Full Text Journal Articles by
Author Yang Gao

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Ce6/Mn2+-chelated [email protected] nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer.

Yang Gao, Luyun Zhang, Yanhong Liu, Sijia Sun, Zhibin Yin, Lili Zhang, Aiguo Li, Guangming Lu, Aiguo Wu, Leyong Zeng,

Black titanium dioxide (TiO2) nanoparticles have attracted great attention due to their application in photothermal therapy (PTT). However, single-mode phototherapy has the risk of recurrence, and the high-dose laser usually imposed to improve the PTT performance can bring a potential threat to security. Here, polydopamine (PDA)-coated black TiO2 ([email protected]) nanoparticles ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(3):1801-1810]

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MLi2Ti6O14 (M = Sr, Ba, and Pb): new cathode materials for magnesium-lithium hybrid batteries.

Caixia Zhu, Yakun Tang, Lang Liu, Xiaohui Li, Yang Gao, Shasha Gao, Yanna NuLi,

Magnesium-lithium hybrid batteries (MLHBs) are playing an increasingly important role in energy storage systems owing to their abundant raw materials and favorable safety characteristics. Consequently, MLi2Ti6O14 (M = Sr, Ba, and Pb) compounds have been synthesized via a sol-gel method, followed by calcination. For the first time, as cathodes for ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(47):17566-17571]

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Development of methionine methylation profiling and relative quantification in human breast cancer cells based on metabolic stable isotope labeling.

Han Liao, Qingce Zang, Qinglin Lv, Yang Gao, Zitong Zhao, Jiuming He, Ruiping Zhang, Yongmei Song, Yanhua Chen, Zeper Abliz,

Methylation of components involved in one-carbon metabolism is extremely important in cancer; comprehensive studies on methylation are essential and may provide us with a better understanding of tumorigenesis, and lead to the discovery of potential biomarkers. Here, we present an improved methodology for methylated metabolite profiling and its relative quantification ... Read more >>

Analyst (The Analyst)
[2019, 144(13):3988-3998]

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Copper-Catalyzed Electrophilic Amination of Arylboronic acids with Anthranils: An Access to N-Aryl-2-aminophenones.

Yang Gao, Simin Yang, Yibiao Li, Yanping Huo, Zongyi Huang, Zumin Chen, Xiao-Qiang Hu,

An efficient copper-catalyzed electrophilic amination strategy has been established for the rapid synthesis of N-aryl-2-aminophenones from the readily available arylboronic acids/esters and anthranils. This protocol features good functional group tolerance, broad substrate scope and operational simplicity. Moreover, a tandem C-H borylation and C-N coupling protocol has also been developed to ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2020, :]

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VASP is upregulated by WDR5-MYC nexus and promotes cell migration in breast cancer

Xiaolong Xu, Yihao Tian, Fangfang Chen, Yang Gao, Jingjing Xu, Qi Jiang, Lei Wei, Jingwei Zhang,

Abstract Backguroud: Breast cancer is one of the most threatening diseases for women, whose metastasis and recurrence are important causes of death in breast cancer patients. Vasodilator-stimulated phosphoprotein (VASP) is a cytoskeletal regulatory protein that promotes invasion and metastasis of tumor cells by regulating cell migration. Bioinformatics data indicated that ... Read more >>

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[Transport Characteristics of Phosphorus Sources at the Multi-scale Watershed and the Associated Ecological Effects on Poyang Lake].

Shuo-Yue Wang, Yang Gao, Yao Lu, Jun-Jie Jia, Zhao-Xi Li, Ming-Zhen Ma, Xue-Fa Wen,

In this study, a cascaded watershed system in the Poyang Lake area was selected as the study site, which ranged from the primary tributaries to the lake area (Xiangxi River→Jiazhu River→Ganjiang River→Poyang Lake). The aims of the study were to monitor the P wet deposition and runoff process in the ... Read more >>

Huan Jing Ke Xue (Huan jing ke xue= Huanjing kexue)
[2020, 41(7):3186-3193]

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Knockouts of a late flowering gene via CRISPR-Cas9 confer early maturity in rice at multiple field locations.

Guokui Wang, Changgui Wang, Guihua Lu, Wei Wang, Guanfan Mao, Jeffrey E Habben, Chao Song, Jiantao Wang, Jian Chen, Yang Gao, Junhua Liu, Thomas W Greene,

KEY MESSAGE:OsGhd7 gene was discovered by screening our rice activation tagging population. CRISPR-Cas9 created knockouts of OsGhd7 conferred early flowering and early maturity in rice varieties across multiple geographical locations in China. Our research shows that OsGhd7 is a good target for breeding early maturity rice varieties, and an excellent ... Read more >>

Plant Mol. Biol. (Plant molecular biology)
[2020, :]

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Cobalt catalyzed stereodivergent semi-hydrogenation of alkynes using H2O as the hydrogen source.

Kangkui Li, Ruhima Khan, Xuexin Zhang, Yang Gao, Yongyun Zhou, Heng Tan, Jingchao Chen, Baomin Fan,

Cobalt-catalyzed stereodivergent semi-hydrogenation of internal alkynes to alkenes is developed. The reaction proceeded through transfer hydrogenation under mild conditions using a base metal CoI2 as the catalyst, and H2O/MeOH as the hydrogen source with Zn as the reductant. The E/Z-selectivity of the product could be switched by changing the solvent ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(39):5663-5666]

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Robust and anti-fatigue hydrophobic association hydrogels assisted by titanium dioxide for photocatalytic activity.

Yang Gao, Song Gu, Lijie Duan, Yuanrui Wang, Guanghui Gao,

Currently, robust and functional hydrogels have attracted extensive attention due to their potential applications in wastewater treatment, farmland water conservation and other fields. Herein, a series of hydrophobic association hydrogels assisted by titanium dioxide (TiO2) was fabricated via one-pot in situ photo-induced polymerization. TiO2 nanoparticles could act as both photo-initiators ... Read more >>

Soft Matter (Soft matter)
[2019, 15(19):3897-3905]

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Confucian values, trust, and family farm adoption of green control techniques.

Lili Yu, Chen Chen, Yang Gao,

Encouraging farmers to adopt green control techniques (GCTs) helps to reduce and control the use of chemical pesticides. However, there is a lack of attention regarding the promotion of culture as an informal institution. As an important part of Chinese culture, Confucian values affect the behavior and decision-making of Chinese ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, :]

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Optogenetics inspired transition metal dichalcogenide neuristors for in-memory deep recurrent neural networks.

Rohit Abraham John, Jyotibdha Acharya, Chao Zhu, Abhijith Surendran, Sumon Kumar Bose, Apoorva Chaturvedi, Nidhi Tiwari, Yang Gao, Yongmin He, Keke K Zhang, Manzhang Xu, Wei Lin Leong, Zheng Liu, Arindam Basu, Nripan Mathews,

Shallow feed-forward networks are incapable of addressing complex tasks such as natural language processing that require learning of temporal signals. To address these requirements, we need deep neuromorphic architectures with recurrent connections such as deep recurrent neural networks. However, the training of such networks demand very high precision of weights, ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):3211]

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Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13.

Yao Liu, Mingfeng Hao, Alan L Leggett, Yang Gao, Scott B Ficarro, Jianwei Che, Zhixiang He, Calla M Olson, Jarrod A Marto, Nicholas P Kwiatkowski, Tinghu Zhang, Nathanael S Gray,

Genetic depletion of cyclin-dependent kinase 12 (CDK12) or selective inhibition of an analog-sensitive CDK12 reduces DNA damage repair gene expression, but selective inhibition of endogenous CDK12 is difficult. Here, we report the development of MFH290, a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2020, :]

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Diagnostic Yield and Bleeding Complications Associated With Bronchoscopic Biopsy of Endobronchial Carcinoid Tumors.

Yang Gao, Teng Moua, David E Midthun, John J Mullon, Paul A Decker, Jay H Ryu,

BACKGROUND:Bronchial carcinoid often appears hypervascular on bronchoscopic visualization and may be associated with hemoptysis. The diagnostic yield and bleeding complications associated with bronchoscopic biopsy of bronchial carcinoid tumors remain unclear. MATERIALS AND METHODS:Patients with bronchial carcinoid tumors that were bronchoscopically visualized and biopsied at our tertiary referral medical center, over ... Read more >>

J Bronchology Interv Pulmonol (Journal of bronchology & interventional pulmonology)
[2020, 27(3):184-189]

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In Vitro Evaluation of the Effectiveness of Bleaching Agents Activated by KTP and Nd:YAG laser.

Yang Gao, Zhuoping Zhao, Li Li, Kuanshou Zhang, Qingmei Liu,

AIM:To compare two different laser sources, a KTP laser with a wavelength of 532 nm and a Nd:YAG laser with a wavelength of 1064 nm, to investigate the relation between laser source and bleaching gel during laser irradiation. METHODS:Extracted human teeth were stained and randomly divided into six groups. Two in-office bleaching ... Read more >>

Photodiagnosis Photodyn Ther (Photodiagnosis and photodynamic therapy)
[2020, :101900]

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A blended intervention to promote physical activity, health and work productivity among office employees using intervention mapping: a study protocol for a cluster-randomized controlled trial.

Yan Sun, Aiwei Wang, Siyue Yu, Martin S Hagger, Xiangyan Chen, Shirley Siu Ming Fong, Chunqing Zhang, Wendy Yajun Huang, Julien S Baker, Frédéric Dutheil, Yang Gao,

BACKGROUND:Regular participation in moderate-to-vigorous physical activity (MVPA) is related to decreased risk of morbidity and mortality. Among working populations, lack of MVPA may also be a risk factor for absenteeism and presenteeism. Both traditional workplace-based and web-based interventions have been suggested as being effective in promoting participation MVPA, health-related outcomes, ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):994]

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Synthesis of Stereodefined 1,1-Diborylalkenes via Copper-Catalyzed Diboration of Terminal Alkynes.

Yang Gao, Zhong-Qian Wu, Keary M Engle,

A copper-catalyzed method for the E-selective 1,1-diboration of terminal alkynes is described. The tandem process involves sequential dehydrogenative borylation of the alkyne substrate with HBdan (1,8-diaminonaphthalatoborane), followed by hydroboration with HBpin (pinacolborane). This method proceeds efficiently under mild conditions, furnishing 1,1-diborylalkenes with excellent stereoselectivity and broad functional group tolerance. Taking ... Read more >>

Org. Lett. (Organic letters)
[2020, 22(13):5235-5239]

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Extreme In-Plane Thermal Conductivity Anisotropy in Titanium Trisulfide Caused by Heat-Carrying Optical Phonons.

Huili Liu, Xiaoxia Yu, Kedi Wu, Yang Gao, Sefaattin Tongay, Ali Javey, Lidong Chen, Jiawang Hong, Junqiao Wu,

High in-plane anisotropies arise in layered materials with large structural difference along different in-plane directions. We report an extreme case in layered TiS3, which features tightly bonded atomic chains along the b-axis direction, held together by weaker, interchain bonding along the a-axis direction. Experiments show thermal conductivity along the chain ... Read more >>

Nano Lett. (Nano letters)
[2020, :]

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Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.

Chunyu Liu, Haruhiko Miyata, Yang Gao, Yanwei Sha, Shuyan Tang, Zoulan Xu, Marjorie Whitfield, Catherine Patrat, Huan Wu, Emmanuel Dulioust, Shixiong Tian, Keisuke Shimada, Jiangshan Cong, Taichi Noda, Hang Li, Akane Morohoshi, Caroline Cazin, Zine-Eddine Kherraf, Christophe Arnoult, Li Jin, Xiaojin He, Pierre F Ray, Yunxia Cao, Aminata Touré, Feng Zhang, Masahito Ikawa,

Sperm malformation is a direct factor for male infertility. Multiple morphological abnormalities of the flagella (MMAF), a severe form of asthenoteratozoospermia, are characterized by immotile spermatozoa with malformed and/or absent flagella in the ejaculate. Previous studies indicated genetic heterogeneity in MMAF. To further define genetic factors underlying MMAF, we performed ... Read more >>

Am. J. Hum. Genet. (American journal of human genetics)
[2020, :]

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The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma

Jiansong Ji, Bufu Tang, Jinyu Zhu, Jie Li, Kai Fan, Yang Gao, Shimiao Cheng, Chunli Kong, Liyun Zheng, Fazong Wu, Qiaoyou Weng, Chenying Lu,

Abstract Background : In this study, we comprehensively analyzed genes related to ferroptosis and iron metabolism to construct diagnostic and prognostic models and explore the relationship with the immune microenvironment in HCC. Methods : Integrated analysis, cox regression and the least absolute shrinkage and selection operator (LASSO) method of 104 ... Read more >>

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Single Electron Activation of Aryl Carboxylic Acids.

Xiao-Qiang Hu, Zi-Kui Liu, Ye-Xing Hou, Yang Gao,

Aryl carboxylic acids are stable and readily available in great structural diversity both from natural and well-established synthetic procedures, which make them promising starting materials in organic synthesis. The conversion of benzoic acids into high-value molecules is of great importance and have gained much interest of synthetic chemists. The recent ... Read more >>

iScience (iScience)
[2020, 23(7):101266]

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The relationship of lipoprotein-associated phospholipase A2 activity with the seriousness of coronary artery disease.

Hao Zhang, Yang Gao, Dan Wu, Dingguo Zhang,

BACKGROUND:The level of lipoprotein-associated phospholipase A2 (LP-PLA2) in serum is independently correlated to coronary artery diseases (CAD). The aim of the study was to determine whether LP-PLA2 activity is positively associated with the seriousness of CAD. METHODS:Amount to 1056 patients suspected of having CAD underwent coronary angiography (CAG) to determine ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):295]

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MR imaging of epithelial ovarian cancer: a combined model to predict histologic subtypes.

LuoDan Qian, JiaLiang Ren, AiShi Liu, Yang Gao, FenE Hao, Lei Zhao, Hui Wu, GuangMing Niu,

OBJECTIVE:To compare the performance of clinical features, conventional MR image features, ADC value, T2WI, DWI, DCE-MRI radiomics, and a combined multiple features model in predicting the type of epithelial ovarian cancer (EOC). METHODS:In this retrospective analysis, 61 EOC patients were confirmed by histology. Significant features (p < 0.05) by multivariate ... Read more >>

Eur Radiol (European radiology)
[2020, :]

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Based on Exosome-Derived Genes for Constructing Diagnostic, Prognostic and Recurrence Models and Predicting Therapeutic Response for Hepatocellular Carcinoma

Jiansong Ji, Bufu Tang, Jinyu Zhu, Yang Gao, Jianfei Tu, Weibin Yang, Shiji Fang, Qiaoyou Weng, Zhongwei Zhao, Min Xu, Yang Yang, Minjiang Chen, Chenying Lu,

Abstract Background: In this study, we performed a comprehensive analysis to identify the optimal gene set derived from exosomes in hepatocellular carcinoma (HCC) with great prognostic value to construct prognostic, recurrence and diagnostic models and predicted therapeutic response for hepatocellular carcinoma. Methods: Differential expression analysis and Weighted Gene Co-Expression Network ... Read more >>

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Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA.

Qi Chang Zheng, Shuai Jiang, Yu Zhe Wu, Dan Shang, Yong Zhang, Shao Bo Hu, Xiang Cheng, Chen Zhang, Ping Sun, Yang Gao, Zi Fang Song, Min Li,

As a gene therapy strategy, RNA interference (RNAi) offers tremendous tumor therapy potential. However, its therapeutic efficacy is restricted by its inferior ability for targeted delivery and cellular uptake of small interfering RNA (siRNA). This study sought to develop a dual-ligand nanoparticle (NP) system loaded with siRNA to promote targeted ... Read more >>

Front Bioeng Biotechnol (Frontiers in Bioengineering and Biotechnology)
[2020, 8:512]

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Global impact of atmospheric arsenic on health risk: 2005 to 2015.

Lei Zhang, Yang Gao, Shiliang Wu, Shaoqing Zhang, Kirk R Smith, Xiaohong Yao, Huiwang Gao,

Arsenic is a toxic pollutant commonly found in the environment. Most of the previous studies on arsenic pollution have primarily focused on arsenic contamination in groundwater. In this study, we examine the impact on human health from atmospheric arsenic on the global scale. We first develop an improved global atmospheric ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(25):13975-13982]

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