Full Text Journal Articles by
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Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis.

Jing-Zhou Li, Xiao-Xia Zhou, Wei-Yin Wu, Hai-Feng Qiang, Guo-Sheng Xiao, Yan Wang, Gang Li,

<h4>Context</h4>Concanavalin A (Con A) exhibited multiple roles in cancer cells. However, the role of Con A in endothelial cells was not reported.<h4>Objective</h4>Our present study investigated the potential angiogenic role of Con A in endothelial cells and ischaemic hind-limb mice.<h4>Materials and methods</h4>Human umbilical vein endothelial cells and Ea.hy926 cells were employed ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2022, 60(1):65-74]

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Circular RNA circ_0073181 contributes to tumorigenesis by regulating protein tyrosine phosphatase receptor type E via miR-548p in hepatocellular carcinoma.

Yan Wang, Hongxia Wang, Yanlin Jia, Xiyuan Wang, Chao Yang, Tongtong Xue,

Hepatocellular carcinoma (HCC) is a major world public problem in the world, with high morbidity and mortality rates. Circular RNA (circRNA) circ_0073181 has been reported to be related to HCC development. However, the mechanism of circ_0073181 in HCC is far from being addressed. Circ_0073181, microRNA-548p (miR-548p) and protein tyrosine phosphatase ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2022, 33(2):167-177]

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N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by competitively sponging miR-139-5p and activating the Wnt signaling pathway

Chengjie Lin, Yan Wang, Yihong Dong, Shihui Lai, Liang Wang, Xiang Zhang, Shangeng Weng,

<h4>Background: </h4> Pancreatic cancer (PC) is highly malignant. Chemotherapy is the main treatment strategy, especially for patients with advanced PC. However, chemoresistance has always been a frequently encountered bottleneck. Hence, there is an urgent need to enhance the sensitivity of PC to gemcitabine (GEM). Methods A patient-derived xenograft model ... Read more >>

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Knockdown of lncRNA HAGLR promotes Treg cell differentiation through increasing the RUNX3 level in dermatomyositis.

Wang Yan, Lulu Wang, Zhaoying Chen, Chengyao Gu, Caijing Chen, Xiaoxia Liu, Qin Ye,

Dermatomyositis (DM) is a systemic autoimmune disease. It's known that the number of regulatory T (Treg) cells was decreased in DM. Besides, Treg cells were increased after treatment in DM patients. Forkhead box P3 (Foxp3) is specifically expressed in Treg cells and Runt-related transcription factor (RUNX3) could regulate Foxp3 transcription. ... Read more >>

J Mol Histol (Journal of molecular histology)
[2022, :]

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Quasihexagonal Platinum Nanodendrites Decorated over CoS2 -N-Doped Reduced Graphene Oxide for Electro-Oxidation of C1-, C2-, and C3-Type Alcohols.

Natarajan Logeshwaran, Iyyappa Rajan Panneerselvam, Shanmugam Ramakrishnan, Ramasamy Santhosh Kumar, Ae Rhan Kim, Yan Wang, Dong Jin Yoo,

The development of efficient and highly durable materials for renewable energy conversion devices is crucial to the future of clean energy demand. Herein, cage-like quasihexagonal structured platinum nanodendrites decorated over the transition metal chalcogenide core (CoS<sub>2</sub> )-N-doped graphene oxide ([email protected]<sub>2</sub> -NrGO) through optimized shape engineering and structural control technology are ... Read more >>

Adv Sci (Weinh) (Advanced science (Weinheim, Baden-Wurttemberg, Germany))
[2022, :e2105344]

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B cell Receptor Signatures Associating with Strong and Poor SARS-CoV-2 Vaccine Response.

Ke Lin, Yawen Zhou, Jingwen Ai, Yan A Wang, Senxin Zhang, Chao Qiu, Chaoyang Lian, Bo Gao, Tingting Liu, Hongyu Wang, Haocheng Zhang, Yi Zhang, Zhangfan Fu, Dan Li, Ning Jiang, Jingxin Guo, Jing Wu, Yan O Wang, Shusen Song, Qiang Li, Yanan Yin, Jia Xia, Yingjie Xu, Leng-Siew Yeap, Xiaoqi Zheng, Ye Gu, Hongyan Liu, Wenhong Zhang, Fei-Long Meng,

Breakthrough infection of SARS-CoV-2 is a serious challenge, as increased cases of infections were documented in fully-vaccinated individuals. Recipients with poor antibody response are highly vulnerable to reinfection, whereas those with strong antibody response achieve sterilizing immunity. Thus far, biomarkers associated with levels of vaccine-elicited antibody response are still lacking. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2022, :1-43]

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Pseudomonas Tumuqiensis Sp. Nov., Isolated From Greenhouse Soil

Delong Kong, Qingqing Li, Yanzheng Zhou, Yan Wang, Xu Jiang, Zhiye Wang, Zhiyong Ruan,

A Gram-stain-negative, aerobic, rod-shaped and motile bacterium, named LAMW06 T , was isolated from greenhouse soil in Beijing, China. In the 16S rRNA gene sequence comparison, strain LAMW06 T had the highest similarity with Pseudomonas cuatrocienegasensis 1N T was 97.4%. Phylogenetic analysis base on the 16S rRNA and three housekeeping ... Read more >>

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Characterization and regulation mechanism analysis of ubiquitin-conjugating family genes in strawberry reveals a potential role in fruit ripening.

Mengyao Li, Liangxin Wang, Yiting Liu, Yuanxiu Lin, Yunting Zhang, Yu Long, Chuanying Luo, Yong Zhang, Qing Chen, Pinwen Chen, Yan Wang, Xiaorong Wang, Haoru Tang, Ya Luo,

<h4>Background</h4>E2 ubiquitin-conjugating (UBC) enzymes are an integral component of the ubiquitin proteasome system that play an important role in plant development, growth, and external stress responses. Several UBC genes have been identified in various plants. However, no studies exploring the functions of UBC genes in regulating fruit of strawberry have ... Read more >>

BMC Plant Biol (BMC plant biology)
[2022, 22(1):39]

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Longitudinal Assessment of Cardiac Outcomes of Multisystem Inflammatory Syndrome in Children Associated With COVID-19 Infections.

Daisuke Matsubara, Joyce Chang, Hunter L Kauffman, Yan Wang, Sumekala Nadaraj, Chandni Patel, Stephen M Paridon, Mark A Fogel, Michael D Quartermain, Anirban Banerjee,

Background In multisystem inflammatory syndrome in children, there is paucity of longitudinal data on cardiac outcomes. We analyzed cardiac outcomes 3 to 4 months after initial presentation using echocardiography and cardiac magnetic resonance imaging. Methods and Results We included 60 controls and 60 cases of multisystem inflammatory syndrome in children. Conventional ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2022, :e023251]

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RiboChat: a chat-style web interface for analysis and annotation of ribosome profiling data.

Mingzhe Xie, Ludong Yang, Gennong Chen, Yan Wang, Zhi Xie, Hongwei Wang,

The increasing volume of ribosome profiling (Ribo-seq) data, computational complexity of its data processing and operational handicap of related analytical procedures present a daunting set of informatics challenges. These impose a substantial barrier to researchers particularly with no or limited bioinformatics expertise in analyzing and decoding translation information from Ribo-seq ... Read more >>

Brief Bioinform (Briefings in bioinformatics)
[2022, :]

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Protective Ileostomy Increased the Incidence of Rectal Stenosis After Anterior Resection of Rectal Cancer

Hui Zhang, Shanshan Li, Xin Jin, Xian Wu, Zhiyuan Zhang, Lijun Shen, Juefeng Wan, Yan Wang, Yaqi Wang, Wang Yang, Menglong Zhou, Jing Zhang, Tao Lv, Yun Deng, Fan Xia, Zhen Zhang,

<h4>Background: </h4> In most of the views, rectal stenosis results from pelvic radiotherapy. However, patients without receiving radiotherapy also suffer stenosis. In this study, we evaluated the factors associated with rectal stenosis after anterior rectal resection (ARR). <h4>Methods: </h4>. We conducted a retrospective study with ARR patients who underwent neoadjuvant ... Read more >>

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Variation of mercury fractionation and speciation in municipal sewage treatment plant: effects of mercury on the atmosphere.

Yunpeng Li, Yan Wang, Ruhai Liu, Long Shao, Xiaoyu Liu, Kun Han, Peng Song,

The speciation of mercury in various processing units of sewage treatment in autumn and winter were studied to understand the conversion and fate of mercury. The results show that the average concentrations of total mercury (THg) in the influent were 130.5 ± 69.8 ng/L and 231.3 ± 107.2 ng/L in autumn and winter, respectively, and the ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2022, :]

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Genome-wide analysis of circular RNAs and validation of hsa_circ_0086354 as a promising biomarker for early diagnosis of cerebral palsy.

Yuanyuan Hu, Xuzhao Bian, Chao Wu, Yan Wang, Yang Wu, Xiaoqin Gu, Suyan Zhuo, Shiquan Sun,

Cerebral palsy (CP) is a spectrum of non-progressive motor disorders caused by brain injury during fetal or postnatal periods. Current diagnosis of CP mainly relies on neuroimaging and motor assessment. Here, we aimed to explore novel biomarkers for early diagnosis of CP. Blood plasma from five children with CP and ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2022, 15(1):13]

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C-Terminal Bacterial Immunoglobulin-like Domain of κ-Carrageenase Serves as a Multifunctional Module to Promote κ-Carrageenan Hydrolysis.

Mengdan Xing, Yan Wang, Yujuan Zhao, Zhe Chi, Zhenming Chi, Guanglei Liu,

κ-Carrageenase is an important component for κ-carrageenan oligosaccharide production. Generally, noncatalytic domains are appended to carbohydrate-active domains and potentiate catalytic activity. However, studies devoted to κ-carrageenase are relatively few. Here, a C-terminal bacterial immunoglobulin-like domain (Big_2) was identified in κ-carrageenase (PpCgk) from <i>Pseudoalteromonas porphyrae</i>. Biochemical characterization of native PpCgk and ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2022, :]

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Self-assembly and photoinduced fabrication of conductive nanographene wires on boron nitride.

Xiaoxi Zhang, Fabian Gärisch, Zongping Chen, Yunbin Hu, Zishu Wang, Yan Wang, Liming Xie, Jianing Chen, Juan Li, Johannes V Barth, Akimitsu Narita, Emil List-Kratochvil, Klaus Müllen, Carlos-Andres Palma,

Manufacturing molecule-based functional elements directly at device interfaces is a frontier in bottom-up materials engineering. A longstanding challenge in the field is the covalent stabilization of pre-assembled molecular architectures to afford nanodevice components. Here, we employ the controlled supramolecular self-assembly of anthracene derivatives on a hexagonal boron nitride sheet, to ... Read more >>

Nat Commun (Nature communications)
[2022, 13(1):442]

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Levels and health risk assessment of pesticides and metals in Lycium barbarum L. from different sources in Ningxia, China.

Yahong Zhang, Jiaqi Qin, Yan Wang, Tongning Zhou, Ningchuan Feng, Caihong Ma, Meilin Zhu,

The berries of Lycium barbarum L. (Goji) are widely used as a Chinese traditional herbal medicine and functional food because of their reported beneficial pharmacological effects. However, there are reports of Goji berries being contaminated by chemical residues that could pose a hazard to humans. In this study, samples of ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):561]

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Predictors of parenchymal hemorrhage after endovascular treatment in acute ischemic stroke: data from ANGEL-ACT Registry.

Dapeng Sun, Baixue Jia, Xu Tong, Peter Kan, Xiaochuan Huo, Anxin Wang, Raynald, Gaoting Ma, Ning Ma, Feng Gao, Dapeng Mo, Ligang Song, Xuan Sun, Lian Liu, Yiming Deng, Xiaoqing Li, Bo Wang, Gang Luo, Yongjun Wang, Zeguang Ren, Zhongrong Miao, ,

<h4>Background</h4>Parenchymal hemorrhage (PH) is a troublesome complication after endovascular treatment (EVT).<h4>Objective</h4>To investigate the incidence, independent predictors, and clinical impact of PH after EVT in patients with acute ischemic stroke (AIS) due to anterior circulation large vessel occlusion (LVO).<h4>Methods</h4>Subjects were selected from the ANGEL-ACT Registry. PH was diagnosed according to the ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2022, :]

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Quantifying the economic effects of ravulizumab versus eculizumab treatment in patients with atypical hemolytic uremic syndrome.

Adrian R Levy, Peter Chen, Karissa Johnston, Yan Wang, Evan Popoff, Ioannis Tomazos,

<h4>Aims</h4>This study compared the aggregate duration of treatment administration of approved eculizumab and ravulizumab treatment regimens and resultant productivity implications for patients with atypical hemolytic uremic syndrome (aHUS) and their caregivers.<h4>Methods</h4>The aggregate duration of treatment administration (which includes waiting time for medication preparation and time for infusion, recovery, and travel ... Read more >>

J Med Econ (Journal of medical economics)
[2022, :1-16]

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An Autofocus Algorithm Considering Wavelength Changes for Large Scale Microscopic Hyperspectral Pathological Imaging System.

Qing Zhang, Yan Wang, Qingli Li, Xiang Tao, Xiufeng Zhou, Yonghe Zhang, Gang Liu,

Microscopic hyperspectral imaging technology has been widely used to acquire pathological information of tissue sections. Autofocus is one of the most important steps in microscopic hyperspectral imaging systems to capture large scale or even whole slide images of pathological slides with high quality and high speed. However, there are quite ... Read more >>

J Biophotonics (Journal of biophotonics)
[2022, :e202100366]

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Biochemical Characteristics of Point Mutated Goat Lysosome Α- Mannosidase

yan wang, Jiangye Zhang, Haofei Xiong, Qinfan Li,

<h4>Background: </h4> Locoweeds are widely distributed all over the world. Goats and other herbivores often get poisoning if they eat a large number of locoweeds by mistake. Swainsonine (SW), the main toxin in locoweeds, can inhibit lysosomes α-Mannosidase (LAM) competitively in animal cells. The insufficient activity of lysosomes α-Mannosidase can ... Read more >>

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Circ_0044520 regulates the progression of laryngeal squamous cell carcinoma via the miR-338-3p/ROR2 axis.

Huijun Yang, Gang Yu, Yan Wang, Xing Guo,

<h4>Background</h4>Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Circular RNA_0044520 (circ_0044520) expression is increased in LSCC. However, the molecular mechanism of circ_0044520 remains unknown.<h4>Methods</h4>The expression of circ_0044520, microRNA-338-3p (miR-338-3p) and receptor tyrosine kinase-like orphan receptor 2 (ROR2) were detected by quantitative real-time ... Read more >>

Histol Histopathol (Histology and histopathology)
[2022, :18420]

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Multi-Modal MRI Image Synthesis via GAN With Multi-Scale Gate Mergence.

Bo Zhan, Di Li, Xi Wu, Jiliu Zhou, Yan Wang,

Multi-modal magnetic resonance imaging (MRI) plays a critical role in clinical diagnosis and treatment nowadays. Each modality of MRI presents its own specific anatomical features which serve as complementary information to other modalities and can provide rich diagnostic information. However, due to the limitations of time consuming and expensive cost, ... Read more >>

IEEE J Biomed Health Inform (IEEE journal of biomedical and health informatics)
[2022, 26(1):17-26]

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Electrostimulus-associated PD-L1 expression on cell membrane revealed by immune SERS nanoprobes.

Xiaozhang Qu, Dan Sun, Yuqi Cheng, Jiafeng Wang, Yan Wang, Weiqing Xu, Guohua Qi, Shuping Xu,

Programmed cell death ligand 1 (PD-L1) is considered a major immune checkpoint protein that mediates antitumor immune suppression and response. Effectively regulating PD-L1 expression and dynamic monitoring has become a significant challenge in immunotherapy. Herein, we adopted smart surface-enhanced Raman scattering (SERS) nanoprobes to discriminate and monitor the dynamic expression ... Read more >>

Analyst (The Analyst)
[2022, :]

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Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis.

Qiong Fang, Jing Liu, Lang Chen, Qiaobin Chen, Yan Wang, Zuanfang Li, Wei Fu, Ying Liu,

Taurine as an essential amino acid in the brain could play an important role in protecting the fetal brain of intrauterine growth restriction (IUGR). The hippocampus with IUGR showed neural metabolic disorder and structure changed that affected memory and learning ability. This study was aimed to identify the effect of ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2022, :]

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Attapulgite-doped electrospun PCL scaffolds for enhanced bone regeneration in rat cranium defects.

Ting Dai, Jiayi Ma, Su Ni, Chun Liu, Yan Wang, Siyu Wu, Jun Liu, Yiping Weng, Dong Zhou, Ana Jimenez-Franco, Hongbin Zhao, Xiubo Zhao,

Electrospun PCL scaffolds have been widely used for tissue engineering as they have shown great potential to mimic the structure of the natural extracellular matrix (ECM). However, the small pore size and low bioactivity of the scaffolds limit cell migration and tissue formation. In this study, PCL (polycaprolactone), PCL/PEG (polyethylene ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2022, :112656]

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