Full Text Journal Articles by
Author Yasser S Abdel Ghany

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Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies.

Nayera W Hassan, Manal N Saudi, Yasser S Abdel-Ghany, Azza Ismail, Perihan A Elzahhar, Dharmarajan Sriram, Rasha Nassra, Marwa M Abdel-Aziz, Soad A El-Hawash,

TB continues to be a leading health threat despite the availability of powerful anti-TB drugs. We report herein the design and synthesis of various hybrid molecules comprising pyrazine scaffold and various formerly identified anti-mycobacterial moieties. Thirty-one compounds were screened in vitro for their activity against Mycobacterium tuberculosis H37Rv strain using ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2020, 96:103610]

Cited: 3 times

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Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.

Ghandoura Moussa, Rana Alaaeddine, Lynn M Alaeddine, Rasha Nassra, Ahmed S F Belal, Azza Ismail, Ahmed F El-Yazbi, Yasser S Abdel-Ghany, Aly Hazzaa,

Click chemistry was used to synthesize a new series of thioquinazolinone molecules equipped with propargyl moiety,1,2,3-triazolyl and isoxazolyl rings. Our design was based on merging pharmacophores previously reported to exhibit COX-2 inhibitory activities to a thioquinazolinone-privileged scaffold. The synthesized compounds were subjected to in vitro cyclooxygenase COX-1/COX-2 and 15-LOX inhibition assays. ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2018, 144:635-650]

Cited: 6 times

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Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.

Adnan A Bekhit, Hayam M A Ashour, Yasser S Abdel Ghany, Alaa El-Din A Bekhit, Azza Baraka,

Four series of pyrazolyl benzenesulfonamide derivatives have been synthesized. The first series was prepared by cyclization of the intermediate N,N-dimethylaminomethylene-4[3-phenyl-4-(substituted thiosemicarbamoyl hydrazonomethyl)-1H-pyrazol-1-yl]benzenesulfonamide 2a-c with ethyl bromoacetate to afford the corresponding thiazolidinyl derivatives 3a-c. The second series was prepared by cyclization of the key intermediates 2a-c with 4-bromophenacyl bromide giving rise ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2008, 43(3):456-463]

Cited: 66 times

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