Full Text Journal Articles by
Author Yasser Abdelrahman

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Polarized Cell Division of Chlamydia trachomatis.

Yasser Abdelrahman, Scot P Ouellette, Robert J Belland, John V Cox,

Bacterial cell division predominantly occurs by a highly conserved process, termed binary fission, that requires the bacterial homologue of tubulin, FtsZ. Other mechanisms of bacterial cell division that are independent of FtsZ are rare. Although the obligate intracellular human pathogen Chlamydia trachomatis, the leading bacterial cause of sexually transmitted infections ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2016, 12(8):e1005822]

Cited: 13 times

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Correction: Polarized Cell Division of Chlamydia trachomatis.

Yasser Abdelrahman, Scot P Ouellette, Robert J Belland, John V Cox,

[This corrects the article DOI: 10.1371/journal.ppat.1005822.]. ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2016, 12(8):e1005866]

Cited: 0 times

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Identification and Partial Characterization of Potential FtsL and FtsQ Homologs of Chlamydia.

Scot P Ouellette, Kelsey J Rueden, Yasser M AbdelRahman, John V Cox, Robert J Belland,

Chlamydia is amongst the rare bacteria that lack the critical cell division protein FtsZ. By annotation, Chlamydia also lacks several other essential cell division proteins including the FtsLBQ complex that links the early (e.g., FtsZ) and late (e.g., FtsI/Pbp3) components of the division machinery. Here, we report chlamydial FtsL and ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2015, 6:1264]

Cited: 5 times

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Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth.

John V Cox, Yasser M Abdelrahman, Jan Peters, Nirun Naher, Robert J Belland,

Phosphatidylcholine is a constituent of Chlamydia trachomatis membranes that must be acquired from its mammalian host to support bacterial proliferation. The CLA1 (SR-B1) receptor is a bi-directional phosphatidylcholine/cholesterol transporter that is recruited to the inclusion of Chlamydia-infected cells along with ABCA1. C. trachomatis growth was inhibited in a dose-dependent manner ... Read more >>

Cell. Microbiol. (Cellular microbiology)
[2016, 18(3):305-318]

Cited: 5 times

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Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.

David F Bruhn, Samanthi L Waidyarachchi, Dora B Madhura, Dimitri Shcherbakov, Zhong Zheng, Jiuyu Liu, Yasser M Abdelrahman, Aman P Singh, Stefan Duscha, Chetan Rathi, Robin B Lee, Robert J Belland, Bernd Meibohm, Jason W Rosch, Erik C Böttger, Richard E Lee,

The antibiotic spectinomycin is a potent inhibitor of bacterial protein synthesis with a unique mechanism of action and an excellent safety index, but it lacks antibacterial activity against most clinically important pathogens. A series of N-benzyl-substituted 3'-(R)-3'-aminomethyl-3'-hydroxy spectinomycins was developed on the basis of a computational analysis of the aminomethyl ... Read more >>

Sci Transl Med (Science translational medicine)
[2015, 7(288):288ra75]

Cited: 5 times

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Developmental expression of non-coding RNAs in Chlamydia trachomatis during normal and persistent growth.

Yasser M Abdelrahman, Lorne A Rose, Robert J Belland,

Chlamydia trachomatis is an obligate intracellular bacterium that exhibits a unique biphasic developmental cycle that can be disrupted by growth in the presence of IFN-γ and β-lactams, giving rise to an abnormal growth state termed persistence. Here we have examined the expression of a family of non-coding RNAs (ncRNAs) that ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2011, 39(5):1843-1854]

Cited: 17 times

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Practical management of sudden cardiac arrest on the football field.

Efraim Benjamin Kramer, Martin Botha, Jonathan Drezner, Yasser Abdelrahman, Jiri Dvorak,

Sudden cardiac arrest (SCA) remains a tragic occurrence on the football field. The limits of preparticipation cardiovascular screening make it compulsory that prearranged emergency medical services be available at all football matches to immediately respond to any collapsed player. Management of SCA involves prompt recognition, immediate cardiopulmonary resuscitation (CPR) and ... Read more >>

Br J Sports Med (British journal of sports medicine)
[2012, 46(16):1094-1096]

Cited: 11 times

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Plasmid-cured Chlamydia caviae activates TLR2-dependent signaling and retains virulence in the guinea pig model of genital tract infection.

Lauren C Frazer, Toni Darville, Kumar Chandra-Kuntal, Charles W Andrews, Matthew Zurenski, Margaret Mintus, Yasser M AbdelRahman, Robert J Belland, Robin R Ingalls, Catherine M O'Connell,

Loss of the conserved "cryptic" plasmid from C. trachomatis and C. muridarum is pleiotropic, resulting in reduced innate inflammatory activation via TLR2, glycogen accumulation and infectivity. The more genetically distant C. caviae GPIC is a natural pathogen of guinea pigs and induces upper genital tract pathology when inoculated intravaginally, modeling ... Read more >>

PLoS ONE (PloS one)
[2012, 7(1):e30747]

Cited: 19 times

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Host HDL biogenesis machinery is recruited to the inclusion of Chlamydia trachomatis-infected cells and regulates chlamydial growth.

John V Cox, Nirun Naher, Yasser M Abdelrahman, Robert J Belland,

Chlamydia trachomatis is an obligate intracellular bacterial pathogen that is the most common cause of sexually transmitted bacterial infections and is the etiological agent of trachoma, the leading cause of preventable blindness. The organism infects epithelial cells of the genital tract and eyelid resulting in a damaging inflammatory response. Chlamydia ... Read more >>

Cell. Microbiol. (Cellular microbiology)
[2012, 14(10):1497-1512]

Cited: 29 times

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The Chlamydia pneumoniae type III secretion-related lcrH gene clusters are developmentally expressed operons.

Scot P Ouellette, Yasser M Abdelrahman, Robert J Belland, Gerald I Byrne,

Two chlamydial homologues of the Yersinia lcrH chaperone for type III secretion system structural components are present within separate gene clusters. Quantitative transcriptional analyses demonstrated that each cluster is differentially regulated and expressed as an operon using major sigma factor elements, suggesting the presence of more elaborate developmental regulation mechanisms ... Read more >>

J. Bacteriol. (Journal of bacteriology)
[2005, 187(22):7853-7856]

Cited: 18 times

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Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarum.

Catherine M O'Connell, Yasser M AbdelRahman, Erin Green, Hillary K Darville, Kazima Saira, Bennett Smith, Toni Darville, Amy M Scurlock, Christopher R Meyer, Robert J Belland,

We previously demonstrated that plasmid-deficient Chlamydia muridarum retains the ability to infect the murine genital tract but does not elicit oviduct pathology because it fails to activate Toll-like receptor 2 (TLR2). We derived a plasmid-cured derivative of the human genital isolate Chlamydia trachomatis D/UW-3/Cx, strain CTD153, which also fails to ... Read more >>

Infect. Immun. (Infection and immunity)
[2011, 79(3):1044-1056]

Cited: 58 times

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Global transcriptional upregulation in the absence of increased translation in Chlamydia during IFNgamma-mediated host cell tryptophan starvation.

Scot P Ouellette, Thomas P Hatch, Yasser M AbdelRahman, Lorne A Rose, Robert J Belland, Gerald I Byrne,

The developmentally regulated intracellular pathogen Chlamydia pneumoniae is a natural tryptophan auxotroph. These organisms survive tryptophan starvation induced by host cell activation with IFNgamma by blocking maturation to the infectious form. In most bacteria, the stringent response is induced during amino acid starvation to promote survival. However, the response of ... Read more >>

Mol. Microbiol. (Molecular microbiology)
[2006, 62(5):1387-1401]

Cited: 51 times

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