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Author Yanling Feng

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The impact of lymph node dissection on survival in patients with clinical early-stage ovarian cancer.

Ting Deng, Qidan Huang, Ting Wan, Xiaoling Luo, Yanling Feng, He Huang, Jihong Liu,

<h4>Objective</h4>To estimate the impact of lymph node dissection on survival in patients with apparent early-stage epithelial ovarian cancer (EOC).<h4>Methods</h4>We conducted a retrospective review of patients with clinical stage I-II EOC. All patients underwent primary surgery at Sun Yat-sen University Cancer Center between January 2003 and December 2015. Demographic features and ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e40]

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Credibility Assessment Method of Sensor Data Based on Multi-Source Heterogeneous Information Fusion

Yanling Feng, Jixiong Hu, Rui Duan, Zhuming Chen,

The credibility of sensor data is essential for security monitoring. High-credibility data are the precondition for utilizing data and data analysis, but the existing data credibility evaluation methods rarely consider the spatio-temporal relationship between data sources, which usually leads to low accuracy and low flexibility. In order to solve this ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2021, 21(7):]

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Evaluation of the CARDS toxin and its fragment for the serodiagnosis of Mycoplasma pneumoniae infections.

Guanhua Xue, Hanqing Zhao, Chao Yan, Shaoli Li, Jinghua Cui, Yanling Feng, Xianghui Xie, Jing Yuan,

Mycoplasma pneumoniae (M. pneumoniae) is an important pathogen in community-acquired pneumonia. The community-acquired respiratory distress syndrome (CARDS) toxin is the only known virulence factor of M. pneumoniae. It is worth exploring whether this toxin can be used as a candidate antigen for the serodiagnosis of M. pneumoniae. In this study, ... Read more >>

Eur J Clin Microbiol Infect Dis (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2021, :]

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Secondary cytoreduction followed by chemotherapy versus chemotherapy alone in platinum-sensitive relapsed ovarian cancer (SOC-1): a multicentre, open-label, randomised, phase 3 trial.

Tingyan Shi, Jianqing Zhu, Yanling Feng, Dongsheng Tu, Yuqin Zhang, Ping Zhang, Huixun Jia, Xiao Huang, Yunlang Cai, Sheng Yin, Rong Jiang, Wenjuan Tian, Wen Gao, Jihong Liu, Huijuan Yang, Xi Cheng, Rongyu Zang,

<h4>Background</h4>The benefits of secondary cytoreduction for platinum-sensitive relapsed ovarian cancer are still widely debated. We aimed to assess the efficacy of secondary cytoreduction plus chemotherapy versus chemotherapy alone in this patient population.<h4>Methods</h4>This multicentre, open-label, randomised, controlled, phase 3 trial (SOC-1), was done in four primarily academic centres in China (two ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, 22(4):439-449]

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Quantitative proteomics analysis of Mycoplasma pneumoniae identifies potential macrolide resistance determinants.

Shaoli Li, Guanhua Xue, Hanqing Zhao, Yanling Feng, Chao Yan, Jinghua Cui, Xianghui Xie, Jing Yuan,

Mycoplasma pneumoniae is one of the leading causes of community-acquired pneumonia in children and adolescents. Because of the wide application of macrolides in clinical treatment, macrolide-resistant M. pneumoniae strains have become increasingly common worldwide. However, the molecular mechanisms underlying drug resistance in M. pneumoniae are poorly understood. In the present ... Read more >>

AMB Express (AMB Express)
[2021, 11(1):26]

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Profiling of specific long non-coding RNA signatures identifies ST8SIA6-AS1 AS a novel target for breast cancer.

Zhanghan Chen, Jie Huang, Yanling Feng, Zehuan Li, Ying Jiang,

<h4>Background</h4>Breast cancer is the most commonly diagnosed cancer among women and is also the leading cause of cancer death for which the treatment and methods of diagnosis remain unsatisfied. Long non-coding RNA (lncRNA) plays an important role in the occurrence and development of tumors, including breast cancer. We aimed to ... Read more >>

J Gene Med (The journal of gene medicine)
[2021, 23(2):e3286]

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The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling.

Zhuo Wang, Wendong Guo, Fei Yi, Tingting Zhou, Xiaoman Li, Yanling Feng, Qiqiang Guo, Hongde Xu, Xiaoyu Song, Liu Cao,

The sirtuins family is well known by its unique nicotinamide adenine dinucleotide (NAD<sup>+</sup>)-dependent deacetylase function. The most-investigated member of the family, Sirtuin 1 (SIRT1), accounts for deacetylating a broad range of transcription factors and coregulators, such as p53, the Forkhead box O (FOXO), and so on. It serves as a ... Read more >>

Int J Biol Sci (International journal of biological sciences)
[2021, 17(1):89-96]

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Minimally invasive surgery vs laparotomy for early stage cervical cancer: A propensity score-matched cohort study.

Danian Dai, He Huang, Yanling Feng, Ting Wan, Zhimin Liu, Chongjie Tong, Jihong Liu,

<h4>Objective</h4>To compare the long-term oncologic outcomes of minimally invasive surgery (MIS) vs laparotomy for patients with stage IB (2018 FIGO) cervical cancer.<h4>Methods</h4>A matched retrospective study of cervical cancer patients who underwent MIS or laparotomy at Sun Yat-sen University Cancer Center from January 2012 to December 2015 was carried out. Patients ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(24):9236-9245]

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Quantitative proteomics analysis of Mycoplasma pneumoniae identifies potential macrolide resistance determinants

shaoli li, guanhua xue, hanqing zhao, yanling feng, chao yan, jinghua cui, xianghui xie, jing yuan,

Mycoplasma pneumoniae is one of the leading causes of community-acquired pneumonia in children and adolescents. Because of the wide application of macrolides in clinical treatment, macrolide-resistant M. pneumoniae strains have become increasingly common worldwide. However, the molecular mechanisms underlying drug resistance in M. pneumoniae are poorly understood. In the present ... Read more >>

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Prediction of COVID-19 Patients at High Risk of Progression to Severe Disease.

Zhenyu Dai, Dong Zeng, Dawei Cui, Dawei Wang, Yanling Feng, Yuhan Shi, Liangping Zhao, Jingjing Xu, Wenjuan Guo, Yuexiang Yang, Xinguo Zhao, Duoduo Li, Ye Zheng, Ao Wang, Minmin Wu, Shu Song, Hongzhou Lu,

In order to develop a novel scoring model for the prediction of coronavirus disease-19 (COVID-19) patients at high risk of severe disease, we retrospectively studied 419 patients from five hospitals in Shanghai, Hubei, and Jiangsu Provinces from January 22 to March 30, 2020. Multivariate Cox regression and orthogonal projections to ... Read more >>

Front Public Health (Frontiers in public health)
[2020, 8:574915]

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SLUG is Enhanced by Chemotherapeutics and Functions to Promote Invasion and Metastasis by Directly Targeting MMP3 in Cervical Cancer

Senwei Jiang, Lan Zhang, Shuting Huang, Yun Zhou, Yanling Feng, Linjing Yuan, Yinan Jiang, Xiaojing Zheng, Jing Xu, Rongzhen Luo, Weihua Jia, Min Zheng,

<h4>Background: </h4> Neoadjuvant chemotherapy(NACT) is a widely used strategy in the treatment of locally advanced cancers. NACT followed by radical surgery for patients in FIGO stages IB2-IIB has proven to reduce tumor volume and numbers. Under certain conditions, however, NACT followed by radical surgery has not been found to improve ... Read more >>

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The Relationship Between Lower Respiratory Tract Microbiome and Allergic Respiratory Tract Diseases in Children

Jinghua Cui, Yuanyuan Zhang, Hanqing Zhao, Zhen Chen, Quan Zhang, Chao Yan, Guanhua Xue, Shaoli Li, Yanling Feng, Han Liu, Chen Chen, Xianghui Xie, Jing Yuan,

<h4>Background: </h4> With the development of sequencing technologies, it has been found that there are microbes similar to those in the upper respiratory tract present in the healthy human lower respiratory tract (LRT), including the lungs and bronchus. Thus, to study the LRT microbiome and evaluate the relationship between this ... Read more >>

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Study of upfront surgery versus neoadjuvant chemotherapy followed by interval debulking surgery for patients with stage IIIC and IV ovarian cancer, SGOG SUNNY (SOC-2) trial concept.

Rong Jiang, Jianqing Zhu, Jae Weon Kim, Jihong Liu, Kazuyoshi Kato, Hee Seung Kim, Yuqin Zhang, Ping Zhang, Tao Zhu, Daisuke Aoki, Aijun Yu, Xiaojun Chen, Xipeng Wang, Ding Zhu, Wei Zhang, Huixun Jia, Tingyan Shi, Wen Gao, Sheng Yin, Yanling Feng, Libing Xiang, Aikou Okamoto, Rongyu Zang,

<h4>Background</h4>Two randomized phase III trials (EORTC55971 and CHORUS) showed similar progression-free and overall survival in primary or interval debulking surgery in ovarian cancer, however both studies had limitations with lower rate of complete resection and lack of surgical qualifications for participating centers. There is no consensus on whether neoadjuvant chemotherapy ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(5):e86]

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Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer.

Zhanghan Chen, Jie Huang, Yanling Feng, Zehuan Li, Ying Jiang,

<h4>Background</h4>The pan-cancer analysis has recently brought us into a novel level of cancer research. Nowadays, the Circular RNAs (circRNAs) is becoming increasingly important in the occurrence and progression of tumors. Nevertheless, the specific expression patterns and functions of circRNAs in the pan-cancer remains unclear. Here we aimed to explore the ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(19):7279-7292]

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Reverse-Transcription Recombinase-Aided Amplification Assay for Rapid Detection of the 2019 Novel Coronavirus (SARS-CoV-2).

Guanhua Xue, Shaoli Li, Weiwei Zhang, Bing Du, Jinghua Cui, Chao Yan, Lei Huang, Lu Chen, Linqing Zhao, Yu Sun, Nannan Li, Hanqing Zhao, Yanling Feng, Zhimin Wang, Shiyu Liu, Qun Zhang, Xianghui Xie, Di Liu, Hailan Yao, Jing Yuan,

A novel coronavirus (SARS-CoV-2) was recently identified in patients with acute respiratory disease and spread quickly worldwide. A specific and rapid diagnostic method is important for early identification. The reverse-transcription recombinase-aided amplification (RT-RAA) assay is a rapid detection method for several pathogens. Assays were performed within 5-15 min as a ... Read more >>

Anal Chem (Analytical chemistry)
[2020, 92(14):9699-9705]

Cited: 6 times

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CircMMP11 acts as a ce-circRNA in breast cancer progression by regulating miR-1204.

Zehuan Li, Zhanghan Chen, Yanling Feng, Guohua Hu, Ying Jiang,

<h4>Background</h4>Numerous studies have found that circular RNAs (circRNA) can serve as competing endogenous RNA (ceRNA) in cancer progression while the expression profiles and functions of competitive endogenous circRNAs (ce-circRNAs) in breast cancer (BC) have not been determined.<h4>Methods</h4>Six pairs of tissue samples were selected to perform ceRNA microarray, and The Cancer ... Read more >>

Am J Transl Res (American journal of translational research)
[2020, 12(6):2585-2599]

Cited: 2 times

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Prognostic value of prostaglandin I2 synthase and its correlation with tumor-infiltrating immune cells in lung cancer, ovarian cancer, and gastric cancer.

Danian Dai, Bo Chen, Yanling Feng, Weizhong Wang, Yanhui Jiang, He Huang, Jihong Liu,

<h4>Background</h4>Prostaglandin I2 synthase (PTGIS) is a crucial gene for the synthesis of prostaglandin I2, which has multiple roles in inflammation and immune modulation. However, studies on the prognostic value of PTGIS and its correlation with tumor-infiltrating immune cells in multiple cancers are still rare.<h4>Results</h4>Multiple datasets of the Oncomine database showed ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(10):9658-9685]

Cited: 1 time

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Potential risks in sentinel lymph node biopsy for cervical cancer: a single-institution pilot study.

Hua Tu, Ting Wan, Xinke Zhang, Haifeng Gu, Yanling Feng, He Huang, Jihong Liu,

<h4>Background</h4>Sentinel lymph node (SLN) biopsy is an attractive technique that is widely performed in many oncological surgeries. However, the potential risks in SLN biopsy for cervical cancer remains largely unclear.<h4>Methods</h4>Seventy-five patients with histologically confirmed cervical cancer were enrolled between May 2014 and June 2016. SLN biopsies were performed followed by ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2020, 18(1):133]

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RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation.

Ling Ren, Tingting Zhou, Yang Wang, Yanmei Wu, Hongde Xu, Jingwei Liu, Xiang Dong, Fei Yi, Qiqiang Guo, Zhuo Wang, Xiaoman Li, Ning Bai, Wendong Guo, Min Guo, Bo Jiang, Xuan Wu, Yanling Feng, Xiaoyu Song, Siyi Zhang, Yue Zhao, Liu Cao, Shuai Han, Chengzhong Xing,

DNA damage signals transducer RING finger protein 8 (RNF8) is involved in maintaining genomic stability by facilitating the repair of DNA double-strand breaks (DSB) via ubiquitin signaling. By analyzing the TCGA database and colon cancer tissue microarrays, we found that the expression level of RNF8 was positively correlated with that ... Read more >>

Int J Biol Sci (International journal of biological sciences)
[2020, 16(12):2051-2062]

Cited: 1 time

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Potential risks in sentinel lymph node biopsy for cervical cancer: a single-institution pilot study

Hua Tu, Ting Wan, Xinke Zhang, Haifeng Gu, Yanling Feng, He Huang, Jihong Liu,

<h4>Background: </h4> : Sentinel lymph node (SLN) biopsy is an attractive technique that widely performed in many oncological surgeries. However, the potential risks in SLN biopsy for cervical cancer remains largely unclear. <h4>Methods: </h4> : Seventy-five patients with histologically confirmed cervical cancer were enrolled between May 2014 and June 2016. ... Read more >>

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A phase II trial of cytoreductive surgery combined with niraparib maintenance in platinum-sensitive, secondary recurrent ovarian cancer: SGOG SOC-3 study.

Tingyan Shi, Sheng Yin, Jianqing Zhu, Ping Zhang, Jihong Liu, Yaping Zhu, Sufang Wu, Xiaojun Chen, Xipeng Wang, Yincheng Teng, Tao Zhu, Aijun Yu, Yingli Zhang, Yanling Feng, He Huang, Wei Bao, Yanli Li, Wei Jiang, Ping Zhang, Jiarui Li, Zhihong Ai, Wei Zhang, Huixun Jia, Yuqin Zhang, Rong Jiang, Jiejie Zhang, Wen Gao, Yuting Luan, Rongyu Zang,

<h4>Background</h4>In China, secondary cytoreductive surgery (SCR) has been widely used in ovarian cancer (OC) over the past two decades. Although Gynecologic Oncology Group-0213 trial did not show its overall survival benefit in first relapsed patients, the questions on patient selection and effect of subsequent targeting therapy are still open. The ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(3):e61]

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Proteomic profiling of hepatic stellate cells in alcohol liver fibrosis reveals proteins involved in collagen production.

Lin Yin, Yujiao Zhang, Huichun Shi, Yanling Feng, Zhanqing Zhang, Lijun Zhang,

<h4>Background</h4>Hepatic stellate cell (HSC) activation has central functions in alcohol-induced liver fibrosis. Proteins of HSCs in alcoholic liver fibrosis (ALF) are still not completely understood. Here, we performed a proteomic study to discover proteins related to ALF using HSCs isolated from a rat model.<h4>Methods</h4>Sprague-Dawley rats were fed with ethanol for ... Read more >>

Alcohol (Alcohol (Fayetteville, N.Y.))
[2020, 86:81-91]

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Profiling and integrated analysis of differentially expressed circRNAs as novel biomarkers for breast cancer.

Zehuan Li, Zhanghan Chen, Guohua Hu, Yong Zhang, Yanling Feng, Ying Jiang, Jin Wang,

Breast cancer (BC) is a globally common cancer with the highest and increasing morbidity and mortality among females. Novel biomarkers are warranted to be discovered for the early detection, treatment, and prognosis of BC. In this study, we investigated the profiles of differentially expressed (DE) circular RNAs (circRNAs) by competing ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2020, 235(11):7945-7959]

Cited: 5 times

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Mycobacterium tuberculosis and Pseudoramibacter alactolyticus coinfection in brain after dental extraction: A case report.

Yixin Liao, Fan Wu, Fahui Dai, Qin Huang, Yanling Feng, Yun Ling, Hongzhou Lu,

<h4>Introduction</h4>More than 1200 different types of microbes were found in the human mouth, only some of these microorganisms were associated with intracranial bacterial infection. However, there are limited data available about the Pseudoramibacter alactolyticus (P alactolyticus) or Mycobacterium tuberculosis (MTB) intracranial infections oral origin.<h4>Patient concerns</h4>Here, we reported a rarely case ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(50):e18289]

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Comparison of PARPis with Angiogenesis Inhibitors and Chemotherapy for Maintenance in Ovarian Cancer: A Network Meta-Analysis.

Yanling Feng, He Huang, Ting Wan, Chuyao Zhang, Chongjie Tong, Jihong Liu,

<h4>Introduction</h4>Seventy-five percent of ovarian cancer would relapse within 18-28 months after platinum-base chemotherapy. Evidence suggests that maintenance chemotherapy is effective in prolonging remission. Recent target therapies such as poly(ADP-ribose) polymerase inhibitors (PARPis) and angiogenesis inhibitors (AIs) are known to ease burden and recurrence of ovarian cancer. There is limited data for ... Read more >>

Adv Ther (Advances in therapy)
[2019, 36(12):3368-3380]

Cited: 5 times

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