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Fluorinated α-Helical Polypeptides Synchronize Mucus Permeation and Cell Penetration toward Highly Efficient Pulmonary siRNA Delivery against Acute Lung Injury.

Chenglong Ge, Jiandong Yang, Shanzhou Duan, Yong Liu, Fenghua Meng, Lichen Yin,

The mucus layer and cell membrane are two major barriers against pulmonary siRNA delivery. Commonly used polycationic gene vectors can hardly penetrate the mucus layer due to the adsorption of mucin glycoproteins that trap and destabilize the polyplexes. Herein, guanidinated and fluorinated bifunctional helical polypeptides were developed to synchronizingly overcome ... Read more >>

Nano Lett. (Nano letters)
[2020, 20(3):1738-1746]

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A study on the relationship between air pollution and pulmonary tuberculosis based on the general additive model in Wulumuqi, China.

Jiandong Yang, Mengxi Zhang, Yanggui Chen, Li Ma, Rayibai Yadikaer, Yaoqin Lu, Pengwei Lou, Yujiao Pu, Ran Xiang, Baolin Rui,

OBJECTIVE:This study aimed to explore the impact of atmospheric pollutants on the incidence of tuberculosis (TB), and provide new ideas for the prevention and control of TB in the future. METHODS:It explored the relationship between air pollutants and meteorological factors, as well as between air pollutants and heating through Spearman ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 96:42-47]

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The efficacy and safety of multiple-dose intravenous tranexamic acid in reducing perioperative blood loss in patients with thoracolumbar burst fracture.

Feng Wang, Liping Nan, Xinmin Feng, Yongxiang Wang, Jiandong Yang, Yuping Tao, Xiaofei Cheng, Shengfei Zhang, Liang Zhang,

OBJECTIVE:To evaluate the efficacy and safety of tranexamic acid (TXA) for single-segment thoracolumbar burst fracture without neurologic injury underwent pedicle screw fixation via Wiltse approach. PATIENTS AND METHODS:We identified 264 patients with single-segment thoracolumbar burst fracture without neurologic injury underwent pedicle screw fixation via Wiltse approach (January 2016-June 2019) at ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2020, 193:105766]

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Complete mtDNA genome of Otus sunia (Aves, Strigidae) and the relaxation of selective constrains on Strigiformes mtDNA following evolution.

Yun Zhong, Ming Zhou, Bo Ouyang, Changjun Zeng, Ming Zhang, Jiandong Yang,

Most of owls are nocturnal raptor and usually use their soft and fluffy feathers to flight silently to catch prey while other diurnal raptors prefer fierce attack and swift flight. For energy cost of these different hunting strategies can be greatly different, we speculate that mitochondrial gene of owls may ... Read more >>

Genomics (Genomics)
[2020, :]

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Changes in the Population Genetic Structure of Captive Forest Musk Deer (Moschus Berezovskii) with the Increasing Number of Generation under Closed Breeding Conditions.

Yonghua Cai, Jiandong Yang, Jianming Wang, Ying Yang, Wenlong Fu, Chengli Zheng, Jianguo Cheng, Yutian Zeng, Yan Zhang, Ling Xu, Yan Ren, Chuanzhi Lu, Ming Zhang,

We investigated the genetic diversity of the population of captive forest musk deer (Moschus berezovskii) in Barkam Musk Deer Breeding Centre using twelve microsatellite markers, and then analyzed the change in genetic structure of successive generation groups from the population. The data provide a new understanding for the evaluation and ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2020, 10(2):]

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miR-26a is Involved in Glycometabolism and Affects Boar Sperm Viability by Targeting PDHX.

Wencan Wang, Kai Liang, Yu Chang, Mingxia Ran, Yan Zhang, Malik Ahsan Ali, Dinghui Dai, Izhar Hyder Qazi, Ming Zhang, Guangbin Zhou, Jiandong Yang, Christiana Angel, Changjun Zeng,

miR-26a is associated with sperm metabolism and can affect sperm motility and apoptosis. However, how miR-26a affects sperm motility remains largely unknown. Our previous study indicated that the PDHX gene is predicted to be a potential target of miR-26a, which is responsible for pyruvate oxidative decarboxylation which is considered as ... Read more >>

Cells (Cells)
[2020, 9(1):]

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Gut microbiota in reintroduction of giant panda.

Jingsi Tang, Chengdong Wang, Hemin Zhang, Jiangchao Zhao, Wei Guo, Sudhanshu Mishra, Fanli Kong, Bo Zeng, Ruihong Ning, Desheng Li, Jiandong Yang, Mingyao Yang, Mingwang Zhang, Qingyong Ni, Yan Li, Ying Li,

Reintroduction is a key approach in the conservation of endangered species. In recent decades, many reintroduction projects have been conducted for conservation purposes, but the rate of success has been low. Given the important role of gut microbiota in health and diseases, we questioned whether gut microbiota would play a ... Read more >>

Ecol Evol (Ecology and evolution)
[2020, 10(2):1012-1028]

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Tet1 Overexpression and Decreased DNA Hydroxymethylation Protect Neurons Against Cell Death After Injury by Increasing Expression of Genes Involved in Cell Survival.

Yongxiang Wang, Jingcheng Wang, Hua Wang, Xinmin Feng, Yuping Tao, Jiandong Yang, Jun Cai,

BACKGROUND:Spinal cord and neuron injury result in loss of muscle function, sensation, or autonomic function in the body. Tet1 produces 5-hydroxymethylcytosin. The conversion was proposed as the initial step of deoxyribonucleic acid demethylation in mammals. However, effects of Tet1 expression and hydroxymethylation status on neuron injury remain unclear. Therefore the ... Read more >>

World Neurosurg (World neurosurgery)
[2019, 126:e713-e722]

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Multiple primary lung cancer versus intrapulmonary metastatic cancer: A case of multiple pulmonary nodules.

Chunquan Liu, Huawei Li, Kaikai Xu, Shuai Song, Ying He, Xianqi Cai, Xiangyu Chu, Jiandong Yang, Yong Cui,

A preoperative chest computed tomography examination of the right breast in a 52-year-old woman with breast cancer revealed multiple nodules in both lungs. The nodule in the apical segment of the upper lobe of the right lung was larger, at a diameter of approximately 2.1 cm. The patient underwent resection ... Read more >>

Thorac Cancer (Thoracic cancer)
[2019, 10(2):352-358]

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The complete mitochondrial genome of Budorcas taxicolor tibetana (Artiodactyla: Bovidae) and comparison with other Caprinae species: Insight into the phylogeny of the genus Budorcas.

Ming Zhou, Jiaojiao Yu, Biao Li, Bo Ouyang, Jiandong Yang,

Takin (Budorcas taxicolor) is one of the most endangered species. However, the taxonomy of takin is still in dispute. Here, the complete mitochondrial genome of Budorcas taxicolor tibetana was reported for the first time, which featured a typical circular molecule of 16,665 bp in length, including 13 PCGs, 22 tRNAs, two ... Read more >>

Int. J. Biol. Macromol. (International journal of biological macromolecules)
[2019, 121:223-232]

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Complete mitochondrial genome of Japalura flaviceps: Deep insights into the phylogeny and gene rearrangements of Agamidae species.

Jiabin Liu, Jiaojiao Yu, Ming Zhou, Jiandong Yang,

Japalura flaviceps is a subarboreal species, which is endemically distributed in China. Here, we determined the complete mitogenome of J. flaviceps. This mitogenome was a typical circular molecule of 17,140 bp in size, containing 13 protein-coding genes, 22 transfer-RNA-coding genes, two ribosomal-RNA-coding genes, and one control region. Our phylogenetic result using ... Read more >>

Int. J. Biol. Macromol. (International journal of biological macromolecules)
[2019, 125:423-431]

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Outcome Evaluation of Zero-Profile Device Used for Single-Level Anterior Cervical Discectomy and Fusion with Osteoporosis Compared without Osteoporosis: A Minimum Three-Year Follow-Up Study.

Liang Zhang, Jingcheng Wang, Xinmin Feng, Yuping Tao, Jiandong Yang, Yongxiang Wang, Shengfei Zhang, Jun Cai,

OBJECTIVE:We compared the mid-term efficacy and safety of anterior cervical discectomy and fusion (ACDF) using a Zero-Profile device for cervical degenerative disc disease (CDDD) with and without osteoporosis. METHODS:We performed a retrospective study of elderly patients with CDDD treated by single-level ACDF with a Zero-Profile device. The patients were divided ... Read more >>

World Neurosurg (World neurosurgery)
[2018, :]

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Correction: Opposing Effects of PI3K/Akt and Smad-Dependent Signaling Pathways in NAG-1-Induced Glioblastoma Cell Apoptosis.

Zhiguo Zhang, Lin Wu, Julei Wang, Gang Li, Dayun Feng, Bin Zhang, Lihong Li, Jiandong Yang, Lianting Ma, Huaizhou Qin,

[This corrects the article DOI: 10.1371/journal.pone.0096283.]. ... Read more >>

PLoS ONE (PloS one)
[2018, 13(10):e0205391]

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DNA hydroxymethylation mediated traumatic spinal injury by influencing cell death-related gene expression.

Hao Sun, Zhigang Miao, Hua Wang, Yuping Tao, Jiandong Yang, Jun Cai, Jingcheng Wang, Yongxiang Wang,

Spinal cord injury (SCI) is a serious neurological disease, often leading to segmental injury following severe limb dysfunction. Recent studies showed that epigenetic regulation is involved in the pathogenesis of SCI. In this study, we examined the change in 5-hydroxymethylcytosine (5hmC), a mechanism of demethylation, and its role in SCI ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2018, 119(11):9295-9302]

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Burden on hydropower units for short-term balancing of renewable power systems.

Weijia Yang, Per Norrlund, Linn Saarinen, Adam Witt, Brennan Smith, Jiandong Yang, Urban Lundin,

There is a general need to change hydropower operational regimes to balance the growing contribution of variable renewable energy sources in power systems. Quantifying the burden on generation equipment is increasingly uncertain and difficult. Here, we propose a framework combining technical and economic indicators to analyze primary frequency control (PFC) ... Read more >>

Nat Commun (Nature communications)
[2018, 9(1):2633]

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Multiarm-polyethylene glycol-polyglutamic acid peptide dendrimer: Design, synthesis, and dissolving thrombus.

Shao-Fei Zhang, Shaoyu Lü, Chunmei Gao, Jiandong Yang, Xiang Yan, Tao Li, Na Wen, Mengjie Huang, Mingzhu Liu,

Thrombotic events affect many individuals in a number of ways, all of which can cause significant morbidity and mortality. Nattokinase (NK), as a novel thrombolytic drug, has been used for thrombolytic therapy. It not only possesses plasminogen activator activity, but also directly digests fibrin through limited proteolysis. However, it may ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2018, 106(6):1687-1696]

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Necrosulfonamide Attenuates Spinal Cord Injury via Necroptosis Inhibition.

Yongxiang Wang, Jingcheng Wang, Hua Wang, Xinmin Feng, Yuping Tao, Jiandong Yang, Jun Cai,

Spinal cord injury (SCI) is a serious trauma without efficient treatment currently. Necroptosis can be blocked post injury by special inhibitors. This study is to investigate the effects, mechanism, and potential benefit of necrosulfonamide (NSA) for SCI therapy.Pathologic condition was detected using hematoxylin-eosin staining on injured spinal cord and other ... Read more >>

World Neurosurg (World neurosurgery)
[2018, 114:e1186-e1191]

Cited: 1 time

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Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in pleuropulmonary blastoma / DICER1 syndrome: a unique variant of the two-hit tumor suppression model

Mark Brenneman, Amanda Field, Jiandong Yang, Gretchen Williams, Leslie Doros, Christopher Rossi, Kris Ann Schultz, Avi Rosenberg, Jennifer Ivanovich, Joyce Turner, Heather Gordish-Dressman, Douglas Stewart, Weiying Yu, Anne Harris, Peter Schoettler, Paul Goodfellow, Louis Dehner, Yoav Messinger, Ashley Hill,

Pleuropulmonary blastoma (PPB) is the most frequent pediatric lung tumor and often the first indication of a pleiotropic cancer predisposition,  DICER1  syndrome, comprising a range of other individually rare, benign and malignant tumors of childhood and early adulthood. The genetics of  DICER1 -associated tumorigenesis are unusual in that tumors typically ... Read more >>

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Metagenomic Study Suggests That the Gut Microbiota of the Giant Panda (Ailuropoda melanoleuca) May Not Be Specialized for Fiber Fermentation.

Wei Guo, Sudhanshu Mishra, Jiangchao Zhao, Jingsi Tang, Bo Zeng, Fanli Kong, Ruihong Ning, Miao Li, Hengzhi Zhang, Yutian Zeng, Yuanliangzi Tian, Yihang Zhong, Hongdi Luo, Yunhan Liu, Jiandong Yang, Mingyao Yang, Mingwang Zhang, Yan Li, Qingyong Ni, Caiwu Li, Chengdong Wang, Desheng Li, Hemin Zhang, Zhili Zuo, Ying Li,

Bamboo-eating giant panda (Ailuropoda melanoleuca) is an enigmatic species, which possesses a carnivore-like short and simple gastrointestinal tract (GIT). Despite the remarkable studies on giant panda, its diet adaptability status continues to be a matter of debate. To resolve this puzzle, we investigated the functional potential of the giant panda ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2018, 9:229]

Cited: 4 times

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Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis.

Liang Zhang, Xin Yin, Jingcheng Wang, Daolinag Xu, Yongxiang Wang, Jiandong Yang, Yuping Tao, Shengfei Zhang, Xinmin Feng, Caifeng Yan,

Results on the relationships between vitamin D receptor (VDR) gene polymorphisms and postmenopausal osteoporosis (PMOP) susceptibility and bone mineral density (BMD) are conflicting. The aim of the study is to identify more eligible studies that calculated pooled OR and WMD with 95% CI to assess their associations. Overall, there were ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):981]

Cited: 7 times

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Multifocal skeletal tuberculosis: A case report.

Liang Zhang, Jingcheng Wang, Xinmin Feng, Yuping Tao, Jiandong Yang, Shenfei Zhang, Jun Cai,

Tuberculosis (TB) of the musculoskeletal system is a rare clinical condition. Multifocal bone involvement is extremely rare and difficult to recognize. Thus, due to the diverse and atypical clinical manifestations of multifocal skeletal TB, the disease is easy to misdiagnose. In the present study, a rare case of atypical disseminated ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2016, 11(4):1288-1292]

Cited: 2 times

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High-Altitude Living Shapes the Skin Microbiome in Humans and Pigs.

Bo Zeng, Jiangchao Zhao, Wei Guo, Siyuan Zhang, Yutong Hua, Jingsi Tang, Fanli Kong, Xuewu Yang, Lizhi Fu, Kun Liao, Xianqiong Yu, Guohong Chen, Long Jin, Surong Shuai, Jiandong Yang, Xiaohui Si, Ruihong Ning, Sudhanshu Mishra, Ying Li,

While the skin microbiome has been shown to play important roles in health and disease in several species, the effects of altitude on the skin microbiome and how high-altitude skin microbiomes may be associated with health and disease states remains largely unknown. Using 16S rRNA marker gene sequencing, we characterized ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2017, 8:1929]

Cited: 3 times

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Embedded vertically aligned cadmium telluride nanorod arrays grown by one-step electrodeposition for enhanced energy conversion efficiency in three-dimensional nanostructured solar cells.

Jun Wang, Shurong Liu, Yannan Mu, Li Liu, Runa A, Jiandong Yang, Guijie Zhu, Xianwei Meng, Wuyou Fu, Haibin Yang,

Vertically aligned CdTe nanorods (NRs) arrays are successfully grown by a simple one-step and template-free electrodeposition method, and then embedded in the CdS window layer to form a novel three-dimensional (3D) heterostructure on flexible substrates. The parameters of electrodeposition such as deposition potential and pH of the solution are varied ... Read more >>

J Colloid Interface Sci (Journal of colloid and interface science)
[2017, 505:1047-1054]

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Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery.

Nan Zheng, Ziyuan Song, Jiandong Yang, Yang Liu, Fangfang Li, Jianjun Cheng, Lichen Yin,

The delivery performance of non-viral gene vectors is greatly related to their intracellular kinetics. Cationic helical polypeptides with potent membrane penetration properties and gene transfection efficiencies have been recently developed by us. However, they suffer from severe drawbacks in terms of their membrane penetration mechanisms that mainly include endocytosis and ... Read more >>

Acta Biomater (Acta biomaterialia)
[2017, 58:146-157]

Cited: 4 times

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Synthesis of uniform cadmium sulphide thin film by the homogeneous precipitation method on cadmium telluride nanorods and its application in three-dimensional heterojunction flexible solar cells.

Jun Wang, Shurong Liu, Yannan Mu, Li Liu, Runa A, Pengyu Su, Jiandong Yang, Guijie Zhu, Wuyou Fu, Haibin Yang,

High-density CdTe nanorod arrays are successfully embedded in a uniform and compact CdS layer, forming a novel three-dimensional (3D) CdTe NRs/CdS heterojunction structure. The CdS layer is prepared by homogeneous precipitation (HP) method using decomposition of urea. The effects of temperature and concentration of reactants on the growth and composition ... Read more >>

J Colloid Interface Sci (Journal of colloid and interface science)
[2017, 505:59-66]

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