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Author Ying Shen

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The PATCH trial: efficacy and safety of 5% lidocaine-medicated plaster for the treatment of patients with trigeminal neuralgia: a study protocol for a multicentric, double-blind, enriched enrolment randomised withdrawal, vehicle-controlled study.

Chunmei Zhao, Niti Shrestha, Hongbing Liu, Ying Shen, Lan Meng, Bifa Fan, Fang Luo,

<h4>Introduction</h4>Trigeminal neuralgia (TN) is characterised by a sudden, severe, electric shock like paroxysmal pain, which is almost always associated with triggers. Carbamazepine is the first-line medical management of TN. However, side effects are common. Currently, there is no ideal treatment for TN. Since there is a known abnormality of Na<sup>+</sup> ... Read more >>

BMJ Open (BMJ open)
[2021, 11(8):e045493]

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Clinical effects of high-intensity laser therapy on patients with chronic refractory wounds: a randomised controlled trial.

Qian Lu, Zhifei Yin, Xuefeng Shen, Jinhua Li, Panpan Su, Min Feng, Xingjun Xu, Weiwei Li, Chuan He, Ying Shen,

<h4>Objective</h4>To investigate the effectiveness of high-intensity laser therapy (HILT) on chronic refractory wounds.<b>Design</b>Randomised controlled trial.<h4>Setting</h4>The outpatient wound care department of the Affiliated Jiangsu Shengze Hospital of Nanjing Medical University from August 2019 to June 2020.<h4>Participants</h4>Sixty patients were enrolled in this study and were randomised into control (n=30) and treatment (n=30) ... Read more >>

BMJ Open (BMJ open)
[2021, 11(7):e045866]

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MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway.

Yuanyuan Lv, Yang Li, Jiangya Wang, Mei Li, Wenhao Zhang, Huifen Zhang, Ying Shen, Chao Li, Yuan Du, Lian Jiang,

Bronchopulmonary dysplasia (BPD) is an inflammation-related respiratory disorder in infants. MiR-382-5p has displayed low expression in developing lungs with BPD, while the effect of miR-382-5p on BPD remains elusive. Here, a hyperoxia (85% oxygen)-induced BPD model in neonatal mice was established. On postnatal days 10 and 15, hyperoxia reduced miR-382-5p ... Read more >>

Genes Cells (Genes to cells : devoted to molecular & cellular mechanisms)
[2021, :]

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Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD.

Yue Pan, Xingzhi He, Cuicui Li, Yanjun Li, Wenwen Li, Hanbin Zhang, Yang Wang, Guangjun Zhou, Jing Yang, Jiarui Li, Jing Qu, Hao Wang, Zhihua Gao, Ying Shen, Tao Li, Hailan Hu, Huan Ma,

Cellular resources must be reorganized for long-term synaptic plasticity during brain information processing, in which coordinated gene transcription and protein turnover are required. However, the mechanism underlying this process remains elusive. Here, we report that activating N-methyl-d-aspartate receptors (NMDARs) induce transcription-dependent autophagy for synaptic turnover and late-phase long-term synaptic depression ... Read more >>

Cell Rep (Cell reports)
[2021, 36(3):109398]

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Downregulated SIRT1 in the CeA is involved in chronic pain-depression comorbidity.

Yi-Man Sun, Ying Shen, Hui Huang, Qiang Liu, Chen Chen, Lin-Hui Ma, Jie Wan, Yin-Ying Sun, Cheng-Hua Zhou, Yu-Qing Wu,

Comorbid chronic pain and depression are increasingly becoming a concerning public problem, but the underlying mechanisms remain unclear. Here, we demonstrate that pain-related depression-like behaviors are induced in a rat model of chronic constriction injury (CCI). Using this model, we found that chronic neuropathic pain decreased the activity and expression ... Read more >>

Brain Res Bull (Brain research bulletin)
[2021, 174:339-348]

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lncRNA TUG1 regulates human pulmonary microvascular endothelial cell apoptosis via sponging of the miR-9a-5p/BCL2L11 axis in chronic obstructive pulmonary disease.

Xichen Chen, Mao Mao, Ying Shen, Xueyong Jiang, Zhifei Yin,

The aim of the present study was to investigate the function of long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) in chronic obstructive pulmonary disease and further assess the underlying molecular mechanisms. Flow cytometry analysis was performed to detect cell apoptosis of human pulmonary microvascular endothelial cells (HPMECs) treated with ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2021, 22(2):906]

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Myeloid Sarcoma Type of Acute Promyelocytic Leukemia With a Cryptic Insertion of RARA Into FIP1L1: The Clinical Utility of NGS and Bioinformatic Analyses.

Yongren Wang, Yaoyao Rui, Ying Shen, Jian Li, Poning Liu, Qin Lu, Yongjun Fang,

<h4>Background</h4>Acute promyelocytic leukemia (APL) is characterized by the presence of coagulopathy at onset and translocation t (15; 17) (q22; 21), meanwhile, other translocation variants of APL have also been reported. The <i>FIP1L1-RARA</i> fusion gene has recently been reported as a novel RARA-associated fusion gene.<h4>Objectives</h4>We report a case of <i>de novo</i> ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:688203]

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Nrg1β as a Proangiogenesis Therapy: How Is Nrg1β Therapy Unique From Other Angiogenesis Therapies?

Ying H Shen, Jun-Ichi Abe,

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2021, 41(8):2315-2317]

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Complementary and Alternative Medicine for Dysmenorrhea Caused by Endometriosis: A Review of Utilization and Mechanism.

Ying Guo, Fang-Yuan Liu, Ying Shen, Jia-Yue Xu, Liang-Zhen Xie, Shi-Ying Li, Dan-Ni Ding, Dan-Qi Zhang, Feng-Juan Han,

Endometriosis (EM) is a common and benign estrogen-dependent gynecological disorder among women of reproductive age, and secondary dysmenorrhea is one of the more severe symptoms. However, the mechanism behind the development of dysmenorrhea is poorly understood, and there is a lack of effective methods for diagnosing and treating EM dysmenorrhea. ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2021, 2021:6663602]

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Novel Mutations in X-Linked, USP26-Induced Asthenoteratozoospermia and Male Infertility.

Chunyu Liu, Ying Shen, Qunshan Shen, Wen Zhang, Jiaxiong Wang, Shuyan Tang, Huan Wu, Shixiong Tian, Jiangshan Cong, Xiaojin He, Li Jin, Feng Zhang, Xiaohui Jiang, Yunxia Cao,

Male infertility is a multifactorial disease with a strong genetic background. Abnormal sperm morphologies have been found to be closely related to male infertility. Here, we conducted whole-exome sequencing in a cohort of 150 Han Chinese men with asthenoteratozoospermia. Two novel hemizygous mutations were identified in <i>USP26</i>, an X-linked gene ... Read more >>

Cells (Cells)
[2021, 10(7):]

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Soluble Expression of Fc-Fused T Cell Receptors Allows Yielding Novel Bispecific T Cell Engagers

Wen-Bin Zhao, Ying Shen, Wen-Hui Liu, Yi-Ming Li, Shi-Jie Jin, Ying-Chun Xu, Li-Qiang Pan, Zhan Zhou, Shu-Qing Chen,

The specific recognition of T cell receptors (TCR) and peptides presented by human leukocyte antigens (pHLAs) is the core step for T cell triggering to execute anti-tumor activity. However, TCR assembly and soluble expression are challenging, which precludes the broad use of TCR in tumor therapy. Herein, we used heterodimeric ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(7):]

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Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy.

Siting Zhu, Ze'e Chen, Mason Zhu, Ying Shen, Leonardo J Leon, Liguo Chi, Simone Spinozzi, Changming Tan, Yusu Gu, Anh Nguyen, Yi Zhou, Wei Feng, Frédéric M Vaz, Xiaohong Wang, Asa B Gustafsson, Sylvia M Evans, Ouyang Kunfu, Xi Fang,

<h4>Background</h4>Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in <i>Tafazzin</i> (<i>TAZ</i>), encoding a mitochondrial acyltransferase required for cardiolipin remodeling. Despite recent description of a mouse model of BTHS cardiomyopathy, an in-depth analysis of specific lipid abnormalities and mitochondrial form and ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2021, 14(6):e008289]

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The 90% Effective Dose of Sufentanil for Epidural Analgesia in the Early First Stage of Labor: A Double-blind, Sequential Dose-Finding Study.

Ting Shen, Jing Zheng, Zifeng Xu, Chen Zhang, Ying Shen, Tao Xu,

<h4>Purpose</h4>Epidural analgesia in the latent phase of the first stage of labor has been recognized and accepted by anesthesiologists worldwide. However, there is no unified consensus on the exact dosage of sufentanil with the combination of ropivacaine in the induction of epidural analgesia in the early first stage of labor. ... Read more >>

Clin Ther (Clinical therapeutics)
[2021, :]

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Evaluation of a high-performance liquid chromatography method for urinary oxalate determination and investigation regarding the pediatric reference interval of spot urinary oxalate to creatinine ratio for screening of primary hyperoxaluria.

Ying Shen, Xia Luo, Huijun Li, Qing Guan, Liming Cheng,

<h4>Background</h4>Urinary oxalate can provide important clues for the screening and monitoring of children with primary hyperoxaluria (PH), which is a potentially life-threatening condition. However, little effort has been devoted to improve the oxalate assay in recent years. We have proposed a reliable and cost-effective high-performance liquid chromatography (HPLC) method for ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2021, :e23870]

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Genetic Spectrum and Clinical Features in a Cohort of Chinese Patients with Autosomal Recessive Cerebellar Ataxias

Hao-Ling Cheng, Ya-Ru Shao, Yi Dong, Hai-Lin Dong, Lu Yang, Yin Ma, Ying Shen, Zhiying Wu,

<h4>Background: </h4> Although many causative genes have been uncovered in recent years, genetic diagnosis is still missing for approximately 50% of autosomal recessive cerebellar ataxia (ARCA) patients. Few studies have been performed to determine the genetic spectrum and clinical profiles of ARCA patients in the Chinese population. <h4>Methods: </h4>: Fifty-four ... Read more >>

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PQBP1: A New Player in Metabotropic Glutamate Receptor Signaling and Synaptic Plasticity.

Li-Da Su, Ying Shen,

Neurosci Bull (Neuroscience bulletin)
[2021, :]

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Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective.

Li-Da Su, Na Wang, Junhai Han, Ying Shen,

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to fine-tuning of synaptic efficacy and control the accuracy and sharpness of neurotransmission. Among eight subtypes, mGluR1 and mGluR5 belong to group 1 (Gp1) family, and are implicated ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211021018]

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Hierarchical Human-Like Deep Neural Networks for Abstractive Text Summarization.

Min Yang, Chengming Li, Ying Shen, Qingyao Wu, Zhou Zhao, Xiaojun Chen,

Developing an abstractive text summarization (ATS) system that is capable of generating concise, appropriate, and plausible summaries for the source documents is a long-term goal of artificial intelligence (AI). Recent advances in ATS are overwhelmingly contributed by deep learning techniques, which have taken the state-of-the-art of ATS to a new ... Read more >>

IEEE Trans Neural Netw Learn Syst (IEEE transactions on neural networks and learning systems)
[2021, 32(6):2744-2757]

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Long Noncoding RNA LINC01518 Modulates Proliferation and Migration in TGF-β1-Treated Human Tenon Capsule Fibroblast Cells Through the Regulation of hsa-miR-216b-5p.

Ning Kong, YaLi Bao, Haixia Zhao, Xin Kang, Xue Tai, Xu Chen, Wenqi Guo, Ying Shen,

In this study, we investigated the expression and functions of long noncoding RNAs (LncRNAs) of LINC01518 in an in vitro model of TGF-β1-treated human Tenon capsule fibroblast (HTF) cells. qRT-PCR was used to examine LINC01518 expression in in situ human glaucoma tissues, and in vitro HTF cells treated with TGF-β1. ... Read more >>

Neuromolecular Med (Neuromolecular medicine)
[2021, :]

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Assessing the accuracy of visual blood loss estimation in postpartum hemorrhage in Shanghai hospitals: A web-based survey for nurses and midwives.

Ying Liu, Wei Zhu, Ying Shen, Jingbo Qiu, Lin Rao, Hong Li,

<h4>Aims and objectives</h4>This study aimed at evaluating the accuracy of visual estimated blood loss in postpartum haemorrhage by midwives and nurses, as well as exploring its influencing factors.<h4>Background</h4>Timely recognition of postpartum haemorrhage is critical in saving maternal lives. Yet midwives and nurses can barely distinguish whether the blood loss has ... Read more >>

J Clin Nurs (Journal of clinical nursing)
[2021, :]

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Effects of Virtual Reality Intervention on Cognition and Motor Function in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis.

Shizhe Zhu, Youxin Sui, Ying Shen, Yi Zhu, Nawab Ali, Chuan Guo, Tong Wang,

<b>Background:</b> Virtual reality (VR) intervention is an innovative and efficient rehabilitative tool for patients affected by stroke, Parkinson's disease, and other neurological disorders. This meta-analysis aims to evaluate the effects of VR intervention on cognition and motor function in older adults with mild cognitive impairment or dementia. <b>Methods:</b> Seven databases ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2021, 13:586999]

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Analysis of Differentiated Chemical Components between Zijuan Purple Tea and Yunkang Green Tea by UHPLC-Orbitrap-MS/MS Combined with Chemometrics.

Mengwan Li, Ying Shen, Tiejun Ling, Chi-Tang Ho, Daxiang Li, Huimin Guo, Zhongwen Xie,

Zijuan tea (<i>Camellia sinensis var. assamica</i> cv. Zijuan) is a unique purple tea. Recently, purple tea has drawn much attention for its special flavor and health benefits. However, the characteristic compounds of purple tea compared with green tea have not been reported yet. The present study employed a non-targeted metabolomics ... Read more >>

Foods (Foods (Basel, Switzerland))
[2021, 10(5):]

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Effectiveness of erenumab and onabotulinumtoxinA on acute medication usage and health care resource utilization as migraine prevention in the United States.

Stewart J Tepper, Juanzhi Fang, Lujia Zhou, Ying Shen, Pamela Vo, Ahmad Abdrabboh, Mrudula B Glassberg, Matias Ferraris,

<b>BACKGROUND:</b> Migraine is a common neurological disease that can have a substantial impact on patients' lives and on society. Erenumab, a fully human monoclonal antibody that targets the calcitonin gene-related peptide receptor, was specifically developed for migraine prevention. The efficacy of erenumab has been established in several clinical trials; however, ... Read more >>

J Manag Care Spec Pharm (Journal of managed care & specialty pharmacy)
[2021, :1-14]

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Pen-2 Negatively Regulates the Differentiation of Oligodendrocyte Precursor Cells into Astrocytes in the Central Nervous System.

Jinxing Hou, Huiru Bi, Zhuoyang Ye, Wenhui Huang, Gang Zou, Xiaochuan Zou, Yun Stone Shi, Ying Shen, Quanhong Ma, Frank Kirchhoff, Yimin Hu, Guiquan Chen,

Mutations on γ-secretase subunits are associated with neurologic diseases. Whereas the role of γ-secretase in neurogenesis has been intensively studied, little is known about its role in astrogliogenesis. Recent evidence has demonstrated that astrocytes can be generated from oligodendrocyte precursor cells (OPCs). However, it is not well understood what mechanism ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2021, 41(23):4976-4990]

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Utility of Volumetric Metabolic Parameters on Preoperative FDG PET/CT for Predicting Tumor Lymphovascular Invasion in Non-Small Cell Lung Cancer.

Chongjiao Li, Yueli Tian, Ying Shen, Bing Wen, Yong He,

<b>Background:</b> Lymphovascular invasion (LVI) is an adverse prognostic indicator in non-small cell lung cancer (NSCLC) and serves as an indication for postoperative adjuvant chemotherapy recommendation after resection. <b>Objective:</b> To assess the utility of clinicopathologic factors and volumetric metabolic parameters from preoperative FDG PET/CT in predicting primary tumor LVI in NSCLC. ... Read more >>

AJR Am J Roentgenol (AJR. American journal of roentgenology)
[2021, :]

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