa Quorum Sensing by Natural Products: Virtual Screening, Evaluation and Biomolecular Interactions.

Lin Zhong, Vinothkannan Ravichandran, Na Zhang, Hailong Wang, Xiaoying Bian, Youming Zhang, Aiying Li,

Natural products play vital roles against infectious diseases since ancient times and most drugs in use today are derived from natural sources. Worldwide, multi-drug resistance becomes a massive threat to the society with increasing mortality. Hence, it is very crucial to identify alternate strategies to control these 'super bugs'. Pseudomonas ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(6):]

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The increased virulence of hypervirulent fowl adenovirus 4 is independent of fiber-1 and penton.

Ruxin Liu, Yuhan Zhang, Huifang Guo, Ning Li, Baiyu Wang, Kaiyue Tian, Zeng Wang, Xia Yang, Yongtao Li, Hailong Wang, Youming Zhang, Jun Fu, Jun Zhao,

Hepatitis-hydropericardium syndrome (HHS) caused by hypervirulent fowl adenovirus 4 (FAdV-4) have been causing great economic losses to Chinese poultry industry since 2015. Elucidation of the pathogenesis of FAdV-4 will lay solid foundation for developing attenuated FAdV-4 vaccine and vaccine vector. Our previous study has demonstrated that the increased virulence of ... Read more >>

Res. Vet. Sci. (Research in veterinary science)
[2020, 131:31-37]

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Discovery of 4,6-O-Thenylidene-β-d-glucopyranoside-(2″-acetamido, 3″-acetyl-di-S-5-fluorobenzothizole/5-fluorobenzoxazole)-4'-demethylepipodophyllotoxin as Potential Less Toxic Antitumor Candidate Drugs by Reducing DNA Damage and Less Inhibition of PI3K.

Jie Cheng, Wei Zhao, Hui Yao, Yuemao Shen, Youming Zhang, Yue-Zhong Li, Qingsheng Qi, Kanokpan Wongprasert, Ya-Jie Tang,

As an FDA-approved drug, teniposide, was utilized in cancer treatment but was accompanied by a strong side effect in long-term clinical trials. This work discovered potential candidate drugs with low toxicity by modifying the molecule structure of teniposide through a structure-guided drug design approach. The IC50 value of novel 4,6-O-thenylidene-β-d-glucopyranoside-(2″-acetamido, ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2020, 63(6):2877-2893]

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Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters.

Wentao Zheng, Xue Wang, Haibo Zhou, Youming Zhang, Aiying Li, Xiaoying Bian,

The Burkholderiales are an emerging source of bioactive natural products. Their genomes contain a large number of cryptic biosynthetic gene clusters (BGCs), indicating great potential for novel structures. However, the lack of genetic tools for the most of Burkholderiales strains restricts the mining of these cryptic BGCs. We previously discovered ... Read more >>

Microb Biotechnol (Microbial biotechnology)
[2020, 13(2):397-405]

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Effect of the nitrogen-fixing bacterium Pseudomonas protegens CHA0-ΔretS-nif on garlic growth under different field conditions

Mei Wang, Zhilong Bian, Jing Shi, Yuxia Wu, Xu Yu, Yan Yang, Haiping Ni, Hanna Chen, Xiaoying Bian, Tao Li, Youming Zhang, Lihua Jiang, Qiang Tu,

Pseudomonas protegens CHA0 is a well-characterized plant-growth promoting rhizobacterium commonly used as biofertilizer or biocontrol agent for plant growth promotion and disease control. Genetically engineered strain CHA0-ΔretS-nif with introduced nitrogen-fixing ability and enhanced bactericidal activity has the potential to stimulate plant growth and suppress phytopathogens. Field experiments was conducted to ... Read more >>

(Industrial crops and products.)
[2020, 145:Not Available]

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Promoter Screening Facilitates Heterologous Production of Complex Secondary Metabolites in Burkholderiales Strains.

Qing Ouyang, Xue Wang, Na Zhang, Lin Zhong, Jiaqi Liu, Xiaoming Ding, Youming Zhang, Xiaoying Bian,

Burkholderiales are an emerging source of bioactive secondary metabolites and have the potential to be a robust chassis for metabolites from Gram-negative bacteria. However, only a few constitutive promoters can be utilized in Burkholderiales. Herein, we described the screening of strong constitutive promoters from Burkholderiales strain DSM 7029, and 37 ... Read more >>

ACS Synth Biol (ACS synthetic biology)
[2020, 9(2):457-460]

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Diagnostic performance of magnetic resonance imaging for colorectal liver metastasis: A systematic review and meta-analysis.

Yitao Mao, Bin Chen, Haofan Wang, Youming Zhang, Xiaoping Yi, Weihua Liao, Luqing Zhao,

The prognosis of colorectal cancer (CRC) is largely dependent on the early detection of hepatic metastases. With the advantages of nonradioactivity and the availability of multiple scanning sequences, the efficacy of magnetic resonance imaging (MRI) in the detection of colorectal liver metastases (CRLM) is not yet clear. We performed this ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1969]

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Identification of Holrhizins E-Q Reveals the Diversity of Nonribosomal Lipopeptides in Paraburkholderia rhizoxinica.

Hanna Chen, Haibo Zhou, Tao Sun, Jiaying Xu, Qiang Tu, Jie Yang, Youming Zhang, Xiaoying Bian,

The products of a nonribosomal peptide synthetase gene, holA, from Paraburkholderia rhizoxinica were investigated using our recently established recombineering technique. Fifteen products, including 13 new linear lipopeptides, holrhizins E-Q (2-8, 10-15), together with the two known holrhizins A and B (1, 9), were detected in the activated mutant, and their ... Read more >>

J. Nat. Prod. (Journal of natural products)
[2020, 83(2):537-541]

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Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.

Zong-Jie Wang, Haibo Zhou, Guannan Zhong, Liujie Huo, Ya-Jie Tang, Youming Zhang, Xiaoying Bian,

Genome mining of Fulvivirga sp. W222 revealed a desferrioxamine-like biosynthetic gene cluster containing an unknown gene fulF that is conserved in many Bacteroidetes species. A series of primary amine-acylated desferrioxamine G1 analogues, fulvivirgamides, were identified, and fulvivirgamides A2, B2, B3, and B4 (1-4) were purified and characterized. The function of ... Read more >>

Org. Lett. (Organic letters)
[2020, 22(3):939-943]

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Red/ET recombineering enhances extracellular lipase production by Burkholderia glumae

Qiang Tu, Zhilong Bian, Qian Fang, Hanna Chen, Zhiling Xie, Deng Pan, Beian You, Liqiu Xia, Youming Zhang, Yaling Gong,

Abstract Background : Microbial lipases are utilized widely in industrial fields, and the LipA lipase produced by Burkholderia glumae PG1 has been used for the production of enantiopure pharmaceuticals. However, efficient lipase expression and secretion are still problematic. LipA is encoded in an operon that also contains the lipase-specific foldase ... Read more >>

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Recombineering for Genetic Engineering of Natural Product Biosynthetic Pathways.

Muhammad Nazeer Abbasi, Jun Fu, Xiaoying Bian, Hailong Wang, Youming Zhang, Aiying Li,

Microbial genomes encode many cryptic and uncharacterized biosynthetic gene clusters (BGCs). Exploiting this unexplored genetic wealth to discover microbial novel natural products (NPs) remains a challenging issue. We review homologous recombination (HR)-based recombineering, mediated by the recombinases RecE/RecT from Rac prophage and Redα/Redβ from lambda phage, which has developed into ... Read more >>

Trends Biotechnol. (Trends in biotechnology)
[2020, 38(7):715-728]

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Enzymatic O-Glycosylation of Etoposide Aglycone by Exploration of the Substrate Promiscuity for Glycosyltransferases.

Kai-Zhi Jia, Li-Wen Zhu, Xudong Qu, Shengying Li, Yuemao Shen, Qingsheng Qi, Youming Zhang, Yue-Zhong Li, Ya-Jie Tang,

The 4-O-β-d-glucopyranoside of DMEP ((-)-4'-desmethylepipodophyllotoxin) (GDMEP), a natural product from Podophyllum hexandrum, is the direct precursor to the topoisomerase inhibitor etoposide, used in dozens of chemotherapy regimens for various malignancies. The biosynthesis pathway for DMEP has been completed, while the enzyme for biosynthesizing GDMEP is still unclear. Here, we report ... Read more >>

ACS Synth Biol (ACS synthetic biology)
[2019, 8(12):2718-2725]

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TOMM40 polymorphism is associated with resting-state functional MRI results in patients with Alzheimer's disease.

Xuewen Xiao, Jingya Wei, Weiwei Zhang, Bin Jiao, Xinxin Liao, Chuzheng Pan, Xiaoyan Liu, Xinxiang Yan, Beisha Tang, Youming Zhang, Dongcui Wang, Wu Xing, Weihua Liao, Lu Shen,

OBJECTIVE:Translocase of outer mitochondrial membrane 40 (TOMM40) encodes translocase of the outer mitochondrial membrane (TOM), which is associated with mitochondrial dysfunction in Alzheimer's disease (AD). TOMM40 rs157581-G has been reported to increase susceptibility to AD. However, the effect of TOMM40 rs157581-G in resting-state functional MRI (rs-fMRI) on AD has not ... Read more >>

Neuroreport (Neuroreport)
[2019, 30(16):1068-1073]

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Differentiation Between Benign and Nonbenign Meningiomas by Using Texture Analysis From Multiparametric MRI.

Chao Ke, Haolin Chen, Xiaofei Lv, Haojiang Li, Yun Zhang, Maodong Chen, Daokun Hu, Guangying Ruan, Yu Zhang, Youming Zhang, Lizhi Liu, Yanqiu Feng,

BACKGROUND:It is difficult to prospectively differentiate between benign (World Health Organization [WHO] I) and nonbenign (WHO II and III) meningiomas. PURPOSE:To evaluate the feasibility of preoperative differentiation between benign and nonbenign meningiomas by using texture analysis from multiparametric MR data. STUDY TYPE:Retrospective. SUBJECTS:In all, 184 patients with meningioma (139 benign ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2020, 51(6):1810-1820]

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Sensorimotor and pain-related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy.

Youming Zhang, Minli Qu, Xiaoping Yi, Pei Zhuo, Jingyi Tang, Xin Chen, Gaofeng Zhou, Ping Hu, Ting Qiu, Wu Xing, Yitao Mao, Bihong T Chen, Jing Wu, Yuanchao Zhang, Weihua Liao,

Although diabetic peripheral neuropathy (DPN) has long been considered a disease of the peripheral nervous system, recent neuroimaging studies have shown that alterations in the central nervous system may play a crucial role in its pathogenesis. Here, we used surface-based morphometry (SBM) and tract-based spatial statistics (TBSS) to investigate gray ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, 41(3):710-725]

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