Nayera W Hassan, Manal N Saudi, Yasser S Abdel-Ghany, Azza Ismail, Perihan A Elzahhar, Dharmarajan Sriram, Rasha Nassra, Marwa M Abdel-Aziz, Soad A El-Hawash,
TB continues to be a leading health threat despite the availability of powerful anti-TB drugs. We report herein the design and synthesis of various hybrid molecules comprising pyrazine scaffold and various formerly identified anti-mycobacterial moieties. Thirty-one compounds were screened in vitro for their activity against Mycobacterium tuberculosis H37Rv strain using ... Read more >>
Bioorg Chem (Bioorganic chemistry)
[2020, 96:103610]
Cited: 3 times
Ghandoura Moussa, Rana Alaaeddine, Lynn M Alaeddine, Rasha Nassra, Ahmed S F Belal, Azza Ismail, Ahmed F El-Yazbi, Yasser S Abdel-Ghany, Aly Hazzaa,
Click chemistry was used to synthesize a new series of thioquinazolinone molecules equipped with propargyl moiety,1,2,3-triazolyl and isoxazolyl rings. Our design was based on merging pharmacophores previously reported to exhibit COX-2 inhibitory activities to a thioquinazolinone-privileged scaffold. The synthesized compounds were subjected to in vitro cyclooxygenase COX-1/COX-2 and 15-LOX inhibition assays. ... Read more >>
Eur J Med Chem (European journal of medicinal chemistry)
[2018, 144:635-650]
Cited: 6 times
Adnan A Bekhit, Hayam M A Ashour, Yasser S Abdel Ghany, Alaa El-Din A Bekhit, Azza Baraka,
Four series of pyrazolyl benzenesulfonamide derivatives have been synthesized. The first series was prepared by cyclization of the intermediate N,N-dimethylaminomethylene-4[3-phenyl-4-(substituted thiosemicarbamoyl hydrazonomethyl)-1H-pyrazol-1-yl]benzenesulfonamide 2a-c with ethyl bromoacetate to afford the corresponding thiazolidinyl derivatives 3a-c. The second series was prepared by cyclization of the key intermediates 2a-c with 4-bromophenacyl bromide giving rise ... Read more >>
Eur J Med Chem (European journal of medicinal chemistry)
[2008, 43(3):456-463]
Cited: 66 times