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Author Yan Zhong Chang

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Caffeine Decreases Hepcidin Expression to Alleviate Aberrant Iron Metabolism under Inflammation by Regulating the IL-6/STAT3 Pathway.

Zhong-Da Li, Meng-Yu Geng, Song-Rui Dou, Xuan Wang, Zi-Han Zhang, Yan-Zhong Chang,

Caffeine is well-known as a psychostimulant, and it can also be beneficial in numerous diseases such as diabetes and different types of cancer. Previous studies have shown that caffeine can have a protective role in bacterial infection-induced inflammation and hyperoxia-mediated pulmonary inflammation. Hepcidin, which is regulated by the IL-6/STAT3 inflammation ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2022, 12(7):1025]

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Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation.

Yating Zhang, Xue Bai, Yi Zhang, Shanshan Yao, Yiduo Cui, Lin-Hao You, Peng Yu, Yan-Zhong Chang, Guofen Gao,

Brain iron overload is positively correlated with the pathogenesis of Alzheimer's disease (AD). However, the role of iron in AD pathology is not completely understood. Furin is the first identified mammalian proprotein convertase that catalyzes the proteolytic maturation of large numbers of prohormones and proproteins. The correlation between altered furin ... Read more >>

Mol Neurobiol (Molecular neurobiology)
[2022, :]

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