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Author Youming Zhang

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Heterologous expression of bacterial natural product biosynthetic pathways.

Liujie Huo, Joachim J Hug, Chengzhang Fu, Xiaoying Bian, Youming Zhang, Rolf Müller,

Covering: 2013 to June 2018 Heterologous expression of natural product biosynthetic pathways is of increasing interest in microbial biotechnology, drug discovery and optimization. It empowers not only the robust production of valuable biomolecules in more amenable heterologous hosts but also permits the generation of novel analogs through biosynthetic engineering. This ... Read more >>

Nat Prod Rep (Natural product reports)
[2019, 36(10):1412-1436]

Cited: 6 times

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Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters.

Wentao Zheng, Xue Wang, Haibo Zhou, Youming Zhang, Aiying Li, Xiaoying Bian,

The Burkholderiales are an emerging source of bioactive natural products. Their genomes contain a large number of cryptic biosynthetic gene clusters (BGCs), indicating great potential for novel structures. However, the lack of genetic tools for the most of Burkholderiales strains restricts the mining of these cryptic BGCs. We previously discovered ... Read more >>

Microb Biotechnol (Microbial biotechnology)
[2020, 13(2):397-405]

Cited: 0 times

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Promoter Screening Facilitates Heterologous Production of Complex Secondary Metabolites in Burkholderiales Strains.

Qing Ouyang, Xue Wang, Na Zhang, Lin Zhong, Jiaqi Liu, Xiaoming Ding, Youming Zhang, Xiaoying Bian,

Burkholderiales are an emerging source of bioactive secondary metabolites and have the potential to be a robust chassis for metabolites from Gram-negative bacteria. However, only a few constitutive promoters can be utilized in Burkholderiales. Herein, we described the screening of strong constitutive promoters from Burkholderiales strain DSM 7029, and 37 ... Read more >>

ACS Synth Biol (ACS synthetic biology)
[2020, :]

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Diagnostic performance of magnetic resonance imaging for colorectal liver metastasis: A systematic review and meta-analysis.

Yitao Mao, Bin Chen, Haofan Wang, Youming Zhang, Xiaoping Yi, Weihua Liao, Luqing Zhao,

The prognosis of colorectal cancer (CRC) is largely dependent on the early detection of hepatic metastases. With the advantages of nonradioactivity and the availability of multiple scanning sequences, the efficacy of magnetic resonance imaging (MRI) in the detection of colorectal liver metastases (CRLM) is not yet clear. We performed this ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1969]

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Identification of Holrhizins E-Q Reveals the Diversity of Nonribosomal Lipopeptides in Paraburkholderia rhizoxinica.

Hanna Chen, Haibo Zhou, Tao Sun, Jiaying Xu, Qiang Tu, Jie Yang, Youming Zhang, Xiaoying Bian,

The products of a nonribosomal peptide synthetase gene, holA, from Paraburkholderia rhizoxinica were investigated using our recently established recombineering technique. Fifteen products, including 13 new linear lipopeptides, holrhizins E-Q (2-8, 10-15), together with the two known holrhizins A and B (1, 9), were detected in the activated mutant, and their ... Read more >>

J. Nat. Prod. (Journal of natural products)
[2020, :]

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Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.

Zong-Jie Wang, Haibo Zhou, Guannan Zhong, Liujie Huo, Ya-Jie Tang, Youming Zhang, Xiaoying Bian,

Genome mining of Fulvivirga sp. W222 revealed a desferrioxamine-like biosynthetic gene cluster containing an unknown gene fulF that is conserved in many Bacteroidetes species. A series of primary amine-acylated desferrioxamine G1 analogues, fulvivirgamides, were identified, and fulvivirgamides A2, B2, B3, and B4 (1-4) were purified and characterized. The function of ... Read more >>

Org. Lett. (Organic letters)
[2020, 22(3):939-943]

Cited: 0 times

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Recombineering for Genetic Engineering of Natural Product Biosynthetic Pathways.

Muhammad Nazeer Abbasi, Jun Fu, Xiaoying Bian, Hailong Wang, Youming Zhang, Aiying Li,

Microbial genomes encode many cryptic and uncharacterized biosynthetic gene clusters (BGCs). Exploiting this unexplored genetic wealth to discover microbial novel natural products (NPs) remains a challenging issue. We review homologous recombination (HR)-based recombineering, mediated by the recombinases RecE/RecT from Rac prophage and Redα/Redβ from lambda phage, which has developed into ... Read more >>

Trends Biotechnol. (Trends in biotechnology)
[2020, :]

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Enzymatic O-Glycosylation of Etoposide Aglycone by Exploration of the Substrate Promiscuity for Glycosyltransferases.

Kai-Zhi Jia, Li-Wen Zhu, Xudong Qu, Shengying Li, Yuemao Shen, Qingsheng Qi, Youming Zhang, Yue-Zhong Li, Ya-Jie Tang,

The 4-O-β-d-glucopyranoside of DMEP ((-)-4'-desmethylepipodophyllotoxin) (GDMEP), a natural product from Podophyllum hexandrum, is the direct precursor to the topoisomerase inhibitor etoposide, used in dozens of chemotherapy regimens for various malignancies. The biosynthesis pathway for DMEP has been completed, while the enzyme for biosynthesizing GDMEP is still unclear. Here, we report ... Read more >>

ACS Synth Biol (ACS synthetic biology)
[2019, :]

Cited: 0 times

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Differentiation Between Benign and Nonbenign Meningiomas by Using Texture Analysis From Multiparametric MRI.

Chao Ke, Haolin Chen, Xiaofei Lv, Haojiang Li, Yun Zhang, Maodong Chen, Daokun Hu, Guangying Ruan, Yu Zhang, Youming Zhang, Lizhi Liu, Yanqiu Feng,

BACKGROUND:It is difficult to prospectively differentiate between benign (World Health Organization [WHO] I) and nonbenign (WHO II and III) meningiomas. PURPOSE:To evaluate the feasibility of preoperative differentiation between benign and nonbenign meningiomas by using texture analysis from multiparametric MR data. STUDY TYPE:Retrospective. SUBJECTS:In all, 184 patients with meningioma (139 benign ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2019, :]

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TOMM40 polymorphism is associated with resting-state functional MRI results in patients with Alzheimer's disease.

Xuewen Xiao, Jingya Wei, Weiwei Zhang, Bin Jiao, Xinxin Liao, Chuzheng Pan, Xiaoyan Liu, Xinxiang Yan, Beisha Tang, Youming Zhang, Dongcui Wang, Wu Xing, Weihua Liao, Lu Shen,

OBJECTIVE:Translocase of outer mitochondrial membrane 40 (TOMM40) encodes translocase of the outer mitochondrial membrane (TOM), which is associated with mitochondrial dysfunction in Alzheimer's disease (AD). TOMM40 rs157581-G has been reported to increase susceptibility to AD. However, the effect of TOMM40 rs157581-G in resting-state functional MRI (rs-fMRI) on AD has not ... Read more >>

Neuroreport (Neuroreport)
[2019, 30(16):1068-1073]

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Sensorimotor and pain-related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy.

Youming Zhang, Minli Qu, Xiaoping Yi, Pei Zhuo, Jingyi Tang, Xin Chen, Gaofeng Zhou, Ping Hu, Ting Qiu, Wu Xing, Yitao Mao, Bihong T Chen, Jing Wu, Yuanchao Zhang, Weihua Liao,

Although diabetic peripheral neuropathy (DPN) has long been considered a disease of the peripheral nervous system, recent neuroimaging studies have shown that alterations in the central nervous system may play a crucial role in its pathogenesis. Here, we used surface-based morphometry (SBM) and tract-based spatial statistics (TBSS) to investigate gray ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, 41(3):710-725]

Cited: 0 times

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Reclassification of 'Polyangium brachysporum' DSM 7029 as Schlegelella brevitalea sp. nov.

Biao Tang, Yucong Yu, Junheng Liang, Youming Zhang, Xiaoying Bian, Xiaoyang Zhi, Xiaoming Ding,

Strain DSM 7029, isolated from a soil sample in Greece, can produce antitumour glidobactins, and has been found, as a heterologous host, to produce useful nonribosomal peptide synthetase-polyketide synthase hybrid molecules known as epothilones. This strain was originally named 'Polyangium brachysporum' of the family Polyangiaceae and the order Myxococcales. However, ... Read more >>

Int. J. Syst. Evol. Microbiol. (International journal of systematic and evolutionary microbiology)
[2019, 69(9):2877-2883]

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An in-depth analysis of glycosylated haemoglobin level, body mass index and left ventricular diastolic dysfunction in patients with type 2 diabetes.

Xin Zuo, Xueting Liu, Runtian Chen, Huiting Ou, Jiabao Lai, Youming Zhang, Dewen Yan,

BACKGROUND:Glycosylated hemoglobin (HbA1c) has a detrimental impact on the myocardium with left ventricular (LV) diastolic dysfunction. Obesity is a risk factor of type 2 diabetes. To understand the relationships between HbA1c, body mass index (BMI) and LV diastolic dysfunction, we performed this interaction analysis in patients with type 2 diabetes. ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2019, 19(1):88]

Cited: 0 times

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Transformation-Invariant Metamaterials.

Youming Zhang, Yu Luo, J B Pendry, Baile Zhang,

The fundamental semiconductor concept of doping has recently been transplanted to photonics in the platform of epsilon-near-zero (ENZ) media. By doping nonmagnetic impurities, ENZ media can exhibit almost arbitrary magnetism. However, this original photonic doping approach results only in isotropic media and thus cannot achieve impedance matching for all incident ... Read more >>

Phys. Rev. Lett. (Physical review letters)
[2019, 123(6):067701]

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Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy.

Lian He, Huijun Yang, Jianli Tang, Zhudong Liu, Yiyan Chen, Binghua Lu, Haocheng He, Sijia Tang, Yunjun Sun, Fei Liu, Xuezhi Ding, Youming Zhang, Shengbiao Hu, Liqiu Xia,

Traditional cancer therapies, such as surgery treatment, radiotherapy, and chemotherapy, often fail to completely eliminate tumor cells in an anaerobic microenvironment of tumor regions. In contrast to these traditional cancer therapies, the use of targeted delivery vectors to deliver anticancer genes or antitumor drugs to hypoxic areas in tumors is ... Read more >>

J Biol Eng (Journal of biological engineering)
[2019, 13:58]

Cited: 0 times

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Chemotherapy Potentially Facilitates the Occurrence of Radiation Encephalopathy in Patients With Nasopharyngeal Carcinoma Following Radiotherapy: A Multiparametric Magnetic Resonance Imaging Study.

Youming Zhang, Xiaoping Yi, Jianming Gao, Li Li, Lizhi Liu, Ting Qiu, Jinlei Zhang, Yuanchao Zhang, Weihua Liao,

Radiation encephalopathy (RE) is deemed to be a disease induced only by radiotherapy (RT), with the effects of chemotherapeutic agents on the brains of nasopharyngeal carcinoma (NPC) patients being largely overlooked. In this study, we investigated structural and functional brain alterations in NPC patients following RT with or without chemotherapy. ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:567]

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MRI-Based Radiomics Predicts Tumor Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer.

Xiaoping Yi, Qian Pei, Youming Zhang, Hong Zhu, Zhongjie Wang, Chen Chen, Qingling Li, Xueying Long, Fengbo Tan, Zhongyi Zhou, Wenxue Liu, Chenglong Li, Yuan Zhou, Xiangping Song, Yuqiang Li, Weihua Liao, Xuejun Li, Lunquan Sun, Haiping Pei, Chishing Zee, Bihong T Chen,

Background: Conventional methods for predicting treatment response to neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC) are limited. Methods: This study retrospectively recruited 134 LARC patients who underwent standard nCRT followed by total mesorectal excision surgery in our institution. Based on pre-operative axial T2-weighted images, machine learning ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:552]

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A New Isolate of Pediococcus pentosaceus (SL001) With Antibacterial Activity Against Fish Pathogens and Potency in Facilitating the Immunity and Growth Performance of Grass Carps.

Liang Gong, Haocheng He, Dongjie Li, Lina Cao, Tahir Ali Khan, Yanping Li, Lifei Pan, Liang Yan, Xuezhi Ding, Yunjun Sun, Youming Zhang, Ganfeng Yi, Shengbiao Hu, Liqiu Xia,

Probiotic-feeding continues to be a promising strategy to control the bacterial pathogens in aquaculture. A new Pediococcus pentosaceus strain (SL001) was isolated from 1000s of soil samples, which exhibited wide antimicrobial spectrum of against fish pathogens, involving Aeromonas hydrophila, Aeromonas veronii, Aeromonas sobria, Edwardsiella tarda, Lactococcus garvieae, and Plesiomonas shigelloide. ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:1384]

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CD73 Expression on Mesenchymal Stem Cells Dictates the Reparative Properties via Its Anti-Inflammatory Activity.

Kezhe Tan, Hongtao Zhu, Jianfang Zhang, Weili Ouyang, Jianfeng Tang, Youming Zhang, Linlin Qiu, Xueqing Liu, Zhaoping Ding, Xiaoming Deng,

Mesenchymal stem cells (MSC) are not universal and may be subject to dynamic changes upon local milieus in vivo and after isolation and cultivation in vitro. Here, we demonstrate that MSC derived from murine pericardial adipose tissue (pMSC) constitute two cohorts of population distinguished by the level of CD73 expression ... Read more >>

Stem Cells Int (Stem cells international)
[2019, 2019:8717694]

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Discovery of a Phenylamine-Incorporated Angucyclinone from Marine Streptomyces sp. PKU-MA00218 and Generation of Derivatives with Phenylamine Analogues.

Tan Liu, Jing Jin, Xiaoyan Yang, Juan Song, Jiahui Yu, Tongtong Geng, Zhongyi Zhang, Xueyang Ma, Guiyang Wang, Hua Xiao, Yuanjie Ge, Xiaoxu Sun, Baiying Xing, Xiaojie Ma, Changbiao Chi, Yi Kuang, Min Ye, Hailong Wang, Youming Zhang, Donghui Yang, Ming Ma,

A new phenylamine-incorporated angucyclinone (1) featuring a unique 1-phenylbenzo[ cd]indol-3(1 H)-one moiety was discovered from marine Streptomyces sp. PKU-MA00218. A series of experimental investigations identified that 1 was produced from the nonenzymatic conversion of a C-ring-cleaved angucyclinone (2) with phenylamine. Utilizing the nonenzymatic conversion, 18 phenylamine-incorporated angucyclinone derivatives with halogen, ... Read more >>

Org. Lett. (Organic letters)
[2019, 21(8):2813-2817]

Cited: 0 times

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Single-Stranded DNA-Binding Protein and Exogenous RecBCD Inhibitors Enhance Phage-Derived Homologous Recombination in Pseudomonas.

Jia Yin, Wentao Zheng, Yunsheng Gao, Chanjuan Jiang, Hongbo Shi, Xiaotong Diao, Shanshan Li, Hanna Chen, Hailong Wang, Ruijuan Li, Aiying Li, Liqiu Xia, Yulong Yin, A Francis Stewart, Youming Zhang, Jun Fu,

The limited efficiency of the available tools for genetic manipulation of Pseudomonas limits fundamental research and utilization of this genus. We explored the properties of a lambda Red-like operon (BAS) from Pseudomonas aeruginosa phage Ab31 and a Rac bacteriophage RecET-like operon (RecTEPsy) from Pseudomonas syringae pv. syringae B728a. Compared with ... Read more >>

iScience (iScience)
[2019, 14:1-14]

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Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales.

Hanna Chen, Zhilong Bian, Vinothkannan Ravichandran, Ruijuan Li, Yi Sun, Liujie Huo, Jun Fu, Xiaoying Bian, Liqiu Xia, Qiang Tu, Youming Zhang,

Widely used as drugs and agrochemicals, polyketides are a family of bioactive natural products, with diverse structures and functions. Polyketides are produced by megaenzymes termed as polyketide synthases (PKSs). PKS biosynthetic pathways are divided into the cis-AT PKSs and trans-AT PKSs; a division based mainly on the absence of an ... Read more >>

Crit. Rev. Microbiol. (Critical reviews in microbiology)
[2019, 45(2):162-181]

Cited: 0 times

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The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation.

Youming Zhang, Saffron A G Willis-Owen, Sarah Spiegel, Clare M Lloyd, Miriam F Moffatt, William O C M Cookson,

RATIONALE:Polymorphisms on chromosome 17q21 confer the major genetic susceptibility to childhood-onset asthma. Risk alleles positively correlate with ORMDL3 (orosomucoid-like 3) expression. The locus influences disease severity and the frequency of human rhinovirus (HRV)-initiated exacerbations. ORMDL3 is known to regulate sphingolipid synthesis by binding serine palmitoyltransferase, but its role in inflammation ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 199(4):478-488]

Cited: 4 times

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Contribution of Microbial Inter-kingdom Balance to Plant Health.

Chunlei Zhang, Youming Zhang, Zhaojun Ding, Yang Bai,

Mol Plant (Molecular plant)
[2019, 12(2):148-149]

Cited: 0 times

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Renal solitary fibrous tumor/hemangiopericytoma: computed tomography findings and clinicopathologic features.

Xiaoping Yi, Jing Wang, Youming Zhang, Zixin Wang, Zinan Zhang, Guanghui Gong, Longfei Liu, Wang Xiang, Weihua Liao, Chishing Zee, Bihong T Chen,

PURPOSE:To retrospectively characterize the clinical, pathological, and computed tomography (CT) findings of renal solitary fibrous tumor/hemangiopericytoma (rSFT/HPC). METHODS:Twelve patients with rSFT/HPCs were enrolled. The CT findings and clinicopathological features were retrospectively reviewed. RESULTS:This study included six male and six female patients (median age: 47; age range: 20-82 years). Eight benign (grade ... Read more >>

Abdom Radiol (NY) (Abdominal radiology (New York))
[2019, 44(2):642-651]

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