Full Text Journal Articles by
Author Yanzhong Chang

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Integrated analysis identifies TfR1 as a prognostic biomarker which correlates with immune infiltration in breast cancer.

Fei Chen, Yumei Fan, Jiajie Hou, Bing Liu, Bo Zhang, Yanan Shang, Yanzhong Chang, Pengxiu Cao, Ke Tan,

Breast cancer (BC) is the most common malignancy with high morbidity and mortality in females worldwide. Emerging evidence indicates that transferrin receptor 1 (TfR1) plays vital roles in regulating cellular iron import. However, the distinct role of TfR1 in BC remains elusive. TfR1 expression was investigated using the TCGA, GEO, ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(17):21671-21699]

Cited: 1 time

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Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2.

Jiaqi Shen, Li Xu, Yuxuan Li, Weichen Dong, Jing Cai, Yutong Liu, Hongting Zhao, Tianze Xu, Esther Meyron Holtz, Yanzhong Chang, Tong Qiao, Kuanyu Li,

Iron regulatory protein 2 (IRP2) deficiency in mice and humans causes microcytic anemia and neurodegeneration due to functional cellular iron depletion. Our previous <i>in vitro</i> data have demonstrated that Irp2 depletion upregulates hypoxia-inducible factor subunits Hif1α and Hif2α expression; inhibition of Hif2α rescues Irp2 ablation-induced mitochondrial dysfunction; and inhibition of ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2021, 15:715222]

Cited: 0 times

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A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism.

Xing Ge, Yong Zuo, Jinhong Xie, Xincheng Li, Yan Li, Anand Thirupathi, Peng Yu, Guofen Gao, Changhao Zhou, Yanzhong Chang, Zhenhua Shi,

Sevoflurane (Sev) is a commonly used anesthetic in hospitals that can cause neurotoxicity. Postoperative cognitive dysfunction (POCD) is a common clinical problem induced by some anesthetics. However, the exact mechanism of neurotoxicity induced by Sev is unclear. Here we studied a new mechanism of POCD induced by Sev. We treated ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(18):22375-22389]

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Ceruloplasmin correlates with immune infiltration and serves as a prognostic biomarker in breast cancer.

Fei Chen, Bihui Han, Yanxiu Meng, Yu Han, Bing Liu, Bo Zhang, Yanzhong Chang, Pengxiu Cao, Yumei Fan, Ke Tan,

Breast-invasive carcinoma (BRCA) is the most frequent and malignant tumor in females. Ceruloplasmin (CP) is a multifunctional molecule involved in iron metabolism, but its expression profile, prognostic potential and relationship with immune cell infiltration in BRCA are unknown. Ceruloplasmin mRNA and protein expression was significantly decreased in BRCA patients according ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(16):20438-20467]

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Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD.

Yong Zuo, Jinhong Xie, Xincheng Li, Yan Li, Anand Thirupathi, Jianhua Zhang, Peng Yu, Guofen Gao, Yanzhong Chang, Zhenhua Shi,

Parkinson's disease (PD) is a progressive nervous system disorder. Until now, the molecular mechanism of its occurrence is not fully understood. Paraquat (PQ) was identified as a neurotoxicant and is linked to increased PD risk and PD-like neuropathology. Ferroptosis is recognized as a new form of regulated cell death. Here, ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:9961628]

Cited: 1 time

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Clioquinol Attenuates Pulmonary Fibrosis through Inactivation of Fibroblasts via Iron Chelation.

Yumeng Zhu, Jing Chang, Ke Tan, Steven K Huang, Xin Liu, Xiaofan Wang, Mengshu Cao, Hongmin Zhang, Shuxin Li, Xianglin Duan, Yanzhong Chang, Yumei Fan, Pengxiu Cao,

Strict control of iron homeostasis is critical for the maintenance of normal lung function. Iron accumulates in the lungs of patients with idiopathic pulmonary fibrosis (PF), but the characteristics of iron metabolism in the pathogenesis of PF and related targeting therapeutics are not well studied. In this study, we investigated ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2021, 65(2):189-200]

Cited: 1 time

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Inhibition of HIF2 Prevents the Development of Neurodegenerative Disorder Induced by Deficiency of IRP2

Jiaqi Shen, Li Xu, Yuxuan Li, Weichen Dong, Jing Cai, Yutong Liu, Hongting Zhao, Tianze Xu, Esther Meyron Holtz, Yanzhong Chang, Tong Qiao, Kuanyu Li,

<h4>Background: </h4> IRP2 (Iron regulatory protein 2) deficiency in mice and humans causes microcytic anemia and neurodegeneration due to functional cellular iron depletion. Our previous in vitro data have demonstrated that Irp2 depletion upregulates hypoxia-inducible factor subunits Hif1α and Hif2α expression and inhibition of Hif2α rescues Irp2 ablation-induced mitochondrial dysfunction ... Read more >>

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Hepcidin Upregulation in Lung Cancer: A Potential Therapeutic Target Associated With Immune Infiltration.

Yumei Fan, Bing Liu, Fei Chen, Zhiyuan Song, Bihui Han, Yanxiu Meng, Jiajie Hou, Pengxiu Cao, Yanzhong Chang, Ke Tan,

Lung cancer has the highest death rate among cancers globally. Hepcidin is a fascinating regulator of iron metabolism; however, the prognostic value of hepcidin and its correlation with immune cell infiltration in lung cancer remain unclear. Here, we comprehensively clarified the prognostic value and potential function of hepcidin in lung ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:612144]

Cited: 1 time

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Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.

Ming Liu, Yumei Fan, Danyu Li, Bihui Han, Yanxiu Meng, Fei Chen, Tianchan Liu, Zhiyuan Song, Yu Han, Liying Huang, Yanzhong Chang, Pengxiu Cao, Akira Nakai, Ke Tan,

Despite recent progress in non-small-cell lung cancer (NSCLC) treatment, treatment outcomes remain poor, mainly because of treatment resistance or toxicity. Erastin is a ferroptosis inducer that has shown promising cytotoxic effects in various types of cancers, including NSCLC. Celastrol is a triterpene extracted from the Tripterygium wilfordii that exhibits potential anticancer ... Read more >>

Mol Oncol (Molecular oncology)
[2021, 15(8):2084-2105]

Cited: 9 times

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Downregulation of FPN1 acts as a prognostic biomarker associated with immune infiltration in lung cancer.

Bing Liu, Zhiyuan Song, Yumei Fan, Guangyu Zhang, Pengxiu Cao, Danyu Li, Xiaopeng Liu, Yanzhong Chang, Ke Tan,

Lung cancer morbidity and mortality remain the leading causes of tumor-associated death worldwide. The discovery of early diagnostic and prognostic markers of lung cancer could significantly improve the survival rate and decrease the mortality rate. FPN1 is the only known mammalian iron exporter. However, the molecular and biological functions of ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(6):8737-8761]

Cited: 2 times

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Effect of sevoflurane on iron homeostasis and toxicity in the brain of mice.

Meiyue Wang, Yong Zuo, Xincheng Li, Yan Li, Anand Thirupathi, Peng Yu, Guofen Gao, Changhao Zhou, Yanzhong Chang, Zhenhua Shi,

Sevoflurane (Sev), a commonly used volatile anesthetic, could induce nerve damage and cognitive deficiency. Oxidative stress induced by iron overload promotes nerve damage and cell apoptosis in the brain. This study revealed a new toxic mechanism of Sev to the brain occurred through the dysfunction of iron metabolism. Twelve-month-old C57BL/6 ... Read more >>

Brain Res (Brain research)
[2021, 1757:147328]

Cited: 1 time

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Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis.

Danyu Li, Bing Liu, Yumei Fan, Ming Liu, Bihui Han, Yanxiu Meng, Xiao Xu, Zhiyuan Song, Xiaopeng Liu, Qiang Hao, Xianglin Duan, Akira Nakai, Yanzhong Chang, Pengxiu Cao, Ke Tan,

<h4>Background and purpose</h4>Acute kidney injury is a common clinical problem with no definitive or specific treatment. Therefore, the molecular mechanisms of acute kidney injury must be fully understood to develop novel treatments. Nuciferine, a major bioactive compound isolated from the lotus leaf, possesses extensive pharmacological activities. Its effect on folic ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2021, 178(5):1182-1199]

Cited: 4 times

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Prenatal sevoflurane exposure: Effects of iron metabolic dysfunction on offspring cognition and potential mechanism.

Yong Zuo, Yanzhong Chang, Anand Thirupathi, Changhao Zhou, Zhenhua Shi,

For decades, the neurotoxicity caused by anesthetics in mammalian brain development has gained increasing attention. Exposure to anesthetics leads to neurotoxicity and apoptosis of nerve cells, which in turn induces cognitive dysfunction. Although most of the data came from animal studies, general anesthetics have been shown to have adverse effects ... Read more >>

Int J Dev Neurosci (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience)
[2021, 81(1):1-9]

Cited: 0 times

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Comparison of Bioactive Phenolic Compounds and Antioxidant Activities of Different Parts of Taraxacum mongolicum.

Li Duan, Chenmeng Zhang, Yang Zhao, Yanzhong Chang, Long Guo,

Herbs derived from <i>Taraxacum</i> genus have been used as traditional medicines and food supplements in China for hundreds of years. <i>Taraxacum mongolicum</i> is a famous traditional Chinese medicine derived from <i>Taraxacum</i> genus for the treatment of inflammatory disorders and viral infectious diseases. In the present study, the bioactive phenolic chemical ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(14):]

Cited: 1 time

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Excess salt intake promotes M1 microglia polarization via a p38/MAPK/AR-dependent pathway after cerebral ischemia in mice.

Tongshuai Zhang, Dandan Wang, Xuan Li, Yixiang Jiang, Chao Wang, Yao Zhang, Qingfei Kong, Chao Tian, Yongfeng Dai, Wei Zhao, Mingyue Jiang, Yanzhong Chang, Guangyou Wang,

A high salt diet (HSD) is among the most important risk factors for many diseases. One mechanism by which HSD aggravates cerebral ischemic injury is independent of blood pressure changes. The direct role of HSD in inflammation after cerebral ischemia is unclear. In this research, after twenty-one days of being ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2020, 81:106176]

Cited: 3 times

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Sevoflurane anesthesia during pregnancy in mice induces cognitive impairment in the offspring by causing iron deficiency and inhibiting myelinogenesis.

Yong Zuo, Bowen Li, Jinhong Xie, Zhao Ma, Anand Thirupathi, Peng Yu, Guofen Gao, Jinjuan Zhou, Changhao Zhou, Hongmeng Xu, Yanzhong Chang, Zhenhua Shi,

Maternal anesthetic exposure during pregnancy is associated with an increased risk of cognitive impairment in offspring. The balance of cerebral iron metabolism is essential for the development of brain tissue. Iron deficiency affects the myelinogenesis and nerve tissue development, especially in fetus or infant, which has a key role in ... Read more >>

Neurochem Int (Neurochemistry international)
[2020, 135:104693]

Cited: 6 times

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Deferasirox protects against hydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination and degradation of p21WAF1/CIP1.

Junhua Miao, Mutao Xu, Yuhuan Kuang, Shuhong Pan, Jianyuan Hou, Pengxiu Cao, Xianglin Duan, Yanzhong Chang, Habelhah Hasem, Nan Zhou, Ke Tan, Yumei Fan,

Deferasirox (DFX) is an iron chelator approved for the treatment of iron overload diseases. However, the role of DFX in oxidative stress-induced cell apoptosis and the exact molecular mechanisms underlying these processes remain poorly understood and require further investigation. In this study, we found that DFX rendered resistant to H2O2-induced ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2020, 524(3):736-743]

Cited: 1 time

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Propofol prevents oxidative stress and apoptosis by regulating iron homeostasis and targeting JAK/STAT3 signaling in SH-SY5Y cells.

Ying Zhang, Yong Zuo, Bowen Li, Jinhong Xie, Zhao Ma, Anand Thirupathi, Peng Yu, Guofen Gao, Mengtong Shi, Changhao Zhou, Hongmeng Xu, Yanzhong Chang, Zhenhua Shi,

The present study aimed to test the hypothesis that propofol (PRO) could exert a neuroprotective effect via inhibiting oxidative stress induced by iron accumulation. Human SH-SY5Y cells were pretreated with ferric citrate (FAC), and then were protected by PRO. Cell viability was measured by MTT method. Iron levels were assayed ... Read more >>

Brain Res Bull (Brain research bulletin)
[2019, 153:191-201]

Cited: 2 times

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Cerebrovascular miRNAs correlate with the clearance of Aβ through perivascular route in younger 3xTg-AD mice.

Lijuan Fu, Ge Jiang, Hope Weng, Gregory M Dick, Yanzhong Chang, Ghassan S Kassab,

The "two-hit vascular hypothesis for Alzheimer's disease (AD)" and amyloid-β (Aβ) oligomer hypothesis suggest that impaired soluble Aβ oligomers clearance through the cerebral vasculature may be an initial step of the AD process. Soluble Aβ oligomers are driven into perivascular spaces from the brain parenchyma and toward peripheral blood flow. ... Read more >>

Brain Pathol (Brain pathology (Zurich, Switzerland))
[2020, 30(1):92-105]

Cited: 3 times

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HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression.

Jingyu Shao, Beibei Han, Pengxiu Cao, Bingwei Zhang, Ming Liu, Danyu Li, Nan Zhou, Qiang Hao, Xianglin Duan, Yanzhong Chang, Akira Nakai, Yumei Fan, Ke Tan,

Heat shock factor 1 (HSF1) is a transcription factor essential for tumorigenesis, and targeting HSF1 may be effective in combined therapeutics for cervical cancer. Cyclosporin A (CsA) is an immunosuppressant that has revolutionized organ transplantation. However, the roles and regulatory mechanisms by which CsA modulates HSP expression remain largely unknown. ... Read more >>

Biochim Biophys Acta Gene Regul Mech (Biochimica et biophysica acta. Gene regulatory mechanisms)
[2019, 1862(8):846-857]

Cited: 3 times

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Iron regulatory protein 2 deficiency may correlate with insulin resistance.

Yaru Zhou, Wenyue Wu, Zhifang Xu, Yan Liu, Hengrui Chang, Peng Yu, Xiaojuan Zhang, Yu Yang, Kuanzhi Liu, Yanzhong Chang,

Iron is known to be a crucial regulator of glucose, and several studies have demonstrated that iron overload is one of the risk factors for insulin resistance and diabetes; however, the mechanism has not yet been clarified. To investigate the effect of iron overload on glucose metabolism and the underlying ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2019, 510(2):191-197]

Cited: 1 time

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Irp2 Knockout Causes Osteoporosis by Inhibition of Bone Remodeling.

Yaru Zhou, Yu Yang, Yan Liu, Hengrui Chang, Kuanzhi Liu, Xiaojuan Zhang, Yanzhong Chang,

It has been found that iron disorder may lead to osteoporosis. However, the mechanism has been little explored. In the present study, we try to investigate the effects of iron disorder on bone metabolism using Irp2 knockout (Irp2<sup>-/-</sup>) mice. Female Irp2<sup>-/-</sup> mice were used in this study. Bone mineral density ... Read more >>

Calcif Tissue Int (Calcified tissue international)
[2019, 104(1):70-78]

Cited: 1 time

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Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State.

Xiang Li, Defang Liu, Yantao Ma, Xiaomin Du, Junzhan Jing, Lipeng Wang, Bingqing Xie, Da Sun, Shaoqiang Sun, Xueqin Jin, Xu Zhang, Ting Zhao, Jingyang Guan, Zexuan Yi, Weifeng Lai, Ping Zheng, Zhuo Huang, Yanzhong Chang, Zhen Chai, Jun Xu, Hongkui Deng,

Direct lineage reprogramming, including with small molecules, has emerged as a promising approach for generating desired cell types. We recently found that during chemical induction of induced pluripotent stem cells (iPSCs) from mouse fibroblasts, cells pass through an extra-embryonic endoderm (XEN)-like state. Here, we show that these chemically induced XEN-like ... Read more >>

Cell Stem Cell (Cell stem cell)
[2017, 21(2):264-273.e7]

Cited: 21 times

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Identification of novel mutations in HFE, HFE2, TfR2, and SLC40A1 genes in Chinese patients affected by hereditary hemochromatosis.

Yongwei Wang, Yali Du, Gang Liu, Shanshan Guo, Bo Hou, Xianyong Jiang, Bing Han, Yanzhong Chang, Guangjun Nie,

Hereditary hemochromatosis (HH) is a group of inherited iron-overload disorders associated with pathogenic defects in the genes encoding hemochromatosis (HFE), hemojuvelin (HJV/HFE2), hepcidin (HAMP), transferrin receptor 2 (TfR2), and ferroportin (FPN1/SLC40A1) proteins, and the clinical features are well described. However, there have been only a few detailed reports of HH ... Read more >>

Int J Hematol (International journal of hematology)
[2017, 105(4):521-525]

Cited: 8 times

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The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss.

Zi Xu, Weijia Sun, Yuheng Li, Shukuan Ling, Chenyang Zhao, Guohui Zhong, Dingsheng Zhao, Jinping Song, Hailin Song, Jinqiao Li, Linhao You, Guangjun Nie, Yanzhong Chang, Yingxian Li,

Iron overload inhibits osteoblast function and promotes osteoclastogenesis. Hepcidin plays an important role in this process. The changes in iron content and the regulation of hepcidin under unloading-induced bone loss remain unknown. A hindlimb suspension model was adopted to simulate unloading-induced bone loss in mice. The results showed that iron ... Read more >>

Bone (Bone)
[2017, 94:152-161]

Cited: 16 times

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