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Identification and validation of the miRNA-mRNA regulatory network in fetoplacental arterial endothelial cells of gestational diabetes mellitus.

Longkai He, Xiaotong Wang, Ya Jin, Weipeng Xu, Yi Guan, Jingchao Wu, Shasha Han, Guosheng Liu,

Gestational diabetes mellitus (GDM) increases the risk of fetal heart malformations, though little is known about the mechanism of hyperglycemia-induced heart malformations. Thus, we aimed to reveal the global landscape of miRNAs and mRNAs in GDM-exposed fetoplacental arterial endothelial cells (dAECs) and establish regulatory networks for exploring the pathophysiological mechanism ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3503-3515]

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Genome-Wide Lymphocytic mRNA Sequencing to Identify Epithelial-Mesenchymal Transition Mechanism in Silicosis

Hai bin Li, Lin Zhang, Yi Guan, Yingzheng Zhao, Ning Li, Nan Liu, Yongheng Wang, Xuezhe Si, Hao Xu, Zhihao Lv, Weidong Wu, Sanqiao Yao,

<h4>Background: </h4> Lymphocytes are immune cells that play dual roles in the pathogenesis of silicosis. Epithelial-mesenchymal transition (EMT), a vital phenomenon in the pathogenesis of silicosis, is regulated by cytokines, chemokines, and other molecules secreted by lymphocytes; however, the underlying regulatory mechanism is unclear. Here, we investigated the role of ... Read more >>

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Occurrence of Sclerotinia sclerotiorum causing Sclerotinia root rot on American ginseng in northeastern China.

Yi Ming Guan, Ying Ying Ma, Lin Lin Zhang, Xiao Xi Pan, Ning Liu, Qiu Xia Wang, Ya Yu Zhang,

American ginseng (<i>Panax quinquefolium</i>) is a valuable medicinal plant that is commercially cultivated in China. In May 2020, <i>Sclerotinia</i> root rot of American ginseng was observed on 4-year-old plants in Fusong County in northeastern China, which is the most important part of the country for American ginseng cultivation. The pathogen ... Read more >>

Plant Dis (Plant disease)
[2021, :]

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Association of the tissue microstructural diffusivity and translocator protein PET in Gulf War Illness.

Chia-Hsin Cheng, Zeynab Alshelh, Yi Guan, Kimberly Sullivan, Marco L Loggia, Bang-Bon Koo,

About a third of all United States veterans who served in the 1991 Gulf War (GW) report a range of chronic health symptoms including fatigue, neurocognitive symptoms, and musculoskeletal pain. There is growing evidence supporting the detrimental effects of maladaptive neuroimmune reactions in this multi-symptom illness. Indeed, recent studies using ... Read more >>

Brain Behav Immun Health (Brain, behavior, & immunity - health)
[2021, 18:100364]

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Elevation of Fatty Acid Biosynthesis Metabolism Contributes to Zhongshengmycin Resistance in Xanthomonas oryzae.

Qiaoxing Wang, Meiyun Lin, Peihua Shen, Yi Guan,

<i>Xanthomonas oryzae</i> severely impacts the yield and quality of rice. Antibiotics are the most common control measure for this pathogen; however, the overuse of antibiotics in past decades has caused bacterial resistance to these antibiotics. The agricultural context is of particular importance as antibiotic-resistant bacteria are prevalent, but the resistance ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2021, 10(10):]

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Investigation of pharmacological mechanism of natural product using pathway fingerprints similarity based on "drug-target-pathway" heterogenous network.

Feifei Guo, Chunhong Jiang, Yujie Xi, Dan Wang, Yi Zhang, Ning Xie, Yi Guan, Fangbo Zhang, Hongjun Yang,

Natural products from traditional medicine inherit bioactivity from their source herbs. However, the pharmacological mechanism of natural products is often unclear and studied insufficiently. Pathway fingerprint similarity based on "drug-target-pathway" heterogeneous network provides new insight into Mechanism of Action (MoA) for natural products compared with reference drugs, which are selected ... Read more >>

J Cheminform (Journal of cheminformatics)
[2021, 13(1):68]

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Screening and Identification of Potential Biomarkers Associated with Cutaneous Squamous Cell Carcinoma

Wenxing Su, Biao Huang, Qingyi Zhang, Wei Han, Lu An, Yi Guan, jiang ji, Daojiang Yu,

Cutaneous squamous cell carcinoma (cSCC) is the leading cause of death in patients with non-melanoma skin cancers (NMSC). However, unclear pathogenesis of cSCC limits the application of molecular targeted therapy. We downloaded three microarray data (GSE2503, GSE45164 and GSE66359) from Gene Expression Omnibus (GEO) and screened out their common difference ... Read more >>

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Dexamethasone Ameliorates Severe Pneumonia But Slightly Enhances Viral Replication in Lung of SARS-CoV-2-Infected Syrian Hamster

Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma, Peiwen Chen, Xuan Liu, Kun Wu, Rirong Chen, Qiwei Liu, Wanheng Hou, Quan Yuan, Qiyi Tang, Tong Cheng, Yi Guan, Ningshao Xia,

Background: The pandemic of SARS-CoV-2 has turned into a global public health crisis. Acute SARS-CoV-2 infection is associated with severe pneumonia, multiple-organ failures and deaths. Currently, treatment for SARS-CoV-2 infection and severe pneumonia is largely lacking. Several clinical trials demonstrated that glucocorticoid dexamethasone is effective to reduce disease severity and ... Read more >>

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Nucleoporin 50 mediates Kcna4 transcription to regulate cardiac electrical activity.

Xueting Gao, Shuai Yu, Yi Guan, Yunli Shen, Liang Xu,

Emerging evidence has demonstrated that nucleoporins (Nups) play a pivotal role in cell-type-specific gene regulation, but how they control the expression and activity of ion channel genes in the heart remains unclear. Here, we show that Nup50, which is localized in the nucleus of cardiomyocytes, selectively induces an increase in ... Read more >>

J Cell Sci (Journal of cell science)
[2021, 134(18):]

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A Prognostic Nomogram for Predicting Overall Survival in Pediatric Wilms Tumor Based on an Autophagy-related Gene Signature.

Longkai He, Xiaotong Wang, Ya Jin, Weipeng Xu, Jun Lyu, Yi Guan, Jingchao Wu, Shasha Han, Guosheng Liu,

<h4>Background</h4>Wilms tumor (WT) is the most common primary renal malignancy in children. Autophagy plays dual roles in the promotion and suppression of various cancers.<h4>Objective</h4>The goal of our study was to develop a novel autophagy-related gene (ARG) prognostic nomogram for WT.<h4>Methods</h4>The Cancer Genome Atlas (TCGA) database was used. We screened the ... Read more >>

Comb Chem High Throughput Screen (Combinatorial chemistry & high throughput screening)
[2021, :]

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De-ubiquitination of SAMHD1 by USP7 overcomes oncogenic stress and contributes to chemotherapy insensitivity

Jingwei Liu, Tingting Zhou, xiang dong, Qiqiang Guo, Lixia Zheng, Xiaoxun Wang, Naijin Zhang, Li Danni, Ling Ren, Fei Yi, Ying Zhang, Zi-wei Li, Xi-wen Wang, chengsi deng, Chunlu Li, Hongde Xu, Yi Guan, Xiaoman Li, Yang Yu, Wendong Guo, Zhuo Wang, Bo Jiang, Xuan Wu, Ning Bai, Yanling Feng, Mengtao Ma, Qingquan Kong, Jiayi Wei, Zhenshuang Wang, Hao Li, Xiaoyu Song, Chengzhong Xing, Liu Cao,

Oncogenic stress induces DNA damage response (DDR) that guards against genetic instability during the evolution of cancer. SAMHD1, a dNTPase protecting cells from viral infections, has been recently found to participate in DNA damage repair process. However, its role in tumorigenesis remains largely unknown. Here, we show that SAMHD1 is ... Read more >>

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A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters.

Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hualong Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingjing Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, Minping Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yunda Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Qingbing Zheng, Shaowei Li, Yixin Chen, Tong Cheng, Jun Zhang, Tianying Zhang, Huachen Zhu, Qinjian Zhao, Quan Yuan, Yi Guan, Ningshao Xia,

Multiple safe and effective vaccines that elicit immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are necessary to respond to the ongoing coronavirus disease 2019 (COVID-19) pandemic. Here, we developed a protein subunit vaccine composed of spike ectodomain protein (StriFK) plus a nitrogen bisphosphonate-modified zinc-aluminum hybrid adjuvant (FH002C). ... Read more >>

Sci Transl Med (Science translational medicine)
[2021, 13(606):]

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Occurrence of postharvest snow rot caused by Sclerotinia nivalis on Asian ginseng in China.

Yi Ming Guan, Ying Ying Ma, Lin Lin Zhang, Zhengbo Liu, Ning Liu, Qiu Xia Wang, Ya Yu Zhang,

Asian ginseng (<i>Panax ginseng</i>) is a valuable medicinal plant that is commercially cultivated in China. A long postharvest storage period is required before ginseng is processed. From October 2019 to May 2020, snow rot was observed on the roots of 4- and 5-year-old fresh ginseng stored in three cold storage ... Read more >>

Plant Dis (Plant disease)
[2021, :]

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Regional Brain Volumes As Mediators of the Association Between Circulating Omega-3 Fatty Acids and Cognitive Function: The Boston Puerto Rican Health Study

Sherman Bigornia, Guan Yi, Bang-Bon Kim, Xiyuan Zhang, Tammy Scott, Rafeeque Bhadelia, Katherine Tucker,

Abstract <h4>Objectives</h4> To assess the mediating role of regional brain volume in the relationship between circulating very-long-chain omega-3 fatty acids and global cognitive function. <h4>Methods</h4> Data are from individuals of the Boston Puerto Rican Health Study with a T1-weighted MRI brain scan available approximately 8 y from the baseline visit ... Read more >>

Curr Dev Nutr (Current developments in nutrition)
[2021, 5(Suppl 2):1014-1014]

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First Report of Anthracnose of American Ginseng caused by Colletotrichum sojae in Northeast China.

Yi Ming Guan, Lin Lin Zhang, Ying Ying Ma, Yue Zhang, Ya Yu Zhang,

American ginseng (<i>Panax quinquefolium</i>) is a medicinal plant that is commercially cultivated in China. Anthracnose is a devastating disease of American ginseng, with annual production losses exceeding 20%. In July 2019, anthracnose of American ginseng was observed on 3-year-old plants in Fusong County, Jilin Province, China, the most important region ... Read more >>

Plant Dis (Plant disease)
[2021, :]

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Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition.

George Sharbeen, Joshua A McCarroll, Anouschka Akerman, Chantal Kopecky, Janet Youkhana, John Kokkinos, Jeff Holst, Cyrille Boyer, Mert Erkan, David Goldstein, Paul Timpson, Thomas R Cox, Brooke A Pereira, Jessica L Chitty, Sigrid K Fey, Arafath K Najumudeen, Andrew D Campbell, Owen J Sansom, Rosa Mistica C Ignacio, Stephanie Naim, Jie Liu, Nelson Russia, Julia Lee, Angela Chou, Amber Johns, Anthony J Gill, Estrella Gonzales-Aloy, Val Gebski, Yi Fang Guan, Marina Pajic, Nigel Turner, Minoti V Apte, Thomas P Davis, Jennifer P Morton, Koroush S Haghighi, Jorjina Kasparian, Benjamin J McLean, Yordanos F Setargew, Phoebe A Phillips, ,

Cancer-associated fibroblasts (CAF) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression through protumor signaling and the generation of fibrosis, the latter of which creates a physical barrier to drugs. CAF inhibition is thus an ideal component of any therapeutic approach for PDAC. SLC7A11 is a cystine transporter that has ... Read more >>

Cancer Res (Cancer research)
[2021, 81(13):3461-3479]

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Clinical decision-making framework against over-testing based on modeling implicit evaluation criteria.

Yang Yang, Hongxing Huo, Jingchi Jiang, Xuemei Sun, Yi Guan, Xitong Guo, Xiang Wan, Shengping Liu,

Different statistical methods include various subjective criteria that can prevent over-testing. However, no unified framework that defines generalized objective criteria for various diseases is available to determine the appropriateness of diagnostic tests recommended by doctors. We present the clinical decision-making framework against over-testing based on modeling the implicit evaluation criteria ... Read more >>

J Biomed Inform (Journal of biomedical informatics)
[2021, 119:103823]

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Alignment free sequence comparison methods and reservoir host prediction.

Bill Lee, David K Smith, Yi Guan,

<h4>Motivation</h4>The emergence and subsequent pandemic of the SARS-CoV-2 virus raised urgent questions about its origin and, particularly, its reservoir host. These types of questions are long-standing problems in the management of emerging infectious diseases and are linked to virus discovery programs and the prediction of viruses that are likely to ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2021, :]

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RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease.

Amy C Mandigo, Wei Yuan, Kexin Xu, Peter Gallagher, Angel Pang, Yi Fang Guan, Ayesha A Shafi, Chellappagounder Thangavel, Beshara Sheehan, Denisa Bogdan, Alec Paschalis, Jennifer J McCann, Talya S Laufer, Nicolas Gordon, Irina A Vasilevskaya, Emanuela Dylgjeri, Saswati N Chand, Matthew J Schiewer, Josep Domingo-Domenech, Robert B Den, Jeff Holst, Peter A McCue, Johann S de Bono, Christopher McNair, Karen E Knudsen,

Loss of the retinoblastoma (RB) tumor suppressor protein is a critical step in reprogramming biological networks that drive cancer progression, although mechanistic insight has been largely limited to the impact of RB loss on cell-cycle regulation. Here, isogenic modeling of RB loss identified disease stage-specific rewiring of E2F1 function, providing ... Read more >>

Cancer Discov (Cancer discovery)
[2021, 11(9):2334-2353]

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Dsk2 involves in conidiation, multi-stress tolerance and thermal adaptation in Beauveria bassiana.

Dingyi Wang, Chao Lv, Yi Guan, Xiangyin Ni, Fuzhong Wu,

Dsk2 is a nuclear-enriched ubiquitin-like polyubiquitin-binding protein that regulates protein degradation in yeast but has not been explored yet in filamentous fungi, such as Beauveria bassiana. Here, we report Beauveria bassiana Dsk2 located both in the nucleus and in cytoplasm of hyphal cells. Deletion of Dsk2 resulted in mild growth ... Read more >>

Environ Microbiol Rep (Environmental microbiology reports)
[2021, 13(3):384-393]

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Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth.

Qian Wang, Yi Fang Guan, Sarah E Hancock, Kanu Wahi, Michelle van Geldermalsen, Blake K Zhang, Angel Pang, Rajini Nagarajah, Blossom Mak, Natasha Freidman, Lisa G Horvath, Nigel Turner, Jeff Holst,

Glutamine is a critical nutrient in cancer; however, its contribution to purine metabolism in prostate cancer has not previously been determined. Guanosine monophosphate synthetase (GMPS) acts in the de novo purine biosynthesis pathway, utilizing a glutamine amide to synthesize the guanine nucleotide. This study demonstrates that GMPS mRNA expression correlates ... Read more >>

J Pathol (The Journal of pathology)
[2021, 254(2):135-146]

Cited: 3 times

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Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster.

Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma, Rirong Chen, Yao Chen, Liqiang Chen, Kun Wu, Minping Cai, Junping Hong, Lifeng Li, Che Liu, Huan Yu, Yali Zhang, Jia Wang, Tianying Zhang, Shengxiang Ge, Jun Zhang, Quan Yuan, Yixin Chen, Qiyi Tang, Honglin Chen, Tong Cheng, Yi Guan, Ningshao Xia,

Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiological results, we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2. Remarkably, high viral titer in nasal washings was detectable in male hamsters who presented symptoms ... Read more >>

Signal Transduct Target Ther (Signal transduction and targeted therapy)
[2021, 6(1):136]

Cited: 6 times

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Investigation of Pharmacological Mechanism of Natural Product Using Pathway Fingerprints Similarity Based on “Drug-Target-Pathway” Heterogenous Network

Feifei Guo, Chunhong Jiang, Yujie Xi, Dan Wang, Yi Zhang, Ning Xie, Yi Guan, Fangbo Zhang, Hongjun Yang,

Natural products from traditional medicine inherit bioactivity from their source herbs. However, the pharmacological mechanism of natural products is often unclear and studied insufficiently. Pathway fingerprint similarity based on “drug-target-pathway” heterogeneous network provides new insight into Mechanism of Action (MoA) for natural products compared with reference drugs, which are selected ... Read more >>

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Ubr1-mediated ubiquitylation orchestrates asexual development, polar growth, and virulence-related cellular events in Beauveria bassiana.

Ding-Yi Wang, Ya-Ni Mou, Xi Du, Yi Guan, Ming-Guang Feng,

The E3 ubiquitin ligase Ubr1 is a core player in yeast ubiquitylation and protein quality control required for cellular events including proteasomal degradation and gene activity but has been rarely explored in filamentous fungi. We show here an essentiality of orthologous Ubr1-mediated ubiquitylation for the activation of central developmental pathway ... Read more >>

Appl Microbiol Biotechnol (Applied microbiology and biotechnology)
[2021, 105(7):2747-2758]

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Diabetes mellitus is a risk factor of acute kidney injury in liver transplantation patients.

Yu-Jia Wang, Jian-Hua Li, Yi Guan, Qiong-Hong Xie, Chuan-Ming Hao, Zheng-Xin Wang,

<h4>Background</h4>Diabetes mellitus has become an increasing global health burden with rapid growing prevalence. Patients with diabetes have higher susceptibility to acute kidney injury (AKI). Liver transplantation (LT) predisposes the kidney to injury. However, the association between diabetes and AKI in LT patients remains unclear.<h4>Methods</h4>We conducted a retrospective cohort study examining ... Read more >>

Hepatobiliary Pancreat Dis Int (Hepatobiliary & pancreatic diseases international : HBPD INT)
[2021, 20(3):215-221]

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