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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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The small protein MafG plays a critical role in MC3T3-E1 cell apoptosis induced by simulated microgravity and radiation.

Honghui Wang, Jingjing Dong, Gaozhi Li, Yingjun Tan, Hai Zhao, Lijun Zhang, Yixuan Wang, Zebing Hu, Xinsheng Cao, Fei Shi, Shu Zhang,

Microgravity and radiation exposure-induced bone damage is one of the most significant alterations in astronauts after long-term spaceflight. However, the underlying mechanism is still largely unknown. Recent ground-based simulation studies have suggested that this impairment is likely mediated by increased production of reactive oxygen species (ROS) during spaceflight. The small ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 555:175-181]

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Thymosin Alpha 1 Reduces the Mortality of Severe Coronavirus Disease 2019 by Restoration of Lymphocytopenia and Reversion of Exhausted T Cells.

Yueping Liu, Yue Pan, Zhenhong Hu, Ming Wu, Chenhui Wang, Zeqing Feng, Congzheng Mao, Yingjun Tan, Ying Liu, Li Chen, Min Li, Gang Wang, Zilin Yuan, Bo Diao, Yuzhang Wu, Yongwen Chen,

<h4>Background</h4>Thymosin alpha 1 (Tα1) had been used in the treatment of viral infections as an immune response modifier for many years. However, clinical benefits and the mechanism of Tα1 treatment for COVID-19 patients are still unclear.<h4>Methods</h4>We retrospectively reviewed the clinical outcomes of 76 severe COVID-19 cases admitted to 2 hospitals ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(16):2150-2157]

Cited: 35 times

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Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)

Bo Diao, Chenhui Wang, Yingjun Tan, Xiewan Chen, Ying Liu, Lifen Ning, Li Chen, Min Li, Yueping Liu, Gang Wang, Zilin Yuan, Zeqing Feng, Yuzhang Wu, Yongwen Chen,

<h4>Summary</h4> <h4>BACKGROUND</h4> The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health, which has been declared a public health emergency of international concern (PHEIC) by the WHO. T cells play a critical role in antiviral immunity but ... Read more >>

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Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19).

Bo Diao, Chenhui Wang, Yingjun Tan, Xiewan Chen, Ying Liu, Lifen Ning, Li Chen, Min Li, Yueping Liu, Gang Wang, Zilin Yuan, Zeqing Feng, Yi Zhang, Yuzhang Wu, Yongwen Chen,

<b>Background:</b> The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear. <b>Methods:</b> We retrospectively reviewed the ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:827]

Cited: 663 times

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Targeted silencing of miRNA-132-3p expression rescues disuse osteopenia by promoting mesenchymal stem cell osteogenic differentiation and osteogenesis in mice.

Zebing Hu, Lijun Zhang, Han Wang, Yixuan Wang, Yingjun Tan, Lei Dang, Ke Wang, Zhongyang Sun, Gaozhi Li, Xinsheng Cao, Shu Zhang, Fei Shi, Ge Zhang,

<h4>Background</h4>Skeletal unloading can induce severe disuse osteopenia that often occurs in spaceflight astronauts or in patients subjected to prolonged bed-rest or immobility. Previously, we revealed a mechano-sensitive factor, miRNA-132-3p, that is closely related to the osteoblast function. The aim of this study was to investigate whether miRNA-132-3p could be an ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2020, 11(1):58]

Cited: 5 times

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Bone-targeted lncRNA OGRU alleviates unloading-induced bone loss via miR-320-3p/Hoxa10 axis.

Ke Wang, Yixuan Wang, Zebing Hu, Lijun Zhang, Gaozhi Li, Lei Dang, Yingjun Tan, Xinsheng Cao, Fei Shi, Shu Zhang, Ge Zhang,

Unloading-induced bone loss is a threat to human health and can eventually result in osteoporotic fractures. Although the underlying molecular mechanism of unloading-induced bone loss has been broadly elucidated, the pathophysiological role of long noncoding RNAs (lncRNAs) in this process is unknown. Here, we identified a novel lncRNA, OGRU, a ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(5):382]

Cited: 4 times

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Risk Factors for In-hospital Progression of Ordinary COVID-19 in Wuhan, China: A Retrospective Cohort Study

Ying Zhang, Xing Fan, Yan Zhao, Fan Zhou, Linlin Zhao, Jing Liu, Haichao Liu, Chengrui Zhou, Ling Tong, Zhenhua Lv, Ying Xiong, Yong Zhang, Yingjun Tan, Airong Yu,

<h4>Objective: </h4> To describe the clinical characteristics and outcomes of ordinary COVID-19 when admitted, to describe how these patients were treated and risk factors for in-hospital progression. <h4>Methods: </h4>: In this retrospective study, we included 291 adult patients diagnosed as ordinary COVID-19 on admission who had been discharged or had ... Read more >>

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Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity.

Caizhi Liu, Guohui Zhong, Yuezhang Zhou, Yuchen Yang, Yingjun Tan, Yuheng Li, Xingcheng Gao, Weijia Sun, Jianwei Li, Xiaoyan Jin, Dengchao Cao, Xinxin Yuan, Zizhong Liu, Shuai Liang, Youyou Li, Ruikai Du, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Jinping Song, Shukuan Ling, Yingxian Li,

<h4>Objectives</h4>Cardiac Ca<sup>2+</sup> signalling plays an essential role in regulating excitation-contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity and hypergravity and the effects on Ca<sup>2+</sup> signalling remain unknown. Here, we elucidate the mechanisms underlying the proliferation and remodelling of HL-1 cardiomyocytes subjected to rotation-simulated microgravity and ... Read more >>

Cell Prolif (Cell proliferation)
[2020, 53(3):e12783]

Cited: 3 times

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Targeted overexpression of the long noncoding RNA ODSM can regulate osteoblast function in vitro and in vivo.

Yixuan Wang, Ke Wang, Lijun Zhang, Yingjun Tan, Zebing Hu, Lei Dang, Hua Zhou, Gaozhi Li, Han Wang, Shu Zhang, Fei Shi, Xinsheng Cao, Ge Zhang,

Ameliorating bone loss caused by mechanical unloading is a substantial clinical challenge, and the role of noncoding RNAs in this process has attracted increasing attention. In this study, we found that the long noncoding RNA osteoblast differentiation-related lncRNA under simulated microgravity (lncRNA ODSM) could inhibit osteoblast apoptosis and promote osteoblast ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(2):133]

Cited: 4 times

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Bone-targeted lncRNA OGRU alleviates unloading-induced bone loss via miR-320-3p/Hoxa10 axis

Ke Wang, Yixuan Wang, Zebing Hu, Lijun Zhang, Gaozhi Li, Lei Dang, Yingjun Tan, Xinsheng Cao, Fei Shi, Shu Zhang, Ge Zhang,

Although the underlying molecular mechanism of unloading-induced bone loss has been broadly elucidated, the pathophysiological role of long noncoding RNAs (lncRNAs) in this process is unknown. Here, we identified a novel lncRNA, OGRU, a 1816-nucleotide transcript with significantly decreased levels in bone specimens from hindlimb-unloaded mice and in MC3T3-E1 cells ... Read more >>

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The mechanosensitive Piezo1 channel is required for bone formation.

Weijia Sun, Shaopeng Chi, Yuheng Li, Shukuan Ling, Yingjun Tan, Youjia Xu, Fan Jiang, Jianwei Li, Caizhi Liu, Guohui Zhong, Dengchao Cao, Xiaoyan Jin, Dingsheng Zhao, Xingcheng Gao, Zizhong Liu, Bailong Xiao, Yingxian Li,

Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone formation remains unclear. Here we report that Piezo1, a bona fide mechanotransducer that is critical for various biological processes, plays ... Read more >>

Elife (eLife)
[2019, 8:]

Cited: 36 times

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Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.

Hongjie Xu, Feng Wu, Hongyu Zhang, Chao Yang, Kai Li, Hailong Wang, Honghui Yang, Yue Liu, Bai Ding, Yingjun Tan, Ming Yuan, Yinghui Li, Zhongquan Dai,

Microgravity influences the activity of osteoblast, induces actin microfilament disruption and leads to bone loss during spaceflight. Mechanical stress such as gravity, regulates cell function, response and differentiation through dynamic cytoskeleton changes, but the mechanotransduction mechanism remains to be fully elucidated. Previous, we demonstrated actin microfilament mediated osteoblast Cbfa1 responsiveness ... Read more >>

Biochimie (Biochimie)
[2017, 138:184-193]

Cited: 11 times

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Integrin αvβ3 mediates the synergetic regulation of core-binding factor α1 transcriptional activity by gravity and insulin-like growth factor-1 through phosphoinositide 3-kinase signaling.

Zhongquan Dai, Feima Guo, Feng Wu, Hongjie Xu, Chao Yang, Jinqiao Li, Peilong Liang, Hongyu Zhang, Lina Qu, Yingjun Tan, Yumin Wan, Yinghui Li,

Mechanical stimulation and biological factors coordinately regulate bone development and regeneration; however, the underlying mechanisms are poorly understood. Microgravity induces bone loss, which may be partly related to the development of resistance to local cytokines, including insulin-like growth factor 1 (IGF-1). Here, we report the involvement of integrin αvβ3 in ... Read more >>

Bone (Bone)
[2014, 69:126-132]

Cited: 5 times

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Actin microfilament mediates osteoblast Cbfa1 responsiveness to BMP2 under simulated microgravity.

Zhongquan Dai, Feng Wu, Jian Chen, Hongjie Xu, Honghui Wang, Feima Guo, Yingjun Tan, Bai Ding, Jinfu Wang, Yumin Wan, Yinghui Li,

Microgravity decreases osteoblastic activity, induces actin microfilament disruption and inhibits the responsiveness of osteoblast to cytokines, but the mechanisms remains enigmatic. The F-actin cytoskeleton has previously been implicated in manifold changes of cell shape, function and signaling observed under microgravity. Here we investigate the involvement of microfilament in mediating the ... Read more >>

PLoS One (PloS one)
[2013, 8(5):e63661]

Cited: 17 times

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Fluid-change cell culture box

YINGJUN TAN, JIELIN NIE, CHUNYAN WANG, BAI DING, JIANRU YU, YINGHUI LI, YUE LIU, ZENGMING HUANG, SHUKUAN LING, GUANGHAN KAN,

The utility model relates to a disposable fluid-change cell culture box which has the capacities of storing and updating cell culture fluid and reagent. The disposable fluid-change cell culture box is characterized by comprising a culture box main body, a bottom plug, a movable sealing plug, a top plug, a ... Read more >>

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Long-term detection system for material bioavailability

YINGHUI LI, YINGJUN TAN, CHUNYAN WANG, JIELIN NIE, JIANRU YU, BAI DING, FEN YANG, ZHONGQUAN DAI, ZENGMING HUANG, SHUKUAN LING,

The utility model relates to a material biocompatibility long-term detecting system, which is characterized by comprising five parts of a liquid storage bottle, a liquid driver, a detecting box, a discard solution collecting bottle and a pipeline, wherein the pipeline is connected with the liquid storage bottle, the detecting box, ... Read more >>

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Combined cell culture bottle

YINGJUN TAN, JIELIN NIE, JIANRU YU, YINGHUI LI, CHUNYAN WANG, BAI DING, FEN YANG, ZHONGQUAN DAI, ZENGMING HUANG, SHUKUAN LING,

The utility model relates to a combined cell culture bottle which is provided with good gas permeable ability and installs cell samples three-dimensionally. The combined cell culture bottle is characterized by comprising five parts of a culture bottle, a sample combined frame, a cell culture piece, semi-permeable membrane and a ... Read more >>

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[The clinical effect of anti-rotation reduction internal fixator on the treatment of fresh thoracolumbar spine fracture].

Xianming Pan, Yi Quan, Yingjun Tan, Bo Zhang, Yuanshan Wang, Tong Huang, Zehui Ma, Dongfa Liao, Ting Li, Jinbiao Liu,

<h4>Objective</h4>To evaluate the effect of self-designed anti-rotation reduction internal fixator (ARRIF) on treating different spine segment fracture.<h4>Methods</h4>From August 1999 to March 2003, 76 patients(48 males and 28 females, aged from 22 to 59 with an average of 34.1) with thoracolumbar fracture were operatively treated by ARRIF. The follow-up period ranged ... Read more >>

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery)
[2005, 19(3):224-228]

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