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Author Yerlan Ramankulov

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Association of polymorphisms in TP53 and the promoter region of IL10 with gastric cancer in a Kazakh population.

Gulmira Kulmambetova, Ivan Shtefanov, Akbota Aitkulova, Meruyert Imanbekova, Aisha Iskakova, Abay Makishev, Yerlan Ramankulov,

The emerging evidence indicates that single nucleotide polymorphisms (SNPs) of the tumor necrosis factor (TNF), interleukin 10 (IL10), tumor protein p53 (TP53), and cluster of differentiation 14 (CD14) genes may determine individual susceptibility to gastric cancer (GC). We aimed to investigate the associations for polymorphisms of the TNF, IL10, TP53, ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):539-546]

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Draft Genome Sequence of the Strain Francisella tularensis subsp. mediasiatica 240, Isolated in Kazakhstan.

Marat Kuibagarov, Alma Kairzhanova, Gilles Vergnaud, Asylulan Amirgazin, Larissa Lukhnova, Uinkul Izbanova, Yerlan Ramankulov, Alexandr Shevtsov,

Francisella tularensis subsp. mediasiatica is the least studied among the four F. tularensis subspecies. We present here the genome data of F. tularensis subsp. mediasiatica 240, isolated in the southern region of Kazakhstan. ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2020, 9(35):]

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Genomic analysis of Latin American-Mediterranean family of Mycobacterium tuberculosis clinical strains from Kazakhstan.

Pavel Tarlykov, Sabina Atavliyeva, Arike Alenova, Yerlan Ramankulov,

The human-adapted strains of the Mycobacterium tuberculosis complex (MTBC) comprise seven phylogenetic lineages originally associated with their geographical distribution. Here, we report the genomes of three drug-resistant clinical isolates of the Latin American-Mediterranean (LAM) family collected in Kazakhstan. We utilised whole-genome sequencing to study the distribution and drug resistance of ... Read more >>

Mem Inst Oswaldo Cruz (Memorias do Instituto Oswaldo Cruz)
[2020, 115:e200215]

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Draft Genome Sequence of a Potential Commercial Biocellulose Producer, Strain Komagataeibacter europaeus GH1.

Gulden Nagmetova, Kalysh Berdimuratova, Asylulan Amirgazin, Vladislav Shevtsov, Aisulu Ismailova, Yerlan Ramankulov, Alexandr Shevtsov, Askar Kurmanbayev,

In this work, we present the draft genome sequence of Komagataeibacter europaeus strain GH1, which is an extremely efficient biocellulose producer. ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2020, 9(42):]

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Draft Genome Sequence of Moraxella bovoculi Strain KZ-1, Isolated from Cattle in North Kazakhstan.

Marat Kuibagarov, Asylulan Amirgazin, Gilles Vergnaud, Alexandr Shustov, Anara Ryskeldina, Yerlan Ramankulov, Alexandr Shevtsov,

Moraxella bovoculi strain KZ-1 was isolated from cattle that had symptoms of infectious bovine keratoconjunctivitis (IBK) in northern Kazakhstan. Here, we report the draft genome sequence of this strain. ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2020, 9(30):]

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Draft Genome Sequences of Three Pasteurella multocida Strains Isolated from Domestic Animals in Kazakhstan.

Asylulan Amirgazin, Gilles Vergnaud, Kasym Mukanov, Marat Kuibagarov, Talgat Karibaev, Yerlan Ramankulov, Alexandr Shevtsov,

We report here the draft genome sequences of three strains of Pasteurella multocida isolated in Kazakhstan from domestic animals that died due to hemorrhagic septicemia. ... Read more >>

(Microbiology resource announcements)
[2020, 9(32):]

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Draft Genome Sequence of a Bacteroides fragilis Strain Isolated from Peritoneal Fluid of a Patient from Kazakhstan.

Elena Zholdybayeva, Saniya Kozhakhmetova, Sabina Atavliyeva, Pavel Tarlykov, Yerlan Ramankulov,

Here, we report the draft genome sequence of Bacteroides fragilis strain KZ02, isolated from a patient with peritonitis hospitalized in a health facility in Nur-Sultan, Kazakhstan. The genome of the strain contains 4,103 protein-coding genes, including the cepA gene, which causes resistance to beta-lactam antibiotics. ... Read more >>

(Microbiology resource announcements)
[2020, 9(26):]

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Draft Genome Sequence of an Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolate, 3485_MTB, from Nur-Sultan, Kazakhstan.

Pavel Tarlykov, Sabina Atavliyeva, Arike Alenova, Yerlan Ramankulov,

Here, we report the draft genome sequence of an extensively drug-resistant Mycobacterium tuberculosis clinical isolate, 3485_MTB, from Nur-Sultan, Kazakhstan. The genome sequence is composed of 4,836,003 bp. The genome will provide more data on the genetic variations occurring in local drug-resistant isolates. ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2020, 9(10):]

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Improvement of Neurological Function in Rats with Ischemic Stroke by Adipose-derived Pericytes.

Vyacheslav Ogay, Venera Kumasheva, Yelena Li, Sholpan Mukhlis, Aliya Sekenova, Farkhad Olzhayev, Andrey Tsoy, Baurzhan Umbayev, Sholpan Askarova, Azat Shpekov, Assylbek Kaliyev, Berik Zhetpisbayev, Yerbol Makhambetov, Serik Akshulakov, Arman Saparov, Yerlan Ramankulov,

Pericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential. The aim of this study was to investigate whether transplantation of adipose-derived pericytes can improve functional recovery and neurovascular plasticity after ischemic stroke in rats. Rat adipose-derived pericytes were isolated ... Read more >>

Cell Transplant (Cell transplantation)
[2020, 29:963689720956956]

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Genetic Diversity of Brucella melitensis in Kazakhstan in Relation to World-Wide Diversity.

Elena Shevtsova, Gilles Vergnaud, Alexandr Shevtsov, Alexandr Shustov, Kalysh Berdimuratova, Kasim Mukanov, Marat Syzdykov, Andrey Kuznetsov, Larissa Lukhnova, Uinkul Izbanova, Maxim Filipenko, Yerlan Ramankulov,

We describe the genetic diversity of 1327 Brucella strains from human patients in Kazakhstan using multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA). All strains were assigned to the Brucella melitensis East Mediterranean group and clustered into 16 MLVA11 genotypes, nine of which are reported for the first time. MLVA11 genotype ... Read more >>

(Frontiers in microbiology)
[2019, 10:1897]

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Genetic Risk Factors for Intracranial Aneurysm in the Kazakh Population.

Elena V Zholdybayeva, Yerkin Z Medetov, Akbota M Aitkulova, Yerbol T Makhambetov, Serik K Akshulakov, Assylbek B Kaliyev, Yerkebulan A Talzhanov, Gulmira N Kulmambetova, Aisha N Iskakova, Yerlan M Ramankulov,

An intracranial aneurysm (IA) is a weak or thin area on a blood vessel in the brain that balloons as it fills with blood. Genetic factors can influence the risk of developing an aneurism. The purpose of this study was to explore the relationship between single nucleotide polymorphisms (SNPs) and ... Read more >>

J. Mol. Neurosci. (Journal of molecular neuroscience : MN)
[2018, 66(1):135-145]

Cited: 3 times

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Epidemiological Outbreaks of Measles Virus in Kazakhstan during 2015.

Arman Abeev, Assylbek Zhylkibayev, Dinara Kamalova, Nadezhda Kusheva, Gauhar Nusupbaeva, Nazim Tleumbetova, Manar Smagul, Sarkit Beissenova, Saltanat Aubakirova, Zhuldiz Kassenova, Balzira Demessinova, Altay Amanbayev, Yerlan Ramankulov, Alexander Shevtsov,

This study involved epidemiological surveillance of the measles virus (MV) in the territory of the Republic of Kazakhstan during 2015-2016. We detected MV genotype D8 in this season of measles outbreak. A total of 2,341 cases were registered and 19 were identified by genotyping. Sixteen of these samples were attributed ... Read more >>

Jpn. J. Infect. Dis. (Japanese journal of infectious diseases)
[2018, 71(5):354-359]

Cited: 1 time

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Obtaining and characterization of monoclonal antibodies against recombinant extracellular domain of human epidermal growth factor receptor 2.

Nurgul Sarina, Sailau Abeldenov, Aigerim Turgimbayeva, Assylbek Zhylkibayev, Yerlan Ramankulov, Bekbolat Khassenov, Saule Eskendirova,

Human epidermal growth factor receptor 2 (HER2) is an important biomarker for detection and treatment of different types of cancers such as breast, ovarian, stomach cancer. In this study, we developed a monoclonal antibody against the extracellular domain (ECD) of HER2 biomarker of breast cancer. For this purpose, the ECD-HER2 ... Read more >>

Hum Antibodies (Human antibodies)
[2018, 26(2):103-111]

Cited: 1 time

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Transient expression of a bovine leukemia virus envelope glycoprotein in plants by a recombinant TBSV vector.

Aiganym T Zhumabek, Laura S Abeuova, Nurzhan S Mukhametzhanov, Herman B Scholthof, Yerlan M Ramankulov, Shuga A Manabayeva,

Plants offer a unique combination of advantages for the production of valuable recombinant proteins in a relatively short time. For instance, a variety of diagnostic tests have been developed that use recombinant antigens expressed in plants. The envelope glycoprotein gp51 encoded by Bovine leukemia virus (BLV) is one of the ... Read more >>

J. Virol. Methods (Journal of virological methods)
[2018, 255:1-7]

Cited: 1 time

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Antimicrobial susceptibility of Brucella melitensis in Kazakhstan.

Alexandr Shevtsov, Marat Syzdykov, Andrey Kuznetsov, Alexandr Shustov, Elena Shevtsova, Kalysh Berdimuratova, Kasim Mukanov, Yerlan Ramankulov,

Background:Kazakhstan belongs to countries with a high level of brucellosis among humans and farm animals. Although antibiotic therapy is the main way to treat acute brucellosis in humans there is still little information on a circulation of the antibiotic-resistant Brucella strains in the Central Eurasia. In this article we describe ... Read more >>

Antimicrob Resist Infect Control (Antimicrobial resistance and infection control)
[2017, 6:130]

Cited: 3 times

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FastPCR: An in silico tool for fast primer and probe design and advanced sequence analysis.

Ruslan Kalendar, Bekbolat Khassenov, Yerlan Ramankulov, Olga Samuilova, Konstantin I Ivanov,

Polymerase chain reaction (PCR) is one of the most important laboratory techniques used in molecular biology, genetics and molecular diagnostics. The success of a PCR-based method largely depends on the correct nucleic acid sequence analysis in silico prior to a wet-bench experiment. Here, we report the development of an online ... Read more >>

Genomics (Genomics)
[2017, 109(3-4):312-319]

Cited: 20 times

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