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Author Yasuyuki Hirashima

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A multi-institutional survey of the quality of life after treatment for uterine cervical cancer: a comparison between radical radiotherapy and surgery in Japan.

Yuko Kaneyasu, Hisaya Fujiwara, Tetsuo Nishimura, Hideyuki Sakurai, Tomoko Kazumoto, Hitoshi Ikushima, Takashi Uno, Sunao Tokumaru, Yoko Harima, Hiromichi Gomi, Takafumi Toita, Midori Kita, Shin-Ei Noda, Takeo Takahashi, Shingo Kato, Ayako Ohkawa, Akiko Tozawa-Ono, Hiroki Ushijima, Yoko Hasumi, Yasuyuki Hirashima, Yuzuru Niibe, Tomio Nakagawa, Tomoyuki Akita, Junko Tanaka, Tatsuya Ohno, ,

This study aimed to research the post-treatment quality of life (QOL) between radiotherapy (RT)- and operation (OP)-treated early cervical cancer survivors, using separate questionnaires for physicians and patients. We administered an observational questionnaire to patients aged 20-70 years old with Stages IB1-IIB cervical cancer who had undergone RT or OP and ... Read more >>

J Radiat Res (Journal of radiation research)
[2021, 62(2):269-284]

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The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.

Hideki Tokunaga, Mikio Mikami, Satoru Nagase, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Toyomi Satoh, Yasuyuki Hirashima, Noriomi Matsumura, Yoshihito Yokoyama, Kei Kawana, Satoru Kyo, Daisuke Aoki, Hidetaka Katabuchi,

The fifth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer was published in 2020. The guidelines contain 6 chapters-namely, (1) overview of the guidelines; (2) epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer; (3) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e49]

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Histopathological features of HER2 overexpression in uterine carcinosarcoma: proposal for requirements in HER2 testing for targeted therapy.

Hiroshi Yoshida, Tadaaki Nishikawa, Koji Matsumoto, Masahiko Mori, Yasuyuki Hirashima, Kazuhiro Takehara, Kazuya Ariyoshi, Kosei Hasegawa, Kan Yonemori,

Uterine carcinosarcoma (UCS) is an uncommon and highly aggressive tumor. There is no HER2 testing protocol for UCS despite the development of HER2 antibody conjugates. We aimed to elucidate histopathological HER2 expression details in UCS, to compare HER2 scores between ASCO/CAP criteria for gastric and breast cancer, and to propose ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2021, :]

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Role of Tumor Mutation Burden Analysis in Detecting Lynch Syndrome in Precision Medicine: Analysis of 2,501 Japanese Cancer Patients.

Yoshimi Kiyozumi, Hiroyuki Matsubayashi, Satomi Higashigawa, Yasue Horiuchi, Nobuhiro Kado, Yasuyuki Hirashima, Akio Shiomi, Takuma Oishi, Sumiko Ohnami, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Ken Yamaguchi,

<h4>Background</h4>Tumor mutation burden (TMB) is the total exonic mutation count per megabase of tumor DNA. Recent advances in precision medicine occasionally detect Lynch syndrome (LS) by germline sequencing for mismatch-repair (g.<i>MMR</i>) genes but not using TMB. The current study analyzes the utility of TMB in detecting LS.<h4>Methods</h4>Whole-exome sequencing (ion-semiconductor sequencing) ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2021, 30(1):166-174]

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Japanese version of The Cancer Genome Atlas, JCGA, established using fresh frozen tumors obtained from 5143 cancer patients.

Takeshi Nagashima, Ken Yamaguchi, Kenichi Urakami, Yuji Shimoda, Sumiko Ohnami, Keiichi Ohshima, Tomoe Tanabe, Akane Naruoka, Fukumi Kamada, Masakuni Serizawa, Keiichi Hatakeyama, Kenya Matsumura, Shumpei Ohnami, Koji Maruyama, Tohru Mochizuki, Masatoshi Kusuhara, Akio Shiomi, Yasuhisa Ohde, Masanori Terashima, Katsuhiko Uesaka, Tetsuro Onitsuka, Seiichiro Nishimura, Yasuyuki Hirashima, Nakamasa Hayashi, Yoshio Kiyohara, Yasuhiro Tsubosa, Hirohisa Katagiri, Masashi Niwakawa, Kaoru Takahashi, Hiroya Kashiwagi, Masahiro Nakagawa, Yuji Ishida, Takashi Sugino, Mitsuru Takahashi, Yasuto Akiyama,

This study aimed to establish the Japanese Cancer Genome Atlas (JCGA) using data from fresh frozen tumor tissues obtained from 5143 Japanese cancer patients, including those with colorectal cancer (31.6%), lung cancer (16.5%), gastric cancer (10.8%) and other cancers (41.1%). The results are part of a single-center study called "High-tech ... Read more >>

Cancer Sci (Cancer science)
[2020, 111(2):687-699]

Cited: 7 times

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Vitamin B12 Deficiency Anemia and Polyneuropathy Due to Chronic Radiation Enteritis.

Hiroyuki Fukuda, Munetaka Takekuma, Yasuyuki Hirashima,

A 62-year-old Japanese woman developed numbness of the extremities and megaloblastic anemia. She had undergone total abdominal hysterectomy, whole-pelvis radiation therapy and chemotherapy for gynecological cancer 10 years before. Chronic abdominal pain, diarrhea and intermittent small-bowel obstruction had afflicted her for a long time. We diagnosed her with vitamin B12 ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2020, 59(6):859-861]

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Metachronous ovarian endometrioid carcinomas in a patient with a PTEN variant: case report of incidentally detected Cowden syndrome.

Hiroyuki Matsubayashi, Satomi Higashigawa, Yoshimi Kiyozumi, Yasue Horiuchi, Yasuyuki Hirashima, Nobuhiro Kado, Masato Abe, Takuma Ohishi, Sumiko Ohnami, Kenichi Urakami, Ken Yamaguchi,

<h4>Background</h4>Somatic PTEN mutation occurs in a proportion of ovarian endometrioid carcinomas. However, these cancers have seldom been reported in diseases associated with germline PTEN variants, such as Cowden syndrome (CS).<h4>Case presentation</h4>The present case was a 39-year-old woman with a left ovarian carcinoma who demonstrated a germline splice variant of PTEN ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):1014]

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A phase II randomized controlled study of pegylated liposomal doxorubicin and carboplatin vs. gemcitabine and carboplatin for platinum-sensitive recurrent ovarian cancer (GOTIC003/intergroup study).

Hiroyuki Fujiwara, Kimio Ushijima, Shoji Nagao, Yuji Takei, Muneaki Shimada, Masashi Takano, Kiyoshi Yoshino, Yoshiaki Kawano, Yasuyuki Hirashima, Satoru Nagase, Shin Nishio, Tadaaki Nishikawa, Kimihiko Ito, Tadahiro Shoji, Eizo Kimura, Tadao Takano, Toru Sugiyama, Junzo Kigawa, Keiichi Fujiwara, Mitsuaki Suzuki,

<h4>Purpose</h4>To compare the efficacy, safety, and tolerability profiles of pegylated liposomal doxorubicin and carboplatin (PLDC) with those of gemcitabine and carboplatin (GC) for the treatment of patients with platinum-sensitive recurrent ovarian cancer.<h4>Methods</h4>Ovarian cancer patients with recurrence > 6 months after first-line platinum and taxane-based therapies were randomly assigned to PLDC [pegylated liposomal doxorubicin ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2019, 24(10):1284-1291]

Cited: 0 times

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Trebananib or placebo plus carboplatin and paclitaxel as first-line treatment for advanced ovarian cancer (TRINOVA-3/ENGOT-ov2/GOG-3001): a randomised, double-blind, phase 3 trial.

Ignace Vergote, Giovanni Scambia, David M O'Malley, Ben Van Calster, Sang-Yoon Park, Josep M Del Campo, Werner Meier, Aristotelis Bamias, Nicoletta Colombo, Robert M Wenham, Al Covens, Christian Marth, Mansoor Raza Mirza, Judith R Kroep, Haijun Ma, Cheryl A Pickett, Bradley J Monk, ,

<h4>Background</h4>Angiopoietin 1 and 2 regulate angiogenesis and vascular remodelling by interacting with the tyrosine kinase receptor Tie2, and inhibition of angiogenesis has shown promise in the treatment of ovarian cancer. We aimed to assess whether trebananib, a peptibody that inhibits binding of angiopoietin 1 and 2 to Tie2, improved progression-free ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2019, 20(6):862-876]

Cited: 9 times

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Quality indicators for cervical cancer care in Japan.

Tomone Watanabe, Mikio Mikami, Hidetaka Katabuchi, Shingo Kato, Masanori Kaneuchi, Masahiro Takahashi, Hidekatsu Nakai, Satoru Nagase, Satoru Nagase, Hitoshi Niikura, Masaki Mandai, Yasuyuki Hirashima, Hiroyuki Yanai, Wataru Yamagami, Satoru Kamitani, Takahiro Higashi,

<h4>Objective</h4>We aimed to propose a set of quality indicators (QIs) based on the clinical guidelines for cervical cancer treatment published by The Japan Society of Gynecologic Oncology, and to assess adherence to standard-of-care as an index of the quality of care for cervical cancer in Japan.<h4>Methods</h4>A panel of clinical experts ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2018, 29(6):e83]

Cited: 1 time

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Phase III study of cisplatin with or without S-1 in patients with stage IVB, recurrent, or persistent cervical cancer.

Yoichi Aoki, Kazunori Ochiai, Soyi Lim, Daisuke Aoki, Shoji Kamiura, Hao Lin, Noriyuki Katsumata, Soon-Do Cha, Jae-Hoon Kim, Byoung-Gie Kim, Yasuyuki Hirashima, Keiichi Fujiwara, Young-Tak Kim, Seok Mo Kim, Hyun Hoon Chung, Ting-Chang Chang, Toshiharu Kamura, Ken Takizawa, Masahiro Takeuchi, Soon-Beom Kang,

<h4>Background</h4>This open-label phase III trial evaluated efficacy and safety of S-1 plus cisplatin vs. cisplatin alone as first-line chemotherapy in patients with stage IVB, recurrent, or persistent cervical cancer.<h4>Methods</h4>Patients were randomised (1:1) to S-1 plus cisplatin (study group) or cisplatin alone (control group). In each cycle, cisplatin 50 mg/m<sup>2</sup> was administered ... Read more >>

Br J Cancer (British journal of cancer)
[2018, 119(5):530-537]

Cited: 4 times

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Lambert-Eaton Myasthenic Syndrome Associated with Synchronous Double Cancer: A Combination of Small Cell Carcinoma of the Cervix and Breast Carcinoma.

Hiroyuki Fukuda, Akira Tanaka, Yasuyuki Hirashima, Ichiro Ito,

Lambert-Eaton myasthenic syndrome (LEMS) is most commonly associated with small cell lung carcinoma, while it is rarely associated with gynecological and breast carcinoma. We herein report a case of LEMS associated with synchronous double cancer, which was a combination of small cell carcinoma of the cervix and breast carcinoma. The ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2018, 57(16):2409-2411]

Cited: 1 time

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Phase II study of adjuvant chemotherapy with paclitaxel and nedaplatin for uterine cervical cancer with lymph node metastasis.

Munetaka Takekuma, Mototsugu Shimokawa, Shin Nishio, Hideo Omi, Tsutomu Tabata, Yuji Takei, Kaei Nasu, Yoshiyuki Takahashi, Shinji Toyota, Yoshikazu Ichikawa, Atsushi Arakawa, Fuminori Ito, Hiroshi Tsubamoto, Taisuke Mori, Yasuyuki Hirashima, Kimihiko Ito,

The purpose of this phase II trial was to assess the efficacy and toxicity of paclitaxel and nedaplatin (TN) as the initial postoperative adjuvant chemotherapy for uterine cervical cancer with lymph node metastases (LNM). Patients with FIGO stage IB1-IIA2 squamous cell carcinoma of the uterine cervix were enrolled. Histological confirmation ... Read more >>

Cancer Sci (Cancer science)
[2018, 109(5):1602-1608]

Cited: 1 time

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A nationwide multi-institutional retrospective study to identify prognostic factors and develop a graded prognostic assessment system for patients with brain metastases from uterine corpus and cervical cancer.

Nakamasa Hayashi, Hideaki Takahashi, Yuzo Hasegawa, Fumi Higuchi, Masamichi Takahashi, Keishi Makino, Masatoshi Takagaki, Jiro Akimoto, Takeshi Okuda, Yoshiko Okita, Koichi Mitsuya, Yasuyuki Hirashima, Yoshitaka Narita, Yoko Nakasu, ,

<h4>Background</h4>The prevalence of brain metastases (BM) from uterine cancer has recently increased because of the improvement of overall survival (OS) of patients with uterine cancer due to its early detection and improved local control as a result of new effective treatments. However, little information is available regarding their clinical characteristics ... Read more >>

BMC Cancer (BMC cancer)
[2017, 17(1):397]

Cited: 4 times

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Phase 1 study of veliparib with carboplatin and weekly paclitaxel in Japanese patients with newly diagnosed ovarian cancer.

Shin Nishio, Munetaka Takekuma, Satoshi Takeuchi, Kouichirou Kawano, Naotake Tsuda, Kazuto Tasaki, Nobutaka Takahashi, Masakazu Abe, Aki Tanaka, Takayuki Nagasawa, Tadahiro Shoji, Hao Xiong, Silpa Nuthalapati, Terri Leahy, Hideyuki Hashiba, Tsukasa Kiriyama, Philip Komarnitsky, Yasuyuki Hirashima, Kimio Ushijima,

This phase 1, open-label, dose-escalation study was conducted to determine the safety, tolerability, pharmacokinetics and preliminary efficacy of veliparib with carboplatin and weekly paclitaxel in Japanese women with newly diagnosed, advanced ovarian cancer. Patients received veliparib at 100 or 150 mg b.i.d. on days 1-21 with carboplatin (area under the concentration-time curve ... Read more >>

Cancer Sci (Cancer science)
[2017, 108(11):2213-2220]

Cited: 6 times

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The issues regarding postoperative adjuvant therapy and prognostic risk factors for patients with stage I-II cervical cancer: A review.

Munetaka Takekuma, Yuka Kasamatsu, Nobuhiro Kado, Shiho Kuji, Aki Tanaka, Nobutaka Takahashi, Masakazu Abe, Yasuyuki Hirashima,

The treatment for most patients with early-stage cervical cancer involves radical hysterectomy and pelvic lymph node dissection, and indications for postoperative adjuvant therapy have been determined by evaluating the prognostic risk factors for recurrence in each case. The aim of this review is to raise and discuss the various issues ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2017, 43(4):617-626]

Cited: 10 times

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A new marker, insulinoma-associated protein 1 (INSM1), for high-grade neuroendocrine carcinoma of the uterine cervix: Analysis of 37 cases.

Shiho Kuji, Reiko Watanabe, Yuichi Sato, Takashi Iwata, Yasuyuki Hirashima, Munetaka Takekuma, Ichiro Ito, Masato Abe, Ryo Nagashio, Katsuhiro Omae, Daisuke Aoki, Toru Kameya,

<h4>Objective</h4>High-grade neuroendocrine carcinoma of uterine cervix (HGNCUC) has been recognized as a highly malignant tumor. Therapeutic strategy specific to neuroendocrine (NE) tumors needs to be considered, but some cases wouldn't allow simple final diagnoses. Insulinoma-associated protein 1 (INSM1), which is a zinc-finger transcription factor related to NE differentiation, is frequently ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2017, 144(2):384-390]

Cited: 20 times

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Adjuvant chemotherapy versus concurrent chemoradiotherapy for high-risk cervical cancer after radical hysterectomy and systematic lymphadenectomy.

Munetaka Takekuma, Yuka Kasamatsu, Nobuhiro Kado, Shiho Kuji, Aki Tanaka, Nobutaka Takahashi, Masakazu Abe, Yasuyuki Hirashima,

<h4>Background</h4>The aims of this study were to evaluate the efficacy and toxicity of chemotherapy (CT) compared with concurrent chemoradiotherapy (CCRT) after radical hysterectomy and lymphadenectomy in high-risk patients with early-stage cervical cancer and to evaluate whether the radicality of the lymphadenectomy would affect the outcome and toxicity of postoperative adjuvant ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2016, 21(4):741-747]

Cited: 15 times

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Reconsideration of postoperative concurrent chemoradiotherapy with fluorouracil and cisplatin for uterine cervical cancer.

Munetaka Takekuma, Yuka Kasamatsu, Nobuhiro Kado, Shiho Kuji, Aki Tanaka, Nobutaka Takahashi, Masakazu Abe, Yasuyuki Hirashima,

<h4>Aim</h4>The aim of this retrospective study was to analyze data for patients with stage IB-IIB uterine cervical cancer who were treated with concurrent chemoradiotherapy with fluorouracil (5-FU) and cisplatin (CCRT-FP) as postoperative adjuvant therapy and to re-examine these issues and further treatment.<h4>Methods</h4>Patients with high risk for recurrence underwent CCRT-FP as ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2015, 41(10):1638-1643]

Cited: 12 times

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Efficacy of Olanzapine Combined Therapy for Patients Receiving Highly Emetogenic Chemotherapy Resistant to Standard Antiemetic Therapy.

Masakazu Abe, Yuka Kasamatsu, Nobuhiro Kado, Shiho Kuji, Aki Tanaka, Nobutaka Takahashi, Munetaka Takekuma, Yasuyuki Hirashima,

<h4>Objective</h4>Olanzapine is proved to be effective for chemotherapy induced nausea and vomiting (CINV). But its efficacy in combination with standard antiemetic therapy is unknown. The purpose of this study is to prove the preventive effect of olanzapine for the prevention of CINV caused by highly emetogenic chemotherapy when used with ... Read more >>

Biomed Res Int (BioMed research international)
[2015, 2015:956785]

Cited: 8 times

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Efficacy and safety of olanzapine combined with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy in gynecological cancer: KCOG-G1301 phase II trial.

Masakazu Abe, Yasuyuki Hirashima, Yuka Kasamatsu, Nobuhiro Kado, Satomi Komeda, Shiho Kuji, Aki Tanaka, Nobutaka Takahashi, Munetaka Takekuma, Hanako Hihara, Yoshikazu Ichikawa, Yui Itonaga, Tomoko Hirakawa, Kaei Nasu, Kanoko Miyagi, Junko Murakami, Kimihiko Ito,

<h4>Purpose</h4>Olanzapine is effective in chemotherapy-induced nausea and vomiting (CINV). In patients receiving highly emetogenic chemotherapy (HEC), its efficacy was reported as rescue therapy for breakthrough emesis refractory to triplet therapy (palonosetron, aprepitant, and dexamethasone). However, its preventive effects with triplet therapy for CINV are unknown. This study aimed to investigate ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2016, 24(2):675-682]

Cited: 28 times

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Platinum sensitivity and non-cross-resistance of cisplatin analogue with cisplatin in recurrent cervical cancer.

Munetaka Takekuma, Shiho Kuji, Aki Tanaka, Nobutaka Takahashi, Masakazu Abe, Yasuyuki Hirashima,

<h4>Objective</h4>The concept of platinum sensitivity and cross-resistance among platinum agents are widely known in the management of recurrent ovarian cancer. The aim of this study was to evaluate two hypotheses regarding the validity of the concept of platinum sensitivity and non-cross-resistance of cisplatin analogue with cisplatin in recurrent cervical cancer.<h4>Methods</h4>In ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2015, 26(3):185-192]

Cited: 12 times

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Microbiology of Pelvic Lymphocyst Infection after Lymphadenectomy for Malignant Gynecologic Tumors.

Ichiro Kawamura, Yasuyuki Hirashima, Mika Tsukahara, Keita Mori, Hanako Kurai,

<h4>Background</h4>Pelvic lymphocyst infection is a rare complication after lymphadenectomy for malignant gynecologic tumors. Although medical therapy is a useful addition to surgical drainage, the appropriate antibiotic regimen is unknown because few studies have examined the causative organisms. The purpose of this case series was to identify the micro-organisms infecting pelvic ... Read more >>

Surg Infect (Larchmt) (Surgical infections)
[2015, 16(3):244-246]

Cited: 5 times

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Efficacy and safety of triple therapy with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy for gynecological cancer: KCOG-G1003 phase II trial.

Nobuhiro Takeshima, Maki Matoda, Masakazu Abe, Yasuyuki Hirashima, Kentaro Kai, Kaei Nasu, Masashi Takano, Kenichi Furuya, Seiya Sato, Hiroaki Itamochi, Hiroshi Tsubamoto, Kosei Hasegawa, Kiminari Terao, Takeo Otsuki, Keiko Kuritani, Kimihiko Ito,

<h4>Purpose</h4>Prevention of chemotherapy-induced nausea and vomiting (CINV) is crucial for maintaining the quality of life of cancer patients. Female patients have been underrepresented in previous clinical studies of aprepitant or palonosetron. We performed a prospective multicenter study to investigate the efficacy and safety of triple therapy comprising these two agents ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2014, 22(11):2891-2898]

Cited: 7 times

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The relationship between positive peritoneal cytology and the prognosis of patients with FIGO stage I/II uterine cervical cancer.

Shiho Kuji, Yasuyuki Hirashima, Satomi Komeda, Aki Tanaka, Masakazu Abe, Nobutaka Takahashi, Munetaka Takekuma,

<h4>Objective</h4>The purpose of this study was to assess whether peritoneal cytology has prognostic significance in uterine cervical cancer.<h4>Methods</h4>Peritoneal cytology was obtained in 228 patients with carcinoma of the uterine cervix (International Federation of Gynecology and Obstetrics [FIGO] stages IB1-IIB) between October 2002 and August 2010. All patients were negative for ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2014, 25(2):90-96]

Cited: 8 times

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