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Author Yong Huang

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Chemical profiling and quantification of multiple components in Jin-Gu-Lian Capsule using a multivariate data processing approach based on UHPLC-Orbitrap Exploris 240 MS and UPLC-MS/MS.

Zu-Ying Zhou, Yong Huang, Jin-Chao Xiao, Hui Liu, Yong-Lin Wang, Zi-Peng Gong, Yue-Ting Li, Ai-Min Wang, Yong-Jun Li, Lin Zheng,

The Jin-Gu-Lian capsule, a Chinese Miao herbal compound, is widely used to treat rheumatoid arthritis. In this study, a rapid, selective and sensitive UHPLC-Orbitrap Exploris 240 MS method was developed to analyze the chemical composition of Jin-Gu-Lian Capsules. A total of 88 compounds were identified, including 23 flavonoids, 23 organic ... Read more >>

J Sep Sci (Journal of separation science)
[2022, :]

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Proteomic biomarkers of progressive fibrosing interstitial lung disease: a multicentre cohort analysis.

Willis S Bowman, Chad A Newton, Angela L Linderholm, Megan L Neely, Janelle Vu Pugashetti, Bhavika Kaul, Vivian Vo, Gabrielle A Echt, William Leon, Rupal J Shah, Yong Huang, Christine Kim Garcia, Paul J Wolters, Justin M Oldham,

Progressive fibrosing interstitial lung disease (ILD) is characterised by parenchymal scar formation, leading to high morbidity and mortality. The ability to predict this phenotype remains elusive. We conducted a proteomic analysis to identify novel plasma biomarkers of progressive fibrosing ILD and developed a proteomic signature to predict this phenotype. Relative ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2022, :]

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"Dual-functional" strontium titanate nanotubes designed based on fusion peptides simultaneously enhancing anti-infection and osseointegration.

Bingbing Wang, Anqi Bian, Fenghuan Jia, Jingpin Lan, Hao Yang, Ke Yan, Lei Xie, Haixia Qiao, Xiaotong Chang, He Lin, Hui Zhang, Yong Huang,

Currently, there is an increasing clinical demand for implants that effectively resist bacterial infections while promoting osseointegration. In this study, the fusion peptide technology was used to linearly fuse the antimicrobial peptide (AMP, HHC36) and the bone-promoting peptide (RGD), so that the titanium (Ti)-based implant modified by the polypeptide had ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2022, :112650]

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Ticlopidine induces cardiotoxicity in zebrafish embryos through AHR-mediated oxidative stress signaling pathway.

Rong Xu, Yong Huang, Chen Lu, Weiming Lv, Shihua Hong, Shuqin Zeng, Wenyan Xia, Li Guo, Huiqiang Lu, Yijian Chen,

Ticlopidine has inhibitory effects on platelet aggregation via ADP (adenosine diphosphate), platelet release reaction and depolymerization. In clinical practice, it is commonly used to prevent heart, cerebrovascular and other thromboembolic diseases. However, ticlopidine has also been reported to have teratogenic effects on the heart, though its specific molecular mechanism remains ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2022, 230:113138]

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A biomimetic nanodrug self-assembled from small molecules for enhanced ferroptosis therapy.

Xueming Xu, Yuan Chen, Jinyong Gui, Peilian Liu, Yong Huang, Baihao Shao, Yuan Ping, Bowen Li,

Ferroptosis drugs often induce oxidative damage or block antioxidant defense due to the key mechanism of ferroptosis involved in cancer treatment, regulating the intracellular redox balance. However, these ferroptosis drugs are unstable during systemic circulation, and they lack tumor-targeting capability. Herein, we developed a stimuli-responsive and cell membrane-coated nanodrug for ... Read more >>

Biomater Sci (Biomaterials science)
[2022, :]

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Transmission and containment of the SARS-CoV-2 Delta variant of concern in Guangzhou, China: A population-based study.

Li Li, Zhi-Gang Han, Peng-Zhe Qin, Wen-Hui Liu, Zhou Yang, Zong-Qiu Chen, Ke Li, Chao-Jun Xie, Yu Ma, Hui Wang, Yong Huang, Shu-Jun Fan, Ze-Lin Yan, Chun-Quan Ou, Lei Luo,

<h4>Background</h4>The first community transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant of concern (VOC) in Guangzhou, China occurred between May and June 2021. Herein, we describe the epidemiological characteristics of this outbreak and evaluate the implemented containment measures against this outbreak.<h4>Methodology/principal findings</h4>Guangzhou Center for Disease Control ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2022, 16(1):e0010048]

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A Circular Dichroism and Photoacoustic Dual-Mode Probe for Detection In Vitro and Imaging In Vivo of Hydroxyl Radicals.

Shulong Wang, Liangliang Zhang, Yanni Luo, Yulong Bai, Yong Huang, Shulin Zhao,

The drug toxicity is a long-term concern in contemporary medical research. Serious drug toxicity may cause acute liver failure or even patient death. Currently, the pathogenesis of drug-induced liver injury (DILI) is not entirely clear, and there is still no specific treatment for patients with DILI. Accordingly, improving the diagnosis ... Read more >>

Anal Chem (Analytical chemistry)
[2022, :]

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Flaw Detection in Highly Scattering Materials Using a Simple Ultrasonic Sensor Employing Adaptive Template Matching.

Biao Wu, Yong Huang,

Ultrasonic sensors have been extensively used in the nondestructive testing of materials for flaw detection. For polycrystalline materials, however, due to the scattering nature of the material, which results in strong grain noise and attenuation of the ultrasonic signal, accurate detection of flaws is particularly difficult. In this paper, a ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2021, 22(1):]

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Efficacy of Recombinant Human Thrombopoietin for the Treatment of Secondary Failure of Platelet Recovery After Allogeneic HSCT.

Yigeng Cao, Mingyang Wang, Biao Shen, Fei Zhao, Rongli Zhang, Xin Chen, Yi He, Weihua Zhai, Qiaoling Ma, Jialin Wei, Yong Huang, Donglin Yang, Aiming Pang, Sizhou Feng, Erlie Jiang, Mingzhe Han,

Secondary failure of platelet recovery (SFPR) is a life-threatening complication that may affect up to 20% of patients after allogeneic hematopoietic stem cell transplantation (HSCT). In this study, to evaluate the efficacy of recombinant human thrombopoietin (rhTPO), we retrospectively analyzed 29 patients who received continuous rhTPO for the treatment of ... Read more >>

Clin Appl Thromb Hemost (Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis)
[2022, 28:10760296211068037]

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A fluorescence aptasensor based on [email protected] and RGO for the detection of Glypican-3.

Huixue Wang, Jinya Liu, Wei Chen, Jintong Na, Yong Huang, Guiyin Li,

Glypican-3 (GPC3), a heparin sulfate proteoglycan, is a potential diagnostic and therapeutic target for hepatocellular carcinoma. In this paper, a novel fluorescent aptasensor for GPC3 detection is constructed via [email protected] quantum dots-labeled GPC3 aptamer ([email protected]<sub>Apt</sub>) as a fluorescence probe. First, [email protected] is screened out with higher fluorescence intensity, which emits ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2021, 270:120798]

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Fatty Acid Synthase Inhibitor Platensimycin Intervenes the Development of Nonalcoholic Fatty Liver Disease in a Mouse Model

Meng Su, Danfeng Cao, Zhe Wang, Yanwen Duan, Yong Huang,

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting about 25% of world population, while there are still no approved targeted therapies. Although platensimycin (PTM) was first discovered to be a broad-spectrum antibiotic, it was also effective against type II diabetes in animal models due to its ability ... Read more >>

Biomedicines (Biomedicines)
[2021, 10(1):]

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Fatty Acid Synthase Inhibitor Platensimycin Intervenes the Development of Nonalcoholic Fatty Liver Disease in a Mouse Model.

Meng Su, Danfeng Cao, Zhe Wang, Yanwen Duan, Yong Huang,

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting about 25% of world population, while there are still no approved targeted therapies. Although platensimycin (PTM) was first discovered to be a broad-spectrum antibiotic, it was also effective against type II diabetes in animal models due to its ability ... Read more >>

Biomedicines (Biomedicines)
[2021, 10(1):]

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Study on community structure and metabolic mechanism of dominant polyphosphate-accumulating organisms (PAOs) and glycogen-accumulating organisms (GAOs) in suspended biofilm based on phosphate recovery.

Min Ni, Yue Chen, Yang Pan, Yong Huang, Da-Peng Li, Lu Li, Bo Huang, Zuowei Song,

Biofilm sequencing batch reactor (BSBR) can achieve efficient phosphate (P) removal and enrichment, but its process performance and metabolic mechanisms for P removal and enrichment of municipal wastewater remain largely unclear. In the present study, we assessed the P removal and enrichment of municipal wastewater at influent P concentrations of ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, :152678]

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The complete mitochondrial genome of the forest crested lizard, Calotes emma (Squamata, Agamidae) in China by the next generation sequencing.

Wenfang Ma, Xiaotong Jing, Xiaomei Wei, Yong Huang,

The whole mitogenome can prove useful tools for phylogenetic reconstruction and efficiently recover with reasonable taxon sampling. <i>Calotes emma</i> is widely distributed and arboreal in habits. However, studies of <i>C. emma</i> are still very limited, including population genetics and evolutionary biology. In this study, we reported the complete mitochondrial genome ... Read more >>

Mitochondrial DNA B Resour (Mitochondrial DNA. Part B, Resources)
[2022, 7(1):141-143]

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Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats.

Yuan Lu, Yanli Wang, Yan He, Jie Pan, Yang Jin, Lin Zheng, Yong Huang, Yongjun Li, Wen Liu,

<h4>Ethnopharmacological relevance</h4>Aidi injection (ADI), a traditional chinese medicine preparation, is widely used in combination with chemotherapy for the treatment of various malignant tumors, such as hepatocellular carcinoma (HCC). Studies have shown that changes in cytochrome P450 (CYP450) activity in disease states would affect the metabolism of drugs in vivo, especially ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2022, 286:114930]

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Effects of transglutaminase cross-linking process on printability of gelatin microgel-gelatin solution composite bioink.

Kaidong Song, Bing Ren, Yingnan Zhai, Wenxuan Chai, Yong Huang,

Three-dimensional (3D) bioprinting has emerged as a powerful engineering approach for various tissue engineering applications, particularly for the development of 3D cellular structures with unique mechanical and/or biological properties. For the jammed gelatin microgel-gelatin solution composite bioink, comprising a discrete phase of microgels (enzymatically gelled gelatin microgels) and a cross-linkable ... Read more >>

Biofabrication (Biofabrication)
[2021, 14(1):]

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KLF4, negatively regulated by miR-7, suppresses osteoarthritis development via activating TGF-β1 signaling.

Jin Li, Mengqing Jiang, Chengwei Xiong, Jienen Pan, Shaohua Jia, Yi Zhang, Junjie Zhang, Nanwei Xu, Xindie Zhou, Yong Huang,

Osteoarthritis (OA) is a chronic degenerative disease which seriously affects the patients' daily activities and quality of life. In our previous findings, we demonstrated that overexpression of miR-7 was found in OA and promoted OA development. Its exact mechanism remains unclear. Herein, we confirmed that KLF4 was the target gene ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2022, 102:108416]

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Predicting the prognosis of liver cancer patients based on cell differentiation trajectory and application of nanomaterials in treatment.

Ximei Xu, Zhikun Zhang, Qiaoying Chen, Tao Wu, Wei Shi, Lu Gan, Xiuli Liu, Runzhe Liu, Yong Huang, Ruirui Zhang, Yongxiang Zhao, Pan Wu, Liping Zhong, Jian He,

Minerva Surg (Minerva surgery)
[2021, :]

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T598 and T601 phosphorylation sites of canine parvovirus NS1 are crucial for viral replication and pathogenicity.

Bichen Miao, Songbiao Chen, Xuezhi Zhang, Peipei Ma, Mengyu Ma, Caiyi Chen, Xiujuan Zhang, Lingling Chang, Qian Du, Yong Huang, Dewen Tong,

Canine parvovirus-2 (CPV-2) is an important pathogen causing severe diseases in dogs and other wild carnivores. Phosphorylation of NS1 may be related to CPV-2 pathogenicity, but the exact mechanism is unclear. Here, we conducted parvovirus disease surveillance in Shaanxi Province of China and 51 fecal swabs were detected to be ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2022, 264:109301]

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Effect of Denonvilliers' Fascia Preservation Versus Resection During Laparoscopic Total Mesorectal Excision on Postoperative Urogenital Function of Male Rectal Cancer Patients: Initial Results of Chinese PUF-01 Randomized Clinical Trial.

Bo Wei, Zongheng Zheng, Jiafeng Fang, Jian'an Xiao, Fanghai Han, Meijin Huang, Qingwen Xu, Xiaozhong Wang, Chuyuan Hong, Gongping Wang, Yongle Ju, Guoqiang Su, Haijun Deng, Jinxin Zhang, Jun Li, Tufeng Chen, Yong Huang, Jianglong Huang, Jianpei Liu, Xiaofeng Yang, Hongbo Wei, ,

<h4>Objective</h4>To compare the outcomes of laparoscopic total mesorectal excision (L-TME) with Denonvilliers' fascia (DVF) preservation versus resection on urogenital function of male patients with rectal cancer.<h4>Background</h4>The protective effect of DVF during L-TME on pelvic autonomic nerves and postoperative urogenital function remains controversial.<h4>Methods</h4>Between August 26, 2015 and July 18, 2019, 253 ... Read more >>

Ann Surg (Annals of surgery)
[2021, 274(6):e473-e480]

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Effectiveness of inactivated SARS-CoV-2 vaccines against the Delta variant infection in Guangzhou: a test-negative case-control real-world study.

Xiao-Ning Li, Yong Huang, Wen Wang, Qin-Long Jing, Chun-Huan Zhang, Peng-Zhe Qin, Wei-Jie Guan, Lin Gan, Yi-Lan Li, Wen-Hui Liu, Hang Dong, Yu-Tian Miao, Shu-Jun Fan, Zhou-Bin Zhang, Ding-Mei Zhang, Nan-Shan Zhong,

The effectiveness of inactivated SARS-CoV-2 vaccines against the Delta variant, which has been associated with greater transmissibility and virulence, remains unclear. We conducted a test-negative case-control study to explore the vaccine effectiveness (VE) in real-world settings. We recruited participants aged 18-59 years who consisted of SARS-CoV-2 test-positive cases (<i>n</i> = 74) and ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1751-1759]

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Molecular characterization of infectious bronchitis virus in Southwestern China for the protective efficacy evaluation of four live vaccine strains.

Shuyun Li, Wen Chen, Yuxi Shen, Jing Xia, Shunyi Fan, Nianning Li, Yuwen Luo, Xinfeng Han, Min Cui, Yang Zhao, Yong Huang,

The high mutation rate of infectious bronchitis virus (IBV) poses a significant threat to the protective efficacy of vaccines. This study aimed at analyzing the S1 genes of IBV field strains isolated in Southwestern China from 2018 to 2020, assessing the pathogenicity of four dominating strains, and evaluating the protective ... Read more >>

Vaccine (Vaccine)
[2022, 40(2):255-265]

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Hematopoietic stem cell and immunotoxicity in zebrafish embryos induced by exposure to Metalaxyl-M.

Suwen Zeng, Yuyang Peng, Jinze Ma, Yurui Ge, Yong Huang, Shuling Xie, Wei Yuan, Chen Lu, Hua Zhang, Qiang Luo, Xinjun Liao, Huiqiang Lu,

Metalaxyl-M (MM), a protective and therapeutic fungicide, has been shown to be a promising candidate, but its toxicity toward aquatic organisms is unknown. In this study, we evaluated for the first time the immunotoxicity of MM in zebrafish embryos. Phenotypes (heart rate, body length, and yolk area) and the number ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 809:152102]

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Protein disulfide isomerase family 6 promotes the imatinib-resistance of renal cell carcinoma by regulation of Wnt3a-Frizzled1 axis.

Yong Huang, Ping He, Juan Ding,

Imatinib is a nontoxic tyrosine kinase inhibitor, used in the treatment of advanced renal cell carcinoma. However, some patients with renal cell carcinoma develop resistance to imatinib. Protein disulfide isomerase family 6 (PDIA6) was involved in the chemo-resistance of lung adenocarcinoma. In this study, the effect of PDIA6 on imatinib-resistance ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):12157-12166]

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A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication.

Yue Sheng, Jiangbo Wei, Fang Yu, Huanzhou Xu, Chunjie Yu, Qiong Wu, Yin Liu, Lei Li, Xiao-Long Cui, Xueying Gu, Bin Shen, Wei Li, Yong Huang, Sumita Bhaduri-McIntosh, Chuan He, Zhijian Qian,

YTHDC1 has distinct functions as a nuclear N6-methyladenosine (m6A) reader in regulating RNA metabolism. Here we show that YTHDC1 is overexpressed in acute myeloid leukemia (AML) and that it is required for the proliferation and survival of human AML cells. Genetic deletion of Ythdc1 markedly blocks AML development and maintenance ... Read more >>

Blood (Blood)
[2021, 138(26):2838-2852]

Cited: 1 time

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