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Author Yashang Lee

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Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment.

Yashang Lee, Katrina Lehmann Blount, Feng Dai, Siobhan Thompson, Jonathan Kaufman Scher, Sherrie Bitterman, Madeline Droher, Erica L Herzog, Gilbert Moeckel, Anil Karihaloo, Neera K Dahl,

BACKGROUND:Semaphorin 7A (SEMA7A) is an immunomodulating protein implicated in lung and liver fibrosis. In autosomal-dominant polycystic kidney disease (ADPKD), the progressive expansion of renal cysts, inflammation, and subsequent renal fibrosis leads to end-stage renal disease (ESRD). SEMA7A may play a role in renal fibrosis and in ADPKD. METHODS:We evaluated Sema7a ... Read more >>

Clin. Exp. Nephrol. (Clinical and experimental nephrology)
[2018, 22(4):906-916]

Cited: 2 times

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Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair.

Elena S Ratner, Yong-Lian Zhu, Philip G Penketh, Julie Berenblum, Margaret E Whicker, Pamela H Huang, Yashang Lee, Kimiko Ishiguro, Rui Zhu, Alan C Sartorelli, Z Ping Lin,

BACKGROUND:Platinum resistance may be attributable to inherent or acquired proficiency in homologous recombination repair (HRR) in epithelial ovarian cancer (EOC). The objective of this study was to evaluate the efficacy of the small molecule inhibitor triapine to disrupt HRR and sensitise BRCA wild-type EOC cells to platinum-based combination therapy in ... Read more >>

Br. J. Cancer (British journal of cancer)
[2016, 114(7):777-786]

Cited: 6 times

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Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.

Xuefei Tian, Jin Ju Kim, Susan M. Monkley, Nanami Gotoh, Ramiro Nandez, Keita Soda, Kazunori Inoue, Daniel M. Balkin, Hossam Hassan, Sung Hyun Son, Yashang Lee, Gilbert Moeckel, David A. Calderwood, Lawrence B. Holzman, David R. Critchley, Roy Zent, Jochen Reiser, Shuta Ishibe,

(The Journal of Clinical Investigation)
[2015, 125(2):882-882]

Cited: 0 times

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Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors.

Amy Yuan, Yashang Lee, Uimook Choi, Gilbert Moeckel, Anil Karihaloo,

Kidney fibrosis is the final common pathway for virtually every type of chronic kidney disease and is a consequence of a prolonged healing response that follows tissue inflammation. Chronic kidney inflammation ultimately leads to progressive tissue injury and scarring/fibrosis. Several pathways have been implicated in the progression of kidney fibrosis. ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2015, 308(5):F459-72]

Cited: 15 times

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GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury.

Sarah C Huen, Larry Huynh, Arnaud Marlier, Yashang Lee, Gilbert W Moeckel, Lloyd G Cantley,

After kidney ischemia/reperfusion (I/R) injury, monocytes home to the kidney and differentiate into activated macrophages. Whereas proinflammatory macrophages contribute to the initial kidney damage, an alternatively activated phenotype can promote normal renal repair. The microenvironment of the kidney during the repair phase mediates the transition of macrophage activation from a ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2015, 26(6):1334-1345]

Cited: 35 times

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Structural and biochemical analyses of alanine racemase from the multidrug-resistant Clostridium difficile strain 630.

Oluwatoyin A Asojo, Sarah K Nelson, Sara Mootien, Yashang Lee, Wanderson C Rezende, Daniel A Hyman, Monica M Matsumoto, Scott Reiling, Alan Kelleher, Michel Ledizet, Raymond A Koski, Karen G Anthony,

Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among hospitalized patients. C. difficile is frequently associated with antibiotic treatment, and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembranous colitis. The severity of C. difficile infections is exacerbated by the emergence of hypervirulent and ... Read more >>

Acta Crystallogr. D Biol. Crystallogr. (Acta crystallographica. Section D, Biological crystallography)
[2014, 70(Pt 7):1922-1933]

Cited: 4 times

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Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.

Xuefei Tian, Jin Ju Kim, Susan M Monkley, Nanami Gotoh, Ramiro Nandez, Keita Soda, Kazunori Inoue, Daniel M Balkin, Hossam Hassan, Sung Hyun Son, Yashang Lee, Gilbert Moeckel, David A Calderwood, Lawrence B Holzman, David R Critchley, Roy Zent, Jochen Reiser, Shuta Ishibe,

Podocytes are specialized actin-rich epithelial cells that line the kidney glomerular filtration barrier. The interface between the podocyte and the glomerular basement membrane requires integrins, and defects in either α3 or β1 integrin, or the α3β1 ligand laminin result in nephrotic syndrome in murine models. The large cytoskeletal protein talin1 ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2014, 124(3):1098-1113]

Cited: 51 times

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Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors.

Z Ping Lin, Elena S Ratner, Margaret E Whicker, Yashang Lee, Alan C Sartorelli,

UNLABELLED:PARP inhibitors exploit synthetic lethality to target epithelial ovarian cancer (EOC) with hereditary BRCA mutations and defects in homologous recombination repair (HRR). However, such an approach is limited to a small subset of EOC patients and compromised by restored HRR due to secondary mutations in BRCA genes. Here, it was ... Read more >>

Mol. Cancer Res. (Molecular cancer research : MCR)
[2014, 12(3):381-393]

Cited: 20 times

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Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinones.

Yashang Lee, Sara Mootien, Carolyn Shoen, Michelle Destefano, Pier Cirillo, Oluwatoyin A Asojo, Kacheong R Yeung, Michel Ledizet, Michael H Cynamon, Paul A Aristoff, Raymond A Koski, Paul A Kaplan, Karen G Anthony,

The genus Mycobacterium includes non-pathogenic species such as M. smegmatis, and pathogenic species such as M. tuberculosis, the causative agent of tuberculosis (TB). Treatment of TB requires a lengthy regimen of several antibiotics, whose effectiveness has been compromised by the emergence of resistant strains. New antibiotics that can shorten the ... Read more >>

Biochem. Pharmacol. (Biochemical pharmacology)
[2013, 86(2):222-230]

Cited: 11 times

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Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage.

Z Ping Lin, Yashang Lee, Fang Lin, Michael F Belcourt, Peining Li, Joseph G Cory, Peter M Glazer, Alan C Sartorelli,

Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in the production of deoxyribonucleoside triphosphates (dNTPs) required for replicative and repair DNA synthesis. Mammalian RNR is a heteromeric enzyme consisting primarily of R1 and R2 subunits during the S phase of the cell cycle. We have shown previously that the presence of ... Read more >>

Mol. Pharmacol. (Molecular pharmacology)
[2011, 80(6):1000-1012]

Cited: 12 times

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Macrophages promote cyst growth in polycystic kidney disease.

Anil Karihaloo, Farrukh Koraishy, Sarah C Huen, Yashang Lee, David Merrick, Michael J Caplan, Stefan Somlo, Lloyd G Cantley,

Polycystic kidney disease (PKD) exhibits an inflammatory component, but the contribution of inflammation to cyst progression is unknown. Macrophages promote the proliferation of tubular cells following ischemic injury, suggesting that they may have a role in cystogenesis. Furthermore, cultured Pkd1-deficient cells express the macrophage chemoattractants Mcp1 and Cxcl16 and stimulate ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2011, 22(10):1809-1814]

Cited: 80 times

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Impacts of baicalein analogs with modification of the 6th position of A ring on the activity toward NF-kappaB-, AP-1-, or CREB-mediated transcription.

Sheng-Teng Huang, Yashang Lee, Elizabeth A Gullen, Yung-Chi Cheng,

The water extract of Scutellariae baicalensis Georgi (S. baicalensis) has potential anti-tumor and anti-inflammatory activities. A major flavonoid isolated from S. baicalensis, baicalein, was also found to have anti-tumor and anti-inflammatory activities. These biological activities could be due to their antioxidant action and/or effect on different signal transduction pathways. We ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & medicinal chemistry letters)
[2008, 18(18):5046-5049]

Cited: 1 time

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Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer therapy.

Min Ye, Shwu-Huey Liu, Zaoli Jiang, Yashang Lee, Robert Tilton, Yung-Chi Cheng,

PHY906 is a Chinese medicine formulation prepared from four medicinal herbs for adjuvant cancer chemotherapy. In this paper, liquid chromatography/electrospray ionization time-of-flight mass spectrometry (LC/ESI-TOFMS) was used to clarify the chemical composition of PHY906. The aqueous extract of PHY906 was separated on a Waters Atlantis C(18) column, and was eluted ... Read more >>

Rapid Commun. Mass Spectrom. (Rapid communications in mass spectrometry : RCM)
[2007, 21(22):3593-3607]

Cited: 47 times

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Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation.

Wolfgang Boehmerle, Kun Zhang, Michael Sivula, Felix M Heidrich, Yashang Lee, Sven-Eric Jordt, Barbara E Ehrlich,

Paclitaxel (Taxol) is a well established chemotherapeutic agent for the treatment of solid tumors, but it is limited in its usefulness by the frequent induction of peripheral neuropathy. We found that prolonged exposure of a neuroblastoma cell line and primary rat dorsal root ganglia with therapeutic concentrations of Taxol leads ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2007, 104(26):11103-11108]

Cited: 46 times

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Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.

Yashang Lee, Hosup Yeo, Shwu-Huey Liu, Zaoli Jiang, Ruben M Savizky, David J Austin, Yung-chi Cheng,

The aqueous extract of Scutellariae baicalensis Georgi has inhibitory activity against P-gp 170, a multiple drug resistant gene product. Baicalein, one of the major flavones, was found to be responsible for this activity. The hydroxyl groups of the A ring of baicalein were systematically alkylated in order to assess the ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2004, 47(22):5555-5566]

Cited: 17 times

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The effect of humic acid on the adhesibility of neutrophils.

Chong-Hua Chen, Jun-Jen Liu, Fung-Jou Lu, Mei-Ling Yang, Yashang Lee, Tien-Shang Huang,

UNLABELLED:Humic acid (HA), a fluorescent allomelanin, has been implicated as an etiological agent of Blackfoot disease (BFD), a peripheral vascular disease prevailing in the southwest of Taiwan. Clinical and pathological studies reveal that it is similar to atherosclerosis. In this report, the effect of HA on human neutrophils is studied ... Read more >>

Thromb. Res. (Thrombosis research)
[2002, 108(1):67-76]

Cited: 9 times

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Free radical scavenging properties of sulfinpyrazone.

Mei-Ling Yang, Tien-Shang Huang, Yashang Lee, Fung-Jou Lu,

Sulfinpyrazone, a potent uricosuric drug, was tested in vitro for its scavenging action against oxygen free radicals. In this study, sulfinpyrazone was able to scavenge 1,1-diphenyl-2-picrylhydrazyl radical with IC50 value of 29.82 micrograms/ml compared to butylated hydroxytoluene (BHT, IC50 value = 20.15 micrograms/ml) and Trolox (IC50 value = 16.01 micrograms/ml). ... Read more >>

Free Radic. Res. (Free radical research)
[2002, 36(6):685-693]

Cited: 9 times

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Inhibition of endogenous thyroid hormone receptor-beta and peroxisome proliferator-activated receptor-alpha activities by humic acid in a human-derived liver cell line.

Mei-Ling Yang, Tien-Shang Huang, Yashang Lee, Tsung-Hwa Chen, Shu-Yi Chen, Fung-Jou Lu,

Humic acid (HA), know to be ubiquitous in the natural environment, is present in almost all soil, surface water, and plants. Earlier studies indicate that HA can affect thyroid economy via binding with iodide, inhibiting both thyroid peroxidase and hepatic 5'-deiodinase in rodents. However, the effect of HA, a peroxisome ... Read more >>

Thyroid (Thyroid : official journal of the American Thyroid Association)
[2002, 12(5):361-371]

Cited: 5 times

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Humic acid extracted from Blackfoot disease-endemic well water induces adipocyte differentiation of C3H10T1/2 fibroblast cells: a possible mechanism leading to atherosclerotic-like plaque in Blackfoot disease.

Mei-Ling Yang, Yashang Lee, Tien-Shang Huang, Fung-Jou Lu,

A unique peripheral vascular disease named "Blackfoot disease" (BFD) is endemic on the southwest coast of Taiwan. Clinically, the signs and symptoms of BFD are similar to those of arteriosclerosis and Buerger disease. Humic acid has been proposed as a causative factor in BFD; however, the relationship between humic acid ... Read more >>

Arch. Toxicol. (Archives of toxicology)
[2002, 76(1):48-54]

Cited: 9 times

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