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Author Yong Jae Lee

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Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men.

Hye-Min Park, Haeyoung Kim, Hye Sun Lee, Yong-Jae Lee,

Low serum bilirubin levels have been associated with increased risk of cardiovascular disease (CVD) and metabolic syndrome. Testosterone deficiency could also contribute to increased risk of CVD and metabolic syndrome. Therefore, this study aimed to examine the relationship between serum bilirubin level and testosterone deficiency in 1284 Korean men aged ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):8026]

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Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans.

Dong-Hyuk Jung, Yong Jae Lee, Byoungjin Park,

<h4>Purpose</h4>Hepatic steatosis has been associated with some cardiovascular risks. Increased alanine aminotransferase (ALT) was suggested to be linked to endothelial dysfunction. We prospectively investigated the joint effect of hepatic steatosis and elevated ALT within the normal range on incident ischemic heart disease (IHD) risk as an extrahepatic complication.<h4>Patients and methods</h4>We ... Read more >>

Clin Interv Aging (Clinical interventions in aging)
[2021, 16:513-523]

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Relationship between muscle mass index and LDL cholesterol target levels: Analysis of two studies of the Korean population.

Jun-Hyuk Lee, Hye Sun Lee, A-Ra Cho, Yong-Jae Lee, Yu-Jin Kwon,

Decreased skeletal muscle mass is an important change in body composition with aging. Maintaining the optimal low-density lipoprotein (LDL) cholesterol level is crucial for the prevention of cardiovascular diseases (CVD). We investigated whether muscle mass was associated with dyslipidemia. We analyzed the data of 17,546 adults from the 2008-2011 Korean ... Read more >>

Atherosclerosis (Atherosclerosis)
[2021, 325:1-7]

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Gallbladder Polyps With Metabolic Comorbidities Increase the Risk of Ischaemic Heart Disease in Korean Adults

Yong-Jae Lee, Byoungjin Park, Kyung-Won Hong, Dong-Hyuk Jung,

<h4>Background: </h4> This study aimed to investigate the longitudinal effects of gallbladder (GB) polyps, as a surrogate metabolic indicator, on incident ischaemic heart disease (IHD). We also assessed the combined effects of GB polyps and comorbidities on the risk of developing IHD. <h4>Methods: </h4> We enrolled 19,612 participants from the ... Read more >>

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Pterostilbene Improves Stress-Related Behaviors and Partially Reverses Underlying Neuroinflammatory and Hormonal Changes in Stress-Challenged Mice.

Byoungjin Park, Yong-Jae Lee,

Pterostilbene is a natural compound contained in various dietary sources that has received tremendous attention due to its antioxidant properties with promising benefits in cancers and vascular diseases. Currently, little is known about pterostilbene-associated neuroimmune endocrine effects. We aimed to examine the efficacy of pterostilbene for improving stress-related behaviors, neuroinflammation, ... Read more >>

J Med Food (Journal of medicinal food)
[2021, 24(3):299-309]

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A single-arm phase II study of olaparib maintenance with pembrolizumab and bevacizumab in BRCA non-mutated patients with platinum-sensitive recurrent ovarian cancer (OPEB-01).

Yong Jae Lee, Myong Cheol Lim, Byoung Gie Kim, Natalie Yl Ngoi, Chel Hun Choi, Sang Yoon Park, David Sp Tan, Yunjung Go, Jung Yun Lee,

<h4>Background</h4>The optimal treatment of <i>BRCA</i> wild-type patients with platinum-sensitive recurrent ovarian cancer remains unknown. Recently, there is an increase in the evidence to support the role of the combination of a poly(adenosine diphosphate-ribose) polymerase inhibitor, anti-angiogenic agents, and immunotherapy as maintenance therapy in <i>BRCA</i> wild-type patients with platinum-sensitive recurrence. We ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e31]

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Calcium Supplements and Risk of Cardiovascular Disease: A Meta-Analysis of Clinical Trials.

Seung-Kwon Myung, Hong-Bae Kim, Yong-Jae Lee, Yoon-Jung Choi, Seung-Won Oh,

<h4>Background</h4>Recent systematic reviews and meta-analyses of randomized, double-blind, placebo-controlled trials (double-blind, placebo-controlled RCTs) have reported controversial findings regarding the associations between calcium supplements on the risk of cardiovascular disease (CVD). This meta-analysis aimed to investigate the association between them.<h4>Methods</h4>We searched PubMed, EMBASE, the Cochrane Library, and the bibliographies of relevant ... Read more >>

Nutrients (Nutrients)
[2021, 13(2):]

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Development of a novel nannochloropsis strain with enhanced violaxanthin yield for large-scale production.

Su-Bin Park, Jin-Ho Yun, Ae Jin Ryu, Joohyun Yun, Ji Won Kim, Sujin Lee, Saehae Choi, Dae-Hyun Cho, Dong-Yun Choi, Yong Jae Lee, Hee-Sik Kim,

<h4>Background</h4>Nannochloropsis is a marine microalga that has been extensively studied. The major carotenoid produced by this group of microalgae is violaxanthin, which exhibits anti-inflammatory, anti-photoaging, and antiproliferative activities. Therefore, it has a wide range of potential applications. However, large-scale production of this pigment has not been much studied, thereby limiting ... Read more >>

Microb Cell Fact (Microbial cell factories)
[2021, 20(1):43]

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Association of Triglyceride Glucose (TyG) Index With Leukoaraiosis in Middle-aged and Older Adults: A Cross-sectional Study

Dong-Hyuk Jung, Byoung Jin Park, Yong-Jae Lee,

<h4>Background: </h4> Leukoaraiosis refers to lesions of high signal intensity in the periventricular and subcortical white matter that result from chronic microvascular ischemic damage to the brain. Increasing evidence suggests that the triglyceride glucose (TyG) index is associated with arterial stiffness and cardiovascular disease, which are both closely related to ... Read more >>

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Positive Association of Serum Alkaline Phosphatase Level with Severe Knee Osteoarthritis: A Nationwide Population-Based Study.

Hye-Min Park, Jun-Hyuk Lee, Yong-Jae Lee,

Serum alkaline phosphatase (ALP), a well-known marker of hepatobiliary and bone disorders, has recently been discovered to be a biochemical marker of cardiometabolic diseases and chronic low-grade inflammation. We aimed to evaluate the association of serum ALP level with knee osteoarthritis in the general population. The study included 3060 men ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(12):]

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Patient-Perceived Outcomes After Nonoperative Treatment of Distal Radius Fracture in Older Adults.

Min Jong Park, Kyoung Hwan Koh, Ki Won Lee, Yong Jae Lee, Hyun Il Lee,

Malunion after distal radius fracture is common in older patients; however, whether patient-perceived outcomes are influenced by radiologic outcome is controversial. This study evaluated patient-perceived outcomes according to radiologic parameters in older patients who underwent nonoperative treatment. The records of 167 patients older than 55 years who had a distal ... Read more >>

Orthopedics (Orthopedics)
[2020, :1-7]

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Leukocyte count, C-reactive protein level and incidence risk of type 2 diabetes among non-smoking adults: A longitudinal finding over 12 years from the Korean Genome and Epidemiology Study.

A-Ra Cho, Jun-Hyuk Lee, Hye Sun Lee, Yong-Jae Lee,

<h4>Aims</h4>Chronic low-grade inflammation is closely linked to the development and progression of type 2 diabetes mellitus (T2DM). Since inflammatory markers tend to be chronically elevated in current smokers, we examined the association of inflammatory markers, including leukocyte counts and C-reactive protein (CRP) levels, with incidence risk of T2DM in non-smoking ... Read more >>

Prim Care Diabetes (Primary care diabetes)
[2021, 15(2):385-390]

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Comparison of single-port laparoscopy and laparotomy in early ovarian cancer surgical staging.

Kyu Hee Cho, Yeon Ju Lee, Kyung Jin Eoh, Yong Jae Lee, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Young Tae Kim, Sang Wun Kim,

<h4>Objective</h4>s The aims of this study were to assess the feasibility of single-port laparoscopic surgical staging (SPLS) in early ovarian cancer and to compare the surgical outcomes of SPLS with those of staging laparotomy.<h4>Methods</h4>Between January 2014 and December 2018, 40 patients underwent SPLS and 41 patients underwent staging laparotomy at ... Read more >>

Obstet Gynecol Sci (Obstetrics & gynecology science)
[2021, 64(1):90-98]

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4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39+ CD8 T cells from primary and metastatic sites of epithelial ovarian cancers.

Galam Leem, Junsik Park, Minwoo Jeon, Eui-Soon Kim, Sang Wun Kim, Yong Jae Lee, Seong Jin Choi, Baekgyu Choi, Seongyeol Park, Young Seok Ju, Inkyung Jung, Sunghoon Kim, Eui-Cheol Shin, Jung Yun Lee, Su-Hyung Park,

<h4>Background</h4>Responses to immunotherapy vary between different cancer types and sites. Here, we aimed to investigate features of exhaustion and activation in tumor-infiltrating CD8 T cells at both the primary and metastatic sites in epithelial ovarian cancer.<h4>Methods</h4>Tumor tissues and peripheral blood were obtained from 65 patients with ovarian cancer. From these ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(2):]

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Real-World Experience of Pembrolizumab Monotherapy in Patients with Recurrent or Persistent Cervical Cancer: A Korean Multi-Center Retrospective Study (KGOG1041).

Min Chul Choi, Yong-Man Kim, Jeong-Won Lee, Yong Jae Lee, Dong Hoon Suh, Sung Jong Lee, Taek Sang Lee, Maria Lee, Dong Choon Park, Min Kyu Kim, Jong-Min Lee, Seung-Hyuk Shim, Seob Jeon, Kyung Jin Min, Mi Kyung Kim, Bo Wook Kim, Jeong Yeol Park, Byoung-Gie Kim, Dae Yeon Kim, Moon-Hong Kim, Hyun-Soo Kim, Jung-Yun Lee,

This study investigated the antitumor activity and safety of pembrolizumab in patients with recurrent cervical cancer in real-world practice. We conducted a multi-center retrospective study of patients with recurrent or persistent cervical cancer treated with pembrolizumab at sixteen institutions in Korea between January 2016 and March 2020. The primary endpoints ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(11):]

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Tinnitus and Its Association With Mental Health and Health-Related Quality of Life in an Older Population: A Nationwide Cross-Sectional Study.

Hye-Min Park, Jinsei Jung, Jong-Koo Kim, Yong-Jae Lee,

This study investigated the relationship of tinnitus with mental health and health-related quality of life (QoL) in older people. Data source included 5,129 community-dwelling men and women ≥60 years old from the Korean National Health and Nutrition Examination Survey. Tinnitus was categorized into three groups: normal, tolerable tinnitus, and annoying ... Read more >>

J Appl Gerontol (Journal of applied gerontology : the official journal of the Southern Gerontological Society)
[2020, :733464820966512]

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The triglyceride-glucose index predicts ischemic heart disease risk in Koreans: a prospective study using National Health Insurance Service data.

Byoungjin Park, Yong-Jae Lee, Hye Sun Lee, Dong-Hyuk Jung,

<h4>Background</h4>Ischemic heart disease (IHD) without diabetes is considered an important challenge to human health and is associated with a poor prognosis, as well as a lack of health awareness. We prospectively investigated the relationship between the triglyceride-glucose (TyG) index, a surrogate marker of early insulin resistance, and incident IHD risk ... Read more >>

Cardiovasc Diabetol (Cardiovascular diabetology)
[2020, 19(1):210]

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Association between the severity of periodontitis and osteoarthritis in middle-aged and older patients with type 2 diabetes: a nationwide population-based study.

Hyoung-Sik Kim, Hye-Min Park, Haeyoung Kim, Yong-Jae Lee,

<h4>Objective</h4>Periodontitis and osteoarthritis are major public health concerns that result in decreased quality of life among middle-aged and older adults. We sought to examine whether the severity of periodontitis is related to osteoarthritis according to the presence of type 2 diabetes.<h4>Methods</h4>This study included 3,527 participants aged ≥50 years from the ... Read more >>

Arthritis Care Res (Hoboken) (Arthritis care & research)
[2020, :]

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A novel histone deacetylase 6 inhibitor improves myelination of Schwann cells in a model of Charcot-Marie-Tooth disease type 1A.

Nina Ha, Young Il Choi, Namhee Jung, Ju Young Song, Dae Kwon Bae, Min Cheol Kim, Yong Jae Lee, Hyeseung Song, Geon Kwak, Soyeon Jeong, Saeyoung Park, Soo Hyun Nam, Sung-Chul Jung, Byung-Ok Choi,

<h4>Background and purpose</h4>Charcot-Marie-Tooth (CMT) disease is the most common hereditary peripheral neuropathy. CMT type 1A (CMT1A) accounts for approximately 50% of CMT patients and is linked to PMP22 gene duplication. Histone deacetylase-6 (HDAC6) has pleiotropic effects, such as regulating lipid homeostasis and cellular stress. Although HDAC6 has been regarded as ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2020, 177(22):5096-5113]

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High-Throughput In Vitro Screening of Changed Algal Community Structure Using the PhotoBiobox.

Dae-Hyun Cho, Kichul Cho, Jina Heo, Urim Kim, Yong Jae Lee, Dong-Yun Choi, Chan Yoo, Hee-Sik Kim, Seunghee Bae,

In a previous study, the sequential optimization and regulation of environmental parameters using the PhotoBiobox were demonstrated with high-throughput screening tests. In this study, we estimated changes in the biovolume-based composition of a polyculture built in vitro and composed of three algal strains: <i>Chlorella</i> sp., <i>Scenedesmus</i> sp., and <i>Parachlorella</i> sp. ... Read more >>

J Microbiol Biotechnol (Journal of microbiology and biotechnology)
[2020, 30(11):1785-1791]

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Relationship Between the Triglyceride-glucose Index and Incident Ischemic Heart Disease Risk: A Prospective Study Using National Health Insurance Data

Byoungjin Park, Yong-Jae Lee, Hye Sun Lee, Dong-Hyuk Jung,

<h4>Background: </h4> Ischemic heart disease (IHD) without diabetes is considered an important challenge to human health and is associated with a poor prognosis as well as a lack of health awareness. Until now, the association between early insulin resistance and IHD among nondiabetic adults has been poorly understood. We prospectively ... Read more >>

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Serum oestradiol levels are inversely associated with C-reactive protein levels in premenopausal women, but not postmenopausal women.

Jae-Min Park, Yong-Jae Lee,

<h4>Objective</h4>Epidemiological studies on the association of serum oestradiol levels and inflammatory markers have reported inconsistent and conflicting results. Therefore, we investigated the association between serum oestradiol and high-sensitivity C-reactive protein (CRP) levels in women on the basis of their menopausal status.<h4>Methods</h4>This cross-sectional study examined the association between serum oestradiol and ... Read more >>

J Int Med Res (The Journal of international medical research)
[2020, 48(10):300060520961228]

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YOLACT++: Better Real-time Instance Segmentation.

Daniel Bolya, Chong Zhou, Fanyi Xiao, Yong Jae Lee,

We present a simple, fully-convolutional model for real-time (> 30 fps) instance segmentation that achieves competitive results on MS COCO evaluated on a single Titan Xp, which is significantly faster than any previous state-of-the-art approach. We accomplish this by breaking instance segmentation into two parallel subtasks: (1) generating a set ... Read more >>

IEEE Trans Pattern Anal Mach Intell (IEEE transactions on pattern analysis and machine intelligence)
[2020, PP:]

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Outcomes Assessment of Sustainable and Innovatively Simple Lifestyle Modification at the Workplace - Drinking Electrolyzed-Reduced Water (OASIS-ERW): A Randomized, Double-Blind, Placebo-Controlled Trial.

Young Ah Choi, Dong Hyeon Lee, Doo-Yeoun Cho, Yong-Jae Lee,

Oxidative stress has been associated with many diseases as well as aging. Electrolyzed-reduced water (ERW) has been suggested to reduce oxidative stress and improve antioxidant potential. This study investigated the effects of drinking ERW on biomarkers of oxidative stress and health-related indices in healthy adults. We conducted a randomized, double-blind, ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2020, 9(7):]

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Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort.

Byoungjin Park, Hye Sun Lee, Yong-Jae Lee,

The rate of undiagnosed type 2 diabetes tends to increase in lean Koreans, while the triglyceride glucose (TyG) index has been proposed as a surrogate marker of peripheral insulin resistance. We investigated the longitudinal relationship between TyG and incident type 2 diabetes among apparently healthy Korean adults. We assessed 4285 ... Read more >>

Transl Res (Translational research : the journal of laboratory and clinical medicine)
[2021, 228:42-51]

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