Full Text Journal Articles by
Author Yanqing Song

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Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation.

Yueming Zhang, Jian Chang, Huan Gao, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song,

<h4>Context</h4>Severe nephrotoxicity greatly limits the clinical use of the common effective chemotherapeutic agent cyclophosphamide (CYP). Huaiqihuang (HQH) is a Chinese herbal complex with various pharmacological activities, widely used for treating kidney disease.<h4>Objective</h4>This study estimates the protective effect of HQH against CYP-induced nephrotoxicity in rats.<h4>Materials and methods</h4>Four groups of 10 Sprague-Dawley ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1425-1431]

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Efficacy and Safety of Vedolizumab for Pediatrics With Inflammatory Bowel Disease: a Systematic Review

Shengbo Fang, Yanqing Song, Chunyan Zhang, Libo Wang,

<h4>Background: </h4> Vedolizumab use in pediatrics is still off-label and the data are limited. We conducted a systematic review evaluating the efficacy and safety of vedolizumab in children and adolescents with inflammatory bowel disease (IBD). <h4>Methods: </h4>: PubMed, EMBASE and Cochrane databases were systematically searched for studies of vedolizumab in ... Read more >>

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Questionnaire and Lactic Acid Sting Test Play Different Role on the Assessment of Sensitive Skin: A Cross-sectional Study.

Yao Pan, Xue Ma, Yanqing Song, Jinfeng Zhao, Shiyu Yan,

<h4>Background</h4>Questionnaires and lactic acid sting test (LAST) are two widely used methods to identify sensitive skin. However, the self-perceived sensitive skin by questionnaires was not consistent with the determination of LAST.<h4>Objective</h4>The aim of the study was to measure the biophysical properties noninvasively of sensitive skin evaluated by questionnaire and LAST ... Read more >>

Clin Cosmet Investig Dermatol (Clinical, cosmetic and investigational dermatology)
[2021, 14:1215-1225]

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Polypharmacy and potentially inappropriate medications among elderly patients in the geriatric department at a single-center in China: A retrospective cross-sectional study.

Lina Tao, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Yueming Zhang, Yanqing Song,

<h4>Abstract</h4>The aging of the population has become a worldwide concern, especially in China. Polypharmacy and potentially inappropriate medications (PIMs) are prominent issues in elderly patients. Therefore, the aim of this study was to investigate the prevalence of polypharmacy and PIMs in older inpatients and further to explore the factors associated ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(42):e27494]

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Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.

Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li Fu,

The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an active component extracted from ginseng, is reported to protect against CP-induced nephrotoxicity. However, the mechanisms ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2021, 35(11):e22896]

Cited: 1 time

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Post-operative procalcitonin and C-reactive protein predict pancreatic fistula after laparoscopic pancreatoduodenectomy.

Jie Ma, Peiqiang Jiang, Bai Ji, Yanqing Song, Yahui Liu,

<h4>Background</h4>Clinically relevant pancreatic fistula (CRPF) is a serious complication following laparoscopic pancreaticoduodenectomy (LPD). This study aimed to determine if C-reactive protein (CRP) and procalcitonin (PCT) serum levels could be used as early biomarkers to predict CRPF after LPD.<h4>Methods</h4>In this retrospective study, we collected peri-operative data of patients who underwent LPD ... Read more >>

BMC Surg (BMC surgery)
[2021, 21(1):171]

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A Potential Combination Therapy of Berberine Hydrochloride With Antibiotics Against Multidrug-Resistant Acinetobacter baumannii.

Xiaobo Li, Yanqing Song, Lina Wang, Guangbo Kang, Ping Wang, Huabing Yin, He Huang,

Multidrug-resistant (MDR) <i>Acinetobacter baumannii</i> strains can cause severe infections in intensive care units, and are rapidly developing resistance to the last-resort of existing antibiotics, posing a major global threat to health care system. Berberine hydrochloride (BBH), a kind of isoquinoline alkaloids extracted from Berberis and other plants, has been widely ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2021, 11:660431]

Cited: 1 time

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Deploying Spatial Data for Coastal Community Resilience: A Review from the Managerial Perspective.

Xiameng Huang, Yanqing Song, Xuan Hu,

The use of spatial data for coastal community resilience applications has diversified as a consequence of the increasing availability of data, and extensive development in data processing. However, the true value of spatial data is not fully exploited as a result of lacking scientific managerial models that incorporate spatial data ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(2):]

Cited: 1 time

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Water/pH dual responsive in situ calcium supplement collaborates simvastatin for osteoblast promotion mediated osteoporosis therapy via oral medication.

Shan Tao, Fangying Yu, Yanqing Song, Wentao Zhou, Jianghong Lv, Rui Zhao, Cheng Wang, Fuqiang Hu, Hong Yuan,

Calcium supplement is the most commonly adopted treatment for osteoporosis but usually requires high dose and frequency. The modality of calcium supplement is therefore overlooked by current nanomedicine-based osteoporosis therapies without proper oral formulations. Herein, we proposed a tetracycline (Tc) modified and monostearin (MS) coated amorphous calcium carbonate (ACC) platform ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2021, 329:121-135]

Cited: 1 time

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Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study.

Yanqing Song, Tingting Hu, Huan Gao, Jinghui Zhai, Jiawei Gong, Yueming Zhang, Lina Tao, Jingmeng Sun, Zhiyuan Li, Xiaoyu Qu,

Cisplatin (CDDP)-induced acute kidney injury (AKI) limits the therapeutic use of CDDP, which urgently needs to be addressed. Our previous study demonstrated that astragaloside IV (AS IV), an active compound of the traditional Chinese herb Astragalus membranaceus, alleviated CDDP-induced AKI. To explore the mechanism, we performed a metabolomics study to ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 183:114299]

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Randomized clinical trial: efficacy and tolerability of two different split dose of low-volume polyethylene glycol electrolytes for bowel preparation before colonoscopy in hospitalized children.

Shengbo Fang, Yanqing Song, Yufei Liu, Libo Wang,

<h4>Background</h4>Eighty milliliter per kilogram of polyethylene glycol (PEG) for bowel preparation (BP) has been recommended, but the amount of liquid orally without nasogastric intubation is difficult to achieve. This study is to compare the efficacy and tolerability of two different low-volume PEG electrolyte solutions for BP in children.<h4>Methods</h4>The randomized, double-blind, ... Read more >>

Pediatr Res (Pediatric research)
[2021, 90(1):171-175]

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Microbial Distribution and Antibiotic Susceptibility in Patients with Complicated Skin and Soft Tissue Infections of the Extremities in North-Eastern China

Jie Ma, Yanqing Song, Xiangfeng Wang, Huiyu Yan, Yue Zhang, nan wang,

<h4>Background: </h4> For complicated skin and soft tissue infections (cSSTIs), inappropriate initial anti-infective treatment often leads to treatment failure. The microbial distribution in patients with extremities’ cSSTIs has been rarely reported. Moreover, whether gram-negative bacteria (GNB) should be covered in addition to gram-positive bacteria (GPB) has been always a difficult ... Read more >>

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Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway.

Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhang,

Severe hepatotoxicity greatly limits the clinical application of the first-line anti-tuberculosis drug isoniazid(INH). Quercetin(Que) has multiple pharmacological properties, and is regarded as a potential protective agent against a variety of organ injuries. However, the exact effect of quercetin on INH-induced hepatotoxicity and the underlying mechanisms are not yet completely understood. ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2020, 85:106634]

Cited: 3 times

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Skin irritation potential of cosmetic preservatives: An exposure-relevant study.

Xue Ma, Huan Wang, Yanqing Song, Yao Pan,

<h4>Background</h4>Preservatives represent one of the main causes of skin irritation and contact allergies.<h4>Aims</h4>To comprehensively evaluate the skin irritation potential of phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, and DMDM hydantoin under regulatory acceptable concentrations.<h4>Methods</h4>A patch test and repeated open application test (ROAT) were applied to evaluate skin irritation in vivo. In vitro ... Read more >>

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2021, 20(1):195-203]

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Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2.

Xiaoyu Qu, Huan Gao, Jinghui Zhai, Jingmeng Sun, Lina Tao, Yueming Zhang, Yanqing Song, Tingting Hu,

Decreased chemosensitivity among tumor cells is often an obstacle in cisplatin (Cis) chemotherapy. Overexpression of multidrug resistance-associated protein 2 (MRP2) is a key mechanism underlying decreased Cis chemosensitivity and resistance. Astragaloside IV (AS IV) is an important component derived from the well-known traditional Chinese herb Astragalus membranaceus. The aim of ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2020, 148:105325]

Cited: 3 times

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Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4/NF-κB/NLRP3 signaling pathway.

Huan Gao, Xiangfeng Wang, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Yueming Zhang, Yanqing Song, Wenrui Zhang,

Renal toxicity is the primary factor that limits clinical use of cisplatin (CP). A previous study showed that omeprazole (OME) protected against CP-induced toxicity in human renal tubular HK-2 cells and rat kidneys. However, the protective mechanisms of OME have not been characterized. We evaluated the ability of OME to ... Read more >>

Toxicology (Toxicology)
[2020, 440:152487]

Cited: 2 times

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Identification of key metabolites during cisplatin-induced acute kidney injury using an HPLC-TOF/MS-based non-targeted urine and kidney metabolomics approach in rats.

Xiaoyu Qu, Huan Gao, Jingmeng Sun, Lina Tao, Yueming Zhang, Jinghui Zhai, Yanqing Song, Tingting Hu, Zhiyuan Li,

Kidney injury is a major adverse effect of cisplatin use. Metabolomics has been used to characterize physiological or pathological conditions through identification of metabolites and characterization of the metabolic pathway. Metabolomics profiling could allow for identification of nephrotoxic mechanisms of cisplatin and identification of biomarkers of cisplatin-induced injury. In this ... Read more >>

Toxicology (Toxicology)
[2020, 431:152366]

Cited: 3 times

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2-Deoxy-Rh2: A novel ginsenoside derivative, as dual-targeting anti-cancer agent via regulating apoptosis and glycolysis.

Huan Gao, Di Liang, Chenchen Li, Guoxing Xu, Mengnan Jiang, Heng Li, Jianyuan Yin, Yanqing Song,

20(S)-Rh2 is a ginsenoside isolated from Panax ginseng, which exhibits anti-cancer activities on various human cancer cells. A novel 20(S)-Rh2 derivative, 2-Deoxy-Rh2 was synthesized and hybridized with protopanaxadiol and 2-deoxy-glucose in an attempt to enhance the anticancer activity. Through screening the antitumor effect against various cell lines by MTT assay, ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 124:109891]

Cited: 2 times

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Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway.

Jinghui Zhai, Lina Tao, Sixi Zhang, Huan Gao, Yueming Zhang, Jingmeng Sun, Yanqing Song, Xiaoyu Qu,

The limitation of doxorubicin (DOX), which is widely used for the treatment of solid tumors and hematologic malignancies, is a vital problem in clinical application. The most serious of limit factors is cardiotoxicity. Calycosin (CA), an isoflavonoid that is the major active component in Radix astragali, has been reported in ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, 34(3):649-659]

Cited: 10 times

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Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway.

Yueming Zhang, Wenrui Zhang, Lina Tao, Jinghui Zhai, Huan Gao, Yanqing Song, Xiaoyu Qu,

Isoniazid (INH) is one of the most commonly used antituberculosis drugs, but its clinical applications have been limited by severe hepatic toxicity. Quercetin (Que), a natural flavonoid, has been proved to have many medicinal properties. This study aimed to clarify the possible protective effects of Que against INH-induced hepatotoxicity using ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2019, 33(9):e22369]

Cited: 3 times

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Dissecting horizontal and vertical gene transfer of antibiotic resistance plasmid in bacterial community using microfluidics.

Bing Li, Yong Qiu, Yanqing Song, Hai Lin, Huabing Yin,

The spread of antibiotic resistance genes (ARGs) has become an emerging threat to the global health. Although horizontal gene transfer (HGT) is regarded as one of the major pathways, more evidence has shown the significant involvement of vertical gene transfer (VGT). However, traditional cultivation-based methods cannot distinguish HGT and VGT, ... Read more >>

Environ Int (Environment international)
[2019, 131:105007]

Cited: 4 times

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Retrospective study of budesonide in children with eosinophilic gastroenteritis.

Shengbo Fang, Yanqing Song, Sixi Zhang, Chunyan Li,

<h4>Background</h4>The effectiveness of budesonide (BUD), a locally active steroid, on eosinophilic gastroenteritis (EGE) is not well understood. This study is to retrospectively evaluate the efficacy of BUD in children with EGE.<h4>Methods</h4>Forty-four children, diagnosed with EGE, were enrolled from 2013 to 2017 in our center. According to patients' preference, all the ... Read more >>

Pediatr Res (Pediatric research)
[2019, 86(4):505-509]

Cited: 1 time

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Salvianolic Acid B Attenuates Apoptosis of HUVEC Cells Treated with High Glucose or High Fat via Sirt1 Activation.

Jinghui Zhai, Lina Tao, Yueming Zhang, Huan Gao, Xiaoyu Qu, Yanqing Song, Sixi Zhang,

High glucose and high fat are important inducements for the development and progression of diabetic cardiopathy. Salvianolic acid B (SAB), which is the most abundant and bioactive compound in Danshen, attenuates oxidative stress-related disorders, such as cardiovascular diseases, cerebral ischemia, and diabetes. However, the effect of SAB on diabetic cardiopathy ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2019, 2019:9846325]

Cited: 4 times

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Dioscorea bulbifera L. delays the excretion of doxorubicin and aggravates doxorubicin-induced cardiotoxicity and nephrotoxicity by inhibiting the expression of P-glycoprotein in mice liver and kidney.

Xiaoyu Qu, Jinghui Zhai, Tingting Hu, Huan Gao, Lina Tao, Yueming Zhang, Yanqing Song, Sixi Zhang,

We aimed to investigate the drug-drug interaction (DDI) between doxorubicin (DOX) and <i>Dioscorea bulbifera L.</i> (DB) solution in mice, and to explore the effect of P-glycoprotein (P-gp) on this type of DDI. The toxicity of DOX in the liver, kidneys, and heart was assessed with alanine aminotransferase (ALT), aspartate aminotransferase ... Read more >>

Xenobiotica (Xenobiotica; the fate of foreign compounds in biological systems)
[2019, 49(9):1116-1125]

Cited: 1 time

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Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats.

Xiaoyu Qu, Huan Gao, Lina Tao, Yueming Zhang, Jinghui Zhai, Jingmeng Sun, Yanqing Song, Sixi Zhang,

The aim of this study was to explore the role of the NOD-like receptor family, pyrin domain containing (NLRP3) inflammasome and autophagy in Astragaloside IV (AS IV)-mediated protection against cisplatin-induced liver and kidney injury in rats. Rats were intraperitoneally administered cisplatin at a dose of 15 mg/kg and orally administered ... Read more >>

J Toxicol Sci (The Journal of toxicological sciences)
[2019, 44(3):167-175]

Cited: 9 times

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