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Author Yi Luo

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Palladium-catalyzed cross-coupling reaction of sulfoxonium ylides and benzyl bromides by carbene migratory insertion.

Kaichuan Yan, Maoyao He, Jianglian Li, Hua He, Ruizhi Lai, Yi Luo, Li Guo, Yong Wu,

A palladium-catalyzed cross-coupling reaction of sulfoxonium ylides and benzyl bromides has been developed, which has potential safety advantages over previous carbene coupling reactions using either diazo compounds or their in situ precursors. This reaction affords polysubstituted olefins, and features good substrate tolerance and is suitable for late-stage modification of biologically ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(91):14287-14290]

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Finding the true pathway for reversible isomerization of a single azobenzene molecule tumbling on Au(111) surface.

Zhen Xie, Sai Duan, Chuan-Kui Wang, Yi Luo,

Switchable trans-cis isomerization of azobenzene (AB) and its derivatives on metallic surfaces have offered rich possibilities to functionalize molecular devices. However, the lack of a good understanding of the isomerization pathway has severely limited our ability for rational design. One of the long-debated issues is the cis configuration of the ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(19):10474-10479]

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A label-free electrochemical sensor for ultrasensitive microRNA-21 analysis based on the poly(L-cysteine)/MoS2 sensing interface.

Yao Yao, Hemeng Pan, Yi Luo, Dan Zhu, Jie Chao, Shao Su, Lianhui Wang,

The label-free detection of nucleic acids has attracted interest of scientists due to the fact that it is simple, fast and efficient. Herein, l-cysteine was electropolymerized on the molybdenum disulfide (MoS2) surface to form a stable and electroactive poly(l-cysteine)-functionalized molybdenum disulfide (Pl-Cys/MoS2) sensing interface. Taking microRNA-21 (miRNA-21) as an analytical ... Read more >>

Analyst (The Analyst)
[2021, :]

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LncRNA HOTTIP facilitates cell proliferation, invasion, and migration in osteosarcoma by interaction with PTBP1 to promote KHSRP level.

Xin-Yu Yao, Jian-Fan Liu, Yi Luo, Xue-Zheng Xu, Jie Bu,

This study designs to investigate the role and potential mechanism of lncNRA HOTTIP in OS progression <i>in vitro</i> and <i>in vivo</i>. HOTTIP, PTBP1, and KHSRP expression levels were tested through qRT-PCR and western blot in OS tissues or cell lines. Cell proliferation was examined via CCK-8 and colony formation. Cell ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2021, :1-15]

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PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway

Zhiqiang Han, Dongming Liu, Lu Chen, Yuchao He, Xiangdong Tian, Lisha Qi, Liwei Chen, Yi Luo, Ziye Chen, Xiaomeng Hu, Guangtao Li, Linlin Zhan, Yu Wang, Qiang Li, Peng Chen, Zhiyong Liu, Hua Guo,

<h4>Background: </h4> Some studies have reported that the activated ribosomes are positively associated with malignant tumors, especially in hepatocellular carcinoma (HCC). The RNA-binding protein PNO1, as a critical ribosome has been rarely reported in human tumors. Thus, the roles of PNO1 in HCC should be explored. Methods We collected ... Read more >>

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Preliminary clinical experience applying donor-derived cell-free DNA to discern rejection in pediatric liver transplant recipients.

Dong Zhao, Tao Zhou, Yi Luo, Cheng Wu, Dongwei Xu, Chengpeng Zhong, Wenming Cong, Qiang Liu, Jianjun Zhang, Qiang Xia,

Donor-derived cell-free DNA (dd-cfDNA) has been of major interest recently as a non-invasive marker of graft injury, but has not yet been extensively tested in children. From May to September in 2019, a total of 76 pediatric patients receiving a liver graft were enrolled and there were 27 patients excluded. ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):1138]

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Completion of the two-dose recombinant zoster vaccine series in adults 50 years and older.

Bradley Ackerson, Lei Qian, Lina S Sy, Katia Bruxvoort, Jun Wu, Yi Luo, John Diaz-Decaro, Carla Talarico, Hung Fu Tseng,

<h4>Background</h4>In 2017, a new adjuvanted recombinant zoster vaccine (RZV) was recommended for adults ≥50 years as two-dose series 2-6 months apart. We evaluated two-dose RZV completion and factors associated with completion.<h4>Methods</h4>The study included Kaiser Permanente Southern California members ≥50 years who received an RZV dose during April-November 2018 and had continuous membership 12 months ... Read more >>

Vaccine (Vaccine)
[2021, :]

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DNA methylation abnormalities of imprinted genes in congenital heart disease: a pilot study.

Shaoyan Chang, Yubo Wang, Yu Xin, Shuangxing Wang, Yi Luo, Li Wang, Hui Zhang, Jia Li,

<h4>Background</h4>Congenital heart disease (CHD) is resulted from the interaction of genetic aberration and environmental factors. Imprinted genes, which are regulated by epigenetic modifications, are essential for the normal embryonic development. However, the role of imprinted genes in the etiology of CHD remains unclear.<h4>Methods</h4>After the samples were treated with bisulfate salt, ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2021, 14(1):4]

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Precipitation events impact on urban lake surface water temperature under the perspective of macroscopic scale.

Kun Yang, Yan Zhang, Yi Luo, Chunxue Shang,

Lake surface water temperature (LSWT) is an important factor affecting a lake's ecological environment. In recent decades, LSWT worldwide has shown an increasing trend in the context of global climate change. This rising trend has been more evident in urban lakes. With the rapid development of urbanization, urban lakes are ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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The virome in early life and childhood and development of islet autoimmunity and type 1 diabetes: A systematic review and meta-analysis of observational studies.

Clare L Faulkner, Yi Xuan Luo, Sonia Isaacs, William D Rawlinson, Maria E Craig, Ki Wook Kim,

Viruses are postulated as primary candidate triggers of islet autoimmunity (IA) and type 1 diabetes (T1D), based on considerable epidemiological and experimental evidence. Recent studies have investigated the association between all viruses (the 'virome') and IA/T1D using metagenomic next-generation sequencing (mNGS). Current associations between the early life virome and the ... Read more >>

Rev Med Virol (Reviews in medical virology)
[2020, :e2209]

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High-Contrast Dynamic Reflecting System Based on Pneumatic Micro/Nanoscale Surface Morphing.

Yang Shen, Qiushun Zou, Bo Wan, Xiaoyi She, Runzhi You, Yi Luo, Chongjun Jin,

Cephalopods offer a fascinating dynamic reflecting system to create desired colors and patterns through contracting and releasing their soft skins in response to environmental stimuli. Inspired by this natural display strategy, we designed a novel dynamic reflecting system based on pneumatic micro/nanoscale surface morphing. This system consists of a thin ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, 13(1):1988-1999]

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DDIT4 is an Innate Protector in Psoriatic Keratinocytes and 1,25(OH)2D3 Exerts Anti-Psoriasis Through Promoting DDIT4 Inducing Macro-Autophagy and Proliferation Inhibition

Xiaojiao Zhang, Fuling Luo, Yi Luo, Jing Li, Jingyuan Wan, LI Hu, Hengguang Zhao,

Psoriasis vulgaris is a chronic inflammatory skin disorder. Its pathogenesis is now still unelucidated and the treatment is far from satisfied. DNA Damage-Inducible Transcript 4 (DDIT4) is a widely expressed protein in different tissue, which can activate cell macro-autophagy through mTORC1 passway. Vitamin D 3 and analogues is a classic ... Read more >>

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Angiotensin-converting enzyme inhibitors have adverse effects in anti-angiogenesis therapy for hepatocellular carcinoma.

Su Zhang, Manqing Cao, Zhenyu Hou, Xiaoying Gu, Yongzi Chen, Lu Chen, Yi Luo, Liwei Chen, Dongming Liu, Hongyuan Zhou, Keyun Zhu, Zhiwei Wang, Xihao Zhang, Xiaolin Zhu, Yunlong Cui, Huikai Li, Hua Guo, Ti Zhang,

At present, anti-angiogenic drugs (AADs) are widely used in the systemic treatment of hepatocellular carcinoma (HCC) or other types of cancer, and have achieved good anti-cancer effect, whereas treatment-related proteinuria can affect the routine use of AADs, which in turn abates the overall efficacy. Currently, most clinicians prescribe angiotensin-converting enzyme ... Read more >>

Cancer Lett (Cancer letters)
[2020, 501:147-161]

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Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD protein vaccine against COVID-19 in adults: pooled analysis of two randomized, double-blind, placebo-controlled, phase 1 and 2 trials

Shilong Yang, Yan Li, Lianpan Dai, Jianfeng Wang, Peng He, Changgui Li, Xin Fang, Chenfei Wang, Xiang Zhao, Enqi Huang, Changwei Wu, Zaixin Zhong, Fengze Wang, Xiaomin Duan, Siyu Tian, Lili Wu, Yan Liu, Yi Luo, Zhihai Chen, Fangjun Li, Junhua Li, Xian Yu, Hong Ren, Lihong Liu, Shufang Meng, Jinghua Yan, Zhongyu Hu, Lidong Gao, George Gao,

<h4>Summary</h4> <h4>Background</h4> A safe and effective coronavirus disease 2019 (COVID-19) vaccine is urgently needed to control the ongoing pandemic. Although progress has been made recently with several candidates reporting positive efficacy results, COVID-19 vaccines developed so far cannot meet the global vaccine demand. We developed a protein subunit vaccine against ... Read more >>

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Emotional Adaptation During A Crisis: Decline in Anxiety and Depression After the Initial Weeks of COVID-19 in the United States

Anastasia Shuster, Madeline O’Brien, Yi Luo, Matthew Heflin, Dongil Chung, Soojung Na, Ofer Perl, Kaustubh Kulkarni, Vincenzo Fiore, Xiaosi Gu,

<h4>Objective</h4> Crises such as the COVID-19 pandemic are known to exacerbate depression and anxiety, though their temporal trajectories remain unclear. The present study aims to investigate fluctuations in depression and anxiety using COVID-19 as a model crisis. <h4>Methods</h4> 1,512 adults living in the U.S. enrolled in this online study on ... Read more >>

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pH-Dependent Morphology Control of Cellulose Nanofiber/Graphene Oxide Cryogels.

Zheng-Ze Pan, Aleksandra Govedarica, Hirotomo Nishihara, Rui Tang, Cong Wang, Yi Luo, Wei Lv, Fei-Yu Kang, Milana Trifkovic, Quan-Hong Yang,

The precise control of the ice crystal growth during a freezing process is of essential importance for achieving porous cryogels with desired architectures. The present work reports a systematic study on the achievement of multi-structural cryogels from a binary dispersion containing 50 wt% 2,2,6,6-tetramethylpiperidin-1-oxyl, radical-mediated oxidized cellulose nanofibers (TOCNs), and ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2021, 17(3):e2005564]

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Autoimmunity to urothelial antigen causes bladder inflammation, pelvic pain and voiding dysfunction: a novel animal model for Hunner type interstitial cystitis.

Yoshiyuki Akiyama, Jian-Rong Yao, Karl J Kreder, Michael A O'Donnell, Susan K Lutgendorf, Dan Lyu, Daichi Maeda, Haruki Kume, Yukio Homma, Yi Luo,

Recent evidence revealed that Hunner type interstitial cystitis (HIC) is a robust inflammatory disease potentially associated with enhanced immune responses and histologically characterized by epithelial denudation and lymphoplasmacytic infiltration with frequent clonal expansion of infiltrating B cells. To date, few animal models that reproduce the histological and clinical correlates of ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2020, :]

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Evaluation of serum hepatic enzyme activities in different COVID-19 phenotypes.

Fan-Lu Liao, Ding-Hui Peng, Wei Chen, Han-Ning Hu, Peng Tang, Yan-Yuan Liu, Yi Luo, Tao Yao,

Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease. Our understanding of the clinical characteristics of liver damage and the relationship with disease severity in COVID-19 is still limited. To investigate the serum hepatic enzyme activities in different phenotypes of COVID-19 patients, evaluate their relationship with the illness severity ... Read more >>

J Med Virol (Journal of medical virology)
[2020, :]

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Emotional Adaptation During a Crisis: Decline in Anxiety and Depression after the Initial Weeks of COVID-19 in the United States

Anastasia Shuster, Madeline O’Brien, Yi Luo, Matthew Heflin, Dongil Chung, Soojung Na, Ofer Perl, Kaustubh Kulkarni, Vincenzo Fiore, Xiaosi Gu,

Background: Crises such as the COVID-19 pandemic are known to exacerbate mental health issues such as depression and anxiety. The temporal trajectories of depression and anxiety under crises, however, remain unclear.<br><br>Methods: 1,512 adults living in the U.S. enrolled in this online study on April 2nd, 2020 ... Read more >>

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Anti-Stem Cell Property of Pterostilbene in Gastrointestinal Cancer Cells.

Shiori Mori, Shingo Kishi, Kanya Honoki, Rina Fujiwara-Tani, Takuma Moriguchi, Takamitsu Sasaki, Kiyomu Fujii, Shinji Tsukamoto, Hiromasa Fujii, Akira Kido, Yasuhito Tanaka, Yi Luo, Hiroki Kuniyasu,

Pterostilbene (PTE) is a natural sterbenoid contained in blueberries that has an antioxidant effect. In contrast, PTE also generates oxidative stress in cancer cells and provides an antitumor effect. Here, we examined the potential mechanism of this contrasting effect of PTE using three gastrointestinal cancer cell lines, namely CT26, HT29, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(24):]

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Cornel Iridoid Glycoside Suppresses Hyperactivity Phenotype in rTg4510 Mice through Reducing Tau Pathology and Improving Synaptic Dysfunction.

Deng-Lei Ma, Yi Luo, Rui Huang, Zi-Run Zhao, Li Zhang, Ya-Li Li, Qi Wang, Lin Li, Lan Zhang,

rTg4510 mice are transgenic mice expressing P301L mutant tau and have been developed as an animal model of tauopathies including Alzheimer's disease (AD). Besides cognitive impairments, rTg4510 mice also show abnormal hyperactivity behavior. Cornel iridoid glycoside (CIG) is an active ingredient extracted from Cornus officinalis, a traditional Chinese herb. The ... Read more >>

Curr Med Sci (Current medical science)
[2020, 40(6):1031-1039]

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Cornel Iridoid Glycoside Regulates Modification of Tau and Alleviates Synaptic Abnormalities in Aged P301S Mice.

Cui-Cui Yang, Yi Luo, Kai-Wen Guo, Ceng-Ceng Zheng, Lin Li, Lan Zhang,

Alzheimer's disease (AD), also defined as a tauopathology, is a common neurodegenerative disease. Hyper-phosphorylation, cleavage or truncation, and aggregation of tau contribute to AD. Thus, targeting the post-translational modifications on tau may be a therapeutic strategy to treat AD. This study understood how cornel iridoid glycoside (CIG) affects tau post-translational ... Read more >>

Curr Med Sci (Current medical science)
[2020, 40(6):1040-1046]

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Novel biomarkers for the prediction of COVID-19 progression a retrospective, multi-center cohort study.

Yalan Yu, Tao Liu, Liang Shao, Xinyi Li, Colin K He, Muhammad Jamal, Yi Luo, Yingying Wang, Yanan Liu, Yufeng Shang, Yunbao Pan, Xinghuan Wang, Fuling Zhou,

A pandemic designated as Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading worldwide. Up to date, there is no efficient biomarker for the timely prediction of the disease progression in patients. To analyze the inflammatory profiles of COVID-19 patients and demonstrate their implications ... Read more >>

Virulence (Virulence)
[2020, 11(1):1569-1581]

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Perfect Impedance Matching with Meta-Surfaces Made of Ultra-Thin Metal Films: A Phenomenological Approach to the Ideal THz Sensors.

Binglei Zhang, Yang Liu, Yi Luo, Feodor V Kusmartsev, Anna Kusmartseva,

The terahertz (THz) frequency range is incredibly important as it covers electromagnetic emissions typical for biological and molecular processes. All molecules emit THz waves in a unique fingerprint pattern, although the intensity of such signals is usually too weak to be detected. To address the efficiency gap in existing THz ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2020, 13(23):]

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Serum-soluble ST2 as a novel biomarker reflecting inflammatory status and illness severity in patients with COVID-19.

Zhikun Zeng, Xiao-Yue Hong, Yunhui Li, Wei Chen, Guangming Ye, Yirong Li, Yi Luo,

<b>Aim:</b> The authors studied the role of soluble ST2 (sST2) in COVID-19 and its relationship with inflammatory status and disease severity. <b>Materials & methods:</b> Serum levels of sST2 and interleukin (IL)-33, C-reactive protein (CRP), serum amyloid protein (SAA), IL-6 and procalcitonin (PCT), and T lymphocyte subsets from 80 subjects diagnosed ... Read more >>

Biomark Med (Biomarkers in medicine)
[2020, 14(17):1619-1629]

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