Full Text Journal Articles by
Author Yaping Joyce Liao

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Rapid Fluctuation of Subretinal Fluid on Encorafenib and Binimetinib.

Angela S Li, Theodore Leng, Seema Nagpal, Yaping Joyce Liao,

Retina (Retina (Philadelphia, Pa.))
[2020, 40(11):e66-e67]

Cited: 0 times

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Dual Specific Phosphatase 14 Deletion Rescues Retinal Ganglion Cells and Optic Nerve Axons after Experimental Anterior Ischemic Optic Neuropathy.

Varun Kumar, Mohammad Ali Shariati, Louise Mesentier-Louro, Angela Jinsook Oh, Kristina Russano, Jeffrey L Goldberg, Yaping Joyce Liao,

PURPOSE:Understanding molecular changes is essential for designing effective treatments for nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in adults older than 50 years. We investigated changes in the mitogen-activated protein kinase (MAPK) pathway after experimental AION and focused on dual specificity phosphatase 14 (Dusp14), an atypical ... Read more >>

Curr Eye Res (Current eye research)
[2020, :1-9]

Cited: 0 times

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Vision Loss in Optic Disc Drusen Correlates With Increased Macular Vessel Diameter and Flux and Reduced Peripapillary Vascular Density.

Yan Yan, Xiao Zhou, Zhongdi Chu, Laurel Stell, Mohammad Ali Shariati, Ruikang K Wang, Yaping Joyce Liao,

PURPOSE:To determine the key optical coherence tomography (OCT) and OCT angiography (OCTA) parameters that correlate with visual field loss in optic disc drusen (ODD). DESIGN:Retrospective cross-sectional study. METHODS:Single academic center. Seventeen patients with ODD (29 eyes) and 35 age-matched controls (53 eyes). Static perimetry, OCT, and OCTA imaging of optic ... Read more >>

Am J Ophthalmol (American journal of ophthalmology)
[2020, 218:214-224]

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Long distance retrograde degeneration of the retino-geniculo-cortical pathway in homonymous hemianopia

Alekya Rajanala, Mohammad Shariati, Yaping Joyce Liao,

Abstract Long-distance retrograde degeneration of the retino-geniculo-cortical pathway has been described in humans and animal models following injury to the brain. In this study, we used optical coherence tomography (OCT) to measure the severity and timing of retrograde degeneration after post-chiasmal visual pathway lesions in patients with homonymous hemianopia. We ... Read more >>

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Geographical variations in ocular and extra-ocular manifestations in Behçet's disease.

Farhad Shahram, Marthe T Mæhlen, Massoomeh Akhlaghi, Fereydoun Davatchi, Yaping Joyce Liao, Cornelia M Weyand,

OBJECTIVE:Behçet's disease (BD) is a rare vasculitis that results in multi-organ inflammatory disease. At-risk populations are most prevalent in the Middle East and East Asia. Clinical data on BD in Western countries, especially in the United States, are scarce. We have compared clinical patterning of BD vasculitis in two geographically ... Read more >>

Eur J Rheumatol (European journal of rheumatology)
[2019, 6(4):199-206]

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Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon.

Varun Kumar, Louise Alessandra Mesentier-Louro, Angela Jinsook Oh, Kathleen Heng, Mohammad Ali Shariati, Haoliang Huang, Yang Hu, Yaping Joyce Liao,

Purpose:Increased endoplasmic reticulum (ER) stress is one of the earliest subcellular changes in neuro-ophthalmic diseases. In this study, we investigated the expression of key molecules in the ER stress pathways following nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in adults over 50, and assessed the ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2019, 60(6):1953-1966]

Cited: 2 times

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Should Antiviral/Anti-Varicella Zoster Virus Treatment Be Used in Patients With Giant Cell Arteritis?

Yaping Joyce Liao, Sachin Kedar,

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2019, 39(1):134-141]

Cited: 1 time

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Anti-Interleukin-6 Antibody as Treatment for Giant Cell Arteritis.

Yaping Joyce Liao,

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2018, 38(4):558-560]

Cited: 0 times

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Direct targeting of the mouse optic nerve for therapeutic delivery.

Louise A Mesentier-Louro, Robert Dodd, Pablo Domizi, Hiroko Nobuta, Marius Wernig, Gerlinde Wernig, Yaping Joyce Liao,

BACKGROUND:Animal models of optic nerve injury are often used to study central nervous system (CNS) degeneration and regeneration, and targeting the optic nerve is a powerful approach for axon-protective or remyelination therapy. However, the experimental delivery of drugs or cells to the optic nerve is rarely performed because injections into ... Read more >>

J Neurosci Methods (Journal of neuroscience methods)
[2019, 313:1-5]

Cited: 0 times

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A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy.

Mohammad Ali Shariati, Varun Kumar, Tao Yang, Chandrani Chakraborty, Ben Anthony Barres, Frank Michael Longo, Yaping Joyce Liao,

PURPOSE:Brain-derived neurotrophic factor (BDNF) and activation of its high affinity receptor tropomyosin kinase (Trk) B promote retinal ganglion cells (RGCs) survival following injury. In this study, we tested the effects of LM22A-4, a small molecule TrkB receptor-specific partial agonist, on RGC survival in vitro and in experimental nonarteritic anterior ischemic ... Read more >>

Curr. Eye Res. (Current eye research)
[2018, 43(12):1489-1499]

Cited: 3 times

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Nonarteritic anterior ischaemic optic neuropathy and its association with obstructive sleep apnoea: a health insurance database study.

Ming-Hui Sun, Chia-Yi Lee, Yaping Joyce Liao, Chi-Chin Sun,

BACKGROUND:Nonarteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic neuropathy in old age. Although there are several known risk factors, the influence of obstructive sleep apnoea (OSA) has not been completely elucidated. The aim of this study was to evaluate the association between NAION and OSA. METHODS:This ... Read more >>

Acta Ophthalmol (Acta ophthalmologica)
[2019, 97(1):e64-e70]

Cited: 1 time

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A simple saccadic reading test to assess ocular motor function in cerebellar ataxia.

Angela Jinsook Oh, Tiffany Chen, Mohammad Ali Shariati, Naz Jehangir, Thomas N Hwang, Yaping Joyce Liao,

Cerebellar ataxia is a neurological disorder due to dysfunction of the cerebellum that affects coordination of fine movement, gait, and balance. Although ataxic patients commonly exhibit abnormal eye movement and have difficulties with saccadic reading, quantification of ocular motor abilities during reading in the clinical setting is rarely done. In ... Read more >>

PLoS One (PloS one)
[2018, 13(11):e0203924]

Cited: 0 times

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Association between obstructive sleep apnea and optic neuropathy: a Taiwanese population-based cohort study.

Ming-Hui Sun, Yaping Joyce Liao, Che-Chen Lin, Rayleigh Ping-Ying Chiang, James Cheng-Chung Wei,

PURPOSE:Obstructive sleep apnea (OSA) is associated with many systemic diseases including diabetes, hypertension, stroke, and cardiovascular disease. The aim of our study was to investigate the association between OSA and optic neuropathy (ON), and to evaluate the efficacy of treatment for OSA on the risk of ON. METHODS:We used the ... Read more >>

Eye (Lond) (Eye (London, England))
[2018, 32(8):1353-1358]

Cited: 1 time

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Refractory Giant Cell Arteritis Complicated by Vision Loss From Optic Atrophy and Maculopathy Associated With Pachymeningitis.

Jorge A Uribe, Ishita Aggarwal, Juthamat Witthayaweerasak, Y Joyce Liao, Gerald J Berry, Umesh K Sab, Cornelia M Weyand,

BACKGROUND:We describe a 75-year-old woman who experienced vision loss in her left eye due to biopsy-proven giant cell arteritis (GCA). She subsequently developed pachymeningitis causing refractory headaches and bilateral optic neuropathy and maculopathy. METHODS:Case report with literature review. RESULTS:Eighteen months after the initial diagnosis of GCA, imaging studies in our ... Read more >>

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2018, 38(1):17-23]

Cited: 0 times

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Slower saccadic reading in Parkinson's disease.

Naz Jehangir, Caroline Yizhu Yu, Jeehey Song, Mohammad Ali Shariati, Steven Binder, Jill Beyer, Veronica Santini, Kathleen Poston, Yaping Joyce Liao,

Idiopathic Parkinson's Disease (PD) is characterized by degeneration of dopaminergic and other neurons, leading to motor and non-motor deficits. Abnormal eye movements in PD, including fixations, saccades, and convergence, are well described. However, saccadic reading, which requires serial and alternating saccades and fixations, is not well studied, despite its obvious ... Read more >>

PLoS One (PloS one)
[2018, 13(1):e0191005]

Cited: 1 time

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Vertical diplopia and oscillopsia due to midbrain keyhole aqueduct syndrome associated with severe cough.

Angela Jinsook Oh, Bryan Alexander Lanzman, Yaping Joyce Liao,

Purpose:Midline structural defects in the neural axis can give rise to neuro-ophthalmic symptoms. We report a rare case of keyhole aqueduct syndrome presenting after two years of severe cough due to gastroesophageal reflux disease. Observations:A 58-year-old woman with a 2-year history of daily, severe cough presented to the neuro-ophthalmology clinic ... Read more >>

Am J Ophthalmol Case Rep (American journal of ophthalmology case reports)
[2018, 10:128-131]

Cited: 0 times

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Structure-Function Analysis of Nonarteritic Anterior Ischemic Optic Neuropathy and Age-Related Differences in Outcome.

Ming-Hui Sun, Yaping Joyce Liao,

The optic nerve head is vulnerable to ischemia leading to anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in those older than 50 years of age.We performed a cross-sectional study of 55 nonarteritic anterior ischemic optic neuropathy (NAION) eyes in 34 patients to assess clinical outcome and ... Read more >>

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2017, 37(3):258-264]

Cited: 3 times

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The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway.

Zhenke Wen, Yi Shen, Gerald Berry, Farhad Shahram, Yinyin Li, Ryu Watanabe, Yaping Joyce Liao, Jörg J Goronzy, Cornelia M Weyand,

Microvascular networks in the adventitia of large arteries control access of inflammatory cells to the inner wall layers (media and intima) and thus protect the immune privilege of the aorta and its major branches. In autoimmune vasculitis giant cell arteritis (GCA), CD4 T helper 1 (TH1) and TH17 cells invade ... Read more >>

Sci Transl Med (Science translational medicine)
[2017, 9(399):]

Cited: 13 times

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Cardinal features of superior oblique myokymia: An infrared oculography study.

Sumeer Thinda, Yi-Ren Chen, Yaping Joyce Liao,

Purpose:Superior oblique myokymia (SOM) is a rare eye movement disorder characterized by unilateral oscillopsia and binocular diplopia. Our study aimed to better understand SOM using infrared oculography. Methods:We examined and recorded five patients with SOM. Results:Binocular infrared oculography showed that in primary gaze, all patients exhibited torsional oscillations, which worsened ... Read more >>

Am J Ophthalmol Case Rep (American journal of ophthalmology case reports)
[2017, 7:115-119]

Cited: 0 times

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Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis.

Hui Zhang, Ryu Watanabe, Gerald J Berry, Augusto Vaglio, Yaping Joyce Liao, Kenneth J Warrington, Jörg J Goronzy, Cornelia M Weyand,

Giant cell arteritis (GCA) causes autoimmune inflammation of the aorta and its large branches, resulting in aortic arch syndrome, blindness, and stroke. CD4+ T cells and macrophages form organized granulomatous lesions in the walls of affected arteries, destroy the tunica media, and induce ischemic organ damage through rapid intimal hyperplasia ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2017, 114(6):E970-E979]

Cited: 46 times

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Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation.

Ming-Hui Sun, Mohammad Ali Shariati, Yaping Joyce Liao,

Diabetes mellitus (DM) is one of the most important risk factors for nonarteritic anterior ischemic optic neuropathy (AION). In this study, we investigated for the first time the impact of experimental AION in a DM model.We induced a photochemical thrombosis model of AION after streptozotocin-induced DM and performed serial optical ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2017, 58(4):2296-2305]

Cited: 1 time

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Report on the National Eye Institute Audacious Goals Initiative: Regenerating the Optic Nerve.

Jeffrey L Goldberg, William Guido, ,

The National Eye Institute (NEI) hosted a workshop on November 19, 2014, as part of the Audacious Goals Initiative (AGI), an NEI-led effort to rapidly expand therapies for eye diseases through coordinated research funding. The central audacious goal aims to demonstrate by 2025 the restoration of usable vision in humans ... Read more >>

Invest Ophthalmol Vis Sci (Investigative ophthalmology & visual science)
[2016, 57(3):1271-1275]

Cited: 9 times

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Dose-Response Modeling of the Visual Pathway Tolerance to Single-Fraction and Hypofractionated Stereotactic Radiosurgery.

Susan M Hiniker, Leslie A Modlin, Clara Y Choi, Banu Atalar, Kira Seiger, Michael S Binkley, Jeremy P Harris, Yaping Joyce Liao, Nancy Fischbein, Lei Wang, Anthony Ho, Anthony Lo, Steven D Chang, Griffith R Harsh, Iris C Gibbs, Steven L Hancock, Gordon Li, John R Adler, Scott G Soltys,

Patients with tumors adjacent to the optic nerves and chiasm are frequently not candidates for single-fraction stereotactic radiosurgery (SRS) due to concern for radiation-induced optic neuropathy. However, these patients have been successfully treated with hypofractionated SRS over 2-5 days, though dose constraints have not yet been well defined. We reviewed ... Read more >>

Semin Radiat Oncol (Seminars in radiation oncology)
[2016, 26(2):97-104]

Cited: 11 times

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Optical coherence tomography study of retinal changes in normal aging and after ischemia.

Mohammad Ali Shariati, Joyce Ho Park, Yaping Joyce Liao,

PURPOSE: Age-related thinning of the retinal ganglion cell axons in the nerve fiber layer has been measured in humans using optical coherence tomography (OCT). In this study, we used OCT to measure inner retinal changes in 3-month-, 1-year-, and 2-year-old mice and after experimental anterior ischemic optic neuropathy (AION). METHODS: ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2015, 56(5):2790-2797]

Cited: 10 times

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Severe, early axonal degeneration following experimental anterior ischemic optic neuropathy.

Gun Ho Lee, Madison P Stanford, Mohammad A Shariati, Jeffrey H Ma, Yaping Joyce Liao,

PURPOSE: Anterior ischemic optic neuropathy (AION) is the most common acute optic neuropathy in adults older than 50 and leads to axonal degeneration, thinning of the retinal nerve fiber layer and loss of the retinal ganglion cells (RGCs). We used experimental AION model to study early axonal changes following ischemia. ... Read more >>

Invest Ophthalmol Vis Sci (Investigative ophthalmology & visual science)
[2014, 55(11):7111-7118]

Cited: 7 times

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