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Author Yazhou Cui

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Effect of video-assisted thoracoscopic surgery on pain stress indicators NO, IL-1β and IL-6 in the treatment of mediastinal tumor in children.

Bo Zhai, Yonghong Zhang, Zhenliang Chen, Fang Yang, Xiangyang Dong, Zhongjian Chen, Yazhou Cui, Penggao Wang, Lei Shi, Wenbo Yu,

This study aimed to investigate the effect of video-assisted thoracoscopic surgery (VATS) on pain stress indicators nitric oxide (NO), interleukin-1β (IL-1β) and IL-6 in the treatment of mediastinal tumor in children, so as to explore the clinical application value of this surgery. A retrospective analysis was performed on 82 children ... Read more >>

Oncol Lett (Oncology letters)
[2020, 19(6):3931-3936]

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Generation and characterization of a human iPSC line derived from congenital clubfoot amniotic fluid cells.

Jing Wang, Yazhou Cui, Kaixuan Xing, Jing Luan, Jinxiang Han,

A human induced pluripotent stem cell (iPSC) line (SMBCi002-A) was established from amniocytes (amniotic fluid cells, AFDCs) from a 16-week-old female fetus with clubfoot. Reprogramming and enhancing factors OCT4, SOX2, KLF4, MYC, LIN28 and EBNA1 were delivered using a nonintegrative strategy based on episomal plasmids. Validation assays indicated that this ... Read more >>

Stem Cell Res (Stem cell research)
[2020, 43:101712]

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Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3.

Yuang Zhang, Yazhou Cui, Lin Wang, Jinxiang Han,

Osteoclasts are responsible for bone resorption and play an important role in physiological and pathological bone metabolism. Osteoclast migration across bone surfaces is essential for bone resorption, and a previous study demonstrated the role of autophagy in osteoclastogenesis and acid secretion. However, the role of autophagy in osteoclast migration remains ... Read more >>

Cell. Signal. (Cellular signalling)
[2020, 67:109505]

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Icariin Promotes the Osteogenic Action of BMP2 by Activating the cAMP Signaling Pathway.

Meng Chen, Yazhou Cui, Hui Li, Jing Luan, Xiaoyan Zhou, Jinxiang Han,

Icariin (ICA) is the main active flavonoid glucoside from herbs of the genus Epimedium; in traditional Chinese medicine, these herbs have long been prescribed for the treatment of bone fractures and osteoporosis. Several studies have shown that treatment with ICA can increase osteogenic differentiation and reduce bone loss in vivo ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2019, 24(21):]

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A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction.

Chen Zhang, Min Cui, Yazhou Cui, Aubryanna Hettinghouse, Chuan-Ju Liu,

Drug Affinity Responsive Target Stability (DARTS) is a robust method for detection of novel small molecule protein targets. It can be used to verify known small molecule-protein interactions and to find potential protein targets for natural products. Compared with other methods, DARTS uses native, unmodified, small molecules and is simple ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2019, (150):]

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Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis.

Ronghan Liu, Yuehong Chen, Wenyu Fu, Shuya Wang, Yazhou Cui, Xiangli Zhao, Zi-Ning Lei, Aubryanna Hettinghouse, Jody Liu, Chao Wang, Chen Zhang, Yufei Bi, Guozhi Xiao, Zhe-Sheng Chen, Chuan-Ju Liu,

OBJECTIVE:Tumour necrosis factor alpha (TNF-α) signalling plays a central role in the pathogenesis of various autoimmune diseases, particularly inflammatory arthritis. This study aimed to repurpose clinically approved drugs as potential inhibitors of TNF-α signalling in treatment of inflammatory arthritis. METHODS:In vitro and in vivo screening of an Food and Drug ... Read more >>

Ann. Rheum. Dis. (Annals of the rheumatic diseases)
[2019, 78(11):1524-1535]

Cited: 1 time

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A preliminary study on the mechanism of skeletal abnormalities in Turner syndrome using inducing pluripotent stem cells (iPS)- based disease models.

Xiaoxiao Cui, Yazhou Cui, Liang Shi, Jing Luan, Xiaoyan Zhou, Jinxiang Han,

Osteoporosis represent one of main characteristics of Turner syndrome (TS), a rare diseases caused by aberrant deletion of X chromosomes, however, the underlying pathological mechanism remains unknown yet. In this study, we used pluripotent stem cells (iPSCs) derived from a Turner syndrome patient and a health control to induce functional ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2019, 8(2):113-119]

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Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against autoimmune diseases

Ronghan Liu, Yuehong Chen, Shuya Wang, Yazhou Cui, Xiangli Zhang, Zi-Ning Lei, Aubryanna Hettinghouse, Jody Liu, Wenyu Fu, Zhe-Sheng Chen, Chuanju Liu,

SUMMARY TNF-α signaling plays a central role in the pathogenesis of various diseases, particularly autoimmune diseases. Screening of a library composed of FDA approved drugs led to the identification of Terfenadine and its active metabolite Fexofenadine as inhibitors of TNF-α signaling. Both Fexofenadine and Terfenadine inhibited TNF/NF-κB signaling in vitro ... Read more >>

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A cellular model for Wilson's disease using patient-derived induced pluripotent stem cells revealed aberrant β-catenin pathway during osteogenesis.

Jing Liu, Yazhou Cui, Liang Shi, Jing Luan, Xiaoyan Zhou, Jinxiang Han,

Wilson's disease (WD) is a rare autosomal recessive disorder of copper metabolism caused by an ATP7B gene mutation. Except for hepatic, neurological symptoms, lower bone mineral density is another most frequent clinical features of WD, but the underlying mechanisms have not been fully understood. This article aims to use induced ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2019, 513(2):386-391]

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ERα and Wnt/β‑catenin signaling pathways are involved in angelicin‑dependent promotion of osteogenesis.

Luna Ge, Yazhou Cui, Baoyan Liu, Xiaoli Yin, Jingxiang Pang, Jinxiang Han,

Reports of the ameliorative effect of angelicin on sex hormone deficiency‑induced osteoporosis have highlighted this compound as a candidate for the treatment of osteoporosis. However, the molecular mechanisms of action of angelicin on osteoblast differentiation have not been thoroughly researched. The aim of the present study was to evaluate the ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2019, 19(5):3469-3476]

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A basic understanding of Turner syndrome: Incidence, complications, diagnosis, and treatment.

Xiaoxiao Cui, Yazhou Cui, Liang Shi, Jing Luan, Xiaoyan Zhou, Jinxiang Han,

Turner syndrome (TS), also known as Congenital ovarian hypoplasia syndrome, occurs when the X chromosome is partially or completely missing in females. Its main clinical manifestations include growth disorders, reproductive system abnormalities, cardiovascular abnormalities, and autoimmune diseases. TS is highly prevalent in China. Timely diagnosis is crucial, and non-invasive prenatal ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2018, 7(4):223-228]

Cited: 1 time

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Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα.

Luna Ge, Yazhou Cui, Kai Cheng, Jinxiang Han,

Isopsoralen (IPRN), one of the main effective ingredients in Psoralea corylifolia Linn, has a variety of biological effects, including antiosteoporotic effects. In vivo studies show that IPRN can increase bone strength and trabecular bone microstructure in a sex hormone deficiency-induced osteoporosis model. However, the mechanism underlying this osteogenic potential has ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2018, 23(10):]

Cited: 3 times

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Establishment of a human trisomy 18 induced pluripotent stem cell line from amniotic fluid cells.

Kaixuan Xing, Yazhou Cui, Jing Luan, Xiaoyan Zhou, Liang Shi, Jinxiang Han,

Trisomy 18 (18T) is the second most common autosomal trisomy syndrome in humans, but the detailed mechanism of its pathology remains unclear due to the lack of appropriate models of this disease. To resolve this problem, the current study reprogrammed human 18T amniotic fluid cells (AFCs) into an induced pluripotent ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2018, 7(2):94-99]

Cited: 1 time

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Methylmalonic acidemia: Current status and research priorities.

Xiaoyan Zhou, Yazhou Cui, Jinxiang Han,

Methylmalonic acidemia (MMA) is a lethal, severe heterogeneous disorder of methylmalonate and cobalamin (cbl; vitamin B12) metabolism with poor prognosis. Two main forms of the disease have been identified, isolated methylmalonic acidurias and combined methylmalonic aciduria and homocystinuria, which is respectively caused by different gene mutations. Here, we review the ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2018, 7(2):73-78]

Cited: 1 time

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Generation of urine-derived induced pluripotent stem cells from a patient with phenylketonuria.

Zijuan Qi, Yazhou Cui, Liang Shi, Jing Luan, Xiaoyan Zhou, Jinxiang Han,

The aim of the study was to establish an induced pluripotent stem cell line from urine-derived cells (UiPSCs) from a patient with phenylketonuria (PKU) in order to provide a useful research tool with which to examine the pathology of this rare genetic metabolic disease. Urine-derived epithelial cells (UCs) from a ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2018, 7(2):87-93]

Cited: 2 times

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Exosomes from C2C12 myoblasts enhance osteogenic differentiation of MC3T3-E1 pre-osteoblasts by delivering miR-27a-3p.

Qian Xu, Yazhou Cui, Jing Luan, Xiaoyan Zhou, Haiying Li, Jinxiang Han,

Many regulators have been identified to participate in the cross-talk between muscle and bone, however, most previous studies focus on secreting proteins. In this study, we demonstrated that exosomes from myoblasts C2C12 can promote pre-osteoblasts MC3T3-E1 differentiation to osteoblasts. We revealed that the effect of C2C12 exosomes depended on its ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2018, 498(1):32-37]

Cited: 4 times

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Association of polymorphisms in TNF and GRN genes with ankylosing spondylitis in a Chinese Han population.

Naiwen Hu, Yazhou Cui, Qingrui Yang, Liya Wang, Xinglin Yang, Hongzhi Xu,

The aim of this study is to investigate the association of the polymorphisms in tumor necrosis factor (TNF) and granulin (GRN) with ankylosing spondylitis (AS) in a Chinese Han population. Five single nucleotide polymorphisms (SNPs) covering TNF and six SNPs covering GRN were investigated in 861 Chinese Han AS patients ... Read more >>

Rheumatol. Int. (Rheumatology international)
[2018, 38(3):481-487]

Cited: 1 time

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Fibrodysplasia ossificans progressiva: Basic understanding and experimental models.

Zijuan Qi, Jing Luan, Xiaoyan Zhou, Yazhou Cui, Jinxiang Han,

Fibrodysplasia ossificans progressive (FOP) is an extremely rare autosomal dominant disorder characterized by congenital malformations of the great toes and progressive heterotopic ossification that can induce a disabling second skeleton. Spontaneously occurring flare-ups can cause inflammatory soft tissue to swell, followed by progressive and disabling heterotopic endochondral ossification. FOP is ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2017, 6(4):242-248]

Cited: 4 times

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Epidemiology, diagnosis, and treatment of Wilson's disease.

Jing Liu, Jing Luan, Xiaoyan Zhou, Yazhou Cui, Jinxiang Han,

Wilson's disease (WD) is an autosomal recessive disease caused by a mutation of the ATP7B gene, resulting in abnormal copper metabolism. The major clinical features of WD include liver disease, neurological disorders, K-F rings, and osteoporosis. The prevalence of WD in China is higher than that in Western countries. Early ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2017, 6(4):249-255]

Cited: 2 times

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Comparative transcriptomic analysis identifies reprogramming and differentiation genes differentially expressed in UiPSCs and ESCs.

Liang Shi, Yazhou Cui, Xiaoyan Zhou, Jing Luan, Linli Wang, Jinxiang Han,

Embryonic stem cells (ESCs) technology has garnered worldwide attention for its therapeutic applications in vivo. Researchers have previously shown that non-viral induced pluripotent stem cells (iPSCs) can be generated from urine. As a potential alternative, Urinary iPSCs (UiPSCs) are highly similar to embryonic stem cells (ESCs) in many aspects such ... Read more >>

Biosci Trends (Bioscience trends)
[2017, 11(3):355-359]

Cited: 1 time

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Defining rare diseases in China.

Yazhou Cui, Jinxiang Han,

China has the world's largest population of people with rare diseases. However, defining rare diseases remains a challenge in China. Over the past few decades, several definitions have been proposed but they have yet to be agreed to by all stakeholders. To overcome this impasse, a list of several rare ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2017, 6(2):148-149]

Cited: 5 times

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MiR-5100 promotes osteogenic differentiation by targeting Tob2.

Huaxin Wang, Yazhou Cui, Jing Luan, Xiaoyan Zhou, Chengzhi Li, Haiying Li, Liang Shi, Jinxiang Han,

MicroRNAs have emerged as pivotal regulators in various physiological and pathological processes, including osteogenesis. Here we discuss the contribution of miR-5100 to osteoblast differentiation and mineralization. We found that miR-5100 was upregulated during osteoblast differentiation in ST2 and MC3T3-E1 cells. Next, we verified that miR-5100 can promote osteogenic differentiation with ... Read more >>

J. Bone Miner. Metab. (Journal of bone and mineral metabolism)
[2017, 35(6):608-615]

Cited: 5 times

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Urine-derived induced pluripotent stem cells as a modeling tool to study rare human diseases.

Liang Shi, Yazhou Cui, Jing Luan, Xiaoyan Zhou, Jinxiang Han,

Rare diseases with a low prevalence are a key public health issue because the causes of those diseases are difficult to determine and those diseases lack a clearly established or curative treatment. Thus, investigating the molecular mechanisms that underlie the pathology of rare diseases and facilitating the development of novel ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2016, 5(3):192-201]

Cited: 8 times

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Estimating epidemiological data of Multiple sclerosis using hospitalized data in Shandong Province, China.

Xiao Liu, Yazhou Cui, Jinxiang Han,

Multiple sclerosis (MS) is a rare chronically debilitating disease. There are few reports on the burden of disease of MS and prevalence in China. The authors intended to estimate disease burden and prevalence of MS in Shandong Province using available epidemiologic data.Prevalence was calculated using DISMOD II software based on ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2016, 11(1):73]

Cited: 4 times

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Using inpatient data to estimate the prevalence of Wegener's granulomatosis in China.

Xiao Liu, Yazhou Cui, Yan Li, Chao Wang, Heng Zhao, Jinxiang Han,

China lacks a registry for most rare diseases, so specific epidemiological data on those diseases are lacking. A strategy involving the DISMOD II model was recently formulated to estimate the epidemiological parameters of rare diseases, and this strategy has been used to study several rare diseases. The current study used ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2016, 5(1):31-35]

Cited: 3 times

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