Full Text Journal Articles by
Author Yasser S Abdel Ghany


Find full text journal articles

Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies.

Nayera W Hassan, Manal N Saudi, Yasser S Abdel-Ghany, Azza Ismail, Perihan A Elzahhar, Dharmarajan Sriram, Rasha Nassra, Marwa M Abdel-Aziz, Soad A El-Hawash,

TB continues to be a leading health threat despite the availability of powerful anti-TB drugs. We report herein the design and synthesis of various hybrid molecules comprising pyrazine scaffold and various formerly identified anti-mycobacterial moieties. Thirty-one compounds were screened in vitro for their activity against Mycobacterium tuberculosis H37Rv strain using ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2020, 96:103610]

Cited: 4 times

View full text PDF listing >>

Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.

Ghandoura Moussa, Rana Alaaeddine, Lynn M Alaeddine, Rasha Nassra, Ahmed S F Belal, Azza Ismail, Ahmed F El-Yazbi, Yasser S Abdel-Ghany, Aly Hazzaa,

Click chemistry was used to synthesize a new series of thioquinazolinone molecules equipped with propargyl moiety,1,2,3-triazolyl and isoxazolyl rings. Our design was based on merging pharmacophores previously reported to exhibit COX-2 inhibitory activities to a thioquinazolinone-privileged scaffold. The synthesized compounds were subjected to in vitro cyclooxygenase COX-1/COX-2 and 15-LOX inhibition assays. ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2018, 144:635-650]

Cited: 7 times

View full text PDF listing >>



1.5261 s