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Author Yan Ling Yang

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Drp1 is widely, yet heterogeneously, distributed in the mouse central nervous system

Ting-Ting Luo, Chun-Qiu Dai, Jia-Qi Wang, Zheng-Mei Wang, Yi Yang, Kun-Long Zhang, Fei-Fei Wu, Yan-Ling Yang, Ya-Yun Wang,

Abstract Objectives: Drp1 is widely expressed in the mouse central nervous system and plays a role in inducing the mitochondrial fission process. Many diseases are associated with Drp1 and mitochondria. However, since the exact distribution of Drp1 has not been specifically observed, it is difficult to determine the impact of ... Read more >>

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Upregulation of TRPC6 Mediated by PAX6 Hypomethylation Is Involved in the Mechanical Allodynia Induced by Chemotherapeutics in Dorsal Root Ganglion.

Xiang-Zhong Zhang, De-Xing Luo, Xiao-Hui Bai, Huan-Huan Ding, Meng Liu, Jie Deng, Jing-Wen Mai, Yan-Ling Yang, Su-Bo Zhang, Xiang-Cai Ruan, Xue-Qin Zhang, Wen-Jun Xin, Ting Xu,

BACKGROUND:Although the action mechanism of antineoplastic agents is different, oxaliplatin, paclitaxel, or bortezomib as first-line antineoplastic drugs can induce painful neuropathy. In rodents, mechanical allodynia is a common phenotype of painful neuropathy for 3 chemotherapeutics. However, whether there is a common molecular involved in the different chemotherapeutics-induced painful peripheral neuropathy ... Read more >>

Int. J. Neuropsychopharmacol. (The international journal of neuropsychopharmacology)
[2020, 23(4):257-267]

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Intensified nitrogen removal by heterotrophic nitrification aerobic denitrification bacteria in two pilot-scale tidal flow constructed wetlands: Influence of influent C/N ratios and tidal strategies.

Xu Tan, Yan-Ling Yang, Xing Li, Zhi-Wei Zhou, Chang-Jian Liu, Yong-Wang Liu, Wen-Chao Yin, Xiao-Yan Fan,

This study investigated the influence of C/N ratios and tidal strategies on nitrogen removal and bacterial communities in two pilot-scale tidal flow constructed wetlands (TFCWs) with simultaneous nitrification-denitrification process. Heterotrophic nitrification aerobic denitrification (HNAD) was the main nitrogen transformation pathway in both TFCWs. High C/N ratios and effluent circulation at ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2020, 302:122803]

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LncRNA GAS5 exacerbates renal tubular epithelial fibrosis by acting as a competing endogenous RNA of miR-96-5p.

Wei Wang, Yi-Jie Jia, Yan-Ling Yang, Meng Xue, Zong-Ji Zheng, Ling Wang, Yao-Ming Xue,

Renal fibrosis is at the core of various renal diseases, including diabetic kidney disease (DKD). Long noncoding RNAs (lncRNAs) are known players in the regulation of renal fibrosis. However, their expression and function in DKD still need to be elucidated. The purpose of this study was to assess how lncRNA ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 121:109411]

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[Effects of acetyl-L-carnitine on the recovery of hindlimb movement afterspinal cord injury in rats and its mechamism].

Juan Shen, Xue-Feng Zhang, Qin Hao, Lin Zhao, Yan-Ling Yang,

OBJECTIVE:To observe the effects of different doses of acetyl-L-carnitine (ALC) on hindlimb motor function and spinal cord tissue structure in rats with spinal cord injury. The study will provide theoretical and experimental evidences for acetyl-L-carnitine's clinical treatment. METHODS:Fifty-five SD rats aged 8-10 weeks were randomly divided into high, medium and ... Read more >>

Zhongguo Ying Yong Sheng Li Xue Za Zhi (Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology)
[2019, 35(5):438-442]

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Xylarichalasin A, a Halogenated Hexacyclic Cytochalasan from the Fungus Xylaria cf. curta.

Wen-Xuan Wang, Xinxiang Lei, Yan-Ling Yang, Zheng-Hui Li, Hong-Lian Ai, Jing Li, Tao Feng, Ji-Kai Liu,

A cytochalasan, xylarichalasin A, was obtained from the endophytic fungus Xylaria cf. curta harbored in Solanum tuberosum. Its structure was elucidated by comprehensive spectroscopic methods including HRESIMS, 1D/2D NMR, and residual dipolar coupling analysis as well as quantum chemistry calculations including DFT GIAO 13C NMR and ECD calculation. It has ... Read more >>

Org. Lett. (Organic letters)
[2019, 21(17):6957-6960]

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[Organic Matter Removal and Membrane Fouling Control of Secondary Effluents Using a Combined Nanofiltration Process].

Ke-Wen Fan, Xing Li, Yan-Ling Yang, Zhi-Wei Zhou,

For cities and various types of constructions, the recycling and reuse of wastewater can be an important and unconventional water source. However, water quality must meet relevant standards, especially with respect to organic matter. In this study, secondary effluents from a large sewage plant in a northern city in China ... Read more >>

Huan Jing Ke Xue (Huan jing ke xue= Huanjing kexue)
[2019, 40(8):3626-3632]

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Identification in Chinese patients with GLIALCAM mutations of megalencephalic leukoencephalopathy with subcortical cysts and brain pathological study on Glialcam knock-in mouse models.

Zhen Shi, Hui-Fang Yan, Bin-Bin Cao, Mang-Mang Guo, Han Xie, Kai Gao, Jiang-Xi Xiao, Yan-Ling Yang, Hui Xiong, Qiang Gu, Ming Li, Ye Wu, Yu-Wu Jiang, Jing-Min Wang,

BACKGROUND:Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare neurological degenerative disorder caused by the mutations of MLC1 or GLIALCAM with autosomal recessive or autosomal dominant inheritance and a different prognosis, characterized by macrocephaly, delayed motor and cognitive development, and bilateral abnormal signals in cerebral white matter (WM) with or ... Read more >>

World J Pediatr (World journal of pediatrics : WJP)
[2019, 15(5):454-464]

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Circulating Serum Myonectin Levels in Obesity and Type 2 Diabetes Mellitus.

Zhu Li, Yan-Ling Yang, Yan-Juan Zhu, Chen-Guang Li, Yun-Zhao Tang, Chang-Lin Ni, Li-Ming Chen, Wen-Yan Niu,

OBJECTIVE:Myonectin is one of the myokines and has gained interest as a potential new strategy to combat obesity and its associated disorders, such as type 2 diabetes mellitus (T2DM).The objective of this study was to investigate circulating serum myonectin levels in nondiabetes and T2DM and elucidate possible relationships between serum ... Read more >>

Exp. Clin. Endocrinol. Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2019, :]

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The Ntail region of nucleocapsid protein is associated with the pathogenicity of pigeon paramyxovirus type 1 in chickens.

Yang Song, Yu Pei, Yan-Ling Yang, Jia Xue, Guo-Zhong Zhang,

The nucleoprotein (NP) of pigeon paramyxovirus type 1 (PPMV-1) and other paramyxoviruses plays an important role in virus proliferation. A previous study found that NP is associated with the low pathogenicity of PPMV-1 strains in chickens. Here, we investigated which domain of NP is responsible for regulating the pathogenicity of ... Read more >>

J. Gen. Virol. (The Journal of general virology)
[2019, 100(6):950-957]

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[Reye syndrome and sudden death symptoms after oral administration of nimesulide due to upper respiratory tract infection in a boy].

Li-Fang Feng, Xiao-Hong Chen, Dong-Xiao Li, Xi-Yuan Li, Jin-Qing Song, Ying Jin, Yan-Ling Yang,

A boy aged 6 years and 3 months developed upper respiratory tract infection and pyrexia 2 months ago and was given oral administration of nimesulide by his parents according to directions. Half an hour later, the boy experienced convulsions and cardiopulmonary arrest, and emergency examination found hypoketotic hypoglycemia, metabolic acidosis, ... Read more >>

Zhongguo Dang Dai Er Ke Za Zhi (Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics)
[2018, 20(11):944-949]

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Identification of a Novel Gene Mutation in a Chinese Pedigree with X-linked Thrombocytopenia.

Jing-Wen Zhang, Yu-Xuan Luo, Yan-Ling Yang, Bing Long, Ying Lu, Xiang-Zhong Zhang,

BACKGROUND:X-linked thrombocytopenia (XLT) is a milder form of Wiskott-Aldrich syndrome (WAS), characterized predominantly by thrombocytopenia with small-sized platelets. Mutations in the WAS gene are responsible for the disease. We herein detected a new mutation in the WAS gene responsible for XLT in a 3-generation Chinese pedigree. METHODS:Peripheral blood samples were ... Read more >>

Clin. Lab. (Clinical laboratory)
[2018, 64(11):]

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Clinical, biochemical, and genetic analysis of the mitochondrial respiratory chain complex I deficiency.

Yan-Yan Ma, Xi-Yuan Li, Zhi-Qin Li, Ji-Qing Song, Jing Hou, Jian-Hua Li, Li Sun, Jun Jiang, Yan-Ling Yang,

Mitochondrial respiratory chain complex I deficiency is one of common mitochondrial disorders. However, the information is relatively little about the features of Chinese patients. In this study, the clinical, biological, and genetic analyses were performed in the children with respiratory chain complex I deficiency, in order to further understand the ... Read more >>

Medicine (Baltimore) (Medicine)
[2018, 97(32):e11606]

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Clinical, Biochemical, and Genetic Findings of Cystinuria in Chinese Children.

Yan-Yan Ma, Yu-Peng Liu, Dongxiao Li, Xi-Yuan Li, Jin-Qing Song, Yan-Ling Yang,

BACKGROUND:Cystinuria is a rare inherited renal stone disease caused by mutations in the SLC3A1 and SLC7A9 genes. The Chinese cystinuria phenotype and genotype have rarely been reported in the literature. METHODS:For this research, the clinical features and genetic etiology were analyzed in seven children, and the clinical characteristics were summarized. ... Read more >>

Clin. Lab. (Clinical laboratory)
[2018, 64(7):1145-1151]

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Busulfan, Fludarabine, and Cyclophosphamide (BFC) conditioning allowed stable engraftment after haplo-identical allogeneic stem cell transplantation in children with adrenoleukodystrophy and mucopolysaccharidosis.

Yao Chen, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Feng-Rong Wang, Kai-Yan Liu, Jiong Qin, Yan-Ling Yang, Xiao-Jun Huang,

Bone Marrow Transplant. (Bone marrow transplantation)
[2018, 53(6):770-773]

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Strategic Combination of Isocratic and Gradient Elution for Simultaneous Separation of Polar Compounds in Traditional Chinese Medicines by HPLC.

Mei-Tuo Zhang, Xiao-Xue Ye, Wei Lan, Yan-Ling Yang, Tsunghsueh Wu, Yu-Sang Li, He-Bin Tang,

A simple high-performance liquid chromatography (HPLC) method for the simultaneous separation of the highly polar and weakly polar components of traditional Chinese medicines was developed via a strategic combination of isocratic and gradient elution methods. Liu-Shen-Wan and Liu-Wei-Di-Huang-Wan were used as representative examples of traditional Chinese medicines. This is the ... Read more >>

J Anal Methods Chem (Journal of analytical methods in chemistry)
[2018, 2018:7569283]

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Eight novel mutations of CBS gene in nine Chinese patients with classical homocystinuria.

Dong-Xiao Li, Xi-Yuan Li, Hui Dong, Yu-Peng Liu, Yuan Ding, Jin-Qing Song, Ying Jin, Yao Zhang, Qiao Wang, Yan-Ling Yang,

BACKGROUND:Classical homocystinuria (homocysteinemia type 1, MIM# 236200) is a rare inherited disorder in Mainland China. This study aimed to identify mutations in the cystathionine β-synthase (CBS) gene which are associated with classical homocystinuria in nine Chinese patients. METHODS:Nine Chinese patients were diagnosed at the age of 5 years 4 months to 18 years ... Read more >>

World J Pediatr (World journal of pediatrics : WJP)
[2018, 14(2):197-203]

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Toward a rational photocatalyst design: a new formation strategy of co-catalyst/semiconductor heterostructures via in situ exsolution.

Yi-Fei Sun, Yan-Ling Yang, Jian Chen, Meng Li, Ya-Qian Zhang, Jian-Hui Li, Bin Hua, Jing-Li Luo,

A new "post-growth" approach to implant metal sulfide nanodots (<5 nm) with high population and uniform dispersion into a semiconductor parent matrix was reported. The encapsulation modality of nanodot co-catalysts grants enhanced visible light absorption and photocatalytic performance, which provides another route for hetero-architecture materials design. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2018, 54(12):1505-1508]

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Dynamics of bridge-loop transformation in a membrane with mixed monolayer/bilayer structures.

Yan-Ling Yang, Min-Yi Chen, Heng-Kwong Tsao, Yu-Jane Sheng,

Instead of forming a typical bilayer or monolayer membrane, both the bridge (I-shape) and loop (U-shape) conformations coexist in the planar membranes formed by ABA triblock copolymers in a selective solvent. The non-equilibrium and equilibrium relaxation dynamics of polymer conformations are monitored. The non-equilibrium relaxation time depends on the initial ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2018, 20(9):6582-6590]

Cited: 2 times

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[Effects of curcumin on the recovery of hind limb function after spinal cord injury in rats and its mechamism].

Qin Hao, Hui-Wei Wang, Qian Yu, Juan Shen, Lin Zhao, Fang-Fang Shi, Mei-Mi Chen, Yan-Ling Yang,

OBJECTIVE:To investigate the effects of curcumin on motor function, and to explore the neuroprotective mechanism of curcumin after the spinal cord injury in rats. The study will theoretical and experimental evidence for curcumin's clinical treatment. METHODS:HI-0400 spinal cord impactor was used to prepare animal models of acute of spinal cord ... Read more >>

Zhongguo Ying Yong Sheng Li Xue Za Zhi (Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology)
[2017, 33(5):441-444]

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Antigenic variation of LaSota and genotype VII Newcastle disease virus (NDV) and their efficacy against challenge with velogenic NDV.

Hui-Ming Yang, Jing Zhao, Jia Xue, Yan-Ling Yang, Guo-Zhong Zhang,

Continued monitoring and evaluation of vaccine efficacy against prevalent or newly isolated strains has great importance in advising Newcastle disease (ND) immunization strategy. In this study, we systematically analysed the antigenic variation between genotype VII NDV aSG10 and the commercial vaccine strain LaSota, and assessed their efficacy against challenge with ... Read more >>

Vaccine (Vaccine)
[2017, 35(1):27-32]

Cited: 7 times

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Association between high levels of Notch3 expression and high invasion and poor overall survival rates in pancreatic ductal adenocarcinoma.

Jin-Xue Zhou, Liang Zhou, Qing-Jun Li, Wen Feng, Pei-Min Wang, Er-Feng Li, Wen-Jing Gong, Ming-Wen Kou, Wei-Ting Gou, Yan-Ling Yang,

Pancreatic ductal adenocarcinoma (PDAC) is a commonly fatal tumour. It is characterized by early metastasis and high mortality. Many patients die as a result of PDAC tumour progression. However, the underlying mechanism of invasion and metastasis in PDAC is still not fully understood. Previous studies showed that the Notch signalling ... Read more >>

Oncol. Rep. (Oncology reports)
[2016, 36(5):2893-2901]

Cited: 4 times

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p53 and mitochondrial dysfunction: novel insight of neurodegenerative diseases.

Chun-Qiu Dai, Ting-Ting Luo, Shi-Cheng Luo, Jia-Qi Wang, Sheng-Ming Wang, Yun-Hu Bai, Yan-Ling Yang, Ya-Yun Wang,

Mitochondria are organelles responsible for vital cell functions. p53 is a transcription factor that regulates the DNA stability and cell growth normality. Recent studies revealed that p53 can influence mitochondrial function changing from normal condition to abnormal condition under different stress levels. In normal state, p53 can maintain mitochondrial respiration ... Read more >>

J. Bioenerg. Biomembr. (Journal of bioenergetics and biomembranes)
[2016, 48(4):337-347]

Cited: 12 times

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[Complex heterogeneity phenotypes and genotypes of glutaric aciduria type 1].

Qiao Wang, Yan-Ling Yang,

Glutaric aciduria type 1 is a rare autosomal recessive disorder. GCDH gene mutations cause glutaryl-CoA dehydrogenase deficiency and accumulation of glutaric acid and 3-hydroxyglutaric acid, resulting in damage of striatum and other brain nucleus and neurodegeneration. Patients with glutaric aciduria type 1 present with complex heterogeneous phenotypes and genotypes. The ... Read more >>

Zhongguo Dang Dai Er Ke Za Zhi (Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics)
[2016, 18(5):460-465]

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[Limb torsion and developmental regression for one month after hand, foot and mouth disease in an infant].

Li-Fang Feng, Xiao-Hong Chen, Dong-Xiao Li, Yuan Ding, Ying Jin, Jin-Qing Song, Yan-Ling Yang,

A one-year-old girl visited the hospital due to limb torsion and developmental regression for one month after hand, foot and mouth disease. At the age of 11 months, she visited a local hospital due to fever for 5 days and skin rash with frequent convulsions for 2 days and was ... Read more >>

Zhongguo Dang Dai Er Ke Za Zhi (Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics)
[2016, 18(5):426-430]

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