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Author Yan Zhong Chang

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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.

Yinlong Zhao, Shukuan Ling, Jianwei Li, Guohui Zhong, Ruikai Du, Youyou Li, Yanqing Wang, Caizhi Liu, Xiaoyan Jin, Wei Liu, Tong Liu, Yuheng Li, Dingsheng Zhao, Weijia Sun, Zizhong Liu, Zifan Liu, Junjie Pan, Xinxin Yuan, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li,

<h4>Aims</h4>3' untranslated region (3' UTR) of mRNA is more conserved than other non-coding sequences in vertebrate genomes, and its sequence space has substantially expanded during the evolution of higher organisms, which substantiates their significance in biological regulation. However, the independent role of 3' UTR in cardiovascular disease was largely unknown.<h4>Methods ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(36):3786-3799]

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Calcitonin increases hepatic hepcidin expression through the BMP6 of kidney in mice.

Yuhua Lei, Chenyang Zhao, Hengrui Chang, Dong Zhang, Yaru Li, Gregory J Anderson, Yongqing Shen, Xianglin Duan, Yan-Zhong Chang,

<h4>Background</h4>Osteoporosis is frequently accompanied by iron disorders. Calcitonin (CT) was approved as a clinical drug to treat osteoporosis. Hepcidin is a peptide hormone that is secreted by the liver and controls body iron homeostasis. Hepcidin deficiency leads to iron overload diseases. This study was aimed at investigating the effect of ... Read more >>

J Trace Elem Med Biol (Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS))
[2021, 68:126796]

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

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Casein Kinase-2 Interacting Protein-1 Regulates Physiological Cardiac Hypertrophy via Inhibition of Histone Deacetylase 4 Phosphorylation.

Yinlong Zhao, Shukuan Ling, Guohui Zhong, Yuheng Li, Jianwei Li, Ruikai Du, Xiaoyan Jin, Dingsheng Zhao, Zizhong Liu, Guanghan Kan, Yan-Zhong Chang, Yingxian Li,

Different kinds of mechanical stimuli acting on the heart lead to different myocardial phenotypes. Physiological stress, such as exercise, leads to adaptive cardiac hypertrophy, which is characterized by a normal cardiac structure and improved cardiac function. Pathological stress, such as sustained cardiac pressure overload, causes maladaptive cardiac remodeling and, eventually, ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:678863]

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Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis.

Peina Wang, Yanmei Cui, Qianqian Ren, Bingqi Yan, Yashuo Zhao, Peng Yu, Guofen Gao, Honglian Shi, Shiyang Chang, Yan-Zhong Chang,

Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated. Increasing evidence has indicated that an excess of iron contributes to brain damage in cerebral ischaemia/reperfusion (I/R) injury. Although mitochondrial ferritin (FtMt) plays a ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(5):447]

Cited: 2 times

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A high-fructose diet in rats induces systemic iron deficiency and hepatic iron overload by an inflammation mechanism.

Chao Wang, Xing Wang, Guangyao Song, Hanying Xing, Linquan Yang, Kang Han, Yan-Zhong Chang,

Nonalcoholic fatty liver disease (NAFLD) correlates with the high intake of fructose-rich soft drinks. Both inflammation and dysregulated iron metabolism are pathogenic factors in the development of NAFLD. The present investigation assessed the effects of a high-fructose diet (HF diet) on inflammation and iron metabolism. In this study, rats were ... Read more >>

J Food Biochem (Journal of food biochemistry)
[2021, 45(1):e13578]

Cited: 1 time

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Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice.

Kang Han, Xiaofang Jin, Xin Guo, Guoli Cao, Siyu Tian, Yiming Song, Yuanyuan Zuo, Peng Yu, Guofen Gao, Yan-Zhong Chang,

The transcription factor NF-E2-related factor 2 (Nrf2) is a central regulator of cellular antioxidant and detoxification response. The association between Nrf2 activity and iron-related oxidative stress in neurodegenerative diseases has been studied, and Nrf2 was found to transcriptionally regulate the expression of iron transporters and ferroptosis-related factors. However, the role ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2021, 162:592-602]

Cited: 2 times

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Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice.

Xinwei Zhang, Yu-Jing Gou, Yating Zhang, Jie Li, Kang Han, Yong Xu, Haiyan Li, Lin-Hao You, Peng Yu, Yan-Zhong Chang, Guofen Gao,

Progressive iron accumulation in the brain and iron-induced oxidative stress are considered to be one of the initial causes of Alzheimer's disease (AD), and modulation of brain iron level shows promise for its treatment. Hepcidin expressed by astrocytes has been speculated to regulate iron transport across the blood-brain barrier (BBB) ... Read more >>

Cell Death Discov (Cell death discovery)
[2020, 6(1):113]

Cited: 1 time

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Brain iron deficiency and affected contextual fear memory in mice with conditional Ferroportin1 ablation in the brain.

Qiong Wu, Qian Hao, Haiyan Li, Bo Wang, Peina Wang, Xiaofang Jin, Peng Yu, Guofen Gao, Yan-Zhong Chang,

Fear memory is a pivotal biological function by which organisms can predict possible danger to avoid or reduce harm. However, dysregulation of fear memory processing may lead to pathological fear or anxiety and produce serious clinical symptoms, such as post-traumatic stress disorder (PTSD). Iron deficiency (ID) is reported to inhibit ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21174]

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Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control System

Guofang Zhang, Qingle Song, Yuqian Zhang, Ruijing Liang, Liang Chen, Nancy Monteiro-Riviere, Diana Boraschi, Yan-Zhong Chang, Hongchang Li, Yang Li,

The cellular protein quality control (PQC) system ensures the intracellular misfolded/unfolded proteins to be detected and eliminated. ER-associated degradation (ERAD) and unfolded protein response (UPR) are the key mechanisms of PQC, which maintain protein homeostasis and ensure cell survival. Here, we show that after internalization by human epithelial cells, gold ... Read more >>

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Astrocyte hepcidin ameliorates neuronal loss through attenuating brain iron deposition and oxidative stress in APP/PS1 mice.

Yong Xu, Yating Zhang, Jian-Hua Zhang, Kang Han, Xinwei Zhang, Xue Bai, Lin-Hao You, Peng Yu, Zhenhua Shi, Yan-Zhong Chang, Guofen Gao,

Iron overload in the brain and iron-induced oxidative damage have been considered to play key roles in the pathogenesis of Alzheimer's disease (AD). Hepcidin is a peptide that regulates systemic iron metabolism by interacting with iron exporter ferroportin 1 (FPN1). Studies have indicated that the astrocyte hepcidin could regulate brain ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2020, 158:84-95]

Cited: 5 times

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Nrf2 knockout dysregulates iron metabolism and increases the hemolysis through ROS in aging mice.

Zhenzhen Liu, Kang Han, Xuege Huo, Bingqi Yan, Mohan Gao, Xin Lv, Peng Yu, Guofen Gao, Yan-Zhong Chang,

AIMS:Dysregulation of iron homeostasis in the body causes a variety of diseases. Iron deficiency leads to anemia, whereas iron overload aggravates cellular oxidative stress. Nuclear factor erythroid-2-related factor 2 (Nrf2) is a protein that is activated in the nucleus and turns on the production of antioxidant enzymes, protecting cell against ... Read more >>

Life Sci (Life sciences)
[2020, 255:117838]

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Physical exercise: An inducer of positive oxidative stress in skeletal muscle aging.

Anand Thirupathi, Ricardo A Pinho, Yan-Zhong Chang,

Oxidative stress is the core of most pathological situations, and its attribution toward disease conversion is not yet well established. The adaptive capacity of a cell can overcome ROS-induced pathology. However, when a cell fails to extend its maximum adaptive capacity against oxidative stress, it could lead a cell to ... Read more >>

Life Sci (Life sciences)
[2020, 252:117630]

Cited: 2 times

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Iron overload induced by IRP2 gene knockout aggravates symptoms of Parkinson's disease.

Yun-Zhe Ci, Haiyan Li, Lin-Hao You, Yu Jin, Rui Zhou, Guofen Gao, Maggie Pui Man Hoi, Chunyan Wang, Yan-Zhong Chang, Peng Yu,

Parkinson's disease (PD) is accompanied by iron overload in the brain. However, whether iron accumulation is the cause or effect of PD is still unknown. Iron regulatory protein 2 (IRP2) plays a critical role in keeping iron homeostasis, and our previous data showed that the deletion of the IRP2 gene ... Read more >>

Neurochem Int (Neurochemistry international)
[2020, 134:104657]

Cited: 2 times

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Transcriptomic analysis reveals the molecular mechanism of Alzheimer-related neuropathology induced by sevoflurane in mice.

Xing Ge, Ying Zhang, Yong Zuo, Muhammad Israr, Bowen Li, Peng Yu, Guofen Gao, Yan-Zhong Chang, Zhenhua Shi,

Anesthetics could induce cognitive dysfunctions, such as Alzheimer's disease in humans or mice. However, the precise molecular mechanism is unclear. Sevoflurane is a common anesthetic widely used in clinical practice. Here, we demonstrated the induction of cognitive dysfunction induced by Sev in mice to corroborate the signaling pathway and the ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2019, 120(10):17555-17565]

Cited: 2 times

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Hypobaric hypoxia regulates iron metabolism in rats.

Yaru Li, Yue Zhou, Dong Zhang, Wen-Yue Wu, Xiaoxuan Kang, Qiong Wu, Peina Wang, Xiaopeng Liu, Guofen Gao, Yaru Zhou, Guangyou Wang, Yan-Zhong Chang,

Intermittent hypobaric hypoxia can produce a protective effect on both the nervous system and non-nervous system tissues. Intermittent hypobaric hypoxia preconditioning has been shown to protect rats from cardiac ischemia-reperfusion injury by decreasing cardiac iron levels and reactive oxygen species (ROS) production, thereby decreasing oxidative stress to achieve protection. However, ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2019, 120(8):14076-14087]

Cited: 5 times

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Role of AMPK and its molecular intermediates in subjugating cancer survival mechanism.

Anand Thirupathi, Yan-Zhong Chang,

The gradual energy dissipation of all organisms allows adapting to energy demands. Pathological situations of uncured diseases such as cancer, diabetes, and other obesity-related diseases are caused by an abrupt energy imbalance. As an energy sensor, AMP-activated kinase (AMPK) can regulate the cellular energy status. In case of increased energy ... Read more >>

Life Sci (Life sciences)
[2019, 227:30-38]

Cited: 7 times

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Brain Iron Metabolism and Regulation.

Peng Yu, Yan-Zhong Chang,

With the development of research, more and more evidences suggested that mutations in the genes associated with brain iron metabolism induced diseases in the brain. Brain iron metabolism disorders might be one cause of neurodegenerative diseases. This review mainly summarizes the normal process of iron entry into the brain across ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2019, 1173:33-44]

Cited: 1 time

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Cellular Iron Metabolism and Regulation.

Guofen Gao, Jie Li, Yating Zhang, Yan-Zhong Chang,

Iron is an essential trace element in the human body, but excess iron is toxic as it contributes to oxidative damage. To keep iron concentration within the optimal physiologic range, iron metabolism at the cellular level and the whole systemic level are tightly regulated. Balance of iron homeostasis depends on ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2019, 1173:21-32]

Cited: 14 times

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Brain Iron Metabolism and CNS Diseases.

Anand Thirupathi, Yan-Zhong Chang,

Iron is the most abundant trace element in the human body. It is well known that iron is an important component of hemoglobin involved in the transport of oxygen. As a component of various enzymes, it participates in the tricarboxylic acid cycle and oxidative phosphorylation. Iron in the nervous system ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2019, 1173:1-19]

Cited: 13 times

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Overexpression of Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin in Dendritic Cells Protecting against Aspergillosis.

Li-Yang Li, Hao-Ru Zhang, Zhi-Long Jiang, Yan-Zhong Chang, Chang-Zhou Shao,

<h4>Background</h4>Dendritic cells (DCs) play an important role in host defense against pathogen infection. DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (SIGN) is a group II C-type lectin receptor and specifically expressed on the surface of DCs. This study aimed to determine whether DC-SIGN affects intracellular signaling activation, Th1/Th2 imbalance and aspergillus immune ... Read more >>

Chin Med J (Engl) (Chinese medical journal)
[2018, 131(21):2575-2582]

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Identification of FECH gene multiple variations in two Chinese patients with erythropoietic protoporphyria and a review.

Zhang-Biao Long, Yong-Wei Wang, Chen Yang, Gang Liu, Ya-Li Du, Guang-Jun Nie, Yan-Zhong Chang, Bing Han,

Erythropoietic protoporphyria (EPP), an autosomal dominant disease, is caused by partial deficiency of ferrochelatase (FECH), which catalyzes the terminal step of heme biosynthesis because of loss-of-function mutations in the FECH gene. To date, only a few cases have been described in Asia. In this study, we describe the clinical features ... Read more >>

J Zhejiang Univ Sci B (Journal of Zhejiang University. Science. B)
[2016, 17(10):813-820]

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Hepcidin and iron regulatory proteins coordinately regulate ferroportin 1 expression in the brain of mice.

Lan Wang, Xiaopeng Liu, Lin-Hao You, Yun-Zhe Ci, Shiyang Chang, Peng Yu, Guofen Gao, Yan-Zhong Chang,

Iron plays an essential role in various cellular metabolic processes of the body. Maintenance of cellular iron homeostasis is particularly important for keeping the normal functions of the cells. Ferroportin 1 (FPN1) is the currently only known iron exporter on the cell membrane. It has been indicated that the regulation ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2019, 234(5):7600-7607]

Cited: 3 times

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Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism.

Yashuo Zhao, Zhen Xin, Nina Li, Shiyang Chang, Yandong Chen, Lina Geng, Hengrui Chang, Honglian Shi, Yan-Zhong Chang,

In order to discover new drug delivery approaches and to understand the mechanism of iron overload in cerebral ischemia/reperfusion (I/R), we aimed to investigate the effects of lycopene (LYC) in the form of nano-liposomes (L-LYC) on iron-regulating proteins and ischemic brain injury. We found that L-LYC significantly increased the LYC ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2018, 124:1-11]

Cited: 13 times

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