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Fine manipulation of terahertz waves via all-silicon metasurfaces with an independent amplitude and phase.

Chenglong Zheng, Jie Li, Guocui Wang, Silei Wang, Jitao Li, Hongliang Zhao, Huaping Zang, Yan Zhang, Yating Zhang, Jianquan Yao,

Integrating independent wavefront controls into one device can meet the increasing demand for high-capacity flat electromagnetic devices. Simultaneously and independently controlling the amplitude and phase is pivotal for completely manipulating the propagation of electromagnetic waves. Here, we propose several all-silicon metasurfaces to achieve multifunctional designs and simultaneous modulation of amplitude ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(11):5809-5816]

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Superior reducing carbon dots from proanthocyanidin for free-radical scavenging and for cell imaging.

Dian Yang, Li Li, Lei Cao, Yan Zhang, Mingfeng Ge, Ruhong Yan, Wen-Fei Dong,

The presence of excessive ROS can cause much harm to the human body and can even cause diseases. Therefore, it is important to detect and remove ROS, but there is no ideal method available for this at present. In this research, using procyanidins, a type of plant extract with strong ... Read more >>

Analyst (The Analyst)
[2021, 146(7):2330-2338]

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Integration of single-molecule detection with endonuclease IV-assisted signal amplification for sensitive DNA methylation assay.

Yan Zhang, Jinping Hu, Xiaoran Zou, Fei Ma, Jian-Ge Qiu, Chun-Yang Zhang,

We demonstrate the development of a new fluorescent biosensor for sensitive DNA methylation assay by integrating single-molecule detection with endo IV-assisted signal amplification. This biosensor possesses the characteristics of good selectivity and high sensitivity with a detection limit of 7.3 × 10<sup>-17</sup> M. It can distinguish as low as 0.01% ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(16):2073-2076]

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Orange emissive carbon nanodots for fluorescent and colorimetric bimodal discrimination of Cu2+ and pH.

Lihong Shi, Yuejing Bao, Yan Zhang, Caihong Zhang, Guomei Zhang, Chuan Dong, Shaomin Shuang,

We have facilely synthesized orange emissive carbon nanodots (O-CDs) via a hydrothermal method using citric acid and 5-aminosalicylic acid. The obtained O-CDs show the excellent characteristics of excitation independence, low toxicity, fabulous photostability and superior biocompatibility. Based on these captivating properties, as-prepared O-CDs have been successfully implemented as a multi-functional ... Read more >>

Analyst (The Analyst)
[2021, 146(6):1907-1914]

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Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells.

Yan Zhang, Qin Wang, Luolan Li, Yi Le, Li Liu, Jing Yang, Yongliang Li, Guochen Bao, Longjia Yan,

In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects against wild type epidermal growth factor receptor tyrosine kinase (EGFR<sup>wt</sup>-TK) and tumour cells (A431, A549, MCF-7, and NCI-H1975). In particular, compound <b>4d</b> 3-fluoro-<i>N</i>-(4-((3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)methoxy)phenyl)benzamide ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1205-1216]

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The lipoprotein NlpD in Cronobacter sakazakii responds to acid stress and regulates macrophage resistance and virulence by maintaining membrane integrity.

Xuemeng Ji, Ping Lu, Juan Xue, Ning Zhao, Yan Zhang, Lu Dong, Xuejiao Zhang, Ping Li, Yaozhong Hu, Jin Wang, Bowei Zhang, Jingmin Liu, Huan Lv, Shuo Wang,

<i>Cronobacter sakazakii</i>, an emerging opportunistic pathogen, is implicated in severe foodborne outbreak infections in premature and full-term infants. Generally, acid tolerance is vital for the pathogenesis of foodborne pathogens; however, its role in <i>C. sakazakii</i> virulence remains largely unknown. To screen out acid-tolerance determinants from transposon mutants, anovel counterselection method ... Read more >>

Virulence (Virulence)
[2021, 12(1):415-429]

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Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages.

Yanchun Wang, Xia Fan, Lin Du, Boyu Liu, Haihan Xiao, Yan Zhang, Yunqiang Wu, Fuli Liu, Yung-Fu Chang, Xiaokui Guo, Ping He,

Leptospirosis, caused by pathogenic <i>Leptospira</i> species, has emerged as a widespread zoonotic disease worldwide. Macrophages mediate the elimination of pathogens through phagocytosis and cytokine production. Scavenger receptor A1 (SR-A1), one of the critical receptors mediating this process, plays a complicated role in innate immunity. However, the role of SR-A1 in ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):939-953]

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First-principles theoretical study on dry reforming of methane over perfect and boron-vacancy-containing h-BN sheet-supported Ni catalysts.

Yan Zhang, Yi-Fan Yao, Yuan-Yuan Qiao, Gui-Chang Wang,

The entire reaction mechanism of the dry reforming of methane (DRM) as well as the competition processes over perfect and boron-vacancy-containing h-BN sheet-supported Ni-catalysts (labeled Ni2/h-BN and Ni2/h-BN-B-D) was studied by density functional theory calculations in the present work. Our calculation results show that B-defected h-BN strongly binds to the ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2021, 23(1):617-627]

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A spiropyran functionalized fluorescent probe for mitochondria targeting and imaging of endogenous hydrogen sulfide in living cells.

Qiaoling Liu, Ying Zhao, Yan Zhang, Kaixin Xie, Ruirong Liu, Borong Ren, Yanmei Yan, Lin Li,

A turn-on spiropyran functionalized fluorescein derivative (FMC) is developed for targeting HS- in mitochondria. FMC exhibits very weak fluorescence at 525 nm under the excitation of 470 nm in aqueous solution due to its colorless spiropyran form; upon addition of HS-, a strong fluorescence enhancement by 6.4-fold is observed with ... Read more >>

Analyst (The Analyst)
[2021, 145(24):8016-8021]

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Conformational dynamics is critical for the allosteric inhibition of cGAS upon acetyl-mimic mutations.

Jingjing Guo, Mengrong Li, Yan Zhang, Lili Xi, Fengling Cui,

Detection of cytosolic dsDNA by cyclic GMP-AMP synthase (cGAS) is critical for the immune system to sense and fight against infection, but chronic activation of cGAS by self-DNA leads to autoimmune diseases without effective treatment yet. It was found that acetylation on either Lys384, Lys394, or Lys414 could inhibit the ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2021, 23(3):2154-2165]

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Early-life supplementation of grape polyphenol extract promotes polyphenol absorption and modulates the intestinal microbiota in association with the increase in mRNA expression of the key intestinal barrier genes.

Feng Lu, Yuanyuan Li, Bing Zhou, Qing Guo, Yan Zhang,

Early-life nutritional supplementation can dramatically influence health status. Dietary polyphenols are a widespread group of phytochemicals with potential bioactive functions. However, how polyphenol intake during early life affects health status remains largely unknown. Mice aged 3- and 6-weeks were used to investigate how grape polyphenol extract (GPE) administration during early ... Read more >>

Food Funct (Food & function)
[2021, 12(2):602-613]

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Lactobacillus rhamnosus GG alleviates β-conglycinin-induced allergy by regulating the T cell receptor signaling pathway.

Xiaoxu Chen, Xiuli Zhao, Yaozhong Hu, Bowei Zhang, Yan Zhang, Shuo Wang,

Currently, the need for safe and effective methods for relieving allergies is an important concern. In this study, we evaluated the role of Lactobacillus rhamnosus GG (LGG) in alleviating β-conglycinin (β-CG)-induced allergies and elucidated the related molecular mechanisms. Typical allergy symptoms and inflammatory factors in the serum showed that LGG ... Read more >>

Food Funct (Food & function)
[2020, 11(12):10554-10567]

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Comparison of protein hydrolysates against their native counterparts in terms of structural and antioxidant properties, and when used as emulsifiers for curcumin nanoemulsions.

Hua Jin, Chang Liu, Shenyi Zhang, Zhuanzhuan Guo, Jishu Li, Qingshan Zhao, Yan Zhang, Jing Xu,

This study investigated the stability and the in vitro digestion of curcumin nanoemulsions stabilized by three protein hydrolysates: peanut protein isolate (PPI), soybean protein isolate (SPI) and whey protein isolate (WPI). After enzymatic hydrolysis, the protein structure became more disordered, and increased antioxidant capacity was also observed for protein hydrolysates. ... Read more >>

Food Funct (Food & function)
[2020, 11(11):10205-10218]

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High expression of FABP4 in colorectal cancer and its clinical significance.

Yan Zhang, Wenjia Zhang, Min Xia, Zhujun Xie, Fangmei An, Qiang Zhan, Wenying Tian, Tianyue Zhu,

<h4>Objectives</h4>To investigate the relationship between the fatty acid-binding protein 4 (FABP4) and colorectal cancer (CRC).<h4>Methods</h4>Using an enzyme-linked immunosorbent assay (ELISA), we measured the expression of FABP4 in plasma of 50 patients who underwent surgery for CRC from October 2017 to May 2018 and 50 healthy controls. The content of the ... Read more >>

J Zhejiang Univ Sci B (Journal of Zhejiang University. Science. B)
[2021, 22(2):136-145]

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Sex modification of the association of the radial augmentation index and incident hypertension in a Chinese community-based population.

Qiao Qin, Fang-Fang Fan, Meng-Yuan Liu, Bo Liu, Jia Jia, Long Zhang, Yu-Xi Li, Yi-Meng Jiang, Peng-Fei Sun, Dan-Mei He, Jian-Ping Li, Ming Chen, Bo Zheng, Yan Zhang,

<h4>Background</h4>Arterial stiffness, as assessed by aortic ultrasound and pulse wave velocity, is associated with incident hypertension. However, there is still no consensus on whether the augmentation index (AI) affects new onset of hypertension. This study investigated the relationship of radial AI (rAI) and incident hypertension in a Chinese community-based population ... Read more >>

J Geriatr Cardiol (Journal of geriatric cardiology : JGC)
[2021, 18(1):39-46]

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Development of a bidirectional isothermal amplification strategy for the sensitive detection of transcription factors in cancer cells.

Yan Zhang, Qing-Nan Li, Dong-Xue Xiang, Kaiyue Zhou, Qinfeng Xu, Chun-Yang Zhang,

We developed a new strategy to sensitively detect transcription factors (TFs) based on the integration of a bidirectional isothermal exponential amplification reaction (EXPAR) with endonuclease IV (endo IV)-assisted cycle digestion of signal probes. This assay exhibits ultrahigh sensitivity with a detection limit of 1.29 × 10<sup>-14</sup> M, and it can ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(63):8952-8955]

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Transparent and Hard Siloxane Based Hybrid UV-Curable Coating Materials with Amphiphobic Properties.

Keuk-Min Jeong, Sung Soo Park, Saravanan Nagappan, Heekyung Jin, Guoquan Min, Yongxu Zhang, Minming Qu, Yan Zhang, Chang-Sik Ha,

In this study, highly transparent siloxane-based hybrid UV-curable coating materials were prepared using (acryloxypropyl)methylsiloxane monomer (APMS), a thiol-ene monomer, with benzoin ethyl ether. For the thiol-ene monomer, either pentaerythritol tetrakis(3-mercaptopropionate) (PETTMP) or trimethylolpropane tris(3-mercaptopropionate) (TMPTMP) was used. The siloxane-based hybrid coating materials were highly transparent and hard (pencil hardness of ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(8):4450-4456]

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An unprecedented polyhydroxycarboxylic acid ligand bridged multi-EuIII incorporated tellurotungstate and its luminescence properties.

Yan Zhang, Dan Wang, Baoxing Zeng, Lijuan Chen, Junwei Zhao, Guo-Yu Yang,

The first polyhydroxycarboxylic acid ligand bridged multi-EuIII-incorporated tellurotungstate K14H10[Eu4(H2O)4W6(H2glu)4O12(B-α-TeW9O33)4]·60H2O (H6glu = d-gluconic acid) (1) was synthesized via an organic ligand-driven self-assembly strategy. The polyhydroxycarboxylic acid ligand bridged tetrameric polyoxoanion [Eu4(H2O)4W6(H2glu)4O12(B-α-TeW9O33)4]24- in 1 can be viewed as an aggregation of four trivacant Keggin [B-α-TeW9O33]8- fragments and an innovative heterometallic [Eu4(H2O)4W6(H2glu)4O12]8+ cluster, ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2020, 49(26):8933-8948]

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Driving force to detect Alzheimer's disease biomarkers: application of a thioflavine [email protected] ratiometric fluorescent sensor for smart detection of presenilin 1, amyloid β-protein and acetylcholine.

Xing Ze Wang, Jing Du, Nan Nan Xiao, Yan Zhang, Ling Fei, Jed D LaCoste, Zhuo Huang, Qian Wang, Xin Rui Wang, Bin Ding,

Currently, the highly sensitive detection of Alzheimer's Disease (AD) biomarkers, namely presenilin 1, amyloid β-protein (Aβ), and acetylcholine (ACh), is vital to helping us prevent and diagnose AD. In this work, a novel metal-organic framework [Er(L)(DMF)<sub>1.27</sub>]<sub>n</sub> (Er-MOF) (H<sub>3</sub>L = terphenyl-3,4'',5-tricarboxylic acid) has been synthesized by solvothermal and ultrasonic methods. Further, ... Read more >>

Analyst (The Analyst)
[2020, 145(13):4646-4663]

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CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

Zeyu Su, Yujia Li, Hang Lv, Xiaoyang Cui, Min Liu, Ziying Wang, Yan Zhang, Junhui Zhen, Wei Tang, Xiaojie Wang, Fan Yi,

Podocyte injury is a major determinant of focal segmental glomerular sclerosis (FSGS) and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance for the treatment of FSGS. CLEC14A is a single-pass transmembrane glycoprotein belonging to the vascular expressed C-type lectin family. CLEC14A is found to be ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21711]

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Multi-praseodymium-and-tungsten bridging octameric tellurotungstate and its 2D honeycomb composite film for detecting estrogen.

Yan Zhang, Jun Jiang, Yifan Liu, Pan Li, Yong Liu, Lijuan Chen, Junwei Zhao,

Under coordination driving force of tungsten and rare-earth (RE) bridges, we synthesized a novel giant multi-tungsten-and-RE-bridging octameric tellurotungstate (TT) [H<sub>2</sub>N(CH<sub>3</sub>)<sub>2</sub>]<sub>16</sub>K<sub>8</sub>Na<sub>6</sub>H<sub>10</sub>[Pr<sub>8</sub>(H<sub>2</sub>O)<sub>20</sub>W<sub>16</sub>O<sub>48</sub>][B-α-TeW<sub>9</sub>O<sub>33</sub>]<sub>8</sub>·70H<sub>2</sub>O (1) in CH<sub>3</sub>CN-H<sub>2</sub>O mixed solvent. The cluster anion {[Pr<sub>8</sub>(H<sub>2</sub>O)<sub>20</sub>W<sub>16</sub>O<sub>48</sub>][B-α-TeW<sub>9</sub>O<sub>33</sub>]<sub>8</sub>}<sup>40-</sup> features sixteen W<sup>VI</sup> bridges, eight Pr<sup>III</sup> bridges and eight trivacant Keggin [B-α-TeW<sub>9</sub>O<sub>33</sub>]<sup>8-</sup> fragments, which the square {W<sub>4</sub>O<sub>12</sub>} cluster can be imagined ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(19):10842-10853]

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The differential magnetic relaxation behaviours of slightly distorted triangular dodecahedral dysprosium analogues in a type of cyano-bridged 3d-4f zig-zag chain compounds.

An-Qi Xue, Yang-Yu Liu, Jia-Xin Li, Yan Zhang, Yin-Shan Meng, Wen-Hua Zhu, Yi-Quan Zhang, Hao-Ling Sun, Fei Wang, Guan-Xia Qiu, Lu-Yu Liang, Xiang Wang, Song Gao,

A class of cyano-bridged 3d-4f zig-zag chain compounds, {RE[TM(CN)6] (PNO)2(H2O)4}·(H2O) {RE = YIII, TM = [FeIII]LS (1); RE = DyIII, TM = [FeIII]LS (2), CoIII (3)}, have been synthesized and characterized by single-crystal X-ray diffraction. The rare earth ions in these compounds are situated in a slightly distorted triangular dodecahedral ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2020, 49(20):6867-6875]

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Trends in the prevalence of hypertension according to severity and phenotype in Chinese adults over two decades (1991-2015).

Qian Yi, Mingming Zha, Qingwen Yang, Yan Zhang, Leying Hou, Xinxin Ye, Ge Chen, Jing Shao, Wei Xia, Peige Song,

Until recently, few studies have reported the secular trend and associated factors of hypertension severities and phenotypes in China. In this study, the authors aimed to assess the trend in the prevalence of hypertension according to severity and phenotype in Chinese adults from 1991 to 2015 and to explore potential ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2021, :]

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Correlation of Gut Microbiota with Efficacy of Chemotherapy in Patients with Diffuse Large B-cell Lymphoma

Li YUAN, Yan ZHANG, Wei ZHANG, Chong WEI, Wei WANG, Danqing ZHAO, Daobin ZHOU, Jingnan LI,

The composition and diversity of gut microbiota (GMB) have been reported to be associated with the occurrence and progression as well as treatment outcome in many diseases. Our previous study demonstrated that the GMB was changed significantly and Proteobacteria phylum was the dominant microbiota in untreated diffuse large B-cell lymphoma ... Read more >>

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Co-occurrence subgroups of child sexual abuse, health risk behaviors and their associations among secondary school students in China.

Yan Zhang, Xiayun Zuo, Yanyan Mao, Qiguo Lian, Shan Luo, Shucheng Zhang, Xiaowen Tu, Chaohua Lou, Weijin Zhou,

<h4>Background</h4>Little is known on the co-occurrence and heterogeneity of child sexual abuse (CSA) or health risk behavior (HRB) prevalence nor the associations among the victims.<h4>Objectives</h4>To detect the prevalence and subgroups of adolescents reporting CSAs or HRBs, and to examine the association between the subgroups.<h4>Methods</h4>Participants were secondary school students in a ... Read more >>

BMC Public Health (BMC public health)
[2021, 21(1):1139]

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