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Intranasal delivery of berberine via in situ thermoresponsive hydrogels with non-invasive therapy exhibits better antidepressant-like effects.

Qiang-Song Wang, Kefeng Li, Li-Na Gao, Ye Zhang, Ke-Ming Lin, Yuan-Lu Cui,

The efficacy of antidepressant therapy is frequently limited by challenges related to the potential to reach the brain. The development of new strategies to deliver more antidepressants to the brain so as to bypass the blood-brain barrier (BBB) is beneficial for the treatment of nervous system diseases, especially depression. Here, ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(10):2853-2865]

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Synthesis and optoelectronics of mixed-dimensional Bi/Te binary heterostructures.

Ye Zhang, Jia Guo, Yiguo Xu, Weichun Huang, Chao Li, Lingfeng Gao, Leiming Wu, Zhe Shi, Chunyang Ma, Yanqi Ge, Xiuwen Zhang, Han Zhang,

Mixed-dimensional binary heterostructures, especially 0D/2D heterostructures, have attracted significant attention due to their unique physical properties. In this contribution, 0D bismuth quantum dots (Bi QDs, VA) are immobilized onto 2D Te nanosheets (Te NSs, VIA) to prepare Bi QDs/Te NSs binary heterostructures (Bi/Te) through a facile and cost-effective hydrothermal method. ... Read more >>

Nanoscale Horiz (Nanoscale horizons)
[2020, 5(5):847-856]

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Immune responses of a CV-A16 live attenuated candidate strain and its protective effects in rhesus monkeys.

Ting Yang, Tianhong Xie, Hua Li, Xia Song, Lei Yue, Xi Wang, Dong Shen, Kaili Ma, Qinfang Jiang, Runxiang Long, Rong Yang, Xin He, Ye Zhang, Zhongping Xie, Qihan Li,

Coxsackievirus A16 (CV-A16) is a major causative pathogen of hand, foot, and mouth diseases (HFMDs). The licensed HFMD vaccine targets EV-A71 without cross-protection against CV-A16. Thus, a CV-A16 vaccine is needed. In this study, the immunogenicity and protective efficacy of a live attenuated CV-A16 candidate, K168-8Ac, were evaluated in a ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):2136-2146]

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Remote and real time control of an FVIO-enzyme hybrid nanocatalyst using magnetic stimulation.

Ran Xiong, Wenting Zhang, Yifan Zhang, Ye Zhang, Yimin Chen, Yuan He, Haiming Fan,

Remote modulation of nanoscale biochemical processes in a living system using magnetic stimulation is appealing but is restricted by the lack of a highly efficient nanomediator which can deliver timely and effective response to biological molecules under an external magnetic field. Herein, we report the development of a novel nanocatalyst ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(39):18081-18089]

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Paired associated magnetic stimulation promotes neural repair in the rat middle cerebral artery occlusion model of stroke.

Bei-Yao Gao, Cheng-Cheng Sun, Guo-Hua Xia, Shao-Ting Zhou, Ye Zhang, Ye-Ran Mao, Pei-Le Liu, Ya Zheng, Dan Zhao, Xu-Tong Li, Janie Xu, Dong-Sheng Xu, Yu-Long Bai,

Paired associative stimulation has been used in stroke patients as an innovative recovery treatment. However, the mechanisms underlying the therapeutic effectiveness of paired associative stimulation on neurological function remain unclear. In this study, rats were randomly divided into middle cerebral occlusion model (MCAO) and paired associated magnetic stimulation (PAMS) groups. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(11):2047-2056]

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Overexpression of microRNA-129-5p in glioblastoma inhibits cell proliferation, migration, and colony-forming ability by targeting ZFP36L1.

Xu Guo, Haozhe Piao, Ye Zhang, Peixin Sun, Bing Yao,

Glioblastoma multiforme (GBM) is a highly invasive cancer with a high recurrence rate. The prognosis of GBM patients remains poor, even after standard surgical resection combined with chemoradiotherapy. Thus, there is an urgent need for new therapeutic targets in GBM. In recent years, microRNAs have received considerable attention due to ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):459-470]

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Early prediction and identification for severe patients during the pandemic of COVID-19: A severe COVID-19 risk model constructed by multivariate logistic regression analysis

Haifeng Hu, Hong Du, Jing Li, Yage Wang, Xiaoqing Wu, Chunfu Wang, Ye Zhang, Gufen Zhang, Yanyan Zhao, Wen Kang, Jianqi Lian,

Background As an emergent and fulminant infectious disease, Corona Virus Disease 2019 (COVID-19) has caused a worldwide pandemic. The early identification and timely treatment of severe patients are crucial to reducing the mortality of COVID-19. This study aimed to investigate the clinical characteristics and early predictors for severe COVID-19, and ... Read more >>

(Journal of Global Health)
[0, 10(2):]

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Qualitative Evidence Synthesis on Self-Collection for Human Papillomavirus-Based Cervical Screening: Protocol for Systematic Review.

Hawa Camara, Ye Zhang, Lise Lafferty, Andrew Vallely, Rebecca Guy, Angela Kelly-Hanku,

BACKGROUND:Cervical cancer is the fourth most common cancer affecting women worldwide. In the 1980s, it was found that the sexually transmitted disease human papillomavirus causes over 90% of all cervical cancer cases. Since that discovery, diagnostic technologies have been developed for the detection of human papillomavirus DNA in cervical samples. ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(10):e21093]

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Gut microbiota of  homologous Chinese soft-shell turtles  ( Pelodiscus sinensis ) in different habitats

Benli Wu, Long Huang, Jing Chen, Ye Zhang, Jun Wang, Jixiang He,

Abstract Background Chinese soft-shell turtle ( Pelodiscus sinensis ) is an important commercial species for their high nutritional value and unique taste, but it has been a vulnerable species due to habitat loss. In this study, homologous juvenile turtles were allocated to lake, pond and paddy field to investigate the ... Read more >>

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Intravesical dexmedetomidine instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study

Hong Chen, Bin Wang, Qin Li, Juan Zhou, Rui Li, Ye Zhang,

Abstract Background: The catheter-related bladder discomfort (CRBD) of male patients is a common clinical problem, albeit lacking effective solutions. The present study aimed to investigate whether intravesical dexmedetomidine instillation alleviates the postoperative urinary discomfort in male patients with catheter under general anesthesia. Methods: This single-blinded, prospective, randomized study included a ... Read more >>

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Transcriptome analysis identifies genes involved in the somatic embryogenesis of Eucalyptus

Yufei Xiao, Junji Li, Ye Zhang, Xiaoning Zhang, Hailong Liu, Zihai Qin, Bowen Chen,

Abstract Background : Eucalyptus, a highly diverse genus of the Myrtaceae family, is the most widely planted hardwood in the world due to its increasing importance for fiber and energy. Somatic embryogenesis (SE) is one large-scale method to provide commercial use of the vegetative propagation of Eucalyptus and dedifferentiation is ... Read more >>

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Intravesical dexmedetomidine instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study.

Hong Chen, Bin Wang, Qin Li, Juan Zhou, Rui Li, Ye Zhang,

BACKGROUND:The catheter-related bladder discomfort (CRBD) of male patients is a common clinical problem, albeit lacking effective solutions. The present study aimed to investigate whether intravesical dexmedetomidine instillation alleviates the postoperative urinary discomfort in male patients with catheter under general anesthesia. METHODS:This single-blinded, prospective, randomized study included a total of 167 ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2020, 20(1):267]

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Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response.

Liu-Ya Tang, Adam Thomas, Ming Zhou, Ying E Zhang,

Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities.  We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with ring finger protein 20 (RNF20) in shaping chromatin landscape and preserving ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2020, :]

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Nudging the N170 forward with prior stimulation – Bridging the gap between N170 and recognition potential

Canhuang Luo, Wei Chen, Rufin VanRullen, Carl Michael Gaspar, Ye Zhang,

Abstract Some neural responses are classified by the stimulus conditions leading up to that response while other neural responses are also classified by the morphology of the responses themselves. However, morphology-based classification may not be appropriate if one can nudge a neural response into looking like another neural response. Morphology-based ... Read more >>

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Engrafted primary type-2 astrocytes improve the recovery of the nigrostriatal pathway in a rat model of Parkinson's disease.

Yanyun Sun, Xiao-Jun Lu, Xinghui Fu, Ye Zhang, Yan Zhan, Jiabing Liu, Lingxia Zhao, Chun-Lin Xia,

Parkinson's disease (PD) is a disorder characterized by a progressive loss of the dopaminergic neurons in the substantia nigra and a depletion of the neurotransmitter dopamine in the striatum. Our published results indicate that fasciculation and elongation protein zeta-1 (FEZ1) plays a role in the astrocyte-mediated protection of dopamine neurons ... Read more >>

Mol Cell Biochem (Molecular and cellular biochemistry)
[2020, :]

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Recognizing Chinese Characters in Peripheral Vision: Different Levels of Processing of Character.

Manni Feng, Dan Sun, Ye Zhang,

It hasn't been clear how holistic and analytic processing contribute to character recognition yet. The current study focused on two issues: (1) whether configural processing is sufficient to support the performance of identifying characters in absence of analytic processing; (2) whether configural processing involves multiple levels of character recognition. We ... Read more >>

J Psycholinguist Res (Journal of psycholinguistic research)
[2020, :]

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A Conservation of Resources schema for exploring the influential forces for air-travel stress.

Ye Zhang, Jase R Ramsey, Melanie P Lorenz,

Effective air-travel stress management is increasingly crucial in determining tourist satisfaction and travel choices, particularly in a time of intensive fear about virus, terrorism, and plane crashes. However, research about air-travel stress, particularly what and how various influential forces shape passenger stress levels, is still in its infancy. The current ... Read more >>

Tour Manag (Tourism management)
[2021, 83:104240]

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Sexual function after tension-free vaginal tape procedure in stress urinary incontinence patients.

Ye Zhang, Xiaochen Song, Jia Kang, Yidi Ma, Congcong Ma, Lan Zhu,

OBJECTIVE:The aim of the study was to evaluate sexual function in women before and after tension-free vaginal tape (TVT) surgery for the treatment of stress urinary incontinence (SUI). METHODS:Between August 2014 and August 2018, 105 sexually active patients with SUI who underwent TVT surgery were enrolled in this prospective cohort ... Read more >>

Menopause (Menopause (New York, N.Y.))
[2020, 27(10):1143-1147]

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Vaginal pessary continuation in symptomatic pelvic organ prolapse patients with prior hysterectomy.

Congcong Ma, Jia Kang, Tao Xu, Ye Zhang, Yidi Ma, Shuo Liang, Yujie Hui, Yuhong Wang, Lan Zhu,

OBJECTIVE:To evaluate the success rate of pessary fitting and continuation rate for symptomatic pelvic organ prolapse (POP) patients with a hysterectomy and to explore potential predictors. METHODS:In this prospective observational study, 119 symptomatic POP patients with a prior hysterectomy received pessary treatment between April 2015 and February 2019. A successful ... Read more >>

Menopause (Menopause (New York, N.Y.))
[2020, 27(10):1148-1154]

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Genome-wide identification of microRNAs associated with the somatic embryogenesis in Eucalyptus

Zihai Qin, Junji Li, Ye Zhang, Yufei Xiao, Xiaoning Zhang, Hailong Liu, Bowen Chen,

Abstract Background : MicroRNAs (miRNAs) are a class of small noncoding RNAs with 18-24 nucleotides in length and function in many biological processes in plant. Although Eucalyptus trees are widely planted across the world, our understanding of the miRNA regulation in the somatic embryogenesis of Eucalyptus is still poor. Here ... Read more >>

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Semihollow Core-Shell Nanoparticles with Porous SiO2 Shells Encapsulating Elemental Sulfur for Lithium-Sulfur Batteries.

Tingting Liu, Ye Zhang, Chien-Hung Li, Maria D Marquez, Hung-Vu Tran, Francisco C Robles Hernández, Yan Yao, T Randall Lee,

Lithium-sulfur batteries have shown great promise as next-generation high energy density power sources, but their commercial applications are hindered by short battery cycle life arising from the dissolution and shuttling of polysulfides. To address this shortcoming, we prepared two types of semihollow core-shell nanoparticles in which (1) elemental sulfur is ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(42):47368-47376]

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Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference.

Joongyu D Song, Tiago C Alves, Douglas E Befroy, Rachel J Perry, Graeme F Mason, Xian-Man Zhang, Alexander Munk, Ye Zhang, Dongyan Zhang, Gary W Cline, Douglas L Rothman, Kitt Falk Petersen, Gerald I Shulman,

Alterations in muscle mitochondrial substrate preference have been postulated to play a major role in the pathogenesis of muscle insulin resistance. In order to examine this hypothesis, we assessed the ratio of mitochondrial pyruvate oxidation (VPDH) to rates of mitochondrial citrate synthase flux (VCS) in muscle. Contrary to this hypothesis, ... Read more >>

Cell Metab (Cell metabolism)
[2020, :]

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Quantifying the Treatment Effect of Kidney Transplantation Relative to Dialysis on Survival Time: New Results Based on Propensity Score Weighting and Longitudinal Observational Data from Sweden.

Ye Zhang, Ulf-G Gerdtham, Helena Rydell, Johan Jarl,

Using observational data to assess the treatment effects on outcomes of kidney transplantation relative to dialysis for patients on renal replacement therapy is challenging due to the non-random selection into treatment. This study applied the propensity score weighting approach in order to address the treatment selection bias of kidney transplantation ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(19):]

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Mid- and long-term efficacy of surgical treatment of Vancouver B2 and B3 periprosthetic femoral fractures.

Jian-Ning Sun, Yu Zhang, Ye Zhang, Jia-Ming Zhang, Xiang-Yang Chen, Shuo Feng,

BACKGROUND:The incidence of fractures around the femoral prosthesis among patients undergoing hip arthroplasty is increasing and has become the third leading cause of hip revision. While numerous methods for the surgical treatment of periprosthetic femoral fractures (PFFs) have been proposed, only few reports have examined the long-term efficacy of surgical ... Read more >>

BMC Surg (BMC surgery)
[2020, 20(1):226]

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Millimeter-Wave Array Radar-Based Human Gait Recognition Using Multi-Channel Three-Dimensional Convolutional Neural Network.

Xinrui Jiang, Ye Zhang, Qi Yang, Bin Deng, Hongqiang Wang,

At present, there are two obvious problems in radar-based gait recognition. First, the traditional radar frequency band is difficult to meet the requirements of fine identification with due to its low carrier frequency and limited micro-Doppler resolution. Another significant problem is that radar signal processing is relatively complex, and the ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(19):]

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