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Author Yi Huang

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Deep Learning Without Neural Networks: Fractal-nets for Rare Event Modeling

Ishanu Chattopadhyay, Yi Huang, James Evans,

Abstract Complex phenomena of societal interest such as weather, seismic activity and urban crime, are often punctuated by rare and extreme events, which are difficult to model and predict. Evidence of long-range persistence of such events has underscored the need to learn deep stochastic structures in data for effective forecasts. ... Read more >>

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DNA methylation of AHCY may increase the risk of ischemic stroke.

Lei Zhao, Xiaosheng Chen, Shengjun Zhou, Zhiqing Lin, Xi Yu, Yi Huang,

Genetic factors play an important role in the pathogenesis of ischemic stroke. Of these, epigenetic modifications provide a new direction for the study of ischemic stroke pathogenesis. This study aimed to determine the correlation between DNA methylation of the gene encoding S-adenosylhomocysteine hydrolase (AHCY) and the risk of ischemic stroke ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):471-476]

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Global trend of diabetes mortality attributed to vascular complications, 2000-2016.

Wei Ling, Yi Huang, Yan-Mei Huang, Rong-Rong Fan, Yi Sui, Hai-Lu Zhao,

BACKGROUND:The global epidemic of diabetes mellitus continues to grow and affects developed and developing countries alike. Intensive glycemic control is thought to modify the risks for vascular complications, hence the risks for diabetes-related death. We investigated the trend of diabetic vascular complication-related deaths between 2000 and 2016 in the global ... Read more >>

Cardiovasc Diabetol (Cardiovascular diabetology)
[2020, 19(1):182]

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SHCBP1 interacting with  EOGT enhanced O-GlcNAcylation of NOTCH1 and promoted the development of pancreatic cancer .

Can Yang, Jianfei Hu, Qian Zhan, Zu-Wei Wang, Ge Li, Jing-Jing Pan, Long Huang, Cheng-Yu Liao, Yi Huang, Yi-Feng Tian, Bai-Yong Shen, Jiang-Zhi Chen, Yao-Dong Wang, Shi Chen,

Abstract Background: Pancreatic cancer(PDAC) remains one of the most lethal cancers worldwide, The accumulation of many abnormal epigenetic abnormalities contribute to the fatal prognosis of PDAC,While available studies are still limited. Many studies have confirmed that the Shc SH2-domain binding protein 1(SHCBP1) plays as proto-oncogene in cancers. However, whether SHCBP1 ... Read more >>

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Establishment of an immune-related gene pair model to predict colon adenocarcinoma prognosis

Jihang Luo, Puyu Liu, Leibo Wang, Yi Huang, Yuanyan Wang, Wenjing Geng, Duo Chen, Yuju Bai, Ze Yang,

Abstract Background. Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported the correlation between the prognosis of COAD and the immune system. The current study aimed to ... Read more >>

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Collagen proportionate area predicts clinical outcomes in patients with alcohol-related liver disease.

Mads Israelsen, Marta Guerrero Misas, Anastasios Koutsoumourakis, Yi Huang, Maja Thiele, Andrew Hall, Ditlev Rasmussen, Claudia Covelli, Elena Buzzetti, Laura Iogna Prat, Davide Roccarina, Sönke Detlefsen, Tu Vinh Luong, Alberto Quaglia, Aleksander Krag, Gary Jeffrey, Massimo Pinzani, Emmanuel A Tsochatzis,

BACKGROUND:No prognostic tools are established for alcohol-related liver disease (ALD). Collagen proportionate area (CPA) measurement is a technique that quantifies fibrous tissue in liver biopsies using digital image analysis. AIM:To assess the predictive value of CPA on hepatic decompensation and liver-related mortality in ALD METHODS: In a multicentre cohort study, ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2020, :]

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Overexpression of GmMYB14 improves high-density yield and drought tolerance through regulating plant architecture mediated by the brassinosteroid pathway.

Limiao Chen, Hongli Yang, Yisheng Fang, Wei Guo, Haifeng Chen, Xiaojuan Zhang, Wenjun Dai, Shuilian Chen, Qingnan Hao, Songli Yuan, Chanjuan Zhang, Yi Huang, Zhihui Shan, Zhonglu Yang, Dezhen Qiu, Xiaorong Liu, Lam-Son Phan Tran, Xinan Zhou, Dong Cao,

MYB transcription factors (TFs) have been reported to regulate the biosynthesis of secondary metabolites, as well as to mediate plant adaption to abiotic stresses, including drought. However, the roles of MYB TFs in regulating plant architecture and yield potential remain poorly understood. Here, we studied the roles of the dehydration-inducible ... Read more >>

Plant Biotechnol J (Plant biotechnology journal)
[2020, :]

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Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients.

Jun Wang, Hongliang Zhang, Xin Sun, Xiaofang Wang, Tingting Ren, Yi Huang, Ranxin Zhang, Bingxin Zheng, Wei Guo,

BACKGROUND:Recent studies indicated that exosomal programmed death-ligand 1 (PD-L1) derived from cancers could induce immunosuppression and tumor pathogenesis. However, it is unclear how exosomes influence osteosarcoma (OS) progression and whether PD-L1 also exists in serum exosomes (Sr-exosomes) of patients with osteosarcoma. We examined serum exosomes from 70 OS patients, 9 ... Read more >>

J Nanobiotechnology (Journal of nanobiotechnology)
[2020, 18(1):151]

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Effect of guideline education on the attitude toward issues in terms of adult community-acquired pneumonia and emphasis of future training programs: a nationwide survey for Chinese physicians in 2018.

Jing Zhang, Wei-Ping Hu, Yi Huang, Jie-Ming Qu, ,

Chin Med J (Engl) (Chinese medical journal)
[2020, :]

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Seeking the "Beauty Center" in the Brain: A Meta-Analysis of fMRI Studies of Beautiful Human Faces and Visual Art.

Hu Chuan-Peng, Yi Huang, Simon B Eickhoff, Kaiping Peng, Jie Sui,

During the past two decades, cognitive neuroscientists have sought to elucidate the common neural basis of the experience of beauty. Still, empirical evidence for such common neural basis of different forms of beauty is not conclusive. To address this question, we performed an activation likelihood estimation (ALE) meta-analysis on the ... Read more >>

Cogn Affect Behav Neurosci (Cognitive, affective & behavioral neuroscience)
[2020, :]

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Glutaminase inhibitors induce thiol-mediated oxidative stress and radio-sensitization in treatment resistant cervical cancers.

Ramachandran Rashmi, Kay Jayachandran, Jin Zhang, Vishnu Menon, Naoshad Muhammad, Michael Zahner, Fiona Ruiz, Sisi Zhang, Kevin Cho, Yuting Wang, Xiaojing Huang, Yi Huang, Michael L McCormick, Buck E Rogers, Douglas R Spitz, Gary J Patti, Julie K Schwarz,

The purpose of the study was to determine if radiation resistant cervical cancers are dependent upon glutamine metabolism driven by activation of the PI3K pathway and test whether PI3K pathway mutation predicts radio-sensitization by inhibition of glutamine metabolism. Cervical cancer cell lines with and without PI3K pathway mutations, including SiHa ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2020, :]

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Transpedicular Bi-vertebrae Wedge Osteotomy in Treatment of Post-tubercular Spinal Deformity: A Retrospective Study

Yi HUANG, Wenhao HU, Jing LI, Tianhao WANG, Huawei LIU, Guoquan ZHENG, Xuesong ZHANG, Yan WANG,

Abstract Background: In the late stage of spinal tuberculosis, the bony destruction and vertebral collapse often leads to significant kyphosis, presenting clinically as a painful gibbus deformity, with increased instability, vertebral body translations and increased risk of neurologic involvement. Spinal osteotomy is thought to be suitable for most patients with ... Read more >>

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MiR-26a targets EphA2 to resist intracellular Listeria monocytogenes in macrophages.

Jiale Zhang, Jiangbei Yuan, Liting Wang, Zihan Zheng, Haiying Ran, Fang Liu, Fei Li, Xiangyu Tang, Junying Zhang, Qingshan Ni, Liyun Zou, Yi Huang, Shanshan Feng, Xuefeng Xia, Ying Wan,

At infection sites, macrophages are sentinels that resist and destroy various pathogens, through direct phagocytosis. In macrophages, microRNAs play a variety of crucial roles, the most striking of which is the regulation of the ability of the host cell to resist infection. However, the underlying mechanisms associated with the anti-infection ... Read more >>

Mol Immunol (Molecular immunology)
[2020, 128:69-78]

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Ultrafine NiFe clusters anchored on N-doped carbon as bifunctional electrocatalysts for efficient water and urea oxidation.

Jingfang Zhang, Fei Xing, Hongjuan Zhang, Yi Huang,

Hydrogen production through electrocatalysis is crucial in renewable energy technologies but significantly impeded by sluggish anodic reactions. Developing bifunctional anode noble-metal-free electrocatalysts towards oxygen evolution reaction (OER) and urea oxidation reaction (UOR) to boost cathodic hydrogen evolution reaction (HER) is promising but challenging to meet different reaction media and multiple ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2020, 49(40):13962-13969]

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Cognitive basis for the development of aesthetic preference: Findings from symmetry preference.

Yi Huang, Jinyun Lyu, Xiaodi Xue, Kaiping Peng,

Where is the visual aesthetic preference rooted from and what's its relationship with the perceptual preference that is emerging early? Do young children naturally prefer some visual stimuli or do they learn to appreciate visual stimuli for aesthetic pleasure? Here, for young preschool children who are on the age that ... Read more >>

PLoS One (PloS one)
[2020, 15(10):e0239973]

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Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside.

Darleny Y Lizardo, Chaoyuan Kuang, Suisui Hao, Jian Yu, Yi Huang, Lin Zhang,

Colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite instability-high (MSI-H) often have sustained responses to immune checkpoint inhibitors (ICIs) including selective monoclonal antibodies against Program Death 1 (PD-1), Programmed Death Ligand 1(PD-L1), and cytotoxic T lymphocyte associated antigen 4 (CTLA-4). However, a substantial fraction of dMMR CRCs do ... Read more >>

Biochim Biophys Acta Rev Cancer (Biochimica et biophysica acta. Reviews on cancer)
[2020, 1874(2):188447]

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The performance of 3D bioscaffolding based on a human periodontal ligament stem cell printing technique.

Yinping Tian, Minyi Liu, Yaoyao Liu, Changzheng Shi, Yayu Wang, Tong Liu, Yi Huang, Peihua Zhong, Jian Dai, Xiangning Liu,

Bone tissue plays an important role in supporting and protecting the structure and function of the human body. Bone defects are a common source of injury and there are many reconstruction challenges in clinical practice. However, 3D bioprinting of scaffolds provides a promising solution. Hydrogels have emerged as biomaterials with ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2020, :]

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Pancreatic Angiopathy Associated With Islet Amyloid and Type 2 Diabetes Mellitus.

Wei Ling, Yi Huang, Yan-Mei Huang, Jian Shen, Shan-Huan Wang, Hai-Lu Zhao,

OBJECTIVES:Type 2 diabetes (T2D) is histopathologically characterized by islet amyloid and is closely connected with vascular complications. Here, we explore the presence of pancreatic angiopathy (PA) associated with islet amyloid and T2D. METHODS:From a total of 172 autopsy cases who had a history of T2D diagnosis, we randomly selected 30 ... Read more >>

Pancreas (Pancreas)
[2020, 49(9):1232-1239]

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The Relationship of Previous Breastfeeding Experiences and Factors Affecting Breastfeeding Rates: A Follow-Up Study.

Jun-Yan Li, Yi Huang, Hao-Qi Liu, Jing Xu, Lu Li, Sharon R Redding, Yan-Qiong Ouyang,

Background/Objective: Many studies have focused on the effects of previous breastfeeding experience (PBE) on subsequent breastfeeding, but few have explored their specific relationships. To explain the relationship between PBE and subsequent breastfeeding behavior based on a follow-up study. Materials and Methods: After delivery, 394 participants who had no PBE completed ... Read more >>

Breastfeed Med (Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine)
[2020, :]

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Obesity in patients with COVID-19: a systematic review and meta-analysis

Yi Huang, Yao Lu, Yan-Mei Huang, Min Wang, Wei Ling, Yi Sui, Hai-Lu Zhao,

Background Obesity is common in patients with coronavirus disease 2019 (COVID-19). The effects of obesity on clinical outcomes of COVID-19 warrant systematical investigation. Objective This study explores the effects of obesity with the risk of severe disease among patients with COVID-19. Methods Body mass index (BMI) and degree of visceral ... Read more >>

Metabolism (Metabolism: clinical and experimental)
[2020, 113:154378-154378]

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Assessments on Sustainability Potential by Upgrade of Existing Heritage Buildings: a case study of Liyuan Courtyard in Qingdao, China

Yi Huang, Yufan Xiao, Fan Yu,

Abstract Background: The existing heritage buildings are considered as symbols of the original spirit of a city, which also contains vitality and resilience through centuries. In Qingdao, the Liyuan courtyard styles are still existed as a very regional and representative colonial residential architecture form in the urban development history from ... Read more >>

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Liquid biopsy for ALK-positive early non-small-cell lung cancer predicts disease relapse.

Ji Li, Wen Dong, Li Na Liu, Yi Jiang Huang, Mei Fang Xiao,

Background: We aimed to determine whether circulating tumor cells (CTCs) and cell-free DNA (cfDNA) aids in prognosis of relapse-free survival (RFS). Methods: Non-small cell lung cancer patients with ALK mutations were recruited prospectively. CTCs and cfDNA were quantified at different time points. RFS was estimated and correlated. Results: Baseline median CTCs and ... Read more >>

Future Oncol (Future oncology (London, England))
[2020, :]

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Obesity in patients with COVID-19: a systematic review and meta-analysis.

Yi Huang, Yao Lu, Yan-Mei Huang, Min Wang, Wei Ling, Yi Sui, Hai-Lu Zhao,

BACKGROUND:Obesity is common in patients with coronavirus disease 2019 (COVID-19). The effects of obesity on clinical outcomes of COVID-19 warrant systematical investigation. OBJECTIVE:This study explores the effects of obesity with the risk of severe disease among patients with COVID-19. METHODS:Body mass index (BMI) and degree of visceral adipose tissue (VAT) ... Read more >>

Metabolism (Metabolism: clinical and experimental)
[2020, 113:154378]

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Pituitary Adenylate Cyclase-Activating Polypeptide Attenuates Brain Edema by Protecting Blood-Brain Barrier and Glymphatic System After Subarachnoid Hemorrhage in Rats.

Yuanjian Fang, Hui Shi, Reng Ren, Lei Huang, Takeshi Okada, Cameron Lenahan, Marcin Gamdzyk, Zachary D Travis, Qin Lu, Lihui Tang, Yi Huang, Keren Zhou, Jiping Tang, Jianmin Zhang, John H Zhang,

Brain edema is a vital contributor to early brain injury after subarachnoid hemorrhage (SAH), which is responsible for prolonged hospitalization and poor outcomes. Pharmacological therapeutic targets on edema formation have been the focus of research for decades. Pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to participate in neural development ... Read more >>

Neurotherapeutics (Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics)
[2020, :]

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Blue Light Induced Photopolymerization and Cross-Linking Kinetics of Poly(acrylamide) Hydrogels.

Guangdong Sun, Yi Huang, Dapeng Li, Qinguo Fan, Jin Xu, Jianzhong Shao,

Blue light induced photopolymerization and photo-cross-linking kinetics of acrylamide (AM), with camphorquinone/diphenyl iodonium hexafluorophosphate (CQ/DPI) as photoinitiators, were investigated. The effects of a number of parameters, including mass fraction of CQ, DPI, and AM (wCQ, wDPI, and wAM) and light intensity (I), on photopolymerization efficiency and photogelation process were systematically ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2020, 36(39):11676-11684]

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