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Author Yao Juan Chu

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Matrine protects retinal ganglion cells from apoptosis in experimental optic neuritis

Jian Kang, Shu-Qing Liu, Yi-Fan Song, Meng-Ru Wang, Yao-Juan Chu, Ya-Min Shi, Feng-Yan Zhang, Lin Zhu,

Abstract Background: Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual disturbance in young adults. Although a high dose of corticosteroids can promote visual recovery, it cannot prevent permanent neuronal damage. ... Read more >>

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Matrine protects oligodendrocytes by inhibiting their apoptosis and enhancing mitochondrial autophagy.

Meng-Ru Wang, Xiao-Jian Zhang, Hong-Chun Liu, Wen-Di Ma, Ming-Liang Zhang, Yuan Zhang, Xing Li, Meng-Meng Dou, Yi-Lei Jing, Yao-Juan Chu, Lin Zhu,

Stressed oligodendrocytes (OLGs) activate microglia to produce an inflammatory response, and the impairment of mitochondria further aggravates OLG damage, which is the earliest pathological change in multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Matrine (MAT), a tetracyclic quinolizine alkaloid derived from the herb radix sophorae ... Read more >>

Brain Res. Bull. (Brain research bulletin)
[2019, 153:30-38]

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Erratum to: Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis.

Quan-Cheng Kan, Hui-Jun Zhang, Yuan Zhang, Xing Li, Yu-Ming Xu, Rodolfo Thome, Ming-Liang Zhang, Nan Liu, Yao-Juan Chu, Guang-Xian Zhang, Lin Zhu,

Mol. Neurobiol. (Molecular neurobiology)
[2017, 54(10):8419]

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Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis.

Quan-Cheng Kan, Hui-Jun Zhang, Yuan Zhang, Xing Li, Yu-Ming Xu, Rodolfo Thome, Ming-Liang Zhang, Nan Liu, Yao-Juan Chu, Guang-Xian Zhang, Lin Zhu,

Myelin-associated inhibitors, such as NogoA, myelin-associated glycoprotein (MAG), and oligodendrocyte myelin glycoprotein (OMgp), play a pivotal role in the lack of neuroregeneration in multiple sclerosis, an inflammatory demyelinating disease of the central nervous system (CNS). Matrine (MAT), a monomer that is used in traditional Chinese medicine as an anti-inflammatory agent, ... Read more >>

Mol. Neurobiol. (Molecular neurobiology)
[2017, 54(10):8404-8418]

Cited: 1 time

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Protective effects of matrine on experimental autoimmune encephalomyelitis via regulation of ProNGF and NGF signaling.

Lin Zhu, Qing-xia Pan, Xiao-Jian Zhang, Yu-Ming Xu, Yao-juan Chu, Nan Liu, Peng Lv, Guang-Xian Zhang, Quan-Cheng Kan,

Inflammation, demyelination, oligodendrocyte (OLG) death, and axonal degeneration are primary characteristics of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). OLGs generate myelin sheaths that surround axons, while damage to OLGs leads to demyelination and neurological functional deficit. Matrine (MAT), a quinolizidine alkaloid derived from the herb ... Read more >>

Exp. Mol. Pathol. (Experimental and molecular pathology)
[2016, 100(2):337-343]

Cited: 5 times

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Matrine ameliorates experimental autoimmune encephalomyelitis by modulating chemokines and their receptors.

Quan-Cheng Kan, Qing-xia Pan, Xiao-Jian Zhang, Yao-juan Chu, Nan Liu, Peng Lv, Guang-Xian Zhang, Lin Zhu,

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are autoimmune diseases characterized by immune-mediated neuroinflammation, demyelination and neurodegeneration of the central nervous system (CNS). While matrine (MAT), a monomer that is used in traditional Chinese medicine as an anti-inflammatory treatment, delayed onset and ameliorated severity of EAE, ... Read more >>

Exp. Mol. Pathol. (Experimental and molecular pathology)
[2015, 99(2):212-219]

Cited: 4 times

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