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Author Yanan Du

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Asporin inhibits collagen matrix-mediated intercellular mechanocommunications between fibroblasts during keloid progression.

Longwei Liu, Hongsheng Yu, Yi Long, Zhifeng You, Rei Ogawa, Yanan Du, Chenyu Huang,

Keloids are fibrotic lesions that grow unceasingly and invasively and are driven by local mechanical stimuli. Unlike other fibrotic diseases and normal wound healing, keloids exhibit little transformation of dermal fibroblasts into α-SMA<sup>+</sup> myofibroblasts. This study showed that asporin is the most strongly expressed gene in keloids and its gene-ontology ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21705]

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cIAP1/2 are involved in the radiosensitizing effect of birinapant on NSCLC cell line in vitro.

Hao Sun, Yanan Du, Ming Yao, Qin Wang, Kaihua Ji, Liqing Du, Chang Xu, Ningning He, Jinhan Wang, Manman Zhang, Yang Liu, Yan Wang, Kaixue Wen, Qiang Liu,

Tumour radioresistance is a major problem for cancer radiation therapy. To identify the underlying mechanisms of this resistance, we used human non-small cell lung cancer (NSCLC) cell lines and focused on the Inhibitor of Apoptosis Protein (IAP) family, which contributes to tumourigenesis and chemoresistance. We investigated the possible correlation between ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, :]

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Design and calculation of photoelectric properties of type-II superlattice photodetectors with diffraction ring structure

Yanan Du, Yun Xu, Bo Cheng, Guofeng Song,

The photoelectric properties of type-II superlattices (T2SLs) infrared detectors with diffraction ring resonance structure are calculated and studied in this paper. In order to improve the quantum efficiency (QE), diffraction rings are designed on the top surface of T2SLs detectors to control the incident light inside. The maximum QE of ... Read more >>

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Efficient endothelial and smooth muscle cell differentiation from human pluripotent stem cells through a simplified insulin-free culture system.

Fengzhi Zhang, Yonglin Zhu, Jing Chen, Wenhua Kuang, Rujin Huang, Fuyu Duan, Yaqian Li, Lin Wang, Hui Qiu, Xia Chen, Jia Ming, Peng Liu, Yanan Du, Sophia Chia-Ning Chang, Ligong Chen, Jie Na,

A major obstacle for using human pluripotent stem cells (hPSCs) derived vascular cells for cell therapy is the lack of simple, cost-saving, and scalable methods for cell production. Here we described a simplified and chemically defined medium (AATS) for endothelial cells (ECs) and smooth muscle cells (SMCs) differentiation. AATS medium ... Read more >>

Biomaterials (Biomaterials)
[2021, 271:120713]

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Multidimensional factors affecting care needs in daily living among community-dwelling older adults: A structural equation modelling approach.

Min Zhang, Changxiang Chen, Yanan Du, Shuoshuo Wang, Mikael Rask,

<h4>Aims</h4>To develop a model illustrating the factors that can influence care needs in daily living (CNDL) of older adults and the pathways between these.<h4>Background</h4>The care needs in community-dwelling older adults have increased sharply. A better understanding of the elderly's CNDL would thus help policymakers define which types of support and ... Read more >>

J Nurs Manag (Journal of nursing management)
[2021, :]

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Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer.

Yanan Du, Hao Sun, François Lux, Yi Xie, Liqing Du, Chang Xu, Hong Zhang, Ningning He, Jinhan Wang, Yang Liu, Géraldine Leduc, Tristan Doussineau, Kaihua Ji, Qin Wang, Zhenhua Lin, Yan Wang, Qiang Liu, Olivier Tillement,

Radiotherapy is the main treatment for cancer patients. A major concern in radiotherapy is the radiation resistance of some tumors, such as human nonsmall cell lung cancer. However, the radiation dose delivered to the tumors is often limited by the possibility of collateral damage to surrounding healthy tissues. A new ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(51):56874-56885]

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Feasibility of T1 mapping with histogram analysis for the diagnosis and staging of liver fibrosis: Preclinical results.

Qing Wang, HaiFeng Liu, ZuHui Zhu, Ye Sheng, YaNan Du, YuFeng Li, JianHong Liu, JiLei Zhang, Wei Xing,

<h4>Purpose</h4>To compare the diagnostic accuracy of parameters derived from the histogram analysis of precontrast, 10-min hepatobiliary phase (HBP) and 20-min HBP T1 maps for staging liver fibrosis (LF).<h4>Methods</h4>LF was induced in New Zealand white rabbits by subcutaneous injections of carbon tetrachloride for 4-16 weeks (n = 120), and 20 rabbits injected with saline ... Read more >>

Magn Reson Imaging (Magnetic resonance imaging)
[2021, 76:79-86]

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Enhanced single-cell encapsulation in microfluidic devices: From droplet generation to single-cell analysis.

Si Da Ling, Yuhao Geng, An Chen, Yanan Du, Jianhong Xu,

Single-cell analysis to investigate cellular heterogeneity and cell-to-cell interactions is a crucial compartment to answer key questions in important biological mechanisms. Droplet-based microfluidics appears to be the ideal platform for such a purpose because the compartmentalization of single cells into microdroplets offers unique advantages of enhancing assay sensitivity, protecting cells ... Read more >>

Biomicrofluidics (Biomicrofluidics)
[2020, 14(6):061508]

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Genetic Correlation Analysis and Transcriptome-wide Association Study Suggest the Overlapped Genetic Mechanism between Gout and Attention-deficit Hyperactivity Disorder: L'analyse de corrélation génétique et l'étude d'association à l'échelle du transcriptome suggèrent un mécanisme génétique superposé entre la goutte et le trouble de déficit de l'attention avec hyperactivité.

Om Prakash Kafle, Xi Wang, Shiqiang Cheng, Miao Ding, Ping Li, Bolun Cheng, Xiao Liang, Li Liu, Yanan Du, Mei Ma, Lu Zhang, Yan Zhao, Yan Wen, Feng Zhang,

<h4>Objectives</h4>Gout is a common inflammatory arthritis, which is caused by hyperuricemia. Limited efforts have been paid to systematically explore the relationships between gout and common psychiatric disorders.<h4>Methods</h4>Genome-wide association study summary data of gout were obtained from the GeneATLAS, which contained 452,264 participants including 3,528 gout cases. Linkage disequilibrium score regression ... Read more >>

Can J Psychiatry (Canadian journal of psychiatry. Revue canadienne de psychiatrie)
[2020, :706743720970844]

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Surface Deformation Evolution in the Pearl River Delta between 2006 and 2011 derived from the ALOS1/PALSAR images

Genger Li, Guangcai Feng, Zhiqiang Xiong, Qi Liu, Rongan Xie, Xiaoling Zhu, Shuran Luo, Yanan Du,

This study monitors the land subsidence of the whole Pearl River Delta (PRD) (area: ~40,000 km 2 ) in China using the ALOS1/PALSAR data (2006-2011) through the SBAS-InSAR method. We also analyze the relationship between the subsidence and the coastline change, river distribution, geological structure as well as the local ... Read more >>

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Comparison of Chondrocytes in Knee Osteoarthritis and Regulation by Scaffold Pore Size and Stiffness.

Yu Zhao, Zhifeng You, Dan Xing, Jiao Jiao Li, Qingxi Zhang, Hesuyuan Huang, Zhikun Li, Shumeng Jiang, Zhaozhao Wu, Yuying Zhang, Wenjing Li, Lin Zhang, Yanan Du, Jianhao Lin,

In knee osteoarthritis (OA), there is more pronounced cartilage damage in the medial compartment ("lesion zone") than the lateral compartment ("remote zone"). This study fills a gap in the literature by conducting a systematic comparison of cartilage and chondrocyte characteristics from these two zones. It also investigates whether chondrocytes from ... Read more >>

Tissue Eng Part A (Tissue engineering. Part A)
[2021, 27(3-4):223-236]

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TGase-mediated cell membrane modification and targeted cell delivery to inflammatory endothelium.

Chunxiao Qi, Yuhong Jin, Yuyang Chen, Wenjing Li, Yaqian Li, Kai Liang, Yan Li, Yonghui Zhang, Yanan Du,

Targeted cell delivery to lesion sites via minimally invasive approach remains an unmet need in regenerative medicine to endow controlled cell distribution and minimized side-effects. Current cell modification approaches to improve cell delivery tend to have adverse effects on cellular phenotype and functionality. Here, we rationally developed a facile and ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120276]

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TGase-Enhanced Microtissue Assembly in 3D-Printed-Template-Scaffold (3D-MAPS) for Large Tissue Defect Reparation.

Hongsheng Yu, Zhifeng You, Xiaojun Yan, Wei Liu, Zhirui Nan, Dan Xing, Chenyu Huang, Yanan Du,

Engineering large and functional tissue constructs with complex structures (e.g., external ear or nose) for reparation and reconstruction of tissue defects remains one of the major challenges in regenerative medicine, which demands abundant cell sources, advanced biofabrication schemes, and satisfactory integration with the host for long-term efficacy post implantation. Here ... Read more >>

Adv Healthc Mater (Advanced healthcare materials)
[2020, 9(18):e2000531]

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Engineering 3D functional tissue constructs using self-assembling cell-laden microniches.

Dan Xing, Wei Liu, Jiao Jiao Li, Longwei Liu, Anqi Guo, Bin Wang, Hongsheng Yu, Yu Zhao, Yuling Chen, Zhifeng You, Cheng Lyu, Wenjing Li, Aifeng Liu, Yanan Du, Jianhao Lin,

Tissue engineering using traditional size fixed scaffolds and injectable biomaterials are faced with many limitations due to the difficulties of producing macroscopic functional tissues. In this study, 3D functional tissue constructs were developed by inducing self-assembly of microniches, which were cell-laden gelatin microcryogels. During self-assembly, the accumulation of extracellular matrix ... Read more >>

Acta Biomater (Acta biomaterialia)
[2020, 114:170-182]

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Establishment of a porcine parvovirus (PPV) LAMP visual rapid detection method.

Kai Zhao, Ruili Hu, Jianping Ni, Jieling Liang, Xizhong He, Yanan Du, Yan Xu, Binan Zhao, Qi Zhang, Chunhua Li,

Porcine parvovirus (PPV) is one of the major causes of reproductive pig disease. Due to its serious nature, wide spread and consequent great damage to the swine industry, an effective, rapid and convenient method for its detection is needed. A loop-mediated isothermal amplification (LAMP) assay was established to detect PPV ... Read more >>

J Virol Methods (Journal of virological methods)
[2020, 284:113924]

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The integrative analysis of DNA methylation and mRNA expression profiles confirmed the role of selenocompound metabolism pathway in Kashin-Beck disease.

Ping Li, Yujie Ning, Weizhuo Wang, Xiong Guo, Blandine Poulet, Xi Wang, Yan Wen, Jing Han, Jingcan Hao, Xiao Liang, Li Liu, Yanan Du, Bolun Cheng, Shiqiang Cheng, Lu Zhang, Mei Ma, Xin Qi, Chujun Liang, Cuiyan Wu, Sen Wang, Hongmou Zhao, Guanghui Zhao, Mary B Goldring, Feng Zhang, Peng Xu,

Kashin-Beck disease (KBD) is an endemic chronic osteochondropathy. The etiology of KBD remains unknown. In this study, we conducted an integrative analysis of genome-wide DNA methylation and mRNA expression profiles between KBD and normal controls to identify novel candidate genes and pathways for KBD. Articular cartilage samples from 17 grade ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2020, 19(18):2351-2366]

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Correction to "A Heterotrimeric Dehydrogenase Complex Functions with 2 Distinct YcaO Proteins to Install 5 Azole Heterocycles in 35-Membered Sulfomycin Thiopeptides".

Yanan Du, Yanping Qiu, Xiang Meng, Junyin Feng, Jiang Tao, Wen Liu,

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(28):12547]

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Quantitative assessment of renal allograft pathologic changes: comparisons of mono-exponential and bi-exponential models using diffusion-weighted imaging.

Min Fan, Zhaoyu Xing, Yanan Du, Liang Pan, Yangyang Sun, Xiaozhou He,

<h4>Background</h4>Diffusion-weighted imaging (DWI) can noninvasively assess renal allograft pathologic changes that provide useful information for clinical management and prognostication. However, it is still unknown whether the bi-exponential model analysis of DWI signals is superior to that of the mono-exponential model.<h4>Methods</h4>Pathologic and DWI data from a total of 47 allografts were ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2020, 10(6):1286-1297]

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Comparing GWAS and Brain Structure-Specific Gene Expression Profiles Identifies Psychiatric Disorder-Related Brain Structures at Different Developmental Stages.

Xin Qi, Cuiyan Wu, Yanan Du, Shiqiang Cheng, Yan Wen, Mei Ma, Chujun Liang, Li Liu, Bolun Cheng, Lu Zhang, Ping Li, Feng Zhang,

Neurosci Bull (Neuroscience bulletin)
[2020, 36(9):1046-1050]

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A Heterotrimeric Dehydrogenase Complex Functions with 2 Distinct YcaO Proteins to Install 5 Azole Heterocycles into 35-Membered Sulfomycin Thiopeptides.

Yanan Du, Yanping Qiu, Xiang Meng, Junyin Feng, Jiang Tao, Wen Liu,

Sulfomycins are sulfur-rich, ribosomally synthesized, and post-translationally modified peptides (RiPPs) that are characterized by a 35-membered macrocyclic ring system with a pyridine domain central to five azoles and additional dehydroamino acids. The pathway through which these large thiopeptide antibiotics are formed in <i>Streptomyces viridochromogene</i> remains elusive. Starting with the cloning ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(18):8454-8463]

Cited: 2 times

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Functional Nanoparticles Activate a Decellularized Liver Scaffold for Blood Detoxification.

Fen Xu, Tianyi Kang, Jie Deng, Junli Liu, Xiaolei Chen, Yuan Wang, Liang Ouyang, Ting Du, Hong Tang, Xiaoping Xu, Shaochen Chen, Yanan Du, Yujun Shi, Zhiyong Qian, Yuquan Wei, Hongxin Deng, Maling Gou,

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(13):e2001267]

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Identifying psychiatric disorder-associated gut microbiota using microbiota-related gene set enrichment analysis.

Shiqiang Cheng, Bei Han, Miao Ding, Yan Wen, Mei Ma, Lu Zhang, Xin Qi, Bolun Cheng, Ping Li, Om Prakash Kafle, Xiao Liang, Li Liu, Yanan Du, Yan Zhao, Feng Zhang,

Psychiatric disorders are a group of complex psychological syndromes with high prevalence. It has been reported that gut microbiota has a dominant influence on the risks of psychiatric disorders through gut microbiota-brain axis. We extended the classic gene set enrichment analysis (GSEA) approach to detect the association between gut microbiota ... Read more >>

Brief Bioinform (Briefings in bioinformatics)
[2020, 21(3):1016-1022]

Cited: 8 times

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Adaptive Smoothness Constraint Ionospheric Tomography Algorithm.

Debao Wen, Dengkui Mei, Yanan Du,

Ionospheric tomography reconstruction based on global navigation satellite system observations is usually an ill-posed problem. To resolve it, an adaptive smoothness constraint ionospheric tomography algorithm is proposed in this work. The new algorithm performs an adaptive adjustment for the constrained weight coefficients of the tomography system. The computational efficiency and ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(8):]

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Evaluating the Correlations Between Osteoporosis and Lifestyle-Related Factors Using Transcriptome-Wide Association Study.

Yanan Du, Ping Li, Yan Wen, Xiao Liang, Li Liu, Bolun Cheng, Miao Ding, Yan Zhao, Mei Ma, Lu Zhang, Shiqiang Cheng, Xiong Guo, Feng Zhang,

Osteoporosis (OP) is a multi-factorial bone disease influenced by genetic factors, age, and lifestyles. The aim of this study is to evaluate the genetic correlations between OP and multiple lifestyle-related factors, and explore the genes underlying the detected genetic correlations. Linkage disequilibrium score regression (LDSC) analysis was applied to evaluate ... Read more >>

Calcif Tissue Int (Calcified tissue international)
[2020, 106(3):256-263]

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Intra-articular Injection of Cell-laden 3D Microcryogels Empower Low-dose Cell Therapy for Osteoarthritis in a Rat Model.

Dan Xing, Wei Liu, Bin Wang, Jiao Jiao Li, Yu Zhao, Hui Li, Aifeng Liu, Yanan Du, Jianhao Lin,

Intra-articular injection of mesenchymal stem cells (MSCs) in an osteoarthritic joint can help slow down cartilage destruction. However, cell survival and the efficiency of repair are generally low due to mechanical damage during injection and a high rate of cell loss. We, thus, investigated an improved strategy for cell delivery ... Read more >>

Cell Transplant (Cell transplantation)
[2020, 29:963689720932142]

Cited: 1 time

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