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The issue of recurrently positive patients who recovered from COVID-19 according to the current discharge criteria: investigation of patients from multiple medical institutions in Wuhan, China.

You Zou, Bin-Ru Wang, Liu Sun, Shan Xu, Yong-Gang Kong, Li-Jun Shen, Geng-Tian Liang, Shi-Ming Chen,

The current discharge criteria for COVID-19 require that patients have two consecutive negative results for RT-PCR detection. Here, we observed that recurrently positive RT-PCR test results in patients with three consecutive negative results (3xNegRPos, 5.4%) were significantly decreased compared with those in patients with two consecutive negative results (2xNegRPos, 20.6%); such patients reported positive RT-PCR ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, :]

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Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.

Mao-Ling Huang, Cheng-Lin Qi, You Zou, Rui Yang, Yang Jiang, Jian-Fei Sheng, Yong-Gang Kong, Ze-Zhang Tao, Shi-Ming Chen,

To explore the relationship between autophagy and cell function, we investigated how PLAC8-mediated autophagy influences proliferation, apoptosis and epithelial-mesenchymal transition (EMT) in NPC. Colony formation analyses and CCK8 assays were used to assess the proliferative capacity of NPC cells. Transmission electron microscopy (TEM) was used to identify autophagosomes. Autophagic flux ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, :]

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Increased Expressions and Roles of CC Chemokine Ligand 21 and CC Chemokine Ligand 25 in Chronic Rhinosinusitis with Nasal Polyps.

Meng-Zhi Liu, Shi-Ming Chen, Yu Xu, Yong-Gang Kong, Yu-Qin Deng, Fen Li, Ze-Zhang Tao,

INTRODUCTION:Chronic rhinosinusitis (CRS) is a local inflammation of the nasal mucosa and sinus that persists for >12 weeks. As CC chemokine ligand (CCL) 19 expression is known to be elevated in CRS, and CCL 19, CCL21, and CCL25 share the same atypical chemokine receptor 4, so we focused on CCL21 ... Read more >>

Int. Arch. Allergy Immunol. (International archives of allergy and immunology)
[2020, 181(3):159-169]

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Different effects of allergic rhinitis on nasal mucosa remodeling in chronic rhinosinusitis with and without nasal polyps.

Rong Xiang, Qing-Ping Zhang, Wei Zhang, Yong-Gang Kong, Lu Tan, Shi-Ming Chen, Yu-Qin Deng, Ze-Zhang Tao, Yu Xu,

BACKGROUND:Allergic rhinitis (AR) has been reported to be associated with chronic rhinosinusitis (CRS). The objective of this study was to investigate the effect of AR on nasal mucosa remodeling in CRS. METHODS:Patients were enrolled and divided into the following groups: CRS with nasal polyps (NP) with allergic rhinitis (AR)(CRSwNPwAR; n = 20), ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2019, 276(1):115-130]

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Effect of transformer noise on the neurophysiology of SD rats.

You Zou, Xing Yi, Jian-Gong Zhang, Xing-Fa Liu, Kun Yang, Yong-Gang Kong, Bo-Kui Xiao, Ze-Zhang Tao, Shi-Ming Chen,

Transformer noise is a type of environmental sound that causes discomfort to individuals. The aim of the present study was to determine the effect of relatively long-term periods of transformer noise on the behavior and neurophysiology of SD rats. A total of 90 healthy SD rats with normal hearing were ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2019, 17(5):3383-3390]

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Tangeretin promotes regulatory T cell differentiation by inhibiting Notch1/Jagged1 signaling in allergic rhinitis.

Shan Xu, Yong-Gang Kong, Wo-Er Jiao, Rui Yang, Yue-Long Qiao, Yu Xu, Ze-Zhang Tao, Shi-Ming Chen,

BACKGROUND AND OBJECTIVE:Tangeretin demonstrates broad anti-inflammatory effects. The present study aimed to assess whether tangeretin functions in regulating T-regulatory cells (Tregs) and alleviating allergic rhinitis (AR). METHODS:An ovalbumin (OVA)-induced AR animal model was constructed to monitor the changes in the allergic symptom score, OVA-specific IgE titers, histopathological characteristics and T-helper ... Read more >>

Int. Immunopharmacol. (International Immunopharmacology)
[2019, 72:402-412]

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Placenta specific 8 gene induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via the TGF-β/Smad pathway.

Mao-Ling Huang, You Zou, Rui Yang, Yang Jiang, Jian-Fei Sheng, Ji-Bo Han, Yong-Gang Kong, Ze-Zhang Tao, Shi-Ming Chen,

The present study aimed to investigate the effects and mechanisms of PLAC8 on the epithelial-mesenchymal transition (EMT) of Nasopharyngeal carcinoma (NPC). The expression of PLAC8 in NPC and nasopharyngitis (NPG) tissues from 150 patients was determined using immunohistochemistry. The levels of PLAC8 in five NPC cell lines and nasopharyngeal permanent ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2019, 374(1):172-180]

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Semaphorin 3A inhibits allergic inflammation by regulating immune responses in a mouse model of allergic rhinitis.

Rong Xiang, Yu Xu, Wei Zhang, Yong-Gang Kong, Lu Tan, Shi-Ming Chen, Yu-Qin Deng, Ze-Zhang Tao,

BACKGROUND:It has been reported that semaphorin 3A (sema3A) could improve allergic symptoms in allergic rhinitis (AR) mice. However, the immunomodulatory roles of sema3A in AR remain unclear. This study was performed to determine the immunoregulatory effects of sema3A on airway inflammation in an AR mice model. METHODS:First, sema3A expression was ... Read more >>

Int Forum Allergy Rhinol (International forum of allergy & rhinology)
[2019, 9(5):528-537]

Cited: 1 time

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Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation.

Wo-Er Jiao, Jin-Feng Wei, Yong-Gang Kong, Yu Xu, Ze-Zhang Tao, Shi-Ming Chen,

BACKGROUND:The Notch signaling pathway plays an important role in regulating human immune function, but the relationship between allergic rhinitis (AR) and Notch signaling remains unclear. OBJECTIVE:To investigate the role of Notch signaling in the pathogenesis of AR and its regulation on Foxp3-Treg cells. METHOD:The sera of 100 patients with AR ... Read more >>

Int. Arch. Allergy Immunol. (International archives of allergy and immunology)
[2019, 178(1):33-44]

Cited: 1 time

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Characteristic expression and significance of CCL19 in different tissue types in chronic rhinosinusitis.

You Zou, Yan Wang, Shui-Bin Wang, Yong-Gang Kong, Y U Xu, Ze-Zhang Tao, Shi-Ming Chen,

Chronic rhinosinusitis (CRS) is a heterogeneous disease, with varying immunological and histopathological features. The CC chemokine ligand 19 (CCL19) can stimulate T cells and antigen-presenting cells into secondary lymphoid node formation, as observed in allergic rhinitis, inflammatory bowel disease and other inflammatory disorders. The purpose of this study was to ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2016, 11(1):140-146]

Cited: 2 times

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LncRNA-LINC00460 facilitates nasopharyngeal carcinoma tumorigenesis through sponging miR-149-5p to up-regulate IL6.

Yong-Gang Kong, Min Cui, Shi-Ming Chen, Yu Xu, Yong Xu, Ze-Zhang Tao,

Long non-coding RNAs (lncRNAs) have played crucial roles in various cancers, including nasopharyngeal carcinoma (NPC). In our study, we focused on the biological function and clinical significance of lncRNA LINC00460 in NPC. It was indicated that LINC00460 was markedly increased in NPC tissues and cells compared to their corresponding controls. ... Read more >>

Gene (Gene)
[2018, 639:77-84]

Cited: 18 times

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Comparison of outcomes between endoscopic surgery and conventional nasal packing for epistaxis in the posterior fornix of the inferior nasal meatus.

You Zou, Yu-Qin Deng, Chang-Wu Xiao, Yong-Gang Kong, Yu Xu, Ze-Zhang Tao, Shi-Ming Chen,

To investigate the clinical features of epistaxis in the posterior fornix of the inferior nasal meatus and compare the treatment outcomes of endoscopic surgery and conventional nasal packing for this intractable form of epistaxis.Between August 2011 and August 2014, the medical records of 53 adult patients with idiopathic epistaxis in ... Read more >>

Pak J Med Sci (Pakistan journal of medical sciences)
[2015, 31(6):1361-1365]

Cited: 1 time

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γ-secretase inhibition combined with cisplatin enhances apoptosis of nasopharyngeal carcinoma cells.

Jun-Xu Zhou, Ji-Bo Han, Shi-Ming Chen, Yu Xu, Yong-Gang Kong, Bo-Kui Xiao, Ze-Zhang Tao,

The Notch signaling pathway plays an important role in the proliferation and differentiation of cells. Although recent studies have shown that Notch plays a role in the mechanisms of cisplatin resistance, the mechanism by which Notch plays roles in intrinsic or acquired cisplatin resistance remains unclear. In the present study, ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2012, 3(2):357-361]

Cited: 11 times

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Staphylococcus aureus superantigens are associated with chronic rhinosinusitis with nasal polyps: a meta-analysis.

Jing Ou, Jun Wang, Yu Xu, Ze-zhang Tao, Yong-gang Kong, Shi-ming Chen, Wen-dan Shi,

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common health problem in the world. However, its etiology remains unclear. Recent researches have hypothesized that Staphylococcus aureus (SA) exotoxins which act as superantigens might be associated with inflammatory mucosal changes seen in CRSwNP. The objective of this study is to evaluate ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2014, 271(10):2729-2736]

Cited: 14 times

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[Relationship between bacterial biofilm and chronic rhinosinusitis: a systematic review].

Sheng-lan Li, Shi-ming Chen, Yu Xu, Yong-gang Kong, Ren-yue Deng, Ze-zhang Tao,

OBJECTIVE: To evaluate the relationship between bacterial biofilm (BBF) and chronic rhinosinusitis (CRS). METHODS: The database on line was searched to collect the studies on BBF and CRS. The method of meta analysis was used to analyze the data of suitable studies. RESULTS: Fourteen studies were included. System evaluation indicated ... Read more >>

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery)
[2012, 47(12):1021-1026]

Cited: 0 times

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Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea: an analysis of 22 cases.

Yong-Gang Kong, Yu-Qin Deng, Yan Wang,

The purpose of this study was to investigate and summarize the surgical procedure and efficacy of transnasal endoscopic repair of cerebrospinal fluid (CSF) rhinorrhea. This is a retrospective study including 22 patients with CSF rhinorrhea who underwent transnasal endoscopic repair between January 2003 and August 2010. The location of the ... Read more >>

Indian J Otolaryngol Head Neck Surg (Indian Journal of Otolaryngology and Head & Neck Surgery)
[2013, 65(Suppl 2):409-414]

Cited: 1 time

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Adenovirus-mediated transfer of tris-shRNAs induced apoptosis of nasopharyngeal carcinoma cell in vitro and in vivo.

Ji-Bo Han, Ze-Zhang Tao, Shi-Ming Chen, Yong-Gang Kong, Bo-Kui Xiao,

RNA interference (RNAi) is an evolutionary conserved mechanism for specific gene silencing. There are currently numerous cancer therapy clinical trials based on RNAi technology. Using an adenoviral system as a delivery mediator of RNAi, we investigated the therapeutic effects of targeting three genes simultaneously in vitro and in vivo. In ... Read more >>

Cancer Lett. (Cancer letters)
[2011, 309(2):162-169]

Cited: 7 times

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