Full Text Journal Articles by
Author Yiying Wang

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Release and metabolism of bound polyphenols from carrot dietary fiber and their potential activity in in vitro digestion and colonic fermentation.

Ruihong Dong, Shuai Liu, Yuting Zheng, Xingjie Zhang, Zhicheng He, Zipei Wang, Yiying Wang, Jianhua Xie, Yi Chen, Qiang Yu,

Dietary fiber is a carrier of abundant polyphenols and the potential benefits have attracted increasing attention. In this study, we performed in vitro simulated digestion in the oral, gastric and intestinal phases, and colonic fermentation with human fecal microbes, to explore the release and metabolism of bound polyphenols from carrot ... Read more >>

Food Funct (Food & function)
[2020, 11(7):6652-6665]

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The prognostic significance of tumor-infiltrating lymphocytes in cervical cancer.

Mengdi He, Yiying Wang, Guodong Zhang, Kankan Cao, Moran Yang, Haiou Liu,

<h4>Objective</h4>To predict the prognosis of cervical cancer, we constructed a novel model with 5 specific cell types and identified a potential biomarker.<h4>Methods</h4>We employed CIBERSORT and xCell method to evaluate the abundances of 23 cells types in tumor microenvironment. Five specific cell types were filtrated to determine different immunotypes by applying ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e32]

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HDAC1 and 2 regulate endothelial VCAM-1 expression and atherogenesis by suppressing methylation of the GATA6 promoter.

Chengxiu Hu, Kai Peng, Qianqian Wu, Yiying Wang, Xing Fan, Dai-Min Zhang, Anthony G Passerini, ChongXiu Sun,

Increased expression of vascular cell adhesion molecule (VCAM)-1 on the activated arterial endothelial cell (EC) surface critically contributes to atherosclerosis which may in part be regulated by epigenetic mechanisms. This study investigated whether and how the clinically available histone deacetylases 1 and 2 (HDAC1/2) inhibitor drug Romidepsin epigenetically modulates VCAM-1 ... Read more >>

Theranostics (Theranostics)
[2021, 11(11):5605-5619]

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The immune landscape during the tumorigenesis of cervical cancer.

Yiying Wang, Mengdi He, Guodong Zhang, Kankan Cao, Moran Yang, Hongwei Zhang, Haiou Liu,

<h4>Objective</h4>Deciphering the determinants of the intralesional immune reaction in cervical carcinogenesis may be conducive to improving the understanding of the disease and then improve outcomes.<h4>Methods</h4>Public gene-expression data and full clinical annotation were searched in Gene Expression Omnibus in the joint analysis of the array-based four eligible cohorts. The infiltrating estimation ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(7):2380-2395]

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Toxicity of Ortho-phthalaldehyde Aerosols in a Human In Vitro Airway Tissue Model.

Yiying Wang, Qiangen Wu, Levan Muskhelishvili, Kelly Davis, Rebecca Wynne, Priya Tripathi, Matthew S Bryant, Diego Rua, Xuefei Cao,

Ortho-phthalaldehyde (OPA) is a chemical disinfectant used for the high-level sterilization of heat-sensitive medical instruments. Although OPA is considered a safer alternative to glutaraldehyde, no exposure limits have been established for respiratory exposures to ensure the safety of OPA sterilization and the safe use of OPA-treated medical instruments. In order ... Read more >>

Chem Res Toxicol (Chemical research in toxicology)
[2021, 34(3):754-766]

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Privacy Policy Compliance of Chronic Disease Management Apps in China: Scale Development and Content Evaluation.

Zhenni Ni, Yiying Wang, Yuxing Qian,

<h4>Background</h4>With the development of mobile health (mHealth), chronic disease management apps have brought not only the possibility of reducing the burden of chronic diseases but also huge privacy risks to patients' health data.<h4>Objective</h4>The purpose of the study was to analyze the extent to which chronic disease management apps in China ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2021, 9(1):e23409]

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Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice.

Siming Fu, Xu Luo, Xuan Wu, Tongyu Zhang, Linggui Gu, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie,

Oxidative stress and neuronal apoptosis play crucial roles in secondary brain injury (SBI) after intracerebral hemorrhage (ICH). Recently, Nle4-D-Phe7-<i>α</i>-melanocyte-stimulating hormone (NDP-MSH), a synthetic agonist of the melanocortin-1 receptor (Mc1r), has been proved to inhibit neuroinflammatory in several diseases. This study is aimed at exploring if NDP-MSH could reduce oxidative stress ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2020, 2020:8864100]

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Changes in the prefrontal cortex after the hippocampus was injected with Aβ25-35 via the P35/P25-CDK5-Tau hyperphosphorylation signaling pathway.

Yiying Wang, Huajun Sheng, Jing Zhao, Ling Guo, Jianing Liu, Jin Xu, Qian Liu, Juan Huang, Rong Jiang, Shengwei Gan, Guoping Qiu, Weitian Lu, Shiye Xu, Shujuan Zhu,

Alzheimer's disease (AD) is one of the common neurodegenerative illnesses in aging populations around the world. Recently, psychiatric symptoms are becoming increasingly important in recognizing the manifestations of AD in addition to cognitive impairment. Some studies suggest that the prefrontal cortex (PFC) is closely related to apathy/depression, and a network ... Read more >>

Neurosci Lett (Neuroscience letters)
[2021, 741:135453]

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Loss of tubal ciliated cells as a risk for "ovarian" or pelvic serous carcinoma.

Tao Tao, Wanrun Lin, Yan Wang, Jing Zhang, Setsuko K Chambers, Bo Li, Jayanthi Lea, Yiying Wang, Yue Wang, Wenxin Zheng,

Recent advances suggest the fallopian tube as the main anatomic site for high-grade ovarian or pelvic serous carcinoma (O/PSC). Many studies on the biologic role of tubal secretory cells in O/PSC development has been performed in the last decade. However, the role of tubal ciliated cells in this regard has ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2020, 10(11):3815-3827]

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NanoReviser: An Error-correction Tool for Nanopore Sequencing Based on a Deep Learning Algorithm

Luotong Wang, Li Qu, Longshu Yang, Yiying Wang, Huaiqiu Zhu,

Nanopore sequencing is regarded as one of the most promising third-generation sequencing (TGS) technologies. Since 2014, Oxford Nanopore Technologies (ONT) has developed a series of devices based on nanopore sequencing to produce very long reads, with an expected impact on genomics. However, the nanopore sequencing reads are susceptible to a ... Read more >>

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Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer.

Moran Yang, Guodong Zhang, Yiying Wang, Mengdi He, Qing Xu, Jiaqi Lu, Haiou Liu, Congjian Xu,

<h4>Background</h4>Tumour associated neutrophils (TANs) play a controversial role in regulating immune surveillance and immune evasion in various malignancies. Here, we investigated the relevance of TANs with the prognosis and immune microenvironment of epithelial ovarian cancer (EOC).<h4>Methods</h4>We characterised TANs using flow cytometric analysis and immunofluorescence analysis. The prognostic merit of TANs ... Read more >>

Br J Cancer (British journal of cancer)
[2020, 123(9):1404-1416]

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NanoReviser: An Error-Correction Tool for Nanopore Sequencing Based on a Deep Learning Algorithm.

Luotong Wang, Li Qu, Longshu Yang, Yiying Wang, Huaiqiu Zhu,

Nanopore sequencing is regarded as one of the most promising third-generation sequencing (TGS) technologies. Since 2014, Oxford Nanopore Technologies (ONT) has developed a series of devices based on nanopore sequencing to produce very long reads, with an expected impact on genomics. However, the nanopore sequencing reads are susceptible to a ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:900]

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Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.

Meng Gao, Weitian Lu, Yue Shu, Zhengyu Yang, Shanquan Sun, Jin Xu, Shengwei Gan, Shujuan Zhu, Guoping Qiu, Fei Zhuo, Shiye Xu, Yiying Wang, Junhong Chen, Xuan Wu, Juan Huang,

<h4>Background</h4>Specific highly polarized aquaporin-4 (AQP4) expression is reported to play a crucial role in blood-brain barrier (BBB) integrity and brain water transport balance. The upregulation of polymerase δ-interacting protein 2 (Poldip2) was involved in aggravating BBB disruption following ischemic stroke. This study aimed to investigate whether Poldip2-mediated BBB disruption and ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2020, 26(12):1288-1302]

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Loss of tubal ciliated cells as a risk for “ovarian” or pelvic serous carcinoma

Yue Wang, Wanrun Lin, Yiying Wang, Yan Wang, Setsuko Chambers, Bo Li, Jayanthi Lea, Wenxin Zheng,

<h4>Background: </h4> Recent advances suggest the fallopian tube as the main anatomic site for high-grade ovarian or pelvic serous carcinoma (O/PSC). Human fallopian tube is mainly lined by two cell types, secretory and ciliated cells. Large number of studies on the biologic role of tubal secretory cells in O/PSC have ... Read more >>

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Limited-Angle Computed Tomography Reconstruction using Combined FDK-Based Neural Network and U-Net.

Yiying Wang, Tao Yang, Weimin Huang,

The limited-angle cone-beam Computed Tomography (CT) is often used in C-arm for clinical diagnosis with the advantages of cheap cost and radiation dose reduction. However, due to incomplete projection data, the 3-dimensional CT images reconstructed by conventional methods, such as the Feldkamp, Davis and Kres (FDK) algorithm [1], suffer from ... Read more >>

Annu Int Conf IEEE Eng Med Biol Soc (Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference)
[2020, 2020:1572-1575]

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IRF-1 mediates the suppressive effects of mTOR inhibition on arterial endothelium.

Kai Peng, Xing Fan, Qiannan Li, Yiying Wang, Xiaolin Chen, Pingxi Xiao, Anthony G Passerini, Scott I Simon, ChongXiu Sun,

<h4>Aims</h4>Mammalian target of rapamycin (mTOR) inhibitors used in drug-eluting stents (DES) to control restenosis have been found to delay endothelialization and increase incidence of late-stent thrombosis through mechanisms not completely understood. We revealed that mTOR inhibition (mTORi) upregulated the expression of cell growth suppressor IRF-1 in primary human arterial endothelial ... Read more >>

J Mol Cell Cardiol (Journal of molecular and cellular cardiology)
[2020, 140:30-41]

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Negative Predictive Value of Human Papillomavirus Testing: Implications for Anal Cancer Screening in People Living with HIV/AIDS.

Yiying Wang, Yan Wang, Michael M Gaisa, Keith Sigel, Wenxin Zheng, Yuxin Liu, Yue Wang,

Objectives:People living with HIV/AIDS (PLWHA) have an increased incidence of anal squamous cell carcinoma. Since high-risk human papillomavirus (hrHPV) is the primary cause, hrHPV DNA testing may play an important role in anal cancer screening. This study aims to determine the negative predictive value (NPV) of hrHPV testing in PLWHA ... Read more >>

J Oncol (Journal of oncology)
[2020, 2020:6352315]

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ACB-PCR Quantification of Low-Frequency Hotspot Cancer-Driver Mutations.

Meagan B Myers, Karen L McKim, Yiying Wang, Malathi Banda, Barbara L Parsons,

Allele-specific competitive blocker PCR (ACB-PCR) is a sensitive and quantitative approach for the selective amplification of a specific base substitution. Using the ACB-PCR technique, hotspot cancer-driver mutations (tumor-relevant mutations in oncogenes and tumor suppressor genes, which confer a selective growth advantage) are being developed as quantitative biomarkers of cancer risk. ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2020, 2102:395-417]

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Hydrolytic Degradation of Comb-Like Graft Poly (Lactide-co-Trimethylene Carbonate): The Role of Comonomer Compositions and Sequences.

Xuefei Leng, Wenwen Zhang, Yiying Wang, Yanshai Wang, Xiaoqing Li, Zhiyong Wei, Yang Li,

The effect of sequence on copolymer properties is rarely studied, especially the degradation behavior of the biomaterials. A series of linear-comb block, gradient, random copolymers were successfully achieved using hydroxylated polybutadiene as the macroinitiator by simple ring-opening polymerization of l-lactide (l-LA) and 1,3-trimethylene carbonate (TMC). The hydrolytic degradation behaviors of ... Read more >>

Polymers (Basel) (Polymers)
[2019, 11(12):]

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Elevated GALNT10 expression identifies immunosuppressive microenvironment and dismal prognosis of patients with high grade serous ovarian cancer.

Guodong Zhang, Jiaqi Lu, Moran Yang, Yiying Wang, Haiou Liu, Congjian Xu,

High grade ovarian serous cancer (HGSC) is a malignant disease with high mortality. Glycosylation plays important roles in tumor invasion and immune evasion, but its effect on the immune microenvironment of HGSC remains unclear. This study examined the association of glycosyltransferase expression with HGSC prognosis and explored the underlying mechanism ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2020, 69(2):175-187]

Cited: 2 times

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Computerized Tomography Radiomics Features Analysis for Evaluation of Perihematomal Edema in Basal Ganglia Hemorrhage.

Xiang Yao, Lishang Liao, Yuxiao Han, Ting Wei, Hai Wu, Yiying Wang, Yanfei Li, Xinyuan Zhang, Ke Ren,

To evaluate the edema area around basal ganglia hemorrhage by the application of computerized tomography (CT)-based radiomics as a prognostic factor and improve the diagnosis efficacy, a total of 120 patients with basal ganglia hemorrhage were analyzed retrospectively. The texture analysis software Mazda 3.3 was used to preprocess the CT ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2019, 30(8):e768-e771]

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NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice.

Xuan Wu, Siming Fu, Yun Liu, Hansheng Luo, Feng Li, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie,

<h4>Background</h4>Neuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently, melanocortin-1 receptor (Mc1r) activation by Nle4-D-Phe7-α-MSH (NDP-MSH) was shown to play a neuroprotective role in an experimental autoimmune encephalomyelitis (EAE) mouse model. This study aimed to investigate whether NDP-MSH could alleviate ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2019, 16(1):192]

Cited: 4 times

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Dr. Daniel Acosta and In Vitro toxicology at the U.S. Food and Drug Administration's National Center for Toxicological Research.

Amy Inselman, Fang Liu, Cheng Wang, Qiang Shi, Li Pang, William Mattes, Matthew White, Beverly Lyn-Cook, Hector Rosas-Hernandez, Elvis Cuevas, Susan Lantz, Syed Imam, Syed Ali, Dayton M Petibone, Jennifer M Shemansky, Rui Xiong, Yiying Wang, Priya Tripathi, Xuefei Cao, Robert H Heflich, William Slikker,

For the past five years, Dr. Daniel Acosta has served as the Deputy Director of Research at the National Center for Toxicological Research (NCTR), a principle research laboratory of the U.S. Food and Drug Administration (FDA). Over his career at NCTR, Dr. Acosta has had a major impact on developing ... Read more >>

Toxicol In Vitro (Toxicology in vitro : an international journal published in association with BIBRA)
[2020, 64:104471]

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Secreted protein acidic and rich in cysteine promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells and acquisition of cancerstem cell phenotypes.

Xin Jiang, Fengchao Liu, Yiying Wang, Jian Gao,

<h4>Background and aim</h4>Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that plays a significant role in tumor development. SPARC has been indicated that promotes tumorigenesis, metastasis, and poor prognosis in prostate cancer and lung cancer. Therefore, we sought to investigate the molecular mechanisms of SPARC in ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2019, 34(10):1860-1868]

Cited: 4 times

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Effect of Progestin Usage on the Interpretation of Cervical High-grade Squamous Intraepithelial Lesion.

Yiying Wang, Hao Chen, Qingping Jiang, Rongzhen Luo, Ping Zhou, Yan Wang, Ruijiao Zhao, Oluwole Fadare, Wenxin Zheng,

Progestin usage can alter the histologic and cytologic features of HSIL, which may potentially lead to the under-diagnosis of this precancerous lesion. The objective of the present study was to assess the relationship between the usage of progesterone-based contraceptives and the cytologic features of high-grade squamous intraepithelial lesion (HSIL) of ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(8):1066-1073]

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