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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Use of CytoSorb therapy to treat critically ill coronavirus disease 2019 patients: a case series.

Yatin Mehta, Chitra Mehta, Saurabh Nanda, Gaurav Kochar, Joby V George, Manish Kumar Singh,

<h4>Background</h4>Acute respiratory distress syndrome is an important clinical presentation of respiratory complications caused by severe acute respiratory syndrome coronavirus 2, a novel coronavirus responsible for the ongoing pandemic. The disease is poorly understood, and immunopathogenesis is constantly evolving. Cytokine release syndrome remains central to pathology of coronavirus disease 2019. Antivirals, ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2021, 15(1):476]

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The Potential Role of Extracorporeal Cytokine Removal in Hemodynamic Stabilization in Hyperinflammatory Shock.

Fatime Hawchar, Cristina Rao, Ali Akil, Yatin Mehta, Christopher Rugg, Joerg Scheier, Harriet Adamson, Efthymios Deliargyris, Zsolt Molnar,

Hemodynamic instability due to dysregulated host response is a life-threatening condition requiring vasopressors and vital organ support. Hemoadsorption with Cytosorb has proven to be effective in reducing cytokines and possibly in attenuating the devastating effects of the cytokine storm originating from the immune over-response to the initial insult. We reviewed ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(7):]

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How Have Nutrition Practices in the ICU Changed in the Last Decade (2011-2020): A Scoping Review.

Subhal B Dixit, Nishant R Tiwari, Kapil G Zirpe, Aditya G Tolat, Khalid I Khatib, Atul P Kulkarni, Yatin Mehta, Rajesh C Mishra, Deepak Govil, Dhruva Chaudhry, Lopa Ahsina Jahan,

Malnutrition is more prevalent in the critically ill than ambulatory patients due to a variety of factors. Strategies employed in the optimization of nutrition practices rely largely on the review of published literature and guidelines. While the last decade was marked by some landmark large randomized controlled trials taking place ... Read more >>

Cureus (Cureus)
[2021, 13(6):e15422]

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Heterotopic caval valve implantation in severe tricuspid regurgitation.

Neeraj Kumar Sharma, Nagendra Singh Chouhan, Manish Bansal, Praveen Chandra, Ajmer Singh, Rajiv Juneja, Yatin Mehta, Naresh Trehan,

Severe symptomatic tricuspid regurgitation (TR) with right heart failure is associated with significant morbidity and mortality. Medical therapy is often ineffective and surgical correction is not feasible due to prohibitive perioperative risk. Transcatheter caval valve implantation (CAVI) is an evolving therapeutic option for this condition. It refers to the heterotopic ... Read more >>

Ann Card Anaesth (Annals of cardiac anaesthesia)
[2021, 24(3):365-368]

Cited: 0 times

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Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial.

Fernando J Martinez, Eric Yow, Kevin R Flaherty, Laurie D Snyder, Michael T Durheim, Stephen R Wisniewski, Frank C Sciurba, Ganesh Raghu, Maria M Brooks, Dong-Yun Kim, Daniel F Dilling, Gerard J Criner, Hyun Kim, Elizabeth A Belloli, Anoop M Nambiar, Mary Beth Scholand, Kevin J Anstrom, Imre Noth, ,

<h4>Importance</h4>Alteration in lung microbes is associated with disease progression in idiopathic pulmonary fibrosis.<h4>Objective</h4>To assess the effect of antimicrobial therapy on clinical outcomes.<h4>Design, setting, and participants</h4>Pragmatic, randomized, unblinded clinical trial conducted across 35 US sites. A total of 513 patients older than 40 years were randomized from August 2017 to June ... Read more >>

JAMA (JAMA)
[2021, 325(18):1841-1851]

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International Nosocomial Infection Control Consortium (INICC) report, data summary of 45 countries for 2013-2018, Adult and Pediatric Units, Device-associated Module.

Victor Daniel Rosenthal, Wieslawa Duszynska, Bat-Erdene Ider, Vaidotas Gurskis, Majeda A Al-Ruzzieh, Sheila Nainan Myatra, Debkishore Gupta, Souad Belkebir, Namita Upadhyay, Farid Zand, Subhash Kumar Todi, Mohit Kharbanda, Pravin K Nair, Sanghamitra Mishra, Gustavo Chaparro, Yatin Mehta, Dolatsinh Zala, Jaroslaw Janc, Guadalupe Aguirre-Avalos, Daisy Aguilar-De-Morós, Blanca Estela Hernandez-Chena, Emrah Gün, Nefise Oztoprak-Cuvalci, Dincer Yildizdas, Mona Moheyeldin Abdelhalim, Suna Secil Ozturk-Deniz, Chin Seng Gan, Nguyen Viet Hung, Hala Joudi, Abeer Aly Omar, Achilleas Gikas, Amani Ali El-Kholy, Amina Barkat, Anjeela Koirala, Antonio Cerero-Gudiño, Asma Bouziri, Katherine Gomez-Nieto, Dale Fisher, Eduardo A Medeiros, Estuardo Salgado-Yepez, Florin Horhat, Hala Mounir Moustafa Agha, Julio César Vimercati, Victoria Villanueva, Kushlani Jayatilleke, Le Thi Thu Nguyet, Lul Raka, María Guadalupe Miranda-Novales, Michael Mihailov Petrov, Anucha Apisarnthanarak, Nadia Tayyab, Naheed Elahi, Nepomuceno Mejia, Rayo Morfin-Otero, Safa Al-Khawaja, Tanja Anguseva, Umesh Gupta, Vladislav A Belskii, Wan Rahiza Wan Mat, Edwin Giovanny Chapeta-Parada, Humberto Guanche-Garcell, Nayide Barahona-Guzmán, Anju Mathew, Kavita Raja, Saroj Kumar Pattnaik, Nirav Pandya, Aruna Ananda Poojary, Rajesh Chawla, Tahsine Mahfouz, Souha S Kanj, Vesna Mioljevic, Sona Hlinkova, Mariana Mrazova, Hail M Al-Abdely, Ertugrul Guclu, Asu Ozgultekin, Volkan Baytas, Recep Tekin, Ata Nevzat Yalçın, Nurettin Erben,

<h4>Background</h4>We report the results of INICC surveillance study from 2013 to 2018, in 664 intensive care units (ICUs) in 133 cities, of 45 countries, from Latin-America, Europe, Africa, Eastern-Mediterranean, Southeast-Asia, and Western-Pacific.<h4>Methods</h4>Prospective data from patients hospitalized in ICUs were collected through INICC Surveillance Online System. CDC-NHSN definitions for device-associated healthcare-associated ... Read more >>

Am J Infect Control (American journal of infection control)
[2021, 49(10):1267-1274]

Cited: 1 time

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Combined off pump coronary artery bypass graft and liver transplant.

Rajiv Juneja, Ajay Kumar, Rajeev Ranjan, P M Hemantlal, Yatin Mehta, Harpreet Wasir, Vijay Vohra, Naresh Trehan,

<h4>Background</h4>Prospective recipients of liver transplant (LT) have a high prevalence rate of coronary artery disease (CAD) requiring revascularization. In patients of Child Turcot Pugh Class B and C performing LT prior to cardiac revascularization on cardiopulmonary bypass leads to a high risk of major adverse cardiovascular events (MACE). Whereas, isolated ... Read more >>

Ann Card Anaesth (Annals of cardiac anaesthesia)
[2021, 24(2):197-202]

Cited: 0 times

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Empagliflozin induced euglycemic diabetic ketoacidosis in a patient undergoing coronary artery bypass graft despite discontinuation of the drug 48 hours prior to the surgery.

Mohammad Shafi Kuchay, Sunil Kumar Mishra, Yatin Mehta,

Diabetes Metab Syndr (Diabetes & metabolic syndrome)
[2021, 15(3):909-911]

Cited: 0 times

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Principles of conducting cardiac anaesthesia services in COVID-19 pandemic.

Yatin Mehta, Naveen Malhotra,

Indian J Anaesth (Indian journal of anaesthesia)
[2021, 65(Suppl 1):S47-S49]

Cited: 0 times

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Tocilizumab plus standard care versus standard care in patients in India with moderate to severe COVID-19-associated cytokine release syndrome (COVINTOC): an open-label, multicentre, randomised, controlled, phase 3 trial.

Arvinder S Soin, Kuldeep Kumar, Narendra S Choudhary, Pooja Sharma, Yatin Mehta, Sushila Kataria, Deepak Govil, Vikas Deswal, Dhruva Chaudhry, Pawan Kumar Singh, Ashish Gupta, Vikas Agarwal, Suresh Kumar, Shashikala A Sangle, Rajesh Chawla, Suneetha Narreddy, Rahul Pandit, Vipul Mishra, Manoj Goel, Athimalaipet V Ramanan,

<h4>Background</h4>Global randomised controlled trials of the anti-IL-6 receptor antibody tocilizumab in patients admitted to hospital with COVID-19 have shown conflicting results but potential decreases in time to discharge and burden on intensive care. Tocilizumab reduced progression to mechanical ventilation and death in a trial population enriched for racial and ethnic ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(5):511-521]

Cited: 19 times

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A career in cardiac anaesthesia in India: The heart of the matter.

Satyajeet Misra, Satyen Parida, Murali Chakravarthy, Yatin Mehta, Goverdhan Dutt Puri,

Cardiac anaesthesia is a demanding, but fulfilling speciality which challenges the skills, knowledge, professional and personal competence of cardiac anaesthesiologists on a daily basis. This article outlines the brief history of the subspecialty of cardiac anaesthesia in India, its growth and progress over the decades, reasons for choosing it as ... Read more >>

Indian J Anaesth (Indian journal of anaesthesia)
[2021, 65(1):12-16]

Cited: 0 times

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Early Detection of Septic Shock Onset Using Interpretable Machine Learners.

Debdipto Misra, Venkatesh Avula, Donna M Wolk, Hosam A Farag, Jiang Li, Yatin B Mehta, Ranjeet Sandhu, Bipin Karunakaran, Shravan Kethireddy, Ramin Zand, Vida Abedi,

<h4>Background</h4>Developing a decision support system based on advances in machine learning is one area for strategic innovation in healthcare. Predicting a patient's progression to septic shock is an active field of translational research. The goal of this study was to develop a working model of a clinical decision support system ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(2):]

Cited: 2 times

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Patient blood management in India - Review of current practices and feasibility of applying appropriate standard of care guidelines. A position paper by an interdisciplinary expert group.

Ajay Gandhi, Klaus Görlinger, Sukesh C Nair, Poonam M Kapoor, Anjan Trikha, Yatin Mehta, Anil Handoo, Anil Karlekar, Jyoti Kotwal, Joseph John, Shashikant Apte, Vijay Vohra, Gajendra Gupta, Aseem K Tiwari, Anjali Rani, Shweta A Singh,

In a developing country like India, with limited resources and access to healthcare facilities, dealing with massive hemorrhage is a major challenge. This challenge gets compounded by pre-existing anemia, hemostatic disorders, and logistic issues of timely transfer of such patients from peripheral hospitals to centers with adequate resources and management ... Read more >>

J Anaesthesiol Clin Pharmacol (Journal of anaesthesiology, clinical pharmacology)
[2021, 37(1):3-13]

Cited: 0 times

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Transcaval aortic valve implantation in a patient with Larsen syndrome: technical and anesthetic challenges.

Ajmer Singh, Aashish Jain, Yatin Mehta, Praveen Chandra,

Transcatheter aortic valve implantation has emerged as a therapeutic option for patients with symptomatic severe aortic stenosis who are inoperable, or at very high risk of open-heart surgery. Recently, we encountered a patient with aortic stenosis and Larsen syndrome, who had short stature, obesity, kyphoscoliosis, multiple musculoskeletal deformities, and severe ... Read more >>

Indian J Thorac Cardiovasc Surg (Indian journal of thoracic and cardiovascular surgery)
[2021, 37(4):434-437]

Cited: 0 times

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Risk factors associated with carbapenem-resistant Klebsiella pneumoniae bloodstream infections in a tertiary-care hospital in India.

Priyanka Gupta, Neha Bollam, Yatin Mehta, Sharmila Sengupta, Sumanth Gandra,

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2020, :1-3]

Cited: 0 times

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A Prospective Observational Study of Rational Fluid Therapy in Asian Intensive Care Units: Another Puzzle Piece in Fluid Therapy.

Matthias Jacob, Sambit Sahu, Yogendra P Singh, Yatin Mehta, Kuang-Yao Yang, Shuenn-Wen Kuo, Farooq Memom, Shirish Prayag, Rajesh Pande, Nirmal Jaiswal, Tan C Cheng, Amit Mandal, Shanti R Deva, Mohan Mathew, Nagarajan Ramakrishnan, Vineya Rai, Luah Wah, Gopinath Ramachandran, Rajesh Chawla, Z A Khan, J V Divatia, Rajesh Mishra, Pravin Amin, Jayant Shelgaokar, Bernhard Zwissler, Hugo Van Aken, Christian Ertmer,

<h4>Introduction</h4>Fluid therapy in critically ill patients, especially timing and fluid choice, is controversial. Previous randomized trials produced conflicting results. This observational study evaluated the effect of colloid use on 90-day mortality and acute kidney injury (RIFLE F) within the Rational Fluid Therapy in Asia (RaFTA) registry in intensive care units.<h4>Materials ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2020, 24(11):1028-1036]

Cited: 2 times

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Critical Care for COVID-19 Affected Patients: Updated Position Statement of the Indian Society of Critical Care Medicine.

Yatin Mehta, Dhruva Chaudhry, O C Abraham, Jose Chacko, Jigeeshu Divatia, Bharat Jagiasi, Arindam Kar, G C Khilnani, Bhuvana Krishna, Prashant Kumar, R K Mani, B K Rao, Pawan K Singh, Sanjeev Singh, Pavan Tiwary, Chand Wattal, Deepak Govil, Subhal Dixit, Srinivas Samavedam,

The management of coronavirus disease-2019 (COVID-19) is witnessing a change as we learn more about the pathophysiology and the severity of the disease. Several randomized controlled trials (RCTs) and meta-analysis have been published over the last few months. Several interventions and therapies which showed promise in the initial days of ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2020, 24(Suppl 5):S225-S230]

Cited: 0 times

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Computational simulation to assess patient safety of uncompensated COVID-19 two-patient ventilator sharing using the Pulse Physiology Engine.

Jeffrey B Webb, Aaron Bray, Philip K Asare, Rachel B Clipp, Yatin B Mehta, Sudheer Penupolu, Aalpen A Patel, S Mark Poler,

<h4>Background</h4>The COVID-19 pandemic is stretching medical resources internationally, sometimes creating ventilator shortages that complicate clinical and ethical situations. The possibility of needing to ventilate multiple patients with a single ventilator raises patient health and safety concerns in addition to clinical conditions needing treatment. Wherever ventilators are employed, additional tubing and ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0242532]

Cited: 1 time

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Brain lesion in a recreational drug user: Isolated cerebral mucormycosis.

Ngoc-Tram Ha, Megan Lowery, Jean Woo, Yatin Mehta, Nitin Bhanot,

Isolated cerebral mucormycosis is a relatively rare and unique variant of mucormycosis which is seen most commonly in patients with intravenous recreational drug use. While this invasive fungal infection in the brain is thought to spread from the sinuses or the lungs in other hosts such as diabetics and those ... Read more >>

IDCases (IDCases)
[2020, 22:e00979]

Cited: 0 times

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Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry.

Ryan P Barbaro, Graeme MacLaren, Philip S Boonstra, Theodore J Iwashyna, Arthur S Slutsky, Eddy Fan, Robert H Bartlett, Joseph E Tonna, Robert Hyslop, Jeffrey J Fanning, Peter T Rycus, Steve J Hyer, Marc M Anders, Cara L Agerstrand, Katarzyna Hryniewicz, Rodrigo Diaz, Roberto Lorusso, Alain Combes, Daniel Brodie, ,

<h4>Background</h4>Multiple major health organisations recommend the use of extracorporeal membrane oxygenation (ECMO) support for COVID-19-related acute hypoxaemic respiratory failure. However, initial reports of ECMO use in patients with COVID-19 described very high mortality and there have been no large, international cohort studies of ECMO for COVID-19 reported to date.<h4>Methods</h4>We used ... Read more >>

Lancet (Lancet (London, England))
[2020, 396(10257):1071-1078]

Cited: 127 times

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Diabetic ketoacidosis precipitated by COVID-19: A report of two cases and review of literature.

Pavan Kumar Reddy, Mohammad Shafi Kuchay, Yatin Mehta, Sunil Kumar Mishra,

<h4>Background and aims</h4>The relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) and diabetes mellitus is bidirectional. On one hand, diabetes mellitus is associated with an increased risk of severe COVID-19. On the other hand, new onset diabetes and severe metabolic complications of pre-existing diabetes, including diabetic ketoacidosis ... Read more >>

Diabetes Metab Syndr (Diabetes & metabolic syndrome)
[2020, 14(5):1459-1462]

Cited: 26 times

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Cytokine Storm in Novel Coronavirus Disease (COVID-19): Expert Management Considerations.

Yatin Mehta, Subhal B Dixit, Kapil G Zirpe, Abdul S Ansari,

<h4>Aim/objective/introduction</h4>Cytokine storm or cytokine release syndrome (CRS) is inevitable in severe and critically ill patients with novel coronavirus disease-2019 (COVID-19). This review aimed to discuss current therapeutic options for the management of CRS in COVID-19.<h4>Background</h4>Cytokine storm is caused by the colossal release of proinflammatory cytokines [e.g., IL (interleukin)-2, IL-6, IL-8 ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2020, 24(6):429-434]

Cited: 3 times

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