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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.

Yinlong Zhao, Shukuan Ling, Jianwei Li, Guohui Zhong, Ruikai Du, Youyou Li, Yanqing Wang, Caizhi Liu, Xiaoyan Jin, Wei Liu, Tong Liu, Yuheng Li, Dingsheng Zhao, Weijia Sun, Zizhong Liu, Zifan Liu, Junjie Pan, Xinxin Yuan, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li,

<h4>Aims</h4>3' untranslated region (3' UTR) of mRNA is more conserved than other non-coding sequences in vertebrate genomes, and its sequence space has substantially expanded during the evolution of higher organisms, which substantiates their significance in biological regulation. However, the independent role of 3' UTR in cardiovascular disease was largely unknown.<h4>Methods ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(36):3786-3799]

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99mTc-MDP 3-Phase Bone Imaging in 3 Cases of Pigmented Villonodular Synovitis.

Tingting Hao, Xiaoliang Xiong, Libo Wang, Xue Shi, Yinlong Zhao,

<h4>Abstract</h4>Pigmented villonodular synovitis (PVNS) is a rare proliferative synovial benign disorder, which is characterized by villonodular hyperplasia of joints, tendon sheath, and synovium; invasion of adjacent tissue; and sometimes visible hemosiderin deposition. Studies regarding bone scan findings of PVNS were relatively limited. Here, we report our findings on 99mTc-MDP 3-phase ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(5):405-408]

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MXene (Ti3C2Tx) Functionalized Short Carbon Fibers as a Cross-Scale Mechanical Reinforcement for Epoxy Composites.

Lu Liu, Guobing Ying, Cheng Sun, Huihua Min, Jianxin Zhang, Yinlong Zhao, Dong Wen, Ziying Ji, Xing Liu, Chen Zhang, Cheng Wang,

The surface modification technology of carbon fibers (CFs) have achieved considerable development, and it has achieved great success in improving the interfacial shear strength (IFSS) of the polymer matrix. Among them, MXene (Ti<sub>3</sub>C<sub>2</sub>T<i><sub>x</sub></i>) functionalized CFs have been proven to improve the interface performance significantly. Unfortunately, the results on the microscopic ... Read more >>

Polymers (Basel) (Polymers)
[2021, 13(11):]

Cited: 1 time

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

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Casein Kinase-2 Interacting Protein-1 Regulates Physiological Cardiac Hypertrophy via Inhibition of Histone Deacetylase 4 Phosphorylation.

Yinlong Zhao, Shukuan Ling, Guohui Zhong, Yuheng Li, Jianwei Li, Ruikai Du, Xiaoyan Jin, Dingsheng Zhao, Zizhong Liu, Guanghan Kan, Yan-Zhong Chang, Yingxian Li,

Different kinds of mechanical stimuli acting on the heart lead to different myocardial phenotypes. Physiological stress, such as exercise, leads to adaptive cardiac hypertrophy, which is characterized by a normal cardiac structure and improved cardiac function. Pathological stress, such as sustained cardiac pressure overload, causes maladaptive cardiac remodeling and, eventually, ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:678863]

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Inkjet Printing Transparent and Conductive MXene (Ti3C2Tx) Films: A Strategy for Flexible Energy Storage Devices.

Dong Wen, Xiang Wang, Lu Liu, Cong Hu, Cheng Sun, Yiran Wu, Yinlong Zhao, Jianxin Zhang, Xudong Liu, Guobing Ying,

MXene is a generic name for a large family of two-dimensional transition metal carbides or nitrides, which show great promise in the field of transparent supercapacitors. However, the manufacturing of supercapacitor electrodes with a high charge storage capacity and desirable transmittance is a challenging task. Herein, a low-cost, large-scale, and ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, 13(15):17766-17780]

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Effect of MicroRNA-210 on the Growth of Ovarian Cancer Cells and the Efficacy of Radiotherapy.

Yinlong Zhao, Shirui Liu, Yu Wen, Lili Zhong,

<h4>Objective</h4>The objective of this study is to explore the role of miR-210 in the growth of ovarian cancer cells and the correlation with radiotherapy and to elucidate underlying molecular mechanisms.<h4>Methods</h4>Human ovarian cancer cell lines OVCAR3 and SKOV3 were cultured in vitro, and miR-210 over-expression and low-expression ovarian cancer cell models ... Read more >>

Gynecol Obstet Invest (Gynecologic and obstetric investigation)
[2021, 86(1-2):71-80]

Cited: 0 times

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Long noncoding RNAs as diagnostic biomarkers for the early detection of digestive tract cancers: a systematic review and meta-analysis.

Yinghui Yu, Yinlong Zhao, Chunpeng Wang, Xueyuan Zhang, Xin Liu,

<h4>Background</h4>long noncoding RNAs (lncRNAs) have attracted attention recently. However, many inconsistencies frequently appeared for the early diagnosis of digestive tract cancers (DTCs). We performed this meta-analysis to describe the diagnostic performance of lncRNAs in the discrimination of DTCs.<h4>Methods</h4>data were extracted from PubMed, Web of Science, Embase, and Cochrane Library. Their ... Read more >>

Rev Esp Enferm Dig (Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva)
[2020, 112(10):797-804]

Cited: 1 time

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Validity of the McDonald criteria in predicting second events in multiple sclerosis.

Kejia Zhang, Yinlong Zhao, Zhenzhen Liang, Chunpeng Wang, Xin Liu,

<h4>Background</h4>The McDonald criteria are designed for predicting the second event in multiple sclerosis. With several revisions made to the McDonald criteria, the criteria get much easier to use, but what about the diagnostic validity? This research is conducted for evaluating the diagnostic validity of the McDonald criteria in multiple sclerosis.<h4>Methods</h4>Pubmed, ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 43:102223]

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Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity.

Caizhi Liu, Guohui Zhong, Yuezhang Zhou, Yuchen Yang, Yingjun Tan, Yuheng Li, Xingcheng Gao, Weijia Sun, Jianwei Li, Xiaoyan Jin, Dengchao Cao, Xinxin Yuan, Zizhong Liu, Shuai Liang, Youyou Li, Ruikai Du, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Jinping Song, Shukuan Ling, Yingxian Li,

<h4>Objectives</h4>Cardiac Ca<sup>2+</sup> signalling plays an essential role in regulating excitation-contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity and hypergravity and the effects on Ca<sup>2+</sup> signalling remain unknown. Here, we elucidate the mechanisms underlying the proliferation and remodelling of HL-1 cardiomyocytes subjected to rotation-simulated microgravity and ... Read more >>

Cell Prolif (Cell proliferation)
[2020, 53(3):e12783]

Cited: 3 times

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DIAGNOSTIC VALUE OF ANTI-MÜLLERIAN HORMONE AS A BIOMARKER FOR POLYCYSTIC OVARY SYNDROME: A META-ANALYSIS UPDATE.

Yang Zhao, Yinlong Zhao, Chunpeng Wang, Zhenzhen Liang, Xin Liu,

<b><i>Objective:</i></b> A previous meta-analysis carried out on the predictive ability of anti-Müllerian hormone (AMH) for polycystic ovary syndrome (PCOS) showed that independent AMH may be a useful initial diagnostic test for PCOS. The aims of this study were to update the meta-analysis and to evaluate the diagnostic efficacy of AMH ... Read more >>

Endocr Pract (Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists)
[2019, 25(10):1056-1066]

Cited: 2 times

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Assessment of risk based on variant pathways and establishment of an artificial neural network model of thyroid cancer.

Yinlong Zhao, Lingzhi Zhao, Tiezhu Mao, Lili Zhong,

<h4>Background</h4>This study aimed to establish an artificial neural network (ANN) model based on variant pathways to predict the risk of thyroid cancer.<h4>Methods</h4>The RNASeq data of 482 thyroid cancer samples were downloaded from the TCGA database. The samples were divided into low-risk and high-risk groups, followed by identification of differentially expressed ... Read more >>

BMC Med Genet (BMC medical genetics)
[2019, 20(1):92]

Cited: 2 times

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Silencing of long noncoding RNA RP11-476D10.1 enhances apoptosis and autophagy while inhibiting proliferation of papillary thyroid carcinoma cells via microRNA-138-5p-dependent inhibition of LRRK2.

Yinlong Zhao, Lingzhi Zhao, Junfeng Li, Lili Zhong,

The distant metastasis in papillary thyroid carcinoma (PTC) is a major threat for PTC patients. Moreover, the involvement of long noncoding RNAs (lncRNAs) in the regulation of PTC progression has been extensively investigated. The aim of this study was to underscore whether lncRNA RP11-476D10.1 affects the proliferation, apoptosis and autophagy ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2019, 234(11):20980-20991]

Cited: 6 times

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Down-regulation of microRNA-31-5p inhibits proliferation and invasion of osteosarcoma cells through Wnt/β-catenin signaling pathway by enhancing AXIN1.

Xue Chen, Lili Zhong, Xijing Li, Wenping Liu, Yinlong Zhao, Junfeng Li,

<h4>Objectives</h4>Recently, the role of microRNA-31-5p (miR-31-5p) in gene expression regulation has been reported in various cancers. Studies have shown that Wnt/β-catenin signaling pathway is involved in the proliferation and invasion of osteosarcoma (OS) cells. Therefore, this study aims to probe into the regulatory role of miR-31-5p targeting AXIN1 in OS ... Read more >>

Exp Mol Pathol (Experimental and molecular pathology)
[2019, 108:32-41]

Cited: 4 times

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A review on the mechanism of iodide metabolic dysfunction in differentiated thyroid cancer.

Yinlong Zhao, Lili Zhong, Heqing Yi,

The incidence of differentiated thyroid cancer (DTC) has been increasing rapidly worldwide, and the risk factors remain unclear. With the growing number of patients with DTC, the related issues have been gradually highlighted. <sup>131</sup>Iodide (<sup>131</sup>I) is an important treatment for DTC and has the potential to reduce the risk of ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2019, 479:71-77]

Cited: 4 times

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Diagnostic accuracy of urine cytokeratin 20 for bladder cancer: A meta-analysis.

Yan Mi, Yinlong Zhao, Fang Shi, Mengmeng Zhang, Chunpeng Wang, Xin Liu,

<h4>Aim</h4>Urine cytokeratin 20 (CK20) has been reported as a novel diagnostic biomarker for bladder cancer (BC). This meta-analysis aims to evaluate the diagnostic value of urine CK20 for BC.<h4>Methods</h4>A systematic search for literatures was performed till March 31, 2018. Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic ... Read more >>

Asia Pac J Clin Oncol (Asia-Pacific journal of clinical oncology)
[2019, 15(2):e11-e19]

Cited: 6 times

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Myocardial CKIP-1 Overexpression Protects from Simulated Microgravity-Induced Cardiac Remodeling.

Shukuan Ling, Yuheng Li, Guohui Zhong, Yongjun Zheng, Qing Xu, Dingsheng Zhao, Weijia Sun, Xiaoyan Jin, Hongxing Li, Jianwei Li, Huiyuan Sun, Dengchao Cao, Jinping Song, Caizhi Liu, Xinxin Yuan, Xiaorui Wu, Yinlong Zhao, Zizhong Liu, Qi Li, Yingxian Li,

Human cardiovascular system has adapted to Earth's gravity of 1G. The microgravity during space flight can induce cardiac remodeling and decline of cardiac function. At present, the mechanism of cardiac remodeling induced by microgravity remains to be disclosed. Casein kinase-2 interacting protein-1 (CKIP-1) is an important inhibitor of pressure-overload induced ... Read more >>

Front Physiol (Frontiers in physiology)
[2018, 9:40]

Cited: 5 times

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Diagnostic value of microRNAs as biomarkers for cholangiocarcinoma.

Zhenzhen Liang, Xin Liu, Qian Zhang, Chunpeng Wang, Yinlong Zhao,

<h4>Background</h4>It has been reported that microRNAs might serve as biomarkers for cholangiocarcinoma (CCA) detection, but their diagnostic accuracy are unclear and controversial.<h4>Aim</h4>To evaluate the diagnostic accuracy of microRNAs for CCA.<h4>Materials and methods</h4>PubMed, Embase, Web of Science and Cochrane Library were systematically searched to identify relevant articles by using the key ... Read more >>

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2016, 48(10):1227-1232]

Cited: 12 times

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The combined use of miRNAs and mRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma.

Yinlong Zhao, Xiaodong Liu, Lili Zhong, Mengzi He, Silin Chen, Tiejun Wang, Shumei Ma,

Thyroid carcinoma (TC) is the most common malignancy of the endocrine system, and papillary thyroid carcinoma (PTC) accounts for the largest proportion of cases with TC. Although histology is considered the gold standard in the diagnosis of PTC, the sensitivity and specificity of this method is low. Therefore, developing novel diagnostic ... Read more >>

Int J Mol Med (International journal of molecular medicine)
[2015, 36(4):1097-1103]

Cited: 14 times

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[Impacts on the life quality of the patients with allergic rhinitis treated with warming acupuncture in winter and summer].

Yilin Xie, Wenrong Wan, Yinlong Zhao, Zhiying Ye, Huiyang Chen, Xiuyu Hong, Lei Wu, Ruiwen Wang, Jingui Yang,

<h4>Objective</h4>To explore the impacts on the life quality and the effect mechanism in the patients of allergic rhinitis (AR) treated with warm acupuncture in winter and summer.<h4>Methods</h4>Two hundred and forty patients of AR were randomized into a summer and winter acupuncture group, a non-summer and winter acupuncture group and a ... Read more >>

Zhongguo Zhen Jiu (Zhongguo zhen jiu = Chinese acupuncture & moxibustion)
[2015, 35(12):1215-1220]

Cited: 1 time

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[Impacts on asthma at persistent stage and immune function in the patients treated with acupuncture for warming yang and benefiting qi].

Yilin Xie, Wenrong Wan, Yinlong Zhao, Junjie Xie, Qiuyan Wu,

<h4>Objective</h4>To compare the difference in clinical efficacy on bronchial asthma at chronic persistent stage between acupuncture for warming yang and benefiting qi and seretide.<h4>Methods</h4>One hundred and eighty patients of bronchial asthma at chronic persistent stage were randomized into an acupuncture group and a western medication group, 90 cases in each ... Read more >>

Zhongguo Zhen Jiu (Zhongguo zhen jiu = Chinese acupuncture & moxibustion)
[2015, 35(11):1089-1093]

Cited: 0 times

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Ionizing radiation-induced adaptive response in fibroblasts under both monolayer and 3-dimensional conditions.

Yinlong Zhao, Rui Zhong, Liguang Sun, Jie Jia, Shumei Ma, Xiaodong Liu,

To observe the adaptive response (AR) induced by ionizing radiation in human fibroblasts under monolayer and 3-dimensional (3-D) condition. Three kinds of fibroblasts were cultured under both monolayer and 3-D condition. Immunofluorescent staining was used to detect the γ-H2AX foci and the morphological texture. Trypan blue staining was used to ... Read more >>

PLoS One (PloS one)
[2015, 10(3):e0121289]

Cited: 10 times

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The combination of TP53INP1, TP53INP2 and AXIN2: potential biomarkers in papillary thyroid carcinoma.

Mengzi He, Yinlong Zhao, Heqing Yi, Hui Sun, Xiaodong Liu, Shumei Ma,

Endocrine (Endocrine)
[2015, 48(2):712-717]

Cited: 5 times

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The different regulatory effects of p53 status on multidrug resistance are determined by autophagy in ovarian cancer cells.

Dejuan Kong, Shumei Ma, Bing Liang, Heqing Yi, Yinlong Zhao, Rui Xin, Li Cui, Lili Jia, Xin Liu, Xiaodong Liu,

<h4>Purpose</h4>Multidrug resistance (MDR) has become an obstacle for chemotherapy of cancer. p53 is reported to participate in the regulation of MDR, but the association between p53 status and MDR are complicated and conditional. It has been verified that apoptosis is not the only mechanism for MDR regulation by p53, the ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2012, 66(4):271-278]

Cited: 24 times

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