Full Text Journal Articles by
Author Yang Cao

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A [email protected] nanocomplex responsive to multiple tumor environmental clues for photoacoustic/fluorescence/magnetic resonance trimodal imaging-guided and enhanced photothermal/photodynamic therapy.

Qian Li, Junjie Ren, Qiubing Chen, Weiwei Liu, Zhigang Xu, Yang Cao, Yuejun Kang, Peng Xue,

Hollow mesoporous copper sulfide nanoparticles (HMCuS NPs) are advantageous for loading small-molecule therapeutic drugs coupled with photothermal ablation for synergistic tumor therapy. However, treatment efficacy mediated by HMCuS NPs is not always satisfactory owing to their insensitivity toward the tumor microenvironment (TME), and unpredictable drug leakage may also result in ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(23):12508-12521]

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A fluorescence assay for microRNA let-7a by a double-stranded DNA modified gold nanoparticle nanoprobe combined with graphene oxide.

Yuanyuan Gao, Jingjing Tian, Xing Zhang, Bin Qiao, Yang Cao, Xiaohong Wang, Qiang Wu,

Graphene oxide (GO) is capable of quenching fluorescence in bound fuel single stranded DNA (ssDNA) labeled with dye. In the presence of target microRNA let-7a, two cascaded toehold-mediated strand displacement reactions (TSDRs) were triggered, thereby desorbing substantial π-π stacking adsorbed fuel DNA from GO through recycling amplification, simultaneously accompanied with ... Read more >>

Analyst (The Analyst)
[2020, 145(4):1190-1194]

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Rational design of oxygen deficient TiO2-x nanoparticles conjugated with chlorin e6 (Ce6) for photoacoustic imaging-guided photothermal/photodynamic dual therapy of cancer.

Xiaodan Jiao, Wei Zhang, Lei Zhang, Yang Cao, Zhigang Xu, Yuejun Kang, Peng Xue,

Oxygen deficient TiO2-x nanoparticles (NPs) have been recognized as a category of new-fashioned photothermal agents to offer safer PTT. However, the surface of TiO2-x NPs is deficient in free active groups or radicals to conjugate functional therapeutic molecules, which seriously impedes their in-depth development for versatile medical applications. In this ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(3):1707-1718]

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A safe, convenient liquid phase pre-sodiation method for titanium-based SIB materials.

Yang Cao, Tianqi Zhang, Xingguo Zhong, Tianyou Zhai, Huiqiao Li,

We develop a pre-sodiation method by simply immersing the electrode in a liquid sodium source to reduce irreversible capacity loss for titanium-based materials. This liquid is more safe in operation and penetrates through the electrode more homogeneously than sodium metal. This method is easily extended to other titanium-based materials, and ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(98):14761-14764]

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The effect of Acot2 overexpression or downregulation on the preadipocyte differentiation in Chinese Red Steppe cattle.

Lixiang Liu, Jian Wu, Yi Gao, Yang Lv, Jiajia Xue, Lihong Qin, Cheng Xiao, Zhongchang Hu, Lichun Zhang, Xiaotong Luo, Yanli Wang, Yang Cao, Yang Cao, Guoliang Zhang,

The quality and nutritional value of beef is closely linked to its content of intramuscular fat (IMF). The differentiation of preadipocytes and the deposition of lipid droplets in the adipocytes are the key to regulate the IMF content. The differentiation of adipocytes is regulated by a series of transcription factors ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):279-289]

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Risk of Injuries around Diagnosis of Cervical Cancer and Its Precursor Lesions: A Nationwide Cohort Study in Sweden.

Qing Shen, Donghao Lu, Bengt Andrae, Maria E C Schelin, Arvid Sjölander, Yang Cao, Pär Sparén, Fang Fang,

BACKGROUND:Highly increased risk of injuries has been noted around the time of cancer diagnosis. Whether there is a similar increase in risk around the diagnosis of cervical cancer and its precursor lesions was unknown. METHODS:We performed a cohort study including 3,016,307 Swedish women that participated in cervical screening during 2001 ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2020, :]

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Pseudomonas Aeruginosa Secreted Protein PA3611 Promotes Bronchial Epithelial Cells Epithelial-Mesenchymal Transition Through TGF-β1 Inducing p38/miRNA/NF-κB Pathway

Lei Shu, Sixia Chen, Xiaolin Chen, Shaoqing Lin, Xingran Du, Kaili Deng, Jing Wei, Yang Cao, Jiaxin Yan, Ziyan Shen, Ganzhu Feng,

Abstract BackgroundPseudomonas aeruginosa (PA) is one of the important pathogens, which has been proven to colonize and cause infection in the respiratory tract of patients with structural lung diseases, and further lead to bronchial fibrosis. Epithelial-Mesenchymal Transition (EMT) of bronchial epithelial cells plays a vital role in the process of ... Read more >>

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Light-Responsive Core-Shell Nanoplatform for Bimodal Imaging-Guided Photothermal Therapy-Primed Cancer Immunotherapy.

Wei Zhang, Cun-Cheng Zhang, Xing-Yue Wang, Lin Li, Qiao-Qi Chen, Wei-Wei Liu, Yang Cao, Hai-Tao Ran,

Photothermal therapy (PTT) as a noninvasive and effective thermal therapeutic approach has attracted tremendously increasing interest because it can effectively eliminate the primary tumor and generate tumor-associated antigens, which could elicit antitumor immune responses. Herein, we report on the rational design and fabrication of copper sulfide (CuS)-based nanoplatform for cancer ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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Bile Duct Clearance and Cholecystectomy for Choledocholithiasis: Definitive Single-Stage Laparoscopic Cholecystectomy with Intra-Operative Endoscopic Retrograde Cholangiopancreatography (ERCP) versus Staged Procedures.

Gary A Bass, Arvid Pourlotfi, Mark Donnelly, Rebecka Ahl, Caroline McIntyre, Sara Flod, Yang Cao, Deirdre McNamara, Babak Sarani, Amy E Gillis, Shahin Mohseni,

BACKGROUND:Clinical equipoise exists regarding optimal sequencing in the definitive management of choledocholithiasis. Our current study compares sequential biliary ductal clearance and cholecystectomy at an interval to simultaneous laparoendoscopic management on index admission in a pragmatic retrospective manner. METHODS:Records were reviewed for all patients admitted between January 2015-December 2018 to a ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2020, :]

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Successful Treatment of a Patient with Chronic Myelogenous Leukemia with Concurrent Janus Kinase 2 (JAK2) R795S Mutation and Breakpoint Cluster Region-ABL1 (BCR-ABL1) Fusion: A Case Report and Literature Review.

Yanhua Yue, Wei Wei, Yanting Guo, Fei Wang, Weimin Dong, Yue Liu, Yan Lin, Yang Cao, Weiying Gu,

BACKGROUND Although the V617F mutation in the Janus kinase 2 (JAK2) gene and the breakpoint cluster region-abl1 (BCR-ABL1) oncogene fusion have been considered mutually exclusive in most myeloproliferative neoplasms (MPNs), many recent studies have described patients with both. This report describes a patient with chronic myelogenous leukemia (CML) and the ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e925151]

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Readmission to a Different Hospital and Worse Outcomes Following Sepsis: A Nationwide Cohort Study

Zhen Lin, Hedong Han, Jinfang Xu, Yang Cao, Yingyi Qin, Cheng Wu, Xin Wei, Jia He,

Abstract BackgroundIn the United States (U.S.), sepsis accounts for 13% of total hospital expenses and more than 50% of hospital deaths. People with sepsis are more likely to be readmitted. Little is known about the prevalence and outcomes of different hospital readmissions (DHR) in sepsis patients, and the factors associated ... Read more >>

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Pseudomonas aeruginosa secreted protein PA3611 promotes bronchial epithelial cells epithelial-mesenchymal transition through TGF-β1 inducing p38/miRNA/NF-κB pathway

Lei Shu, Sixia Chen, Xiaolin Chen, Shaoqing Lin, Xingran Du, Kaili Deng, Jing Wei, Yang Cao, Jiaxin Yan, Ziyan Shen, Ganzhu Feng,

Abstract Pseudomonas aeruginosa (PA) is one of the important pathogens, which has been proven to colonize and cause infection in the respiratory tract of patients with structural lung diseases, and further lead to bronchial fibrosis. Epithelial-Mesenchymal Transition (EMT) of bronchial epithelial cells plays a vital role in the process of ... Read more >>

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Asymptomatic Subclinical Cases of Coronavirus Disease 2019 without Viral Transmission in Three Independent Families.

Xian Zhang, Liting Chen, Jia Wei, Jianfeng Zhou, Yang Cao, Gaoxiang Wang,

Purpose:There is increasing evidence indicating that considerable fractions of cases of SARS-CoV-2 infection are asymptomatic. We traced three asymptomatic clusters to investigate the infectivity of subclinical cases of coronavirus disease 2019 (COVID-19). Patients and Methods:Three medical staff who were asymptomatic were diagnosed with coronavirus disease 2019 by serological tests. Their ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2020, 13:3267-3271]

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Pulse wave velocity, augmentation index, and carotid intima-media thickness are each associated with different inflammatory protein signatures in young healthy adults: The lifestyle, biomarkers and atherosclerosis study.

Paul Pettersson-Pablo, Yang Cao, Lars H Breimer, Torbjörn K Nilsson, Anita Hurtig-Wennlöf,

BACKGROUND AND AIMS:We aimed to identify plasma protein biomarkers related to inflammation that correlated with physiological measurements of vascular function and structure in healthy individuals. METHODS:We used the OLINK proteomics panel, which measures 92 inflammatory proteins, in 834 young, healthy non-smokers (ages 18-26). Principal component analysis (PCA) was employed to ... Read more >>

Atherosclerosis (Atherosclerosis)
[2020, 313:150-155]

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Cell cycle control and environmental response by second messengers in Caulobacter crescentus.

Chunrui Xu, Bronson R Weston, John J Tyson, Yang Cao,

BACKGROUND:Second messengers, c-di-GMP and (p)ppGpp, are vital regulatory molecules in bacteria, influencing cellular processes such as biofilm formation, transcription, virulence, quorum sensing, and proliferation. While c-di-GMP and (p)ppGpp are both synthesized from GTP molecules, they play antagonistic roles in regulating the cell cycle. In C. crescentus, c-di-GMP works as a ... Read more >>

BMC Bioinformatics (BMC bioinformatics)
[2020, 21(Suppl 14):408]

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The natural course of hereditary angioedema in a Chinese cohort.

Yang Cao, Shuang Liu, Yuxiang Zhi,

BACKGROUND:Hereditary angioedema (HAE) is a rare disease with potential life-threatening risks. To study the natural course of HAE under therapy-free conditions throughout patient life is essential for practitioners and patients to avoid possible risk factors and guide treatment. OBJECTIVES:Describe the natural course of HAE and explore possible risk factors, providing ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):257]

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The c-Jun signaling pathway has a protective effect on nucleus pulposus cells in patients with intervertebral disc degeneration

Ming Lei, Kun Wang, Shuai Li, Kangcheng Zhao, Wenbin Hua, Xinghuo Wu, Cao Yang,

Among a range of diverse clinical symptoms, intervertebral disc degeneration (IDD) contributes mostly to the onset of lower back pain. The present study aimed to investigate the effects of c-Jun on nucleus pulposus (NP) cells of IDD and its regulation on molecular mechanisms. Intervertebral disc (IVD) tissues were collected from ... Read more >>

(Experimental and Therapeutic Medicine)
[2020, 20(5):]

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The synthesis of two-dimensional [email protected] core-shell nanosheets for fluorescence/photoacoustic/infrared (FL/PA/IR) tri-modal imaging-guided photothermal/photodynamic combination therapy.

Zhihao Zhou, Wei Zhang, Lei Zhang, Yang Cao, Zhigang Xu, Yuejun Kang, Peng Xue,

Two-dimensional Bi2Te3 nanosheets (NSs) have recently been validated as a new type of photothermal agent to provide an alternative option for tumor ablation via light-induced hyperthermia. However, the surface of Bi2Te3 NSs lacks active radicals for the conjugation of functional molecules, which undoubtedly impedes their versatile utilization in medical areas. ... Read more >>

Biomater Sci (Biomaterials science)
[2020, :]

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Reply.

Yang Cao, Jia Wei, Gaoxiang Wang, Liting Chen, Hui Luo, Jianfeng Zhou,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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A Rapid and Efficient Protocol for Adventitious Shoot Regeneration and Genetic Transformation of Manchurian Ash (Fraxinus mandshurica Rupr.) using Hypocotyl Explants

Lin Liu, Yang Cao, Yaguang Zhan, Fenghui Qi,

Abstract Background: Manchurian ash ( Fraxinus mandshurica Rupr.) is an endangered hardwood tree species, providing both economic and medicinal benefits. However, observations such as browning of adventitious shoot buds and high rate of somatic embryo abnormality, were presented in protocols of F. mandshurica regeneration. Therefore, a rapid and high-efficiency regeneration ... Read more >>

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A new isolation device for shortening gene flow distance in small-scale transgenic maize breeding.

Lili Zhang, Shanshan Huo, Yang Cao, Xiang Xie, Yanhua Tan, Yuliang Zhang, Hui Zhao, Pingping He, Jingyuan Guo, Qiyu Xia, Xia Zhou, Huan Long, Anping Guo,

The transmission of pollen is the main cause of maize gene flow. Under the compulsory labeling system for genetically modified (GM) products in China, isolation measures are crucial. At present, there is no effective isolation device for preventing and controlling the short-range flow of GM maize pollen. The purposes of ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):15733]

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Association between metabolic surgery and cardiovascular outcome in patients with hypertension: A nationwide matched cohort study.

Erik Stenberg, Yang Cao, Richard Marsk, Magnus Sundbom, Tomas Jernberg, Erik Näslund,

BACKGROUND:Hypertension, together with obesity, is a leading cause of mortality and disability. Whilst metabolic surgery offers remission of several metabolic comorbidities, the effect for patients with hypertension remains controversial. The objective of the present study was to evaluate the effect of metabolic surgery on cardiovascular events and mortality on patients ... Read more >>

PLoS Med (PLoS medicine)
[2020, 17(9):e1003307]

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The c-Jun signaling pathway has a protective effect on nucleus pulposus cells in patients with intervertebral disc degeneration.

Ming Lei, Kun Wang, Shuai Li, Kangcheng Zhao, Wenbin Hua, Xinghuo Wu, Cao Yang,

Among a range of diverse clinical symptoms, intervertebral disc degeneration (IDD) contributes mostly to the onset of lower back pain. The present study aimed to investigate the effects of c-Jun on nucleus pulposus (NP) cells of IDD and its regulation on molecular mechanisms. Intervertebral disc (IVD) tissues were collected from ... Read more >>

(Experimental and therapeutic medicine)
[2020, 20(5):123]

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Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage.

Jianfeng Zhuang, Yucong Peng, Chi Gu, Huihui Chen, Zheng Lin, Hang Zhou, Xiao Wu, Jianru Li, Xiaobo Yu, Yang Cao, Hanhai Zeng, Xiongjie Fu, Chaoran Xu, Peiyu Huang, Shenglong Cao, Chun Wang, Feng Yan, Gao Chen,

Intracerebral hemorrhage (ICH) is a cerebrovascular disease with high mortality and morbidity for which effective treatments are currently lacking. Wogonin is a major flavonoid compound isolated from Scutellaria radix. Accumulating evidence suggests that wogonin plays a crucial role in anti-inflammatory and anti-oxidative stress. Treatment of microglia with nuclear receptor agonists ... Read more >>

Transl Stroke Res (Translational stroke research)
[2020, :]

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Construction of a Prognostic Immune Signature for Squamous-Cell Lung Cancer to Predict Survival.

Rui-Lian Chen, Jing-Xu Zhou, Yang Cao, Ling-Ling Sun, Shan Su, Xiao-Jie Deng, Jie-Tao Lin, Zhi-Wei Xiao, Zhuang-Zhong Chen, Si-Yu Wang, Li-Zhu Lin,

Background:Limited treatment strategies are available for squamous-cell lung cancer (SQLC) patients. Few studies have addressed whether immune-related genes (IRGs) or the tumor immune microenvironment can predict the prognosis for SQLC patients. Our study aimed to construct a signature predict prognosis for SQLC patients based on IRGs. Methods:We constructed and validated ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:1933]

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