Full Text Journal Articles by
Author Yoshihito Yokoyama

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Fertility Awareness and Subclinical Infertility Among Women Trying to Get Pregnant at Home 

kaori iino, Rie Fukuhara, Megumi Yokota, Yoshihito Yokoyama,

<h4>Background: </h4> Recent studies on fertility awareness in the reproductive population have reported the lack of accurate knowledge about fertility and assisted reproductive technologies. However, these researches were conducted among university students or fertility patients. Therefore, there was little information among women trying to get pregnant at home on the ... Read more >>

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The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.

Hideki Tokunaga, Mikio Mikami, Satoru Nagase, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Toyomi Satoh, Yasuyuki Hirashima, Noriomi Matsumura, Yoshihito Yokoyama, Kei Kawana, Satoru Kyo, Daisuke Aoki, Hidetaka Katabuchi,

The fifth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer was published in 2020. The guidelines contain 6 chapters-namely, (1) overview of the guidelines; (2) epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer; (3) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e49]

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Significance of IL36RN mutation analyses in the management of impetigo herpetiformis: A case report and review of published cases.

Miyuki Yoshikawa, Daiki Rokunohe, Atsuko Kimura, Mika Takahashi, Ayumi Korekawa, Koji Nakajima, Hajime Nakano, Minako Yokoyama, Kanji Tanaka, Yoshihito Yokoyama, Daisuke Sawamura,

Impetigo herpetiformis (IH) is a rare variant of generalized pustular psoriasis (GPP), which develops during pregnancy. GPP is associated with mutations of IL36RN, but it is still unclear whether the same is true of IH. A 20-year-old Japanese woman developed erythema and pustules on her trunk during the 27th week ... Read more >>

J Dermatol (The Journal of dermatology)
[2021, :]

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Phase 2 single-arm study on the safety of maintenance niraparib in Japanese patients with platinum-sensitive relapsed ovarian cancer.

Kazuhiro Takehara, Takashi Matsumoto, Junzo Hamanishi, Kosei Hasegawa, Motoki Matsuura, Kiyonori Miura, Shoji Nagao, Hidekatsu Nakai, Naotake Tanaka, Hideki Tokunaga, Kimio Ushijima, Hidemichi Watari, Yoshihito Yokoyama, Yoichi Kase, Shuuji Sumino, Ajit Suri, Hiroaki Itamochi, Nobuhiro Takeshima,

<h4>Objective</h4>The primary objective of this study was to evaluate the safety of niraparib 300 mg/day in Japanese patients with platinum-sensitive, relapsed ovarian cancer in a maintenance setting.<h4>Methods</h4>Phase 2, multicenter, open-label, single-arm study enrolled Japanese patients with platinum-sensitive, relapsed ovarian cancer who had received ≥2 platinum-based regimens. The primary endpoint (incidence ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e21]

Cited: 1 time

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Phase 2 single-arm study on the efficacy and safety of niraparib in Japanese patients with heavily pretreated, homologous recombination-deficient ovarian cancer.

Aikou Okamoto, Eiji Kondo, Toshiaki Nakamura, Satoshi Yanagida, Junzo Hamanishi, Kenichi Harano, Kosei Hasegawa, Takeshi Hirasawa, Kensuke Hori, Shinichi Komiyama, Motoki Matsuura, Hidekatsu Nakai, Hiroko Nakamura, Jun Sakata, Tsutomu Tabata, Kazuhiro Takehara, Munetaka Takekuma, Yoshihito Yokoyama, Yoichi Kase, Shuuji Sumino, Junpei Soeda, Ajit Suri, Daisuke Aoki, Toru Sugiyama,

<h4>Objective</h4>To evaluate the efficacy and safety of niraparib in Japanese women with heavily pretreated ovarian cancer.<h4>Methods</h4>This Phase 2 open-label, single-arm study enrolled Japanese women with homologous recombination deficiency-positive relapsed, high-grade serous ovarian, fallopian tube, or primary peritoneal cancer who had completed 3-4 lines of therapy. The starting dose of niraparib ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e16]

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A semen-based stimulation method to analyze cytokine production by uterine CD56bright natural killer cells in women with recurrent pregnancy loss.

Ayako Taima, Atsushi Fukui, Ayano Yamaya, Megumi Yokota, Rie Fukuhara, Yoshihito Yokoyama,

Cytokine secretion by NK cells is abnormal in some women with recurrent pregnancy loss (RPL). Cytokine production is usually evaluated after stimulation with PMA and ionomycin. However, stimulation of uterine NK cells with semen corresponds more closely to physiological conditions at the time of conception. As seminal plasma has immunomodulatory ... Read more >>

J Reprod Immunol (Journal of reproductive immunology)
[2020, 142:103206]

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Spontaneous partial uterine laceration in primigravida at 16 weeks of gestation: A case report.

Kaori Iino, Kanji Tanaka, Anna Takabayashi, Asami Akaishi, Kana Ishihara, Yoshihito Yokoyama,

<h4>Introduction</h4>Although uterine rupture is well discussed, uterine laceration and partial myometrial laceration are little known. A previous report hypothesized that the stress of labor was associated with uterine laceration.<h4>Presentation of case</h4>We present a rare case of uterine laceration in a patient in the second trimester. A 34-year-old primigravida woman at ... Read more >>

Int J Surg Case Rep (International journal of surgery case reports)
[2020, 73:154-156]

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Quantitative evaluation of chemotherapy-induced peripheral neuropathy by using intraepidermal electrical stimulation.

Fumie Oyama, Masayuki Futagami, Hiroe Oikiri, Anna Takabayashi, Asami Akaishi, Tomoe Kodama, Mami Matsumoto, Masahiro Kanamori, Maika Oishi, Rie Miura, Hachidai Hirakawa, Yoshihito Yokoyama,

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequently observed treatment-related adverse effect, particularly associated with taxane-based chemotherapy, which affects the quality of life of the patients. To date, CIPN has been subjectively evaluated by patients or physicians. Intraepidermal electrical stimulation (IES) may be applied to evaluate the function of small fibers ... Read more >>

Mol Clin Oncol (Molecular and clinical oncology)
[2020, 13(2):169-174]

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Preventive effect of daikenchuto, a traditional Japanese herbal medicine, on onset of ileus after gynecological surgery for malignant tumors.

Fumie Oyama, Masayuki Futagami, Tatsuhiko Shigeto, Rie Miura, Yuuki Osawa, Maika Oishi, Hiroe Oikiri, Minako Yokoyama, Anna Takabayashi, Yoshihito Yokoyama,

<h4>Background</h4>Postoperative ileus is a major complication of abdominal surgical procedures. The purpose of this study was to investigate preventive effect of daikenchuto (DKT) on onset of ileus in patients who received gynecological surgery for malignant tumors.<h4>Methods</h4>A total of 904 patients who received gynecological surgery for malignant tumors by opening retroperitoneum ... Read more >>

Asia Pac J Clin Oncol (Asia-Pacific journal of clinical oncology)
[2020, 16(4):254-258]

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Clinical status and prognostic factors in Japanese patients with uterine leiomyosarcoma.

Kazuhiro Takehara, Natsumi Yamashita, Reiko Watanabe, Norihiro Teramoto, Hitoshi Tsuda, Takashi Motohashi, Kenichi Harano, Toru Nakanishi, Hideki Tokunaga, Nobuyuki Susumu, Yutaka Ueda, Yoshihito Yokoyama, Toshiaki Saito,

OBJECTIVE:Uterine leiomyosarcoma (uLMS) is a rare gynecologic malignancy for which the currently available treatments do not consistently provide long-term disease control. This study aimed to reveal the current clinical status of uLMS to support future clinical trials. METHODS:This study enrolled patients with uLMS treated at 53 Japanese institutions from 2000 ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 157(1):115-120]

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Clinical and reproductive outcomes of fertility-sparing surgery in stage I epithelial ovarian cancer.

Takafumi Watanabe, Shu Soeda, Hiroshi Nishiyama, Yuichiroh Kiko, Hideki Tokunaga, Shogo Shigeta, Nobuo Yaegashi, Hidekazu Yamada, Tsuyoshi Ohta, Satoru Nagase, Tadahiro Shoji, Masahiro Kagabu, Tsukasa Baba, Dai Shimizu, Naoki Sato, Yukihiro Terada, Masayuki Futagami, Yoshihito Yokoyama, Keiya Fujimori,

The aim of the present study was to evaluate the oncologic safety and reproductive outcome in patients with stage I epithelial ovarian cancer (EOC) treated with fertility-sparing surgery (FSS). Women aged ≤40 years with stage I EOC who had undergone FSS between 2000 and 2010 were retrospectively reviewed. Survival was ... Read more >>

Mol Clin Oncol (Molecular and clinical oncology)
[2020, 12(1):44-50]

Cited: 2 times

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Analysis of the relapse patterns and risk factors of endometrial cancer following postoperative adjuvant chemotherapy in a phase III randomized clinical trial.

Hiroyuki Nomura, Daisuke Aoki, Nobuyuki Susumu, Mika Mizuno, Hidekatsu Nakai, Masahide Arai, Shin Nishio, Hideki Tokunaga, Toru Nakanishi, Yoh Watanabe, Nobuo Yaegashi, Yoshihito Yokoyama, Kazuhiro Takehara,

<h4>Objective</h4>This study was to analyze patterns and risk factors of relapse after postoperative adjuvant chemotherapy for endometrial cancer.<h4>Methods</h4>Among patients enrolled in a randomized phase III trial (JGOG2043) investigating the efficacy of adjuvant chemotherapy for endometrial cancer at a high risk of progression, the recurrent patients were studied. Clinical information were ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 155(3):413-419]

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Inhibitory effect of carbonyl reductase 1 against peritoneal progression of ovarian cancer: evaluation by ex vivo 3D-human peritoneal model.

Hiroe Oikiri, Yoshiya Asano, Michiya Matsusaki, Mitsuru Akashi, Hiroshi Shimoda, Yoshihito Yokoyama,

The current authors previously reported that a carbonyl reductase 1 (CR1) DNA-dendrimer complex could potentially be used in gene therapy for peritoneal metastasis of ovarian cancer. The aims of the current study were to observe the cellular dynamics of peritoneal metastasis of epithelial ovarian cancer cells and to ascertain changes ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2019, 46(5):4685-4697]

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Daidzein Intake Is Associated with Equol Producing Status through an Increase in the Intestinal Bacteria Responsible for Equol Production.

Chikara Iino, Tadashi Shimoyama, Kaori Iino, Yoshihito Yokoyama, Daisuke Chinda, Hirotake Sakuraba, Shinsaku Fukuda, Shigeyuki Nakaji,

Equol is a metabolite of isoflavone daidzein and has an affinity to estrogen receptors. Although equol is produced by intestinal bacteria, the association between the status of equol production and the gut microbiota has not been fully investigated. The aim of this study was to compare the intestinal bacteria responsible ... Read more >>

Nutrients (Nutrients)
[2019, 11(2):]

Cited: 8 times

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Differences in semen characteristics between patients with testicular cancer and other malignancies using various cut-off values.

Itsuto Hamano, Shingo Hatakeyama, Rika Nakamura, Rie Fukuhara, Daisuke Noro, Toshikazu Tanaka, Tohru Yoneyama, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Yoshihito Yokoyama, Chikara Ohyama,

<h4>Objectives</h4>To compare semen parameters between patients with testicular cancer and other malignancies using various cut-off values, and to evaluate the correlation between semen parameters and intracytoplasmic sperm injection outcomes.<h4>Methods</h4>We retrospectively investigated semen parameters before cancer treatment in 117 patients with malignancies who cryopreserved sperm at Hirosaki University Hospital between November ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2018, 25(9):817-824]

Cited: 3 times

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Multicenter Clinicopathological Study of High-Grade Serous Carcinoma Presenting as Primary Peritoneal Carcinoma.

Shinichi Komiyama, Yoshihiro Nishijima, Haruhiro Kondo, Hiroyuki Nomura, Satoshi Yamaguchi, Masayuki Futagami, Hiroharu Arai, Yoshihito Yokoyama, Nao Suzuki, Mikio Mikami, Kaneyuki Kubushiro, Daisuke Aoki, Yasuhiro Udagawa, Ryuichiro Nishimura,

OBJECTIVE:We conducted a multicenter clinicopathological study to characterize patients with high-grade serous carcinoma presenting as primary peritoneal carcinoma (clinical PPC). METHODS:At 9 sites in Japan, patients with clinical PPC diagnosed according to Gynecologic Oncology Group criteria were enrolled retrospectively. The Gynecologic Oncology Group criteria allow for minor ovarian involvement by ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2018, 28(4):657-665]

Cited: 3 times

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Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report.

Itsuto Hamano, Shingo Hatakeyama, Rika Nakamura, Rie Fukuhara, Daisuke Noro, Hiroko Seino, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Yoshihito Yokoyama, Chikara Ohyama,

Background:Although oncologic testicular sperm extraction (onco-TESE) has been increasingly practiced, the evidence of onco-TESE performed in patients with testicular cancer is insufficient. Furthermore, in bilateral testicular cancer, accounting for 0.5%-1% of testicular cancers, onco-TESE is more challenging and has been insufficiently reported. Case presentation:Here we report the case of a ... Read more >>

Basic Clin Androl (Basic and clinical andrology)
[2018, 28:1]

Cited: 2 times

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Measurement of endometrial thickness in premenopausal women in office gynecology.

Hiroshi Tsuda, Yoichi M Ito, Yukiharu Todo, Takahiro Iba, Keiichi Tasaka, Yuji Sutou, Kozo Hirai, Koichiro Dozono, Yoshifusa Dobashi, Mami Manabe, Tomomi Sakamoto, Ritsu Yamamoto, Katsufumi Ueda, Moe Akatsuka, Yasuhiko Kiyozuka, Nobutaka Nagai, Manami Imai, Koji Kobiki, Hiromasa Fujita, Hiroaki Itamochi, Takafumi Oshita, Takahiro Kawarada, Masayuki Hatae, Yoshihito Yokoyama,

<h4>Purpose</h4>To define the median endometrial thickness (ET) in office gynecology is thought to be important for clinical practice. However, there are few reports about ET that have included the general female population on a large scale. The median ET was determined prospectively in premenopausal women who attended office gynecology for ... Read more >>

Reprod Med Biol (Reproductive medicine and biology)
[2018, 17(1):29-35]

Cited: 2 times

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A phase II study of irinotecan and pegylated liposomal doxorubicin in platinum-resistant recurrent ovarian cancer (Tohoku Gynecologic Cancer Unit 104 study).

Tadahiro Shoji, Eriko Takatori, Hideo Omi, Masahiro Kagabu, Tatsuya Honda, Masayuki Futagami, Yoshihito Yokoyama, Michiko Kaiho, Hideki Tokunaga, Takeo Otsuki, Tadao Takano, Nobuo Yaegashi, Takanobu Kojimahara, Tsuyoshi Ohta, Satoru Nagase, Shu Soeda, Takafumi Watanebe, Hiroshi Nishiyama, Toru Sugiyama,

<h4>Purpose</h4>We report a phase II clinical study of the combination of irinotecan (CPT-11) and pegylated liposomal doxorubicin (PLD) in platinum- and taxane-resistant recurrent ovarian cancer, based on the recommended doses determined in a phase I trial.<h4>Methods</h4>PLD was administered intravenously at a dose of 30 mg/m<sup>2</sup> on day 3. CPT-11 was administered ... Read more >>

Cancer Chemother Pharmacol (Cancer chemotherapy and pharmacology)
[2017, 80(2):355-361]

Cited: 1 time

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Whole-genome sequencing revealed novel prognostic biomarkers and promising targets for therapy of ovarian clear cell carcinoma.

Hiroaki Itamochi, Tetsuro Oishi, Nao Oumi, Satoshi Takeuchi, Kosuke Yoshihara, Mikio Mikami, Nobuo Yaegashi, Yasuhisa Terao, Kazuhiro Takehara, Kimio Ushijima, Hidemichi Watari, Daisuke Aoki, Tadashi Kimura, Toshiaki Nakamura, Yoshihito Yokoyama, Junzo Kigawa, Toru Sugiyama,

<h4>Background</h4>Ovarian clear cell carcinoma (OCCC) is mostly resistant to standard chemotherapy that results in poor patient survival. To understand the genetic background of these tumours, we performed whole-genome sequencing of OCCC tumours.<h4>Methods</h4>Tumour tissue samples and matched blood samples were obtained from 55 Japanese women diagnosed with OCCC. Whole-genome sequencing was ... Read more >>

Br J Cancer (British journal of cancer)
[2017, 117(5):717-724]

Cited: 15 times

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Hypertensive disorders of pregnancy increase the risk for chronic kidney disease: A population-based retrospective study.

Maika Oishi, Kaori Iino, Kanji Tanaka, Kana Ishihara, Yoshihito Yokoyama, Ippei Takahashi, Hideki Mizunuma,

Hypertensive disorders of pregnancy (HDP) and chronic kidney disease (CKD) are well-known risk factors for cardiovascular disease (CVD) in later life. However, few studies have investigated the association of HDP with CKD. Moreover, these studies utilized either registry- or clinical-based data and did not include subclinical CKD patients. To address ... Read more >>

Clin Exp Hypertens (Clinical and experimental hypertension (New York, N.Y. : 1993))
[2017, 39(4):361-365]

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Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences.

Yoshihito Yokoyama, Tatsuhiko Shigeto, Rie Miura, Asami Kobayashi, Makito Mizunuma, Aisa Yamauchi, Masayuki Futagami, Hideki Mizunuma,

Protoporphyrin IX (PpIX) levels are crucial to the antitumor action of photodynamic therapy (PDT). In the present study, the underling molecular mechanisms for the variation in PpIX levels in ovarian cancer cells were investigated. Five ovarian cancer cell lines were subcutaneously grafted onto the backs of nude mice. Once tumors ... Read more >>

Oncol Lett (Oncology letters)
[2017, 13(6):4933-4938]

Cited: 2 times

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Contributions of the Japanese Gynecologic Oncology Group (JGOG) in Improving the Quality of Life in Women With Gynecological Malignancies.

Masayuki Futagami, Yoshihito Yokoyama, Muneaki Shimada, Shinya Sato, Etsuko Miyagi, Akiko Tozawa-Ono, Nao Suzuki, Masaki Fujimura, Yoichi Aoki, Satoru Sagae, Toru Sugiyama,

The Japanese Gynecologic Oncology Group (JGOG) is leading Japan in the treatment of gynecological malignancies. The JGOG consists of three treatment committees focusing on uterine cervical cancer, endometrial cancer, and ovarian cancer. Each committee makes efforts to improve treatment and diagnosis. In addition, the Supportive and Palliative Care Committee was ... Read more >>

Curr Oncol Rep (Current oncology reports)
[2017, 19(4):25]

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Functional role of the Tau protein in epithelial ovarian cancer cells.

Aisa Yamauchi, Asami Kobayashi, Hiroe Oikiri, Yoshihito Yokoyama,

<h4>Aim</h4>The microtubule-associated Tau protein is a marker of paclitaxel sensitivity in ovarian cancer. The aim of the present study was to elucidate the function of the Tau protein in epithelial ovarian cancer.<h4>Methods</h4>The correlation between Tau protein expression and the response to paclitaxel by using several ovarian cancer cell lines was ... Read more >>

Reprod Med Biol (Reproductive medicine and biology)
[2017, 16(2):143-151]

Cited: 4 times

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Current Status of Uterine Leiomyosarcoma in the Tohoku Region: Results of the Tohoku Translational Center Development Network Survey.

Hideki Tokunaga, Fumiaki Takahashi, Hiroki Yamamoto, Tsuyoshi Honda, Takafumi Watanabe, Tadahiro Shoji, Toru Sugiyama, Hidekazu Yamada, Tomoe Tando, Kosuke Yoshinaga, Satoko Kagabu, Takeo Otsuki, Shogo Kin, Yoshihito Yokoyama, Satoshige Wagatsuma, Kazuyo Sato, Hirokazu Sato, Takashi Oishi, Yuji Yoshida, Tadashi Hayasaka, Toshihiko Matsui, Noriaki Imai, Hidekazu Nishigori, Hiroaki Shimokawa, Nobuo Yaegashi, Yoh Watanabe,

<h4>Background</h4>To prepare for a future clinical trial for improving the long-term prognosis of patients with uterine leiomyosarcoma (ULMS), we conducted a multi-institutional survey in the Tohoku region of Japan.<h4>Methods</h4>We conducted a retrospective cohort study between 2011 and 2014 in member institutions of the Tohoku Translational Research Center Development Network.<h4>Results</h4>A total ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2017, 22(3):541-547]

Cited: 1 time

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